Three new drimane sesquiterpenoids(1–3)together with the known 2a-hydroxyisodrimeninol(4),and a new isochromone derivative(5),were obtained from the solid cultures of fungal strain Pestalotiopsis sp.M-23,an endophyti...Three new drimane sesquiterpenoids(1–3)together with the known 2a-hydroxyisodrimeninol(4),and a new isochromone derivative(5),were obtained from the solid cultures of fungal strain Pestalotiopsis sp.M-23,an endophytic fungus isolated from the leaves of Leucosceptrum canum(Labiatae).Their structures were determined by comprehensive 1D and 2D NMR,and MS analyses.The metabolites were evaluated for their antibacterial activities,and compound 3 showed weak inhibitory activity against Bacillus subtilis.展开更多
Soil-derived fungi represent an insufficiently tapped reservoir for discovering new and bioactive natural products(NPs),and despite an ever-increasing number of unknown NPs have been discovered over the past few decad...Soil-derived fungi represent an insufficiently tapped reservoir for discovering new and bioactive natural products(NPs),and despite an ever-increasing number of unknown NPs have been discovered over the past few decades,much of the hidden biosynthetic potential is still in an urgent need to be disclosed.In this research,a chemical inves-tigation was performed on a wetland soil-derived fungus Aspergillus calidoustus TJ403-EL05,leading to the isolation of a total of fourteen drimane sesquiterpenoids(1-14),incorporating three new ones,namely ustusols F-H(1-3).Their structures,comprising absolute configurations,were completely authenticated by widespread spectroscopic data,quantum chemical 13C NMR and ECD calculations,and X-ray crystallography experiments.Compound 14 exhibited moderate anti-inflammatory activity by inhibiting the LPS-induced NO release(IC_(50)=25.6μM).展开更多
Two new drimane sesquiterpenoids(1 and 2),as well as five known compounds(3-7),were isolated from the basidiomycete Trichaptum biforme.The structures of new compounds were elucidated by extensive spectroscopic methods...Two new drimane sesquiterpenoids(1 and 2),as well as five known compounds(3-7),were isolated from the basidiomycete Trichaptum biforme.The structures of new compounds were elucidated by extensive spectroscopic methods,and the known compounds were identified by comparing their spectroscopic data with those reported in the literature.The cytotoxicities results against five human cancer cell lines of compounds 1 and 2 were negligible.展开更多
Four new sesquiterpenoids,namely 12-hydroxy-3-oxodrimenol(1),11-hydroxyacetoxydrim-7-en-3b-ol(2),2,6-dimethyl-7,10-epoxy-10-hydroxymethyldodeca-2,11-dien-6-ol(3),and 7,10-epoxy-2,6,10-trimethyldodeca-2,11-diene-4,6-di...Four new sesquiterpenoids,namely 12-hydroxy-3-oxodrimenol(1),11-hydroxyacetoxydrim-7-en-3b-ol(2),2,6-dimethyl-7,10-epoxy-10-hydroxymethyldodeca-2,11-dien-6-ol(3),and 7,10-epoxy-2,6,10-trimethyldodeca-2,11-diene-4,6-diol(4),along with fourteen known compounds,were isolated from the cultures of Phellinidium sulphurascens.The structures of compounds 1–4 were established on the basis of extensive spectroscopic analysis.All of them were evaluated for their cytotoxic activities.展开更多
In the saturate fractions of crude oils from the Zhu1 and Zhu2 depressions of the Pearl River Mouth Basin,two novel C_(15) sesquiterpanes have been detected except for drimanes and rearranged drimanes.By comparison wi...In the saturate fractions of crude oils from the Zhu1 and Zhu2 depressions of the Pearl River Mouth Basin,two novel C_(15) sesquiterpanes have been detected except for drimanes and rearranged drimanes.By comparison with spectra and retention times in previous studies,they have been identified as 2,2,4α,7,8-pentamethyl-trans-decalin and 2,2,4α,7,8-pentamethyl-cis-decalin,respectively,which are related to the D/Eringsof18α(H)-and18β(H)-oleanane.ResultsshowthatthenovelC15sesquiterpanesarerelativelyabundantincondensateoilsthathavehighPr/PhratiosandarerichinterrigenoustriterpanessuchasoleananeandbicadinanesfromtheZhu2depression,butevidentlylowinlacustrineoilsthathavelowPr/Phratiosandarerichin4-methylsteranesfromtheZhu1depression.ThissuggeststhatthenovelC15sesquiterpanescouldberelatedtoterrigenousorganicmatterinoriginandcanhelpdistinguishtheoriginandsourceofcrudeoilsinthestudyarea.Inaddition,thereexistcompletelydifferentcorrelationsbetweentherelativeabundancesofdifferentC15sesquiterpanesthathavedifferentsourcesandthePr/Phratio,whichindicatesredoxconditionsinthecrudeoils.Forexample,thenovelC15sesquiterpanesandcadinanethatindicateterrigenousinputarepositivelycorrelatedwiththePr/Phratio,butdrimanesandrearrangeddrimaneshavingmicrobialoriginarenegativelycorrelatedwiththePr/Phratio.ThisimpliesthattheformationofthenovelC15sesquiterpanesrequiresrelativelyoxicconditions.ThenovelC15sesquiterpanesaremuchmoreabundantincarbonaceousmudstone(Pr/Ph=7.39)thanindarkmudstone(Pr/Ph=2.19)fromtheEnpingformation,althoughtheirorganicmatterishumic.However,theyarenotcommoninsapropeliclacustrinesourcerocks(Pr/Ph=2.29)fromtheWenchangFormation.Thissuggeststhatterrigenousorganicmatterisonlyasufficientcondition,butanoxicenvironmentduringdepositionanddiagenesismaybeaprerequisitefortheformationofnovelC15sesquiterpanes.展开更多
Samples involved in this paper are 35 pieces of crude oils and 43 pieces of source rocks, from which a series of biomarkers, capable of indicating paleoecology and paleoenvironment. This will provide a scientific basi...Samples involved in this paper are 35 pieces of crude oils and 43 pieces of source rocks, from which a series of biomarkers, capable of indicating paleoecology and paleoenvironment. This will provide a scientific basis for tracing back to sedimenta-y paleoenvironment and paleoecology.展开更多
By using GC-MS to analyze the extracts of source rocks, coal and crude oil samplesformed in different sedimentary environments in China, New Zealand and Australia, twenty-two compounds of five types of bicyclic alkane...By using GC-MS to analyze the extracts of source rocks, coal and crude oil samplesformed in different sedimentary environments in China, New Zealand and Australia, twenty-two compounds of five types of bicyclic alkanes have been dis covered in the samples. Thispaper makes an exposition of stereochemical structure, abundance and distributive features ofthese compounds and their relation to sedimentary environments and thermal evolution. Furt-thermore, it demonstrates how the abundance ratios of bicyclic alkanes to steranes and ter-panes, drimane to homodramane and the relative abundance of C_(15),C_(16),C_(12)-C_(14) series of bicyclic-alkane compounds can be used to judge and determine types of oil and gas forming environ-ments (the depositive environments of source rocks from which the oil and gas wereformed), characteristics of source rocks and degree of maturation.展开更多
基金This work was supported financially by the National Natural Science Foundation of China(Nos.31525005,U1202263,31570362)the Youth Innovation Promotion association of Chinese Academy of Sciences(awarded to Shi-Hong Luo)+1 种基金the“Western Light”Program of Chinese Academy of Sciences(awarded to Shi-Hong Luo)the“Hundred Talents Program”of the Chinese Academy of Sciences(awarded to Sheng-Hong Li).
文摘Three new drimane sesquiterpenoids(1–3)together with the known 2a-hydroxyisodrimeninol(4),and a new isochromone derivative(5),were obtained from the solid cultures of fungal strain Pestalotiopsis sp.M-23,an endophytic fungus isolated from the leaves of Leucosceptrum canum(Labiatae).Their structures were determined by comprehensive 1D and 2D NMR,and MS analyses.The metabolites were evaluated for their antibacterial activities,and compound 3 showed weak inhibitory activity against Bacillus subtilis.
基金The National Natural Science Foundation for Distinguished Young Scholars,81725021,Yonghui Zhangthe National Natural Science Foundation of China,Nos.81573316,31870326+4 种基金the Innovative Research Groups of the National Natural Science Foundation of China,No.81721005,Yonghui Zhangthe Fundamental Research Funds for the Central Universities,No.2020kfyXJJS083,Zhengxi Huthe National Key R&D Program of China,No.2021YFA0910500,Yonghui Zhangthe Research and Development Program of Hubei Province,No.2020BCA058,Jianping Wangthe Chinese Medicine Research Foundation of Health Commission of Hubei Province,No.ZY2021Z019,Jianping Wang.
文摘Soil-derived fungi represent an insufficiently tapped reservoir for discovering new and bioactive natural products(NPs),and despite an ever-increasing number of unknown NPs have been discovered over the past few decades,much of the hidden biosynthetic potential is still in an urgent need to be disclosed.In this research,a chemical inves-tigation was performed on a wetland soil-derived fungus Aspergillus calidoustus TJ403-EL05,leading to the isolation of a total of fourteen drimane sesquiterpenoids(1-14),incorporating three new ones,namely ustusols F-H(1-3).Their structures,comprising absolute configurations,were completely authenticated by widespread spectroscopic data,quantum chemical 13C NMR and ECD calculations,and X-ray crystallography experiments.Compound 14 exhibited moderate anti-inflammatory activity by inhibiting the LPS-induced NO release(IC_(50)=25.6μM).
基金This project was supported by the National Basic Research Program of China(973 Program,2009CB522300)the National Natural Sciences Foundation of China(U1132607)Youth Innovation Promotion Association of Chinese Academy of Sciences.
文摘Two new drimane sesquiterpenoids(1 and 2),as well as five known compounds(3-7),were isolated from the basidiomycete Trichaptum biforme.The structures of new compounds were elucidated by extensive spectroscopic methods,and the known compounds were identified by comparing their spectroscopic data with those reported in the literature.The cytotoxicities results against five human cancer cell lines of compounds 1 and 2 were negligible.
基金National Natural Science Foundation of China(U1132607,81102346)Natural Science Fund of Yunnan province(2011FB099).
文摘Four new sesquiterpenoids,namely 12-hydroxy-3-oxodrimenol(1),11-hydroxyacetoxydrim-7-en-3b-ol(2),2,6-dimethyl-7,10-epoxy-10-hydroxymethyldodeca-2,11-dien-6-ol(3),and 7,10-epoxy-2,6,10-trimethyldodeca-2,11-diene-4,6-diol(4),along with fourteen known compounds,were isolated from the cultures of Phellinidium sulphurascens.The structures of compounds 1–4 were established on the basis of extensive spectroscopic analysis.All of them were evaluated for their cytotoxic activities.
基金financially supported by the National Natural Science Foundation of China(Grant No.41272169)the National Science and Technology Major Project(Grant No.2008ZX05025-03)
文摘In the saturate fractions of crude oils from the Zhu1 and Zhu2 depressions of the Pearl River Mouth Basin,two novel C_(15) sesquiterpanes have been detected except for drimanes and rearranged drimanes.By comparison with spectra and retention times in previous studies,they have been identified as 2,2,4α,7,8-pentamethyl-trans-decalin and 2,2,4α,7,8-pentamethyl-cis-decalin,respectively,which are related to the D/Eringsof18α(H)-and18β(H)-oleanane.ResultsshowthatthenovelC15sesquiterpanesarerelativelyabundantincondensateoilsthathavehighPr/PhratiosandarerichinterrigenoustriterpanessuchasoleananeandbicadinanesfromtheZhu2depression,butevidentlylowinlacustrineoilsthathavelowPr/Phratiosandarerichin4-methylsteranesfromtheZhu1depression.ThissuggeststhatthenovelC15sesquiterpanescouldberelatedtoterrigenousorganicmatterinoriginandcanhelpdistinguishtheoriginandsourceofcrudeoilsinthestudyarea.Inaddition,thereexistcompletelydifferentcorrelationsbetweentherelativeabundancesofdifferentC15sesquiterpanesthathavedifferentsourcesandthePr/Phratio,whichindicatesredoxconditionsinthecrudeoils.Forexample,thenovelC15sesquiterpanesandcadinanethatindicateterrigenousinputarepositivelycorrelatedwiththePr/Phratio,butdrimanesandrearrangeddrimaneshavingmicrobialoriginarenegativelycorrelatedwiththePr/Phratio.ThisimpliesthattheformationofthenovelC15sesquiterpanesrequiresrelativelyoxicconditions.ThenovelC15sesquiterpanesaremuchmoreabundantincarbonaceousmudstone(Pr/Ph=7.39)thanindarkmudstone(Pr/Ph=2.19)fromtheEnpingformation,althoughtheirorganicmatterishumic.However,theyarenotcommoninsapropeliclacustrinesourcerocks(Pr/Ph=2.29)fromtheWenchangFormation.Thissuggeststhatterrigenousorganicmatterisonlyasufficientcondition,butanoxicenvironmentduringdepositionanddiagenesismaybeaprerequisitefortheformationofnovelC15sesquiterpanes.
基金The research is a cooperation project carried out by Academia Sinica and NSF, USA as well as a partial result of the project 4870137 supported by the National Natural Science Foundation of China
文摘Samples involved in this paper are 35 pieces of crude oils and 43 pieces of source rocks, from which a series of biomarkers, capable of indicating paleoecology and paleoenvironment. This will provide a scientific basis for tracing back to sedimenta-y paleoenvironment and paleoecology.
文摘By using GC-MS to analyze the extracts of source rocks, coal and crude oil samplesformed in different sedimentary environments in China, New Zealand and Australia, twenty-two compounds of five types of bicyclic alkanes have been dis covered in the samples. Thispaper makes an exposition of stereochemical structure, abundance and distributive features ofthese compounds and their relation to sedimentary environments and thermal evolution. Furt-thermore, it demonstrates how the abundance ratios of bicyclic alkanes to steranes and ter-panes, drimane to homodramane and the relative abundance of C_(15),C_(16),C_(12)-C_(14) series of bicyclic-alkane compounds can be used to judge and determine types of oil and gas forming environ-ments (the depositive environments of source rocks from which the oil and gas wereformed), characteristics of source rocks and degree of maturation.
