Background:Based on clinical data mining,we introduce the medication rule and clinical application of Professor Wang Lifen in the treatment of chronic urticaria,as the reference of clinical treatment of chronic urtica...Background:Based on clinical data mining,we introduce the medication rule and clinical application of Professor Wang Lifen in the treatment of chronic urticaria,as the reference of clinical treatment of chronic urticaria.Methods:we collected 110 traditional Chinese medicine prescriptions for the treatment of chronic urticaria,and found out tastes,functions and channel tropism of Chinese medicine.After collecting and sorting,we inputted the data into excel 2010 software and established drug electronic database.We calculated the frequency of tastes,functions and channel tropism using the Spss 20.0 and analyzed the potential relationship between the drugs using Weka 3.8.We used Cytoscape 3.6.1 to draw the related network and combine it into a new prescription.Then the clinical data of prescriptions were statistically analyzed.Results:The statistical analysis showed that the high-frequency drugs for the treatment of the disease were Gancao(Glycyrrhizae radix et rhizoma),Huangqin(Radix scutellariae),Desmopeel,Jingjie(Herba schizonepetae),parsnip,etc.,accounting for more than 69.50%of the total frequency.Moreover,the combination and drug pairs with the strongest and most commonly used high-frequency drugs were found.From the point of medicinal properties of these drugs in the treatment of chronic urticaria,the main drugs are cold,followed by warm and smooth,accounting for 70.75%of the total frequency.From the perspective of the efficacy of these drugs in the treatment of chronic urticaria,heat-clearing drugs are the main ones,followed by relieving drugs and Tonic drugs,accounting for 68.25%of the total frequency.From the perspective of medicine taste,sweet taste is the most important,followed by bitter and pungent taste,accounting for 68.00%of the total frequency.From the perspective of drugs channel tropism,the meridian of spleen is the most important,followed by the meridian of lung,liver,heart,stomach,etc.,accounting for 71.62%of the total frequency.Conclusion:According to the data mining results,traditional Chinese medicine treatment of chronic urticaria is mainly based on dispelling wind,clearing heat and removing dampness,cooling blood and detoxifying,supplemented by nourishing blood and nourishing deficiency.This data mining conforms to the law and principle of traditional Chinese medicine treatment of chronic urticaria,which has certain reference and enlightenment significance for clinical treatment of chronic urticaria.展开更多
Objective:To explore the general differentiation and treatment of insomnia by Professor Gao Ying through drug clustering and group correspondence analysis,and provide reference for clinical diagnosis and treatment.Met...Objective:To explore the general differentiation and treatment of insomnia by Professor Gao Ying through drug clustering and group correspondence analysis,and provide reference for clinical diagnosis and treatment.Methods:Collect retrospective case data from outpatient system,use SPSS20.0 software to perform frequency and cluster analysis on high-frequency symptoms and drug data,and perform corresponding analysis on the clustered drug syndrome groups.Results:A total of 349 consultations in 204 patients were included.Cluster analysis of 35 symptoms and 40 flavors with a frequency of more than 10%resulted in a corresponding relationship between 7 symptom groups,6 drug groups and 5 drug syndrome groups.The medicine symptom group has a high degree of matching;the doctors distinguish and tre at insomnia with calming,clearing heat,nourishing yin,liver,spleen,qi and phlegm as the core treatment,with consistent decoction,two to pill,lily ground Huang Tang,Lily Zhimu Decoction,Wendan Decoction,Sini San,Xiao Chai Hu Tang,Xiaoyao San,etc.are commonly used prescriptions;the physician's experience is to add or subtract Danshen and Zao Ren drink,which has a wide range of applicability to various insomnia syndrome.Conclusion:Based on the cluster analysis of drug symptoms and group correspondence analysis,it can reveal the pathogenesis,treatment and class information hidden in the data of drug symptoms,which can reflect the general law of physicians'syndrome differentiation and treatment of insomnia.This method has a reference for the exploration of TCM clinical experience significance;The results of this study can provide feedback to guide the clinical diagnosis and treatment of insomnia.展开更多
目的采用数据挖掘技术探讨中医药治疗银屑病血燥证的用药规律。方法以“银屑病”OR“白庀”为主题词,“血燥”OR“养血润燥”为自由词,采用主题词与自由词结合的方式检索中国知网(CNKI)、维普全文数据库(VIP)及万方数据知识服务平台,根...目的采用数据挖掘技术探讨中医药治疗银屑病血燥证的用药规律。方法以“银屑病”OR“白庀”为主题词,“血燥”OR“养血润燥”为自由词,采用主题词与自由词结合的方式检索中国知网(CNKI)、维普全文数据库(VIP)及万方数据知识服务平台,根据纳入及排除标准,建立原始数据库,进一步规范数据后使用Microsoft Excel 2016对药物频数及性味归经进行分析,利用统计产品与服务解决方案25(Statistical Product and Service Solutions,SPSS 25)对高频药物进行聚类分析和采用IBM数据挖掘平台SPSS Modeler 18.0对高频药物进行关联规则分析。以此筛选出高频药物,从药物性味、归经、功效等角度,观察其治疗银屑病血燥证的规律;并分析药物间的相关性;得出新的核心处方。结果(1)共收集符合标准的处方共117首,涉及中药141味。(2)高频药物排名前十:生地黄、当归、土茯苓、甘草、鸡血藤、白鲜皮、麦冬、丹参、牡丹皮、川芎;药物功效分类以清热药、补虚药、活血化瘀药、解表药为主;药性以寒性、温性为主;药味以甘、苦、辛为主;归经以肝经、心经、胃经为主。(3)关联规则得出生地黄、土茯苓,生地黄、鸡血藤,当归、麦冬,当归、何首乌等核心药对。(4)聚类分析得出聚类方4个。结论中医药治疗银屑病血燥证以“润”为大法,在“润”的基础上常配合凉血、活血、补血、养阴、祛风之品,为临床用药提供思考。展开更多
文摘Background:Based on clinical data mining,we introduce the medication rule and clinical application of Professor Wang Lifen in the treatment of chronic urticaria,as the reference of clinical treatment of chronic urticaria.Methods:we collected 110 traditional Chinese medicine prescriptions for the treatment of chronic urticaria,and found out tastes,functions and channel tropism of Chinese medicine.After collecting and sorting,we inputted the data into excel 2010 software and established drug electronic database.We calculated the frequency of tastes,functions and channel tropism using the Spss 20.0 and analyzed the potential relationship between the drugs using Weka 3.8.We used Cytoscape 3.6.1 to draw the related network and combine it into a new prescription.Then the clinical data of prescriptions were statistically analyzed.Results:The statistical analysis showed that the high-frequency drugs for the treatment of the disease were Gancao(Glycyrrhizae radix et rhizoma),Huangqin(Radix scutellariae),Desmopeel,Jingjie(Herba schizonepetae),parsnip,etc.,accounting for more than 69.50%of the total frequency.Moreover,the combination and drug pairs with the strongest and most commonly used high-frequency drugs were found.From the point of medicinal properties of these drugs in the treatment of chronic urticaria,the main drugs are cold,followed by warm and smooth,accounting for 70.75%of the total frequency.From the perspective of the efficacy of these drugs in the treatment of chronic urticaria,heat-clearing drugs are the main ones,followed by relieving drugs and Tonic drugs,accounting for 68.25%of the total frequency.From the perspective of medicine taste,sweet taste is the most important,followed by bitter and pungent taste,accounting for 68.00%of the total frequency.From the perspective of drugs channel tropism,the meridian of spleen is the most important,followed by the meridian of lung,liver,heart,stomach,etc.,accounting for 71.62%of the total frequency.Conclusion:According to the data mining results,traditional Chinese medicine treatment of chronic urticaria is mainly based on dispelling wind,clearing heat and removing dampness,cooling blood and detoxifying,supplemented by nourishing blood and nourishing deficiency.This data mining conforms to the law and principle of traditional Chinese medicine treatment of chronic urticaria,which has certain reference and enlightenment significance for clinical treatment of chronic urticaria.
基金Traditional Chinese Medicine Inheritance and Innovation"Hundreds of Millions"Talent Project(QiHuang Project)-Qihuang Scholars(National Education and Development of Traditional Chinese Medicine[2018]No.12)。
文摘Objective:To explore the general differentiation and treatment of insomnia by Professor Gao Ying through drug clustering and group correspondence analysis,and provide reference for clinical diagnosis and treatment.Methods:Collect retrospective case data from outpatient system,use SPSS20.0 software to perform frequency and cluster analysis on high-frequency symptoms and drug data,and perform corresponding analysis on the clustered drug syndrome groups.Results:A total of 349 consultations in 204 patients were included.Cluster analysis of 35 symptoms and 40 flavors with a frequency of more than 10%resulted in a corresponding relationship between 7 symptom groups,6 drug groups and 5 drug syndrome groups.The medicine symptom group has a high degree of matching;the doctors distinguish and tre at insomnia with calming,clearing heat,nourishing yin,liver,spleen,qi and phlegm as the core treatment,with consistent decoction,two to pill,lily ground Huang Tang,Lily Zhimu Decoction,Wendan Decoction,Sini San,Xiao Chai Hu Tang,Xiaoyao San,etc.are commonly used prescriptions;the physician's experience is to add or subtract Danshen and Zao Ren drink,which has a wide range of applicability to various insomnia syndrome.Conclusion:Based on the cluster analysis of drug symptoms and group correspondence analysis,it can reveal the pathogenesis,treatment and class information hidden in the data of drug symptoms,which can reflect the general law of physicians'syndrome differentiation and treatment of insomnia.This method has a reference for the exploration of TCM clinical experience significance;The results of this study can provide feedback to guide the clinical diagnosis and treatment of insomnia.
文摘目的采用数据挖掘技术探讨中医药治疗银屑病血燥证的用药规律。方法以“银屑病”OR“白庀”为主题词,“血燥”OR“养血润燥”为自由词,采用主题词与自由词结合的方式检索中国知网(CNKI)、维普全文数据库(VIP)及万方数据知识服务平台,根据纳入及排除标准,建立原始数据库,进一步规范数据后使用Microsoft Excel 2016对药物频数及性味归经进行分析,利用统计产品与服务解决方案25(Statistical Product and Service Solutions,SPSS 25)对高频药物进行聚类分析和采用IBM数据挖掘平台SPSS Modeler 18.0对高频药物进行关联规则分析。以此筛选出高频药物,从药物性味、归经、功效等角度,观察其治疗银屑病血燥证的规律;并分析药物间的相关性;得出新的核心处方。结果(1)共收集符合标准的处方共117首,涉及中药141味。(2)高频药物排名前十:生地黄、当归、土茯苓、甘草、鸡血藤、白鲜皮、麦冬、丹参、牡丹皮、川芎;药物功效分类以清热药、补虚药、活血化瘀药、解表药为主;药性以寒性、温性为主;药味以甘、苦、辛为主;归经以肝经、心经、胃经为主。(3)关联规则得出生地黄、土茯苓,生地黄、鸡血藤,当归、麦冬,当归、何首乌等核心药对。(4)聚类分析得出聚类方4个。结论中医药治疗银屑病血燥证以“润”为大法,在“润”的基础上常配合凉血、活血、补血、养阴、祛风之品,为临床用药提供思考。
