Objective: To find out whether high resection rate and low incidence of disability can be obtained from operations for tumors on cerebral functional areas by applying “combined acupuncture-drug anesthesia”Methods: A...Objective: To find out whether high resection rate and low incidence of disability can be obtained from operations for tumors on cerebral functional areas by applying “combined acupuncture-drug anesthesia”Methods: According to the route of entry of operations, two different groups of acupoints for body acupuncture combined with ear acupuncture therapy were applied.Results: Among the 80 patients operated on, 20 were suffering from tumors in the speech center, 60 in the sensorimotor center. Good result was obtained from all the operations. Grade 1 effective rate of acupuncture anesthesia reached 100%. None of the patients experienced aggravation of dysphasia or dysfunction. Five patients showed aggravation of myasthenia and dysesthesia, but all of them recovered within 2-4 weeks.Conclusions: High resection rate and low incidence of disability may result from operations performed with “combined acupuncture-drug anesthesia;” so this kind of anesthesia can be used as a routine anesthetic method for operations.展开更多
The use of ＂bath salts＂ or other new psychoactive substances,otherwise known as ＂legal highs＂,is increasing.Illicit drug use during pregnancy is not uncommon.Nevertheless,literature reporting bath salts and their ...The use of ＂bath salts＂ or other new psychoactive substances,otherwise known as ＂legal highs＂,is increasing.Illicit drug use during pregnancy is not uncommon.Nevertheless,literature reporting bath salts and their effect on pregnancy is scant.Besides,there seems to be no literature about bath salts and conduct of general anesthesia.This case report describes a general anesthetic for the surgical delivery of an infant to a woman under the acute influence of bath salts and methamphetamines.展开更多
Long QT syndrome incidence is increasing in general population.A careful pre-,peri-and post-operative management is needed for patients with this syndrome because of the risk of Torsades de Pointes and malignant arrhy...Long QT syndrome incidence is increasing in general population.A careful pre-,peri-and post-operative management is needed for patients with this syndrome because of the risk of Torsades de Pointes and malignant arrhythmias.The available data regarding prevention of lethal Torsades de Pointes during anesthesia in patients with long QT syndrome is scant and conflicting:only case reports and small case series with different outcomes have been published.Actually,there are no definitive guidelines on pre-,peri-and post-operative anesthetic management of congenital long QT syndrome.Our review focuses on anesthetic recommendations for patients diagnosed with congenital long QT syndrome furnishing some key points for preoperative optimization,intraoperative anesthetic agents and postoperative care plan,which could be the best for patients with c-long QT syndrome who undergo surgery.展开更多
AIM: To investigate CYP2E1 IgG4 autoantibody levels and liver biochemical markers in adult patients after anesthesia with desflurane. METHODS: Forty patients who were > 18 years old and undergoing elective surgery ...AIM: To investigate CYP2E1 IgG4 autoantibody levels and liver biochemical markers in adult patients after anesthesia with desflurane. METHODS: Forty patients who were > 18 years old and undergoing elective surgery under general anes-thesia with desflurane were studied. Alpha-glutathione-S-transferase(aGST) and IgG4 antibodies againstCYP2E1 were measured preoperatively and 96 h post-operatively, as well as complete blood count, prothrom-bin time(PT), activated partial thromboplastin time(aPTT), international normalized ratio(INR), aspartate aminotransferase(SGOT), alanine aminotransferase(SGPT), g-glutamyl-transpeptidase(gGT), alkaline phosphatase, total serum proteins, albumin and bili-rubin. A separate group of 8 patients who received re-gional anesthesia was also studied for calibration of the methodology used for CYP2E1 IgG4 and aGST measure-ments. Student's t-test and the Mann-Whitney U test were used for comparison of the continuous variables, and Fisher's exact test was used for the categorical variables. All tests were two-tailed, with statistical sig-nificance set as P < 0.05.RESULTS: None of the patients developed postopera-tive liver dysfunction, and all patients were successfully discharged from the hospital. No statistically significant difference was observed regarding liver function tests(SGOT, SGPT, γGT, bilirubin, INR), aGST and CYP2E1 IgG4, before and after exposure to desflurane. After dividing patients into two subgroups based on whether or not they had received general anesthesia in the past, no significant difference in the levels of CYP2E1 IgG4 was observed at baseline or 96 h after desflurane administration(P = 0.099 and P = 0.051, respectively). Alpha-GST baseline levels and levels after the interven-tion also did not differ significantly between these two subgroups(P > 0.1). The mean aGST differences were statistically elevated in men by 2.15 ng/mL compared to women when adjusted for BMI, duration of anesthe-sia, number of times anesthesia was administered pre-viously and length of hospital stay. No significant dif-ference was observed between patients who received desflurane and those who received regional anesthesia at any time point.CONCLUSION: There was no difference in CYP2E1 IgG4 or aGST levels after desflurane exposure; furtherresearch is required to investigate their role in desflu-rane-induced liver injury.展开更多
文摘Objective: To find out whether high resection rate and low incidence of disability can be obtained from operations for tumors on cerebral functional areas by applying “combined acupuncture-drug anesthesia”Methods: According to the route of entry of operations, two different groups of acupoints for body acupuncture combined with ear acupuncture therapy were applied.Results: Among the 80 patients operated on, 20 were suffering from tumors in the speech center, 60 in the sensorimotor center. Good result was obtained from all the operations. Grade 1 effective rate of acupuncture anesthesia reached 100%. None of the patients experienced aggravation of dysphasia or dysfunction. Five patients showed aggravation of myasthenia and dysesthesia, but all of them recovered within 2-4 weeks.Conclusions: High resection rate and low incidence of disability may result from operations performed with “combined acupuncture-drug anesthesia;” so this kind of anesthesia can be used as a routine anesthetic method for operations.
文摘The use of ＂bath salts＂ or other new psychoactive substances,otherwise known as ＂legal highs＂,is increasing.Illicit drug use during pregnancy is not uncommon.Nevertheless,literature reporting bath salts and their effect on pregnancy is scant.Besides,there seems to be no literature about bath salts and conduct of general anesthesia.This case report describes a general anesthetic for the surgical delivery of an infant to a woman under the acute influence of bath salts and methamphetamines.
文摘Long QT syndrome incidence is increasing in general population.A careful pre-,peri-and post-operative management is needed for patients with this syndrome because of the risk of Torsades de Pointes and malignant arrhythmias.The available data regarding prevention of lethal Torsades de Pointes during anesthesia in patients with long QT syndrome is scant and conflicting:only case reports and small case series with different outcomes have been published.Actually,there are no definitive guidelines on pre-,peri-and post-operative anesthetic management of congenital long QT syndrome.Our review focuses on anesthetic recommendations for patients diagnosed with congenital long QT syndrome furnishing some key points for preoperative optimization,intraoperative anesthetic agents and postoperative care plan,which could be the best for patients with c-long QT syndrome who undergo surgery.
文摘AIM: To investigate CYP2E1 IgG4 autoantibody levels and liver biochemical markers in adult patients after anesthesia with desflurane. METHODS: Forty patients who were > 18 years old and undergoing elective surgery under general anes-thesia with desflurane were studied. Alpha-glutathione-S-transferase(aGST) and IgG4 antibodies againstCYP2E1 were measured preoperatively and 96 h post-operatively, as well as complete blood count, prothrom-bin time(PT), activated partial thromboplastin time(aPTT), international normalized ratio(INR), aspartate aminotransferase(SGOT), alanine aminotransferase(SGPT), g-glutamyl-transpeptidase(gGT), alkaline phosphatase, total serum proteins, albumin and bili-rubin. A separate group of 8 patients who received re-gional anesthesia was also studied for calibration of the methodology used for CYP2E1 IgG4 and aGST measure-ments. Student's t-test and the Mann-Whitney U test were used for comparison of the continuous variables, and Fisher's exact test was used for the categorical variables. All tests were two-tailed, with statistical sig-nificance set as P < 0.05.RESULTS: None of the patients developed postopera-tive liver dysfunction, and all patients were successfully discharged from the hospital. No statistically significant difference was observed regarding liver function tests(SGOT, SGPT, γGT, bilirubin, INR), aGST and CYP2E1 IgG4, before and after exposure to desflurane. After dividing patients into two subgroups based on whether or not they had received general anesthesia in the past, no significant difference in the levels of CYP2E1 IgG4 was observed at baseline or 96 h after desflurane administration(P = 0.099 and P = 0.051, respectively). Alpha-GST baseline levels and levels after the interven-tion also did not differ significantly between these two subgroups(P > 0.1). The mean aGST differences were statistically elevated in men by 2.15 ng/mL compared to women when adjusted for BMI, duration of anesthe-sia, number of times anesthesia was administered pre-viously and length of hospital stay. No significant dif-ference was observed between patients who received desflurane and those who received regional anesthesia at any time point.CONCLUSION: There was no difference in CYP2E1 IgG4 or aGST levels after desflurane exposure; furtherresearch is required to investigate their role in desflu-rane-induced liver injury.
