Effects of piperacillin synthesis on the infterfacial tensions and droplet sizes

Piperacillin is a polar organic substance,and can reduce the interfacial tension of oil and water when dissolved in water.In this study,changes in dichloromethane–water interfacial tensions and microdroplet sizes during piperacillin synthesis from an aqueous solution of ampicillin and dichloromethane solution of 4-ethyl-2,3-dioxo-1-piperazine carbonyl chloride(EDPC)were observed using a pendent drop technique and a coaxial ring tube system with embedded high-speed camera,respectively.It was found that the rapid N-acylation reaction caused the piperacillin at the interface to synthesize rapidly and diffuse out slowly,resulting in the interfacial tension decreased from 19.5 m N·m-1 to 7.2 m N·m-1 rapidly and then increased slowly as the concentrations of ampicillin and EDPC were 0.05 mol·L-1 and 0.1 mol·L-1.Meanwhile,the increase in the concentration of EDPC increased the peak concentration of piperacillin at the interface,and the addition of ethyl acetate to the ampicillin solution promoted mass transfer and reduced the aggregation of piperacillin effectively.During synthesis,the interfacial tension decreased,leading to a change in droplet sizes in the micro-reaction system.The two-phase reaction was carried out in a coaxial ring tube,with ampicillin and EDPC solutions as continuous and dispersed phases,respectively.The reaction reduced the dripping flow area,and the addition of ethyl acetate to the ampicillin solution slightly affected the division of the flow pattern.Under the same flow conditions,the droplet sizes of the reaction group were smaller than those of the no reaction group.The experimental results demonstrated that the increase of the continuous phase,decrease in the dispersed phase flow rate,or increase in EDPC concentration making droplet sizes smaller,and the addition of ethyl acetate slightly affected droplet sizes.These findings are important for the design and optimization of piperacillin synthesis reactors.

An experimental study on oil droplet size distribution in subsurface oil releases

Oil droplet size distribution （ODSD） plays a critical role in the rising velocity and transport of oil droplets in subsurface oil releases. In this paper, subsurface oil release experiments were conducted to study ODSD under different experimental conditions in a laboratory water tank observed by two high-speed cameras in March and April 2017. The correlation formulas Oh=lO.2Re-~ and Oh=39.2Re-1 （Re represents Reynolds number and Oh represents Ohnesorge number） were established to distinguish the boundaries of the three instability regimes in dimensionless space based on the experimental results. The oil droplet sizes from the experimental data showed an excellent match to the Rosin-Rammler distribution function with determination coefficients ranging from 0.86 to 1.00 for Lvda 10-1 oil. This paper also explored the influence factors on and change rules ofoil droplet size. The volume median diameter d50 decreased steadily with increasing jet velocity, and a sharp decrease occurred in the laminar-breakup regime. At Weber numbers （We） 〈100, the orifice diameter and oil viscosity appeared to have a large influence on the mean droplet diameter. At 100〈We〈1 000, the oil viscosity appeared to have a larger influence on the relative mean droplet diameter.

In-Situ Measurement of Droplet Size Distribution by Light Scattering Method

Inversion of droplet size distribution in two-phase flow from light scattering has been considered involved because it is in general reduced to the solution of Fredholm integral equation of the first kind that was always ill-posed. By using the Rosin-Rammler distributiona priori as the particulate size distribution model in the liquid-gas two-phase flow, a method via the solution of a two-parameter nonlinear programming problem to determine the droplet size distribution has been developed. A measurement system based on the technique is designed and applied in the shock test of blades of steam turbine. 100-hours continuous monitoring of the droplets in the liquid-gas two-phase flow of 8.0 Pa and 120 °C was performed and the details of the experiments are given out. It is shown that the technique is simple and efficient for in-situ real time measuring droplets in the liquid-gas two-phase flow.

A Correction Algorithm for Atmospheric Visibility Based on Fog Droplet Size Data Obtained on a Moving Ship During 2016 Arctic Cruise

In this study, we measured the droplet size distribution(DSD) and visibility of sea fog using a fog droplet spectrometer and visibility meter, respectively, during the July 23-August 3 and August 22-September 13 periods of the 2016 Chinese National Arctic Research Expedition. We calculated the visibility using the Mie theory and the DSD data and then compared the calculated with the observed visibility. The comparison shows that the deviations in the calculated visibility caused by DSD data sampling errors cannot be ignored. During navigation, wind and ship speeds tended to push or pull the sampled air and cause turbulence pulsation, which influenced the sampling of the fog droplet spectrometer. This influence is weak when the liquid water content(LWC) is high but becomes stronger as the LWC decreases. Taking the sailing speed and heading into consideration, the wind speed component parallel and perpendicular to the air inlet of the fog droplet spectrometer exhibit different laws in the deviation. By performing a fitting analysis of the calculated and observed visibilities under different wind speeds and wind directions, here, we present two sets of correction coefficients for the two wind-speed components and a method for correcting the calculated visibility. This correction method shows excellent results.

Droplet Size Distribution on the Large-holed Compound Sieve Tray in the Spray Regime

The droplet size distribution with large-holed compound sieve tray operating in the spray regime is measured by using a double electrical probes technique in a cold model column of 400 mm diameter. The results indicate that the hole F-factor Fo and surface tension are the main factors which influence the liquid dispersion expressed by the Sauter mean diameter D32. A correlation of D32 on surface tension, viscosity, F-factor, weir height and liquid flow rate is proposed.

Effect of Velocity Ratio,Viscosity Ratio,Contact Angle,and Channel Size Ratio on Droplet Formation

This study uses a T-junction to examine the effects of different parameters(velocity ratio,viscosity,contact angle,and channel size ratio)on the generation of microdroplets,related rate,and size.More specifically,numerical simulations are exploited to investigate situations with a velocity varying from 0.004 to 1.6 m/s for the continuous phase and from 0.004 to 0.8 m/s for the dispersed phase,viscosity ratios(0.668,1,6.689,10,66.899),contact angle 80°<θ<270°and four different canal size ratios(1,1.5,2 and 4).The results show that canal size influences droplet size and the generation rate.The contact angle has an impact on the form and the quality of generated droplets.Moreover,the relationship between velocity and viscosity ratios,droplet size,and generation rate is non-monotonic.

Production of Artificial Fog in the PAVIN Fog and Rain Platform: In Search of Big Droplets Fog

In fog, visibility is reduced. This reduction in visibility is measured by the meteorological optical range (MOR), which is important for studying human perception and various sensors in foggy conditions. The Cerema PAVIN Fog & Rain platform is capable of producing calibrated fog in order to better analyses it and understand its consequences. The problem is that the droplets produced by the platform are not large enough to resemble real fog. This can have a major impact on measurements since the interaction between electromagnetic waves and fog depends on the wavelength and diameter of the droplets. To remedy this, Cerema is building a new platform with new equipment capable of generating fog. This study analyses different nozzles and associated usage parameters such as the type of water used and the pressure used. The aim is to select the best nozzle with the associated parameters for producing large-diameter droplets and therefore more realistic fog.

Research into Configuration and Flow of Wall Oil Film in Bearing Chamber Based on Droplet Size Distribution

The lubrication design and heat transfer determination of bearing chambers in aeroengine require a sufficient understanding of the oil droplet-film interaction and physical characteristic in an oil/air two-phase flow state. The analyses of oil droplet movement, mass and momentum transfer during the impingement of droplet/wall, as well as wall oil film thickness and flow velocity are very important for the bearing chamber lubrication and heat transfer calculation. An integrated model in combination with droplet movement, droplet/wall impact and film flow analysis is put forward initially based on the consideration of droplet size distribution. The model makes a contribution to provide more practical and feasible technical approach, which is not only for the study of droplet-film interaction and physical behavior in bearing chambers with oil/air two-phase flow phenomena, but also useful for an insight into the essence of physical course through droplet movement and deposition, film formation and flow. The influences of chamber geometries and operating conditions on droplet deposition mass and momentum transfer, and wall film thickness and velocity distribution are discussed. The feasibility of the method by theoretical analysis is also verified by the ex- isting experimental data. The current work is conducive to expose the physical behavior of wall oil film configuration and flow in bearing chamber, and also significant for bearing chamber lubrication and heat transfer study under oil/air two-phase flow conditions.

Droplet size and spray pattern characteristics of PWM-based continuously variable spray

A Pulse-Width-Modulation-based(PWM-based)continuously variable sprayer was developed using a proportional regulating solenoid valve.Variable flow-rate was obtained by varying the duty cycle of the actuating signal with 24 kHz frequency.Flow-rate regulating ranges of the PWM-based continuously variable spray(i.e.the turndown ratio responding to 100%-40%duty cycle)are 7.14:1,3.57:1,and 3.70:1 for flat-fan,hollow-cone and solid-cone nozzles,respectively.The purpose of the study was to evaluate the PWM-based continuously variable spray.The method was to quantify the effects of flow-rate control on spray characteristics in terms of droplet size spectra,spray distribution patterns,and spray angle for flat-fan,hollow-cone,solid-cone nozzles.For all nozzles tested,spray distribution concentrated on the center of the spray field with the decrease of flow-rate.But the spray shape is still symmetrical.The sensitivities of the spray angles to flow-rate were 0.83,0.67,and 0.58(o)/%respectively for flat-fan,hollow-cone and solid-cone nozzles.Compared with the sensitivities of spray angle for PWM-based intermittent variable spray,they are somewhat larger.As flow-rate was reduced from the maximum(100%flow-rate)to the minimum controllable rate,the observed median diameter of spray droplets decreased by 5.4%,9.8%,and 9.9%for flat-fan,hollow-cone and solid-cone nozzles,respectively.This indicates that spray droplet size was affected slightly by flow-rate control.

Effects of droplet size and spray volume parameters on droplet deposition of wheat herbicide application by using UAV

With the characteristic of flexible and precise,unmanned aerial vehicles(UAVs)for low volume applications are increasing substantially and quickly around the globe.However,little attention has been paid to the study of wheat herbicides with UAV,especially the research on the spray volume and droplet size of the herbicide sprayed by UAVs.The objectives of this study were to compare the droplet deposition from a typical commercial UAV under four different spray volumes of 7.5 L/hm2,15.0 L/hm2,22.5 L/hm2,and 30.0 L/hm2 and three different volume median diameter(VMD)of 150μm,200μm,and 300μm during winter wheat weeding period.DepositScan software was used to analyze droplet deposition parameters including the percentage of spray coverage and the number of droplets in various sampling positions.The test results showed that the droplet deposition waseffected by each factor andtheirinteractions.When the spray volume was 7.5 L/hm2,the effect of VMD on the percentage of spray coverage was not significant.However,these variation rules were changed to smaller droplets with greater coverage when the spray volume higher than 15.0 L/hm2.In all treatments,the number of droplets increased with decreasing VMD or increasing spray volume.The maximum percentage of spray coverage and the number of droplets that were achieved under the VMD of 150μm and the spray volume of 30.0 L/hm2 were 12.8%and 40.0 droplets/cm2,respectively.The variation coefficients of the percentage of spray coverage and the number of droplets were 29.0%-73.3%and 20.2%-54.1%,respectively.The most uniform deposition was achieved under the spray volume of 15.0 L/hm2and the VMD of 150μm.The results revealed the effect of droplet size and spray volume parameters on droplet deposition,which was useful for guiding farmers on how to use UAVs for weeding in winter wheat fields.

Studies on Droplet Size Distributions during Coalescence in Immiscible Polymer Blends Filled with Silica Nanoparticles

The effect of silica nanoparticles on the morphology of （10/90 wt%） PDMS/PBD blends during the shear induced coalescence of droplets of the minor phase at low shear rate was investigated systematically in situ by using an optical shear technique. Two blending procedures were used： silica nanoparticles were introduced to the blends by pre-blending silica particles first in PDMS dispersed phase （procedure 1） or in PBD matrix phase （procedure 2）. Bimodal or unimodal droplet size distributions were observed for the filled blends during coalescence, which depend not so much on the surface characteristics of silica but mainly on blending procedure. For pure （10/90 wt%） PDMS/PBD blend, the droplet size distribution exhibits bimodality during the early coalescence. When silica nanoparticles （hydrophobic and hydrophilic） were added to the blends with procedure l, bimodal droplet size distributions disappear and unimodal droplet size distributions can be maintained during coalescence; the shape of the different peaks is invariably Gaussian. Simultaneously, coalescence of the PDMS droplets was suppressed efficiently by the silica nanoparticles. It was proposed that with this blending procedure the nanoparticles should be mainly kinetically trapped at the interface or in the PDMS dispersed phase, which provides an efficient steric barrier against coalescence of the PDMS dispersed phase. However, bimodal droplet size distributions in the early stage of coalescence still occur when incorporating silica nanoparticles into the blends with procedure 2, and then coalescence of the PDMS droplets cannot be suppressed efficiently by the silica nanoparticles. It was proposed that with this blending protocol the nanoparticles should be mainly located in the PBD matrix phase, which leads to an inefficient steric barrier against coalescence of the PDMS dispersed phase; thus the morphology evolution in these filled blends is similar to that in pure blend and bimodal droplet size distributions can be observed during the early coalescence. These results imply that exploiting non-equilibrium processes by varying preparation protocol may provide an elegant route to regulate the temporal morphology of the filled blends during coalescence.

Effects of droplet size and spray interval on root-to-shoot ratio,photosynthesis efficiency,and nutritional quality of aeroponically grown butter head lettuce

The proper selection of the atomizer(droplet size)and nutrient solution spray interval is one of the most important factors to be investigated in aeroponics system for sustainable agriculture.The aim of this study was to research the effects of four aeroponics atomizing nozzles(one air-assisted;A_(1),two air-less;A_(2) and A_(3),and one ultrasonic fogger;A_(4))with droplet sizes of 11.24μm,26.35μm,17.38μm,and 4.89μm,respectively,four spray intervals(15 min(I_(1)),30 min(I_(2)),45 min(I_(3))and 60 min(I_(4)))at a 5 min of constant spray time by atomizing the Hoagland’s nutrient solution on growth,root-to-shoot ratio,photosynthesis characteristics,pigments,and nutritional quality of the aeroponically grown lettuce.The experimental results demonstrated that in A_(1) atomizer and I_(2) interval,the growth,photosynthesis efficiency,chlorophyll,carotenoids,and nutritional values of the lettuce were significantly higher compared to that grown in A_(2) and A_(3) atomizers at all spray intervals.The shoot developments were more constrained than root,prominent to the alteration of root-to-shoot ratio(fresh and dry)in the influence of different droplet sizes and spray intervals.Moreover,the plants did not grow well in A_(4) atomizer associated with proposed spray intervals.The results disclosed that there was an obvious interaction between droplet sizes(atomizers)and spray intervals for growth,the ratio of root to shoot,photosynthesis efficiency,pigments,and nutritional quality of the aeroponically grown lettuce.This research study increases the awareness of the proper droplet size(atomizer)and the regulation of nutrient solution spray interval for leafy vegetables grown in an aeroponics system.

Effect of droplet size on the jet breakup characteristics of n-butanol during impact on a heated surface

Jet breakup during droplet impacted on heated surface has received wide concerns due to its regularity.The Weber number(We)is a common used dimensionless parameter to classify and analyze the phenomenon,but it is unable to summarize all detailed phenomenon variations and related theory.Thus,the effect of droplet size on jet breakup was investigated by considering its significant difference in various scenarios.The behavior of n-butanol droplets with diameter range from 1.71 mm to 2.84 mm impacts a heated surface with jet breakup was recorded by backlit technology.Three parameters,the jet breakup time,the jet breakup length and the jet ligament diameter,were analyzed to illustrate the phenomenon.The results showed that these parameters are affected by the droplet size largely at 10<We<35,but affected lightly at higher Weber numbers.The sub-droplet diameter reduces with Weber number for all initial size droplets while the larger initial droplet corresponds to larger sub-droplet.The breakup time,breakup length and jet liga­ment diameter increase with the initial diameter.The time of jet breakup versus agrees well with the theory of Rayleigh instability regardless of droplet diameter.In addition,the jet breakup phenomenon was observed to evolve into pancake bouncing with an ultrafine high-speed jet when the We was above 50.

SIZE DISTRIBUTION OF DROPLETS ABOVE A ROTATING STREAM TRAY AND MODEL OF DROPLET MOTION THEREIN

Droplet size distributions have been investigated with a two-probe system above a rotatingstream tray of 300 mm diameter.The measured distributions are found to follow the upper limitedlognormal distribution with three parameters dependent primarily on gas hole F-factor.A probabilitymethod is used to describe the initial state of the droplet population above the tray,and a model fordroplet motion is presented.The results computed with model agree well with experimental data.

DETERMINATION OF DROPLET SIZE DISTRIBUTION AND WETNESS OF FLOWING STEAM FROM LIGHT EXTINCTION MEASUREMENTS

提出一种新方法，用光全散射测量数据确定流动蒸汽的湿度及水滴分布，并应用于一试验汽轮机的测量结果，计算得到的汽轮机排汽湿度与测功器的结果吻合良好。该法采用线性优化及合理的物理限制条件，可推广应用于光部分散射测量分析。

Study on imaging method for measuring droplet size in large sprays

Information of droplet size and size distribution lays the basis for investigations of atomization mechanisms and performance optimization, However, the laser diffraction and phase Doppler particle analyzers have difficulty in accurately characterizing sprays with a wide range of droplet sizes and very large droplets, especially ira large number of droplets are aspherical. A method to measure size in such large- droplet sprays based on digital imaging with backward illumination was developed, including an image acquisition system and image process programs. Calibration of the measurement system was performed using a dot calibration target with different dot sizes. An experimental setup was designed and established to characterize spray nozzles under different operation loads, as well as different nozzle arrangements. Results show that the droplet size of sprays ranges from dozens of microns to several millimeters. The superiority of wide load range for such nozzles was indicated by the size-measurement results under half-load to full-load operations. The present study revealed that the image processing technique can be effectively implemented for in-line size measurements of sprays with a wide distribution of droplet size and aspherical droplets, which would be difficult to characterize bv other methods.

不同结构参数对喷头雾化特性的影响规律

针对目前雾化喷嘴存在的雾化压力高、雾化范围小等问题,设计了一种雾化喷头,并分析了该喷头的雾化特性.利用激光粒度测试仪探究压力为0.15~0.30 MPa、出口直径为0.3~0.9 mm等条件下对喷头雾化锥角、速度场和液滴粒径的影响,获取了不同试验条件下流场流动特性的变化规律:在低压力下,雾化锥角受喷头出口直径的影响较大,出口收缩角越大则雾化特性越优良;出口直径为0.9 mm的喷头,喷腔长孔比为1、出口收缩角为75°时更能实现大范围的作业;随着喷雾压力增大,水滴速度最大值也显著增大,但压力对雾化流场整体速度分布趋势的影响不大.水滴直径也随着喷头出口直径增大而增大,且喷头出口直径对水滴直径影响显著,但水滴直径相同时,出口直径越大,水滴速度越小.该结果为雾化喷头在中低压范围内的应用提供了理论参考.

喷头雾化雾滴尺寸和速度的空间分布实验研究

雾滴尺寸及其运动速度直接影响药液的着靶效果和农药利用效率。为研究喷头雾化区域雾滴尺寸和雾滴速度空间分布,选取空气诱导扇形喷头IDK120-03、万能型平面扇形喷头LU120-03和防飘移扇形喷头AD120-03等3种典型喷头,利用相位多普勒粒子干涉仪测量了所选喷头在不同压力下的雾滴尺寸和雾滴速度,建模分析了喷头雾化后雾滴尺寸和雾滴速度空间分布规律。结果表明:在雾滴尺寸分布中,IDK120-03、LU120-03和AD120-03各喷头中心垂直方向上雾滴尺寸与垂直距离无明显关系,雾滴尺寸随喷雾压力增加而减小,呈线性关系,线性系数在-0.85~-0.54之间,相关程度均在0.96以上;水平方向上雾滴尺寸随水平距离增加而增大,对雾滴尺寸与水平距离二次多项式拟合,相关程度平均在0.90以上;垂直和水平方向上,IDK120-03喷头雾滴尺寸最大、LU120-03喷头最小。在雾滴速度分布中,各喷头中心垂直方向上雾滴速度随垂直距离增加而减小,呈线性关系,线性系数在-0.14~-0.01之间,相关程度均在0.99以上;水平方向上各喷头雾滴速度随水平距离增加而减小,对雾滴速度与水平距离二次多项式拟合,相关程度平均在0.96以上,AD120-03喷头雾滴速度最大,IDK120-03喷头最小,LU120-03喷头雾滴速度降低最快,IDK120-03喷头雾滴速度降低最慢。喷头雾化雾滴尺寸和速度的空间分布的研究可为提高施药质量提供依据。

风送喷雾辅助气流对雾滴粒径影响规律研究

风送喷雾技术被广泛运用在果园喷雾机研究中,辅助气流能够对雾滴进行二次雾化以进一步降低雾滴粒径。为进一步研究扇形喷头与辅助气流的角度和距离对雾滴粒径的影响,设计了一种喷头角度和喷头距离可调的喷雾装置,研究了喷头角度、喷头距离和喷雾压力对雾滴粒径的影响规律。结果表明:在辅助气流作用下,喷雾压力增大,雾滴粒径呈现降低趋势,但雾滴粒径均匀度先减小后增大;当喷雾压力0.3MPa、喷头角度10°~20°、喷头距离约为95mm时,雾滴粒径明显降低但雾滴粒径均匀度变大,雾滴粒径相对无辅助气流作用降低了10.35%。