Cases of foodborne doping are frequently reported in sports events and can cause severe consequences for athletes.The foodborne doping can be divided into natural endogenous and artifi cially added foods according to ...Cases of foodborne doping are frequently reported in sports events and can cause severe consequences for athletes.The foodborne doping can be divided into natural endogenous and artifi cially added foods according to the sources,including anabolic agents,stimulants,diuretics,β-blockers,β2 agonists and others.In order to control foodborne doping,chromatographic technique,immunoassay,nuclear magnetic resonance,biosensor technology,pyrolytic spectroscopy,comprehensive analysis and electrochemical analysis have usually used as analytical and inspection strategies.Meanwhile,the legislation of anti-doping,the improvement of testing standard and technology,and the prevention and control of food safety,as well as the improvement of risk perception of athletes are highly necessary for achieving the effective risk control and supervision of foodborne doping,which will be benefi cial for athletes,doctors and administrators to avoid the risks of foodborne doping test and reduce foodborne doping risks for the health of athletes.展开更多
With the Rio Olympics just a few months past,we remember the excitement,the incredible performances,and the controversies.As happens so often,the Olympic Games focus attention not only on athletic achievements but als...With the Rio Olympics just a few months past,we remember the excitement,the incredible performances,and the controversies.As happens so often,the Olympic Games focus attention not only on athletic achievements but also on how athletes may reach ever-increasing levels of performance.Doping,medical展开更多
本研究利用一步化学气相沉积技术制备了Sn_(x)Mo_(1−x)S_(2)/MoS_(2)横向异质结高性能二极管.通过选择性掺杂Sn原子到单层MoS_(2)的边缘,形成了与MoS_(2)相同晶格常数的Sn_(x)Mo_(1−x)S_(2).在边缘的Sn_(x)Mo_(1−x)S_(2)和内部的MoS_(2...本研究利用一步化学气相沉积技术制备了Sn_(x)Mo_(1−x)S_(2)/MoS_(2)横向异质结高性能二极管.通过选择性掺杂Sn原子到单层MoS_(2)的边缘,形成了与MoS_(2)相同晶格常数的Sn_(x)Mo_(1−x)S_(2).在边缘的Sn_(x)Mo_(1−x)S_(2)和内部的MoS_(2)上分别沉积铬/金电极,形成肖特基势垒,其中势垒高度不同导致载流子仅在一个方向上传输.通过控制掺杂浓度和栅极电压,可实现MoS_(2)和Sn_(x)Mo_(1−x)S_(2)之间费米能级的对齐调节,实现了可调整的整流比,最高达到104.令人印象深刻的是,该二极管还表现出优异的光伏特性,该器件在λ=400 nm处实现了40%的外量子效率值.此外,我们在无外部偏压条件下实现了自供电光电探测,该异质结二极管在400和650 nm波长处的响应率分别为0.12和0.16 A W^(-1).对应的探测率分别是4.9×10^(10)和6.4×10^(10)Jones.可调的掺杂浓度为进一步创造高效器件提供了可能.这种合成二维侧向二极管的策略丰富了异质结二极管的材料多样性,并为开发新型电子和光电器件提供了新的平台.展开更多
Screening and confirmation methods of the major urinary metabolite of finasteride–carboxy-finasteride for doping control purpose were developed.Liquid–liquid extraction was adopted for the sample preparation.Analyte...Screening and confirmation methods of the major urinary metabolite of finasteride–carboxy-finasteride for doping control purpose were developed.Liquid–liquid extraction was adopted for the sample preparation.Analytes were detected by positive electrospray ionization in single quadrupole and triple quadrupole mass spectrometer.In the screening method,selected ion monitoring(SIM)mode was used to monitor m/z 403 for carboxy-finasteride.In the confirmation method,product ion mode was used to monitor the precursor ion m/z 403.The limit of detection was below 2 ng/mL for the screening method.Good linearity was obtained in the range 10.0–500.0 ng/mL.The intra-run and inter-run precision calculated from quality control(QC)samples was less than 5.3%.The accuracy as determined from QC samples was within ±6.6%.The screening method was applied for the analysis of excretion samples,allowing the detection of carboxy-finasteride for up to 49 h in urine specimen collected after an oral administration of 5 mg of finasteride.展开更多
基金financially supported by the Donghu Xuezi Program from Wuhan Sports University in China to Wei Chenthe Key Special Project of Disciplinary Development, Hubei Superior Discipline Groups of Physical Education and Health Promotionthe Chutian Scholar Program and Innovative Start-Up Foundation from Wuhan Sports University to Ning Chen。
文摘Cases of foodborne doping are frequently reported in sports events and can cause severe consequences for athletes.The foodborne doping can be divided into natural endogenous and artifi cially added foods according to the sources,including anabolic agents,stimulants,diuretics,β-blockers,β2 agonists and others.In order to control foodborne doping,chromatographic technique,immunoassay,nuclear magnetic resonance,biosensor technology,pyrolytic spectroscopy,comprehensive analysis and electrochemical analysis have usually used as analytical and inspection strategies.Meanwhile,the legislation of anti-doping,the improvement of testing standard and technology,and the prevention and control of food safety,as well as the improvement of risk perception of athletes are highly necessary for achieving the effective risk control and supervision of foodborne doping,which will be benefi cial for athletes,doctors and administrators to avoid the risks of foodborne doping test and reduce foodborne doping risks for the health of athletes.
文摘With the Rio Olympics just a few months past,we remember the excitement,the incredible performances,and the controversies.As happens so often,the Olympic Games focus attention not only on athletic achievements but also on how athletes may reach ever-increasing levels of performance.Doping,medical
基金supported by the National Key R&D Program of China(2022YFA1505200,2018YFA0306900)the National Natural Science Foundation of China(21872114,92163103)the Fundamental Research Funds for the Central Universities(20720210009)。
文摘本研究利用一步化学气相沉积技术制备了Sn_(x)Mo_(1−x)S_(2)/MoS_(2)横向异质结高性能二极管.通过选择性掺杂Sn原子到单层MoS_(2)的边缘,形成了与MoS_(2)相同晶格常数的Sn_(x)Mo_(1−x)S_(2).在边缘的Sn_(x)Mo_(1−x)S_(2)和内部的MoS_(2)上分别沉积铬/金电极,形成肖特基势垒,其中势垒高度不同导致载流子仅在一个方向上传输.通过控制掺杂浓度和栅极电压,可实现MoS_(2)和Sn_(x)Mo_(1−x)S_(2)之间费米能级的对齐调节,实现了可调整的整流比,最高达到104.令人印象深刻的是,该二极管还表现出优异的光伏特性,该器件在λ=400 nm处实现了40%的外量子效率值.此外,我们在无外部偏压条件下实现了自供电光电探测,该异质结二极管在400和650 nm波长处的响应率分别为0.12和0.16 A W^(-1).对应的探测率分别是4.9×10^(10)和6.4×10^(10)Jones.可调的掺杂浓度为进一步创造高效器件提供了可能.这种合成二维侧向二极管的策略丰富了异质结二极管的材料多样性,并为开发新型电子和光电器件提供了新的平台.
文摘Screening and confirmation methods of the major urinary metabolite of finasteride–carboxy-finasteride for doping control purpose were developed.Liquid–liquid extraction was adopted for the sample preparation.Analytes were detected by positive electrospray ionization in single quadrupole and triple quadrupole mass spectrometer.In the screening method,selected ion monitoring(SIM)mode was used to monitor m/z 403 for carboxy-finasteride.In the confirmation method,product ion mode was used to monitor the precursor ion m/z 403.The limit of detection was below 2 ng/mL for the screening method.Good linearity was obtained in the range 10.0–500.0 ng/mL.The intra-run and inter-run precision calculated from quality control(QC)samples was less than 5.3%.The accuracy as determined from QC samples was within ±6.6%.The screening method was applied for the analysis of excretion samples,allowing the detection of carboxy-finasteride for up to 49 h in urine specimen collected after an oral administration of 5 mg of finasteride.
基金financially supported by the National Natural Science Foundation of China (51525202, 61635001, 52072117 and 21703059)the Key Program of the Hunan Provincial Science and Technology Department (2019XK2001)the International Science and Technology Innovation Cooperation Base of Hunan Province (2018WK4004)
