The Uranium-238 (<sup>238</sup>U), Thorium-232 (<sup>232</sup>Th) families and Potassium-40 (<sup>40</sup>K) are of terrestrial origin and contribute generally to an individual’s e...The Uranium-238 (<sup>238</sup>U), Thorium-232 (<sup>232</sup>Th) families and Potassium-40 (<sup>40</sup>K) are of terrestrial origin and contribute generally to an individual’s external exposure through our presence in this environment. They also contribute to the internal exposure through the ingestion of products and beverages such as water that are close to the earth. The aim of this work is to determine the committed effective dose or Total Indicative Dose (TID) due to gamma radioactivity of the borehole water from the Nord Riviera (NR) well field operated by the Côte d’Ivoire Water Distribution Company (SODECI) for the supply of drinking water to part of the population of Abidjan. In addition, the populations, with their habits, could use these borehole waters directly as drinking water. To this end, water samples from the seven (07) functional boreholes were collected and analyzed on a gamma spectrometry chain, equipped with an HPGe detector in the laboratory of the Radiation Protection Institute (RPI) of the GHANA Atomic Energy Commission (GAEC). The results of the specific activities of <sup>238</sup>U, <sup>232</sup>Th and <sup>40</sup>K obtained were transcribed into TID. As the natural radioactivity of the borehole water is high [1], the TIDs calculated from the activity results of the natural radionuclides<sup>238</sup>U, <sup>232</sup>Th, and <sup>40</sup>K vary for the seven boreholes from 0.150 to 0.166 mSv/yr with an average of 0.161 ± 0.034 mSv/yr. The TID of the control tower, where the borehole water is mixed and treated for household use, is equal to 0.136 ± 0.03 mSv/yr. The TIDs obtained are therefore all slightly greater than the WHO reference dose value of 0.1 mSv/yr. But all remain below the UNSCEAR reference dose of 0.29 mSv/yr.展开更多
Purpose: To quantitatively evaluate four different Proton SFUD PBS initial planning strategies for lung mobile tumor. Methods and Materials: A virtual lung patient’s four-dimensional computed tomography (4DCT) was ge...Purpose: To quantitatively evaluate four different Proton SFUD PBS initial planning strategies for lung mobile tumor. Methods and Materials: A virtual lung patient’s four-dimensional computed tomography (4DCT) was generated in this study. To avoid the uncertainties from target delineation and imaging artifacts, a sphere with diameter of 3 cm representing a rigid mobile target (GTV) was inserted into the right side of the lung. The target motion is set in superior-inferior (SI) direction from ?5 mm to 5 mm. Four SFUD planning strategies were used based on: 1) Maximum-In-tensity-Projection Image (MIP-CT);2) CT_average with ITV overridden to muscle density (CTavg_muscle);3) CT_average with ITV overridden to tumor density (CTavg_tumor);4) CT_average without any override density (CTavg_only). Dose distributions were recalculated on each individual phase and accumulated together to assess the “actual” treatment. To estimate the impact of proton range uncertainties, +/?3.5% CT calibration curve was applied to the 4DCT phase images. Results: Comparing initial plan to the dose accumulation: MIP-CT based GTV D98 degraded 2.42 Gy (60.10 Gy vs 57.68 Gy). Heart D1 increased 6.19 Gy (1.88 Gy vs 8.07 Gy);CTavg_tumor based GTV D98 degraded 0.34 Gy (60.07 Gy vs 59.73 Gy). Heart D1 increased 2.24 Gy (3.74 Gy vs 5.98 Gy);CTavg_muscle based initial GTV D98 degraded 0.31 Gy (60.4 Gy vs 60.19 Gy). Heart D1 increased 3.44 Gy (4.38 Gy vs 7.82 Gy);CTavg_only based Initial GTV D98 degraded 6.63 Gy (60.11 Gy vs 53.48 Gy). Heart D1 increased 0.30 Gy (2.69 Gy vs 2.96 Gy);in the presence of ±3.5% range uncertainties, CTavg_tumor based plan’s accumulated GTV D98 degraded to 57.99 Gy (+3.5%) 59.38 Gy (?3.5%), and CTavg_muscle based plan’s accumulated GTV D98 degraded to 59.37 Gy (+3.5%) 59.37 Gy (?3.5%). Conclusion: This study shows that CTavg_Tumor and CTavg_Muscle based planning strategies provide the most robust GTV coverage. However, clinicians need to be aware that the actual dose to OARs at distal end of target may increase. The study also indicates that the current SFUD PBS planning strategy might not be sufficient to compensate the CT calibration uncertainty.展开更多
This work investigated the absorbed dose to water rate under reference conditions in a Cyberknife VSI system using radiochromic films EBT3 and MD-V3 and three ionization chambers: an Exradin A12 and two FC65P Welh&...This work investigated the absorbed dose to water rate under reference conditions in a Cyberknife VSI system using radiochromic films EBT3 and MD-V3 and three ionization chambers: an Exradin A12 and two FC65P Welhöfer Scanditronix with different serial numbers. The correction factor,, was studied using a Varian iX linac and the Cyberknife system. The measurements in the Varian iX were performed in a 10 × 10 cm2 field, 10 cm depth in liquid water at 90 cm and 70 cm SSD and in a 5.4 × 5.4 cm2 field, 10 cm depth at 70 cm SSD to simulate the Cyberknife conditions. In the Cyberknife system, measurements were performed using ionization chambers and both film types at 70 cm SSD and 10 cm depth in its 6 cm diameter reference field. The results indicate that ?is independent of the dosimeters and the evaluation methods. Maximum differences of 0.22% - 0.55% (combined uncertainties of 1.22% - 1.98%, k = 1) are obtained on ?using Varian iX, whereas discrepancies of 2.08% - 2.09% (combined uncertainties of 1.87% - 2.13%, k = 1) are observed using the Cyberknife system. Given the agreement between detectors and the combined standard uncertainties, the data from Varian iX could be considered the most accurate and consequently a weighted average factor of 0.902 ± 0.006 could be used for the Cyberknife VSI system reference field. Within measurement uncertainties, the absorbed dose rate measured in the Cyberknife VSI system reference field was found to be independent of the dosimeters used. These results suggest that the absorbed dose measured at a point within a given field size should be the same, regardless the dosimeter used, if their dosimetric characteristics are well known. This highlighted the importance of performing dosimetry by controlling all parameters that could affect the dosimeter response. One can conclude that radiochromic film dosimetry can be considered as an appropriate alternative for measuring absorbed dose to water rate.展开更多
The purpose of this study was to grasp current potential problems of dose error in intensity-modulated proton therapy (IMPT) plans. We were interested in dose differences of the Varian Eclipse treatment planning syste...The purpose of this study was to grasp current potential problems of dose error in intensity-modulated proton therapy (IMPT) plans. We were interested in dose differences of the Varian Eclipse treatment planning system (TPS) and the fast dose calculation method (FDC) for single-field optimization (SFO) and multi-field optimization (MFO) IMPT plans. In addition, because some authors have reported dosimetric benefit of a proton arc therapy with ultimate multi-fields in recent years, we wanted to evaluate how the number of fields and beam angles affect the differences for IMPT plans. Therefore, for one brain cancer patient with a large heterogeneity, SFO and MFO IMPT plans with various multi-angle beams were planned by the TPS. Dose distributions for each IMPT plan were calculated by both the TPS’s conventional pencil beam algorithm and the FDC. The dosimetric parameters were compared between the two algorithms. The TPS overestimated 400 - 500 cGy (RBE) for minimum dose to the CTV relative to the dose calculated by the FDC. These differences indicate clinically relevant effect on clinical results. In addition, we observed that the maximum difference in dose calculated between the TPS and the FDC was about 900 cGy (RBE) for the right optic nerve, and this quantity also has a possibility to have a clinical effect. The major difference was not seen in calculations for SFO IMPT planning and those for MFO IMPT planning. Differences between the TPS and the FDC in SFO and MFO IMPT plans depend strongly on beam arrangement and the presence of a heterogeneous body. We advocate use of a Monte Carlo method in proton treatment planning to deliver the most precise proton dose in IMPT.展开更多
本文针对不同结构、尺寸的石墨烯场效应晶体管(graphene field effect transistors,GFET)开展了基于10 keV-X射线的总剂量效应研究.结果表明,随累积剂量的增大,不同结构GFET的狄拉克电压V_(Dirac)和载流子迁移率μ不断退化;相比于背栅型...本文针对不同结构、尺寸的石墨烯场效应晶体管(graphene field effect transistors,GFET)开展了基于10 keV-X射线的总剂量效应研究.结果表明,随累积剂量的增大,不同结构GFET的狄拉克电压V_(Dirac)和载流子迁移率μ不断退化;相比于背栅型GFET,顶栅型GFET的辐射损伤更加严重;尺寸对GFET器件的总剂量效应决定于器件结构;200μm×200μm尺寸的顶栅型GFET损伤最严重,而背栅型GFET是50μm×50μm尺寸的器件损伤最严重.研究表明:对于顶栅型GFET,辐照过程中在栅氧层中形成的氧化物陷阱电荷的积累是V_(Dirac)和μ降低的主要原因.背栅型GFET不仅受到辐射在栅氧化层中产生的陷阱电荷的影响,还受到石墨烯表面的氧吸附的影响.在此基础上,结合TCAD仿真工具实现了顶栅器件氧化层中辐射产生的氧化物陷阱电荷对器件辐射响应规律的仿真.相关研究结果对于石墨烯器件的抗辐照加固研究具有重大意义.展开更多
AIM:To study the peripheral dose(PD) from highenergy photon beams in radiotherapy using the metal oxide semiconductor field effect transistor(MOSFET) dose verification system.METHODS:The radiation dose absorbed by the...AIM:To study the peripheral dose(PD) from highenergy photon beams in radiotherapy using the metal oxide semiconductor field effect transistor(MOSFET) dose verification system.METHODS:The radiation dose absorbed by the MOSFET detector was calculated taking into account the manufacturer's Correction Factor,the Calibration Factor and the threshold voltage shift.PD measurements were carried out for three different field sizes(5 cm×5 cm,10 cm×10 cm and 15 cm×15 cm) and for various depths with the source to surface distance set at 100 cm.Dose measurements were realized on the central axis and then at distances(1 to 18 cm) parallel to the edge of the field,and were expressed as the percentage PD(% PD) with respect to the maximum dose(dmax).The accuracy of the results was evaluated with respect to a calibrated 0.3 cm3 ionization chamber.The reproducibility was expressed in terms of standard deviation(s) and coefficient of variation.RESULTS:% PD is higher near the phantom surface and drops to a minimum at the depth of dmax,and then tends to become constant with depth.Internal scatter radiation is the predominant source of PD and the depth dependence is determined by the attenuation of the primary photons.Closer to the field edge,where internal scatter from the phantom dominates,the % PD increases with depth because the ratio of the scatter to primary increases with depth.A few centimeters away from the field,where collimator scatter and leakage dominate,the % PD decreases with depth,due to attenuation by the water.The % PD decreases almost exponentially with the increase of distance from the field edge.The decrease of the % PD is more than 60% and can reach up to 90% as the measurement point departs from the edge of the field.For a given distance,the % PD is significantly higher for larger field sizes,due to the increase of the scattering volume.Finally,the measured PD obtained with MOSFET is higher than that obtained with an ionization chamber with percentage differences being from 0.6% to 34.0%.However,when normalized to the central dmax this difference is less than 1%.The MOSFET system,in the early stage of its life,has a dose measurement reproducibility of within 1.8%,2.7%,8.9% and 13.6% for 22.8,11.3,3.5 and 1.3 cGy dose assessments,respectively.In the late stage of MOSFET life the corresponding values change to 1.5%,4.8%,11.1% and 29.9% for 21.8,2.9,1.6 and 1.0 cGy,respectively.CONCLUSION: Comparative results acquired with the MOSFET and with an ionization chamber show fair agreement, supporting the suitability of this measurement for clinical in vivo dosimetry.展开更多
A formula describing the percentage depth dose curve for <sup>60</sup>Co γ beams is theoretically developed. The formula only needs a few data determined by measuring directly in water phantom and can be ...A formula describing the percentage depth dose curve for <sup>60</sup>Co γ beams is theoretically developed. The formula only needs a few data determined by measuring directly in water phantom and can be used to calculate the whole set of percentage depth dose (PDD) and tissuse air ratios (TAR) for the wide range of SSD (from 20cm to 100cm), field size (from 4cm×4cm to 20cm×20cm) and depth (from d<sub>m</sub> to 30cm). The data calculated by the formula fits very well to the data currently used in clinics with the maximum error less than 1% and probable error of about 0.1%-0.3%. Using this formula can overcome the time-exhausting work in measurement of PDD and TAR.展开更多
文摘The Uranium-238 (<sup>238</sup>U), Thorium-232 (<sup>232</sup>Th) families and Potassium-40 (<sup>40</sup>K) are of terrestrial origin and contribute generally to an individual’s external exposure through our presence in this environment. They also contribute to the internal exposure through the ingestion of products and beverages such as water that are close to the earth. The aim of this work is to determine the committed effective dose or Total Indicative Dose (TID) due to gamma radioactivity of the borehole water from the Nord Riviera (NR) well field operated by the Côte d’Ivoire Water Distribution Company (SODECI) for the supply of drinking water to part of the population of Abidjan. In addition, the populations, with their habits, could use these borehole waters directly as drinking water. To this end, water samples from the seven (07) functional boreholes were collected and analyzed on a gamma spectrometry chain, equipped with an HPGe detector in the laboratory of the Radiation Protection Institute (RPI) of the GHANA Atomic Energy Commission (GAEC). The results of the specific activities of <sup>238</sup>U, <sup>232</sup>Th and <sup>40</sup>K obtained were transcribed into TID. As the natural radioactivity of the borehole water is high [1], the TIDs calculated from the activity results of the natural radionuclides<sup>238</sup>U, <sup>232</sup>Th, and <sup>40</sup>K vary for the seven boreholes from 0.150 to 0.166 mSv/yr with an average of 0.161 ± 0.034 mSv/yr. The TID of the control tower, where the borehole water is mixed and treated for household use, is equal to 0.136 ± 0.03 mSv/yr. The TIDs obtained are therefore all slightly greater than the WHO reference dose value of 0.1 mSv/yr. But all remain below the UNSCEAR reference dose of 0.29 mSv/yr.
文摘Purpose: To quantitatively evaluate four different Proton SFUD PBS initial planning strategies for lung mobile tumor. Methods and Materials: A virtual lung patient’s four-dimensional computed tomography (4DCT) was generated in this study. To avoid the uncertainties from target delineation and imaging artifacts, a sphere with diameter of 3 cm representing a rigid mobile target (GTV) was inserted into the right side of the lung. The target motion is set in superior-inferior (SI) direction from ?5 mm to 5 mm. Four SFUD planning strategies were used based on: 1) Maximum-In-tensity-Projection Image (MIP-CT);2) CT_average with ITV overridden to muscle density (CTavg_muscle);3) CT_average with ITV overridden to tumor density (CTavg_tumor);4) CT_average without any override density (CTavg_only). Dose distributions were recalculated on each individual phase and accumulated together to assess the “actual” treatment. To estimate the impact of proton range uncertainties, +/?3.5% CT calibration curve was applied to the 4DCT phase images. Results: Comparing initial plan to the dose accumulation: MIP-CT based GTV D98 degraded 2.42 Gy (60.10 Gy vs 57.68 Gy). Heart D1 increased 6.19 Gy (1.88 Gy vs 8.07 Gy);CTavg_tumor based GTV D98 degraded 0.34 Gy (60.07 Gy vs 59.73 Gy). Heart D1 increased 2.24 Gy (3.74 Gy vs 5.98 Gy);CTavg_muscle based initial GTV D98 degraded 0.31 Gy (60.4 Gy vs 60.19 Gy). Heart D1 increased 3.44 Gy (4.38 Gy vs 7.82 Gy);CTavg_only based Initial GTV D98 degraded 6.63 Gy (60.11 Gy vs 53.48 Gy). Heart D1 increased 0.30 Gy (2.69 Gy vs 2.96 Gy);in the presence of ±3.5% range uncertainties, CTavg_tumor based plan’s accumulated GTV D98 degraded to 57.99 Gy (+3.5%) 59.38 Gy (?3.5%), and CTavg_muscle based plan’s accumulated GTV D98 degraded to 59.37 Gy (+3.5%) 59.37 Gy (?3.5%). Conclusion: This study shows that CTavg_Tumor and CTavg_Muscle based planning strategies provide the most robust GTV coverage. However, clinicians need to be aware that the actual dose to OARs at distal end of target may increase. The study also indicates that the current SFUD PBS planning strategy might not be sufficient to compensate the CT calibration uncertainty.
文摘This work investigated the absorbed dose to water rate under reference conditions in a Cyberknife VSI system using radiochromic films EBT3 and MD-V3 and three ionization chambers: an Exradin A12 and two FC65P Welhöfer Scanditronix with different serial numbers. The correction factor,, was studied using a Varian iX linac and the Cyberknife system. The measurements in the Varian iX were performed in a 10 × 10 cm2 field, 10 cm depth in liquid water at 90 cm and 70 cm SSD and in a 5.4 × 5.4 cm2 field, 10 cm depth at 70 cm SSD to simulate the Cyberknife conditions. In the Cyberknife system, measurements were performed using ionization chambers and both film types at 70 cm SSD and 10 cm depth in its 6 cm diameter reference field. The results indicate that ?is independent of the dosimeters and the evaluation methods. Maximum differences of 0.22% - 0.55% (combined uncertainties of 1.22% - 1.98%, k = 1) are obtained on ?using Varian iX, whereas discrepancies of 2.08% - 2.09% (combined uncertainties of 1.87% - 2.13%, k = 1) are observed using the Cyberknife system. Given the agreement between detectors and the combined standard uncertainties, the data from Varian iX could be considered the most accurate and consequently a weighted average factor of 0.902 ± 0.006 could be used for the Cyberknife VSI system reference field. Within measurement uncertainties, the absorbed dose rate measured in the Cyberknife VSI system reference field was found to be independent of the dosimeters used. These results suggest that the absorbed dose measured at a point within a given field size should be the same, regardless the dosimeter used, if their dosimetric characteristics are well known. This highlighted the importance of performing dosimetry by controlling all parameters that could affect the dosimeter response. One can conclude that radiochromic film dosimetry can be considered as an appropriate alternative for measuring absorbed dose to water rate.
文摘The purpose of this study was to grasp current potential problems of dose error in intensity-modulated proton therapy (IMPT) plans. We were interested in dose differences of the Varian Eclipse treatment planning system (TPS) and the fast dose calculation method (FDC) for single-field optimization (SFO) and multi-field optimization (MFO) IMPT plans. In addition, because some authors have reported dosimetric benefit of a proton arc therapy with ultimate multi-fields in recent years, we wanted to evaluate how the number of fields and beam angles affect the differences for IMPT plans. Therefore, for one brain cancer patient with a large heterogeneity, SFO and MFO IMPT plans with various multi-angle beams were planned by the TPS. Dose distributions for each IMPT plan were calculated by both the TPS’s conventional pencil beam algorithm and the FDC. The dosimetric parameters were compared between the two algorithms. The TPS overestimated 400 - 500 cGy (RBE) for minimum dose to the CTV relative to the dose calculated by the FDC. These differences indicate clinically relevant effect on clinical results. In addition, we observed that the maximum difference in dose calculated between the TPS and the FDC was about 900 cGy (RBE) for the right optic nerve, and this quantity also has a possibility to have a clinical effect. The major difference was not seen in calculations for SFO IMPT planning and those for MFO IMPT planning. Differences between the TPS and the FDC in SFO and MFO IMPT plans depend strongly on beam arrangement and the presence of a heterogeneous body. We advocate use of a Monte Carlo method in proton treatment planning to deliver the most precise proton dose in IMPT.
文摘本文针对不同结构、尺寸的石墨烯场效应晶体管(graphene field effect transistors,GFET)开展了基于10 keV-X射线的总剂量效应研究.结果表明,随累积剂量的增大,不同结构GFET的狄拉克电压V_(Dirac)和载流子迁移率μ不断退化;相比于背栅型GFET,顶栅型GFET的辐射损伤更加严重;尺寸对GFET器件的总剂量效应决定于器件结构;200μm×200μm尺寸的顶栅型GFET损伤最严重,而背栅型GFET是50μm×50μm尺寸的器件损伤最严重.研究表明:对于顶栅型GFET,辐照过程中在栅氧层中形成的氧化物陷阱电荷的积累是V_(Dirac)和μ降低的主要原因.背栅型GFET不仅受到辐射在栅氧化层中产生的陷阱电荷的影响,还受到石墨烯表面的氧吸附的影响.在此基础上,结合TCAD仿真工具实现了顶栅器件氧化层中辐射产生的氧化物陷阱电荷对器件辐射响应规律的仿真.相关研究结果对于石墨烯器件的抗辐照加固研究具有重大意义.
基金Supported by The Greek Central Council of Health (110Κ/93)
文摘AIM:To study the peripheral dose(PD) from highenergy photon beams in radiotherapy using the metal oxide semiconductor field effect transistor(MOSFET) dose verification system.METHODS:The radiation dose absorbed by the MOSFET detector was calculated taking into account the manufacturer's Correction Factor,the Calibration Factor and the threshold voltage shift.PD measurements were carried out for three different field sizes(5 cm×5 cm,10 cm×10 cm and 15 cm×15 cm) and for various depths with the source to surface distance set at 100 cm.Dose measurements were realized on the central axis and then at distances(1 to 18 cm) parallel to the edge of the field,and were expressed as the percentage PD(% PD) with respect to the maximum dose(dmax).The accuracy of the results was evaluated with respect to a calibrated 0.3 cm3 ionization chamber.The reproducibility was expressed in terms of standard deviation(s) and coefficient of variation.RESULTS:% PD is higher near the phantom surface and drops to a minimum at the depth of dmax,and then tends to become constant with depth.Internal scatter radiation is the predominant source of PD and the depth dependence is determined by the attenuation of the primary photons.Closer to the field edge,where internal scatter from the phantom dominates,the % PD increases with depth because the ratio of the scatter to primary increases with depth.A few centimeters away from the field,where collimator scatter and leakage dominate,the % PD decreases with depth,due to attenuation by the water.The % PD decreases almost exponentially with the increase of distance from the field edge.The decrease of the % PD is more than 60% and can reach up to 90% as the measurement point departs from the edge of the field.For a given distance,the % PD is significantly higher for larger field sizes,due to the increase of the scattering volume.Finally,the measured PD obtained with MOSFET is higher than that obtained with an ionization chamber with percentage differences being from 0.6% to 34.0%.However,when normalized to the central dmax this difference is less than 1%.The MOSFET system,in the early stage of its life,has a dose measurement reproducibility of within 1.8%,2.7%,8.9% and 13.6% for 22.8,11.3,3.5 and 1.3 cGy dose assessments,respectively.In the late stage of MOSFET life the corresponding values change to 1.5%,4.8%,11.1% and 29.9% for 21.8,2.9,1.6 and 1.0 cGy,respectively.CONCLUSION: Comparative results acquired with the MOSFET and with an ionization chamber show fair agreement, supporting the suitability of this measurement for clinical in vivo dosimetry.
文摘A formula describing the percentage depth dose curve for <sup>60</sup>Co γ beams is theoretically developed. The formula only needs a few data determined by measuring directly in water phantom and can be used to calculate the whole set of percentage depth dose (PDD) and tissuse air ratios (TAR) for the wide range of SSD (from 20cm to 100cm), field size (from 4cm×4cm to 20cm×20cm) and depth (from d<sub>m</sub> to 30cm). The data calculated by the formula fits very well to the data currently used in clinics with the maximum error less than 1% and probable error of about 0.1%-0.3%. Using this formula can overcome the time-exhausting work in measurement of PDD and TAR.