青年职场“Gap day”现象探究

青年职场“Gap day”现象引起了社会的广泛关注和热烈讨论。青年职场“Gap day”现象的典型特征是:通过语言上的拼贴与再造,表达部分职业青年的困顿疲倦情绪;通过行为上的放空与逃离,排解青年在工作中积攒的情绪和压力;通过价值上的戏谑与自嘲,赋予青年的短暂休息以正向意义。青年职场“Gap day”现象的深层原因是:青年在高压生存环境中的“弹性姿态”、在加速社会运行中的“精神逃离”和在社会时钟齿轮下的“自我审视”。对青年职场“Gap day”现象的有效治理,既要着眼于青年发展,运用公共政策实现青年发展的普遍性诉求,又要立足于青年就业,采取切实措施促进青年实现高质量充分就业。

Enhanced Cooling Efficiency of Urban Trees on Hotter Summer Days in 70 Cities of China

Increasing the urban tree cover percentage(TCP) is widely recognized as an efficient way to mitigate the urban heat island effect. The cooling efficiency of urban trees can be either enhanced or attenuated on hotter days, depending on the physiological response of urban trees to rising ambient temperature. However, the response of urban trees' cooling efficiency to rising urban temperature remains poorly quantified for China's cities. In this study, we quantify the response of urban trees' cooling efficiency to rising urban temperature at noontime [~1330 LT(local time), LT=UTC+8] in 17summers(June, July, and August) from 2003–19 in 70 economically developed cities of China based on satellite observations. The results show that urban trees have stronger cooling efficiency with increasing temperature, suggesting additional cooling benefits provided by urban trees on hotter days. The enhanced cooling efficiency values of urban trees range from 0.002 to 0.055℃ %-1 per 1℃ increase in temperature across the selected cities, with larger values for the lowTCP-level cities. The response is also regulated by background temperature and precipitation, as the additional cooling benefit tends to be larger in warmer and wetter cities at the same TCP level. The positive response of urban trees' cooling efficiency to rising urban temperature is explained mainly by the stronger evapotranspiration of urban trees on hotter days.These results have important implications for alleviating urban heat risk by utilizing urban trees, particularly considering that extreme hot days are becoming more frequent in cities under global warming.

A Dear Price to Regret Over:On Mr.Stevens’Dignity and Professionalism in The Remains of the Day

The Remains of the Day is one of Kazuo Ishiguro’s renowned novels.The protagonist Stevens is an English butler whose life is deeply entwined with the concepts of dignity and honor.Set against the backdrop of post-World War II Britain and reflecting on the interwar period,the novel examines Stevens’devotion to his role and the traditional values of English aristocracy.The essay discusses how Stevens’identity is shaped by his unwavering commitment to professionalism and his admiration for British gentleman culture and highlights the identity crisis Stevens faces as he realizes the flawed nature of his employer and the outdated ideals he upheld.Through Stevens’journey of self-reassessment and eventual epiphany,the essay delves into the complexities of his internal struggle to reconstruct his identity,ultimately advocating for a more authentic understanding of dignity and honor.

Interrelationships between Length of the Day, Moon Distance, Phanerozoic Geodynamic Cycles, Tidal Dissipation and Earth’s Core: Review and Analysis

The rotation of the Earth and the related length of the day (LOD) are predominantly affected by tidal dissipation through the Moon and the growth of the Earth’s core. Due to the increased concentration of mass around the rotation axis of the spinning Earth during the growth of the core the rotation should have been accelerated. Controversially the tidal dissipation by the Moon, which is mainly dependent on the availability of open shallow seas and the kind of Moon escape from a nearby position, acts towards a deceleration of the rotating Earth. Measurements of LOD for Phanerozoic and Precambrian times open ways to solve questions concerning the geodynamical history of the Earth. These measurements encompass investigations of growth patterns in fossils and depositional patterns in sediments (Cyclostratigraphy, Tidalites, Stromatolites, Rhythmites). These patterns contain information on the LOD and on the changing distance between Earth and Moon and can be used as well for a discussion about the growth of the Earth’s core. By updating an older paper with its simple approach as well as incorporating newly published results provided by the geoscientific community, a moderate to fast growth of the core in a hot early Earth will be favored controversially to the assumption of a delayed development of the core in an originally cold Earth. Core development with acceleration of Earth’s rotation and the contemporaneous slowing down due to tidal dissipation during the filling of the ocean may significantly interrelate.

Analysis of the disease entities and typical characteristics of day surgery based on three Public Tertiary A hospitals in China

Background:In recent years,day surgery has gained widespread attention in the medical industry.This thesis focuses on three tertiary general hospitals in different regions in China where day surgery has been carried out earlier,is more developed,has a more comprehensive range of day surgery procedures,and has an annual volume of 10,000 or more day surgery cases.The study will provide hands-on experience for other medical institutions to carry out day surgery.Methods:67,337 valid items of data were retrieved from the Hospital Information Systems of the three hospitals.In this thesis,descriptive analysis was carried out on basic information about day surgery patients,including composition of patients’major diseases,hospitalization costs.Non-parametric tests were used to compare the data in each group,the median and interquartile range were used to show the trend in the concentration of the relevant indicators.The difference was considered statistically significant at P<0.05.Results:The largest proportion of day surgery patients were between the ages of 51 and 70.About 57.30%of day surgery patients paid for their medical care with the basic medical insurance of urban employees.Senile cataract,benign breast tumor,and endometrial polyp were the top three major diagnoses of day surgery patients.The average inpatient expenditure for day surgery patients was 8982.10 yuan,with consumables cost representing the highest proportion at approximately 46.01%of the total hospitalization cost,followed by treatment cost at around 31.01%of the total cost.Conclusions:Day surgery is more suitable for middle-aged patients and may not be the best choice for children and elderly patients over 80 years old.Most day surgery cases are elective surgeries for non-emergency situations.The distribution of day surgery patients is primarily concentrated in ophthalmic,breast,and reproductive system diseases,although each hospital has its own unique characteristics.The development of day surgery presents both economic and social benefits.

Bisoprolol reverses down-regulation of potassium channel proteins in ventricular tissues of rabbits with heart failure

Remodeling of ion channels is an important mechanism of arrhythmia induced by heart failure （HF）. We investigated the expression of potassium channel encoding genes in the ventricles of rabbit established by volumeoverload operation followed with pressure-overload. The reversible effect of these changes with bisoprolol was also evaluated. The HF group exhibited left ventricular enlargement, systolic dysfunction, prolongation of corrected QT interval （QTc）, and increased plasma brain natriuretic peptide levels in the HF rabbits. Several potassium channel subunit encoding genes were consistently down-regulated in the HF rabbits. After bisoprolol treatment, heart function was improved significantly and QTc was shortened. Additionally, the mRNA expression of potassium channel subunit genes could be partially reversed. The down-regulated expression of potassium channel subunits Kv4.3, Kv1.4, KvLQT1, minK and Kir 2.1 may contribute to the prolongation of action potential duration in the heart of rabbits induced by volume combined with pressure overload HF. Bisoprolol could partially reverse these down-regulations and improve heart function.

Down-regulation of Hsp90 could change cell cycle distribution and increase drug sensitivity of tumor cells

AIM:To construct Hsp90 antisense RNA eukaryotic expression vector, transfect it into SGC7901 and SGC7901/VCR of MDR-type human gastric cancer cell lines, HCC7402 of human hepatic cancer and Ec109 of human esophageal cancer cell lines, and to study the cell cycle distribution of the gene transected cells and their response to chemotherapeutic drugs.METHODS:A 1.03kb cDNA sequence of Hsp90beta was obtained from the primary plasmid phHSP90 by EcoR I and BamH I nuclease digestion and was cloned to the EcoR I and BamH I site of the pcDNA by T4DNA ligase and an antisense orientation of Hsp90beta expression vector was constructed. The constructs were transfected with lipofectamine and positive clones were selected with G418. The expression of RNA was determined with dot blotting and RNase protection assay, and the expression of Hsp90 protein determined with western blot. Cell cycle distribution of the transfectants was analyzed with flow cytometry, and the drug sensitivity of the transfectants to Adriamycin (ADR), vincrinstine (VCR), mitomycin (MMC) and cyclophosphamide (CTX) with MTT and intracellular drug concentration of the transfectants was determined with flow cytometry.RESULTS:In EcoR I and BamH I restriction analysis, the size and the direction of the cloned sequence of Hsp90beta remained what had been designed and the gene constructs were named pcDNA-Hsp90.AH-SGC7901, AH-SGC7901/VCR, AH-HCC7402 and AH-Ec109 cell clones all expressed Hsp90 anti-sense RNA. The expression of Hsp90 was down-regulated in AH-SGC7901, AH-SGC7901/VCR, AH-HCC7402 and AH-Ec109 cell clones. Cell cycle distribution was changed differently. In AH-SGC7901/VCR and AH-Ec109 cells, G(1) phase cells were increased; S phase and G(2) phase cells were decreased as compared with their parental cell lines. In AH-SGC7901 cell, G(1)phase cells were decreased, G(2) phase cells increased and S phase cells were not changed, and in AH-HCC7402 cells G(1), S and G(2) phase cells remained unchanged as compared with their parental cell lines. The sensitivity of AH-SGC7901, AH-SGC7901/VCR, AH-HCC7402 and AH-Ec109 to chemotherapeutic drugs, the sensitivity of AH-SGC7901/VCR to ADR, VCR, MMC and CTX the sensitivity of AH-HCC7402 to ADR and VCR, and the sensitivity of Ec109 to ADR, VCR and CTX all increased as compared with their parental cell lines. The mean fluorescence intensity of ADR in AH-SGC7901, AH-SGC7901/VCR, AH-HCC7402 and AH-Ec109 was also significantly elevated (P 【 0.05).CONCLUSION: Down-regulation of Hsp90 could change cell cycle distribution and increase the drug sensitivity of tumor cells.

Inactivated Sendai Virus Induces Apoptosis in Murine Melanoma Cells by IGF-1R Down-regulation

The mortality of cancer patients has considerably improved due to progress in surgery, chemotherapy and radiotherapy. However, some types of cancers, such as melanoma, remain refractory to conventional strategies. Although melanoma accounts for only 4% of all dermatological malignancies, it is responsible for 80% of mortalities from skin tumors[11. The reported survival rate of melanoma over 5 years is not yet encouraging due to its chemo-resistance and rapid metastasis. Therefore, it is necessary to develop new drugs with potent activity and weak side-effect against melanoma.

LncRNA LUCAT1 Activation Mediated by theDown-regulation of DNMT1 Is Involved inCell Apoptosis Induced by PM2.5

Particulate matter （PM）, which is a great environmental concern, has been classified as a Group 1 human carcinogen by the International Agency for Research on Cancer （IARC）;.Epidemiological and experimental studies have indicated that chronic exposure to PM, especially PM;(particles with an aerodynamic diameter less than

Seasonal Prediction of Extreme High-Temperature Days in Southwestern China Based on the Physical Precursors

Extreme high temperatures frequently occur in southwestern China,significantly impacting the local ecological system and economic development.However,accurate prediction of extreme high-temperature days(EHDs)in this region is still an unresolved challenge.Based on the spatiotemporal characteristics of EHDs over China,a domain-averaged EHD index over southwestern China(SWC-EHDs)during April-May is defined.The simultaneous dynamic and thermodynamic fields associated with the increased SWC-EHDs are a local upper-level anticyclonic(high-pressure)anomaly and wavy geopotential height anomaly patterns over Eurasia.In tracing the origins of the lower boundary anomalies,two physically meaningful precursors are detected for SWC-EHDs.They are the tripolar SST change tendency from December-January to February-March in the northern Atlantic and the February-March mean snow depth in central Asia.Using these two selected predictors,a physics-based empirical model prediction was applied to the training period of 1961–2005 to obtain a skillful prediction of the EHDs index,attaining a correlation coefficient of 0.76 in the independent prediction period(2006–19),suggesting that 58%of the total SWC-EHDs variability is predictable.This study provides an estimate for the lower bound of the seasonal predictability of EHDs as well as for the hydrological drought over southwestern China.

Down-regulation of glucocorticoid receptor mRNA by glucocorticoids in rats

The effect of glucocorticoids on the down-regulation of glucocorticoidreceptor (GR) mRNA was studied in intact rats.GR mRNA was characterized byNorthern blot hybridization and quantitated by dot blot hybridization using a hu-man GR cDNA fragment as a probe.Administration of hydrocortisone (F) inpolyvinyl alcohol (PVA) resulted in a rapid increase in plasma glucocorticoidswhich maintained at stress levels (20 to 40μg/dl) for about 3 d.HepaticGR mRNA decreased significantly to 73.5±6.3% of control values 6h followingF treatment,after which the decline of GR mRNA was gradual,reaching a mini-mum of 44.0±5.0% of control levels 3d after the treatment.The effect of F onthe down-regulation of hepatic GR mRNA lasted up to 11 d.In contrast,F treat-ment had no effect on GR mRNA in rat brain.These results are consistent withthe changes in GR in rats as reported previously,except that even though thehepatic cytosol GR decreased markedly,no significant changes in hepatic GRmRNA were found 1h after F treatment,strongly suggesting that thedown-regulation of GR by its ligands in vivo occurs at both transcriptional andposttranscriptional levels and is of tissue-specific fashion.

Hybrid model based on K-means++ algorithm, optimal similar day approach, and long short-term memory neural network for short-term photovoltaic power prediction

Photovoltaic(PV) power generation is characterized by randomness and intermittency due to weather changes.Consequently, large-scale PV power connections to the grid can threaten the stable operation of the power system. An effective method to resolve this problem is to accurately predict PV power. In this study, an innovative short-term hybrid prediction model(i.e., HKSL) of PV power is established. The model combines K-means++, optimal similar day approach,and long short-term memory(LSTM) network. Historical power data and meteorological factors are utilized. This model searches for the best similar day based on the results of classifying weather types. Then, the data of similar day are inputted into the LSTM network to predict PV power. The validity of the hybrid model is verified based on the datasets from a PV power station in Shandong Province, China. Four evaluation indices, mean absolute error, root mean square error(RMSE),normalized RMSE, and mean absolute deviation, are employed to assess the performance of the HKSL model. The RMSE of the proposed model compared with those of Elman, LSTM, HSE(hybrid model combining similar day approach and Elman), HSL(hybrid model combining similar day approach and LSTM), and HKSE(hybrid model combining K-means++,similar day approach, and LSTM) decreases by 66.73%, 70.22%, 65.59%, 70.51%, and 18.40%, respectively. This proves the reliability and excellent performance of the proposed hybrid model in predicting power.

Impacts of Sea Surface Temperature on the Interannual Variability of Winter Haze Days in Guangdong Province

The impact of sea surface temperature(SST)on winter haze in Guangdong province(WHDGD)was analyzed on the interannual scale.It was pointed out that the northern Indian Ocean and the northwest Pacific SST play a leading role in the variation of WHDGD.Cold(warm)SST anomalies over the northern Indian Ocean and the Northwest Pacific stimulate the eastward propagation of cold(warm)Kelvin waves through the Gill forced response,causing Ekman convergence(divergence)in the western Pacific,inducing abnormal cyclonic(anticyclonic)circulation.It excites the positive(negative)Western Pacific teleconnection pattern(WP),which results in the temperature and the precipitation decrease(increase)in Guangdong and forms the meteorological variables conditions that are conducive(not conducive)to the formation of haze.ENSO has an asymmetric influence on WHDGD.In El Niño(La Niña)winters,there are strong(weak)coordinated variations between the northern Indian Ocean,the northwest Pacific,and the eastern Pacific,which stimulate the negative(positive)phase of WP teleconnection.In El Niño winters,the enhanced moisture is attributed to the joint effects of the horizontal advection from the surrounding ocean,vertical advection from the moisture convergence,and the increased atmospheric apparent moisture sink(Q2)from soil evaporation.The weakening of the atmospheric apparent heat source(Q1)in the upper layer is not conducive to the formation of inversion stratification.In contrast,in La Niña winters,the reduced moisture is attributed to the reduced upward water vapor transport and Q2 loss.Due to the Q1 increase in the upper layer,the temperature inversion forms and suppresses the diffusion of haze.

Load-forecasting method for IES based on LSTM and dynamic similar days with multi-features

To fully exploit the rich characteristic variation laws of an integrated energy system(IES)and further improve the short-term load-forecasting accuracy,a load-forecasting method is proposed for an IES based on LSTM and dynamic similar days with multi-features.Feature expansion was performed to construct a comprehensive load day covering the load and meteorological information with coarse and fine time granularity,far and near time periods.The Gaussian mixture model(GMM)was used to divide the scene of the comprehensive load day,and gray correlation analysis was used to match the scene with the coarse time granularity characteristics of the day to be forecasted.Five typical days with the highest correlation with the day to be predicted in the scene were selected to construct a“dynamic similar day”by weighting.The key features of adjacent days and dynamic similar days were used to forecast multi-loads with fine time granularity using LSTM.Comparing the static features as input and the selection method of similar days based on non-extended single features,the effectiveness of the proposed prediction method was verified.

Maternal Lead Exposure Induces Down-regulation of Hippocampal Insulin-degrading Enzyme and Nerve Growth Factor Expression in Mouse Pups

Lead exposure is a known potential risk factor for neurodegenerative diseases such as Alzheimer’s disease （AD）. Exposure to lead during the critical phase of brain development has been linked with mental retardation and hypophrenia in later life.

Glypican 4 down-regulation in pluripotent stem cells as a potential strategy to improve differentiation and to impair tumorigenicity of cell transplants

Recent advances in stem cell technologies have opened new avenues for the treatment of a number of diseases still lacking effective therapeutic options.Cell transplantation has emerged as among the most promising clinical intervention for disorders such as injuries,diabetes,liver diseases, neurodegeneration and heart failure （Lee et al., 2013; Forbes and Rosenthal, 2014; Tabar and Studer, 2014）.

Pregnancy Outcomes for Day 5 Versus Day 6 Single Frozen-thawed Blastocyst Transfer with Different Qualities of Embryos: A Large Matched-cohort Study

Objective This study aimed to determine whether the day of blastocyst expansion affects pregnancy outcomes in frozen-thawed blastocyst transfer(FBT)cycles.Methods A retrospective match-cohort study was conducted.Patients who underwent blastocyst transfer in frozen-thawed cycles at day 5 or 6 were matched for potential confounding factors.A total of 2207 matched pairs of FBT cycles were included from January 2016 to December 2019 in our Reproductive Medicine Center.Results The clinical pregnancy rate(CPR)and live birth rate(LBR)were significantly increased in day 5 blastocyst transfers when compared to day 6 blastocyst transfers,in terms of the same embryo quality.For FBT cycles with good-quality embryo,the CPR at day 5 and 6 was 61.30%and 57.56%,respectively(P=0.045),and the LBR was 44.79%and 36.16%,respectively(P<0.001).For FBT cycles with poor-quality embryo,the CPR at day 5 and 6 was 48.61%and 40.89%,respectively(P=0.006),and the LBR was 31.71%and 25.74%,respectively(P=0.019).The CPR for FBT cycles with good-quality embryo was statistically higher at day 6 than that at day 5 with poor-quality embryo transferred(57.56%vs.48.61%,P=0.001).Maternal age,anti-Müllerian hormone(AMH),endometrial thickness,embryo quality,and the day of blastocyst expansion were independently correlated with the CPR and LBR.The FBT cycles at day 5 had significantly higher CPR(adjusted odds ratio[OR]=1.246,95%confidence intervals[CI]:1.097–1.415,P=0.001)and LBR(adjusted OR=1.435,95%CI:1.258–1.637,P<0.001)than those at day 6.Conclusion The embryo quality is the primary indicator for FBT cycles.Day 5 blastocysts should be preferred when the quality of embryo at day 5 is the same as that at day 6.

International Children's Day Activity for Chinese and Lao Students Launched at Xishuangbanna

Jointly sponsored by the China Charity Federation and the Ministry of Education and Sports of Laos,the sixth"Belt and Road,People-to-People Bonds"Student's Hand-inHand Activity and the International Children's Day Activity for Chinese and Lao Students was launched in Xishuangbanna on May 24.

Down-regulation of Notch-1 gene expression inhibits growth of TJ-905 glioblastoma

Objective To study the inhibitory effect of siRNA on glioblastoma (GBM) Notch-1 gene expression in addition to the growth of TJ-905 glioblastoma. Methods Three small interference RNAs (siRNAs) targeting Notch1 gene,named siRNA1,siRNA2,siRNA3,synthesized chemically in vitro with gene bank BLAST. TJ-905 cells were transfected twice with the siRNA by using Oligofectamine

Interannual Variation and Statistical Prediction of Summer Dry and Hot Days in South China from 1970 to 2018

The frequent occurrence of dry and hot(DH)days in South China in summer has a negative impact on social development and human health.This study explored the variation characteristics of DH days and the possible reasons for this knotty problem.The findings revealed a notable increase in the number of DH days across most stations,indicating a significant upward trend.Additionally,DH events were observed to occur frequently.The number of DH days increased during 1970-1990,decreased from 1991 to 1997,and stayed stable after 1997.The key climate factors affecting the interannual variability of the number of DH days were the Indian Ocean Basin warming(IOBW)in spring and the East Asian Summer Monsoon(EASM).Compared with the negative phase of IOBW,in the positive phase of IOBW,500 hPa and 850 hPa geopotential height enhanced,the West Pacific subtropical high strengthened and extended abnormally to the west,more solar radiation reached the surface,surface outgoing longwave radiation increased,and there was an anomalous anticyclone in eastern South China.The atmospheric circulation characteristics of the positive and negative phases of ESAM were opposite to those of IOBW,and the abnormal circulation of the positive(negative)phases of ESAM was unfavorable(favorable)for the increase in the number of DH days.A long-term prediction model for the number of summer DH days was established using multiple linear regression,incorporating the key climate factors.The correlation coefficient between the observed and predicted number of DH days was 0.65,and the root-mean-square error was 2.8.In addition,independent forecasts for 2019 showed a deviation of just 1 day.The results of the independent recovery test confirmed the stability of the model,providing evidence that climatic factors did have an impact on DH days in South China.