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Practice of Perioperative Rational Use of Antibacterial Drugs Based on Drug Pathway
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作者 Changkai ZHOU Fanbo JING +1 位作者 Haijun QU Jing GAO 《Medicinal Plant》 2024年第2期57-60,64,共5页
[Objectives]To establish a new management model for rational use of perioperative antibacterial drugs in surgical departments.[Methods]Based on evidence-based medicine,the department s drug pathway was formulated,and ... [Objectives]To establish a new management model for rational use of perioperative antibacterial drugs in surgical departments.[Methods]Based on evidence-based medicine,the department s drug pathway was formulated,and the new mode of rational drug use control was established by using fine pharmaceutical technology intervention,and the intervention effect was evaluated by the intensity of antibacterial drug use,per capita drug costs and the proportion of drugs.[Results]After adopting drug pathway in departments,the intensity of antibacterial drug use,per capita drug costs and the proportion of drugs decreased significantly,and the effect of rational drug use control was remarkable.[Conclusions]The drug pathway provides a new management and control mode for the rational use of perioperative antibacterial drugs in surgical departments of hospitals.Thus,it is worthy of popularization and application. 展开更多
关键词 Perioperative period Antibacterial drugs drug pathway rational drug use Management model
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Present situation of rational drug use in plateau area
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作者 Yanbin Chu Rong Wang 《Frigid Zone Medicine》 2023年第2期92-96,共5页
Plateau is characterized by low oxygen,low pressure,strong radiation,cold and dryness,among which low oxygen is the main factor that affects the normal life activities of human body.Altitude hypoxia leads to significa... Plateau is characterized by low oxygen,low pressure,strong radiation,cold and dryness,among which low oxygen is the main factor that affects the normal life activities of human body.Altitude hypoxia leads to significant changes in the metabolic characteristics of drugs in vivo,which in turn affects the efficacy and adverse actions of drugs.This paper summarizes the present situation of rational drug use in plateau area and pinpoints the existing problems.Meanwhile,we posit the strategies and measures for realizing rational and precise pharmacotherapy of plateau residents.First,we need to acquire a panoramic view of differential and relative pharmacokinetics and pharmacodynamics in between plateau area and plain area by carrying out comparative studies on drug metabolisms and on comprehensive drug efficacies and mechanisms.Second,we must apply the findings from basic research to clinical practice and formulate guidelines and recommendations of drug use for plateau habitants.Finally,we should eventually achieve precise and individualized drug use for plateau habitants based on their characteristic etiology and pathogenesis. 展开更多
关键词 PLATEAU HYPOXIA rational drug use PHARMACOKINETICS
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Analysis on the Problems of Rational Drug Use Carrying Out by Hospital Pharmacists in China
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作者 Han Yang Yongfa Chen 《Open Journal of Preventive Medicine》 2021年第6期251-258,共8页
Pharmacists are the implementers of clinical drug management, and they play an irreplaceable role in promoting the improvement of rational drug use. However, the current role of pharmacists in the supervision and prot... Pharmacists are the implementers of clinical drug management, and they play an irreplaceable role in promoting the improvement of rational drug use. However, the current role of pharmacists in the supervision and protection of rational drug use has not been fully exerted. This article is aimed to investigate the current situation of pharmacists’ work of rational drug use from the perspectives of pharmacists, physicians, and patients. It is found that the professional value of pharmacists in the rational drug use has not been valued by medical institutions, physicians, and patients. Pharmacists face problems such as workload, working conditions, and doctor-patient cooperation in the rational drug use. Suggestions are made for further exerting the professional value of pharmacists in promoting the level of rational drug use. Relevant managers should pay full attention to the professional value of pharmacists, and provide corresponding system and facility guarantees for pharmacists to carry out rational drug use. 展开更多
关键词 Hospital Pharmacist rational drug use Investigation and Analysis
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Investigation and Analysis of Rational Drug Use of Residents in Changshou District of Chongqing, China
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作者 Yu Jiangxia Fan Yongtong +1 位作者 Wu Ruizhu Ji Huanhuan 《Journal of Clinical and Nursing Research》 2018年第4期16-19,共4页
The objective of this study was to acquire the information about residents of Changshou District’s knowledge levels and their behaviors of drug use so that implementation strategies of rational drug use can be formul... The objective of this study was to acquire the information about residents of Changshou District’s knowledge levels and their behaviors of drug use so that implementation strategies of rational drug use can be formulated accordingly to promote and spread health education of rational drug use.Online and offline surveys were randomly conducted about rational drug use conditions of residents in Changshou District by questionnaires.Online questionnaires were sent to residents of Changshou District by Wenjuanxing,a professional platform used for surveys.Offline questionnaires were mainly distributed to residents of communities in Changshou District.All the online and offline statistics were analyzed and counted.309 questionnaires were distributed(176 online questionnaires and 133 paper questionnaires),and the effective recovery rate was 75.4%.According to investigation and survey,conditions of resident’s rational drug use were optimistic.Only 8.15%of residents who participated in the survey(or research subjects)took paracetamol tablets and Vitamin C Yinqiao tablets(also known as VC Honeysuckle Pills)at the same time when they had a cold or fever.Among 8.15%of residents,5.15%frequently took paracetamol,caffeine,and aspirin powder(also known as headache powder),80.26%checked expiration date of drugs before taking medicine,and>50%knew that drinking after taking medicines such as cephalosporin is prohibited.Common irrational problems caused by drug use were as follows:40%of research subjects took dietary supplements as drugs and 28%of them failed to know the correct usage and dosage of drugs.Proportion of drugs that were taken with irrational usage and dosage was antibiotics(64%),antibacterial(52%),drugs for patients with diabetes mellitus(36%),drugs for patients with hyperlipidemia,hypertension,and hyperglycemia(32%),vitamins(24%),drugs for the treatment of common cold and cough(20%),and others.Publicity of rational drug use should not be restricted to specific population,and knowledge of safe drug use is supposed to be actively popularized.Contents of rational drug use are as follows:Guide the public to correctly understand the functions of vitamins and dietary supplements strengthen publicity of rational use of drugs such as antibiotics,antibacterial drugs,drugs for chronic diseases,cold,and cough.Focus should be given on usage and dosage of drugs,use of antibacterial drugs,and repeated and excessive use of drugs caused by joint use of drugs with same ingredients of OTC drugs for the treatment of common cold and cough. 展开更多
关键词 CHONGQING Changzhou DISTRICT RESIDENTS rational drug use INVESTIGATION and analysis
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The Level of Knowledge, Behaviors, and Attitudes on Rational Use of Drugs of Patients Who Applied to the Family Health Center in Istanbul, Türkiye: A Cross-Sectional Study
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作者 Kezban Yavuz Emik Ayşe Emel Önal Emel Rüya Önal 《Pharmacology & Pharmacy》 2023年第12期493-512,共20页
Background: This study, it was aimed to determine the level of knowledge, attitudes, and behaviors of patients who applied to a family health center about the rational use of drugs. Irrational use of drugs is a major ... Background: This study, it was aimed to determine the level of knowledge, attitudes, and behaviors of patients who applied to a family health center about the rational use of drugs. Irrational use of drugs is a major problem worldwide. WHO reports that half of the patients do not use their drugs correctly. Methods: This cross-sectional study was conducted between 1 October 2017 and 30 November 2018 at Istanbul Fatih Family Health Center No 7. The sample size was determined as 301 people selected by systematic sampling method from patients aged 18 and older. Results: The mean age of the participants was 53.8% ± 16.8%, 59.8% were female, 62.5% were married, and 52.5% were primary school graduates. 63.9% of the participants knew the names of the drugs they used, and 79.9% of them knew the indication for use. 89% of individuals check the expiry date of the drugs before using them, and 83.1% read the drug prospectus. 84% of the participants support the prohibition of using over-the-counter drugs. Conclusion: The level of knowledge of the participants about the rational use of drugs is above the societal average. However, some issues need more awareness. The high level of rational use of drugs awareness of physicians and pharmacists will also strengthen the rational use of drugs and indirectly increase the awareness of the public. 展开更多
关键词 rational use of drugs Irrational use of drugs Family Health Center Over-The-Counter drugs
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The Guiding Role of Pharmaceutical Care in the Rational Drug Use of Bronchial Asthma
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作者 Hongmei Chen 《Journal of Integrative Medicine(双语)》 2019年第1期23-26,共4页
Objective:To investigate the guiding role of pharmaceutical care in the treatment of bronchial asthma.Methods:Eighty patients with bronchial disease admitted to our hospital from November 2008 to December 1818 were en... Objective:To investigate the guiding role of pharmaceutical care in the treatment of bronchial asthma.Methods:Eighty patients with bronchial disease admitted to our hospital from November 2008 to December 1818 were enrolled in this research.The computer program was used to generate random numbers.The method was divided into two groups:control group and observation group,40 cases respectively.40 patients in the control group were treated with normal medication according to the doctor’s advice;40 patients in the observation group were enrolled in the pharmacological care on the basis of the control group,and the rational drug use was compared between the two groups.Results:The incidence of adverse reactions in the observation group and the control group were 5.00%and 17.50%,respectively,and the difference was statistically significant(P<0.05);the incidence of medication error events in the observation group was 7.50%,which was significantly lower than that of the control group,which was 25.00%,and the difference was statistically significant(P<0.05).The medication errors mainly include improper administration,incorrect dosage,and unscientific administration.Conclusion:The guiding role of pharmaceutical care in bronchial asthma rational drug use can reduce medication error events and ensure rational drug use,which is worthy of popularization in clinical practice. 展开更多
关键词 Pharmaceutical care Bronchial Asthma rational drug use ROLE
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Current State of Nanoemulsions in Drug Delivery 被引量:5
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作者 Charles Lovelyn Anthony A. Attama 《Journal of Biomaterials and Nanobiotechnology》 2011年第5期626-639,共14页
Nanoemulsions have attracted great attention in research, dosage form design and pharmacotherapy. This is as a result of a number of attributes peculiar to nanoemulsions such as optical clarity, ease of preparation, t... Nanoemulsions have attracted great attention in research, dosage form design and pharmacotherapy. This is as a result of a number of attributes peculiar to nanoemulsions such as optical clarity, ease of preparation, thermodynamic stability and increased surface area. Nanoemulsions also known as submicron emulsions serve as vehicles for the delivery of active pharmaceutical ingredients as well as other bioactives. They are designed to address some of the problems associated with conventional drug delivery systems such as low bioavailability and noncompliance. The importance of design and development of emulsion nanocarrier systems aimed at controlling and/or improving required bioavailability levels of therapeutic agents cannot be overemphasized. Reducing droplet sizes to the nanoscale leads to some very interesting physical properties, such as optical transparency and unusual elastic behaviour. This review sheds light on the current state of nanoemulsions in the delivery of drugs and other bioactives. The morphology, formulation, characteristics and characterization of nanoemulsions were also addressed. 展开更多
关键词 NANOEMULSION preparation CHARACTERIZATION application in drug Delivery Patents
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The role of drug utilization evaluation in medical sciences
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作者 Ruby Gangwar Arvind Kumar +2 位作者 Abrar Ahmed Zargar Amit Sharma Ranjeet Kumar 《Global Health Journal》 2023年第1期3-8,共6页
Background:Drug utilization evaluation(DUE)is defined by the World Health Organization(WHO)and focuses on the medical,social,and economic consequences of pharmaceutical marketing,distribution,prescribing,and usage in ... Background:Drug utilization evaluation(DUE)is defined by the World Health Organization(WHO)and focuses on the medical,social,and economic consequences of pharmaceutical marketing,distribution,prescribing,and usage in society.The WHO recommends a physician to every 1000 people.According to the recent data from the Health Ministry in 2019,in which 1.16 million doctors are of active population with just 80%,or 0.9 million,practicing.As a result,a ratio of 0.68 doctors for every 1000 people,which is much below as per the WHO reports.This article describes history,types,WHO guidelines,need and purpose of DUE.Objective:The main aim of this paper is to provide information about the rational use of medication in outpa­tient and inpatient department with special emphasis of DUEs.It also provides awareness directly to healthcare professionals,researchers,academicians,pharmacist and nurses to reduce the irrationality of medicines.Methods:The method used to compile this review information gathered from websites,Google scholar,PubMed,Research gate,and studies published on DUE from July 20 to Oct 22 were included as source of information.Results:We studied more than 35 published study on DUE,that reveals most of the physicians prescribed branded drugs not generic drugs,but WHO prescribing indicator allows to prescribe generic drugs in the hospital pharmacy to maintain better inventory control.It may also help to prevent pharmacist misunderstanding during dispensing.Conclusion:The use of generic prescription names avoids the possibility of medication product duplication and lowers patient costs.It is important to remember that incorrect medication prescriptions have impact on both patients and their family members.WHO indicators identify irrational prescribing behaviours to make therapy more rational and cost-effective. 展开更多
关键词 Anatomical therapeutic chemical classification drug utilization evaluation Prescribing indicators Pregnancy risk classification rational use of the drug
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Mining Typical Treatment Duration Patterns for Rational Drug Use from Electronic Medical Records 被引量:2
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作者 Jingfeng Chen Chonghui Guo +1 位作者 Leilei Sun Menglin Lu 《Journal of Systems Science and Systems Engineering》 SCIE EI CSCD 2019年第5期602-620,共19页
Rational drug use requires that patients receive medications for an adequate period of time.The adequate duration time of medications not only improve the therapeutic effect of medicines,but also reduce the side effec... Rational drug use requires that patients receive medications for an adequate period of time.The adequate duration time of medications not only improve the therapeutic effect of medicines,but also reduce the side effects and adverse reactions of medicines.This paper proposes a data-driven method to mine typical treatment duration patterns for rational drug use from electronic medical records (EMRs).Firstly,a quintuple is defined to describe drug use duration statistics (DUDS) for each drug and treatment record is further represented with DUDS vector (DUDSV).Next a similarity measure method is adopted to compute the similarity between treatment records.Meanwhile,a clustering algorithm is used to cluster all patient treatment records to extract typical treatment duration patterns including typical drug sets,effective drug use day sets,and the DUDSs of each typical drug.Then the extracted typical treatment duration patterns are evaluated and annotated based on patients' demographic information,disease severity scores,treatment outcome and diagnostic information.Finally,a real-world EMR dataset is performed to indicate that the approach we proposed can effectively mine typical treatment duration patterns from EMRs and recommend the appropriate treatment regimens for patients based on their admission information. 展开更多
关键词 EMR data MINING rational drug use TYPICAL treatment DURATION pattern SIMILARITY measure clustering
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基于多学科协作管理模式结合PDCA质量管理工具对中药注射剂的管控效果分析 被引量:1
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作者 马娟娟 程月召 +4 位作者 石婧 高旭 范顺心 陈品英 程杰 《中国医院用药评价与分析》 2024年第2期252-256,共5页
目的:探讨多学科协作管理模式结合PDCA质量管理工具用于医院中药注射剂管理的成效,为促进中药注射剂的合理应用提供参考。方法:成立多学科协作管理小组,运用PDCA质量管理工具,采取综合干预措施管控河北省中医院(以下简称“该院”)中药... 目的:探讨多学科协作管理模式结合PDCA质量管理工具用于医院中药注射剂管理的成效,为促进中药注射剂的合理应用提供参考。方法:成立多学科协作管理小组,运用PDCA质量管理工具,采取综合干预措施管控河北省中医院(以下简称“该院”)中药注射剂的临床应用。以2020年为干预前、2021年为第1阶段干预后、2022年为第2阶段干预后,对比干预效果。结果:干预前,该院中药注射剂合理使用率为92.38%(3 008/3 256),第1阶段干预后、第2阶段干预后分别升高至94.64%(3 740/3 952)、97.34%(3 766/3 869),与干预前的差异有统计学意义(P<0.001),中药注射剂不合理使用情况得到明显改善。第2阶段干预后,在超疗程、未冲管方面较第1阶段干预后明显改善,差异均有统计学意义(P<0.001),且未发现中西药混合输注、溶剂剂量不适宜、给药途径不适宜、溶剂种类选择不当等问题。干预后,中药注射剂相关不良反应占药品总不良反应的比例呈逐年降低趋势,尤其是第2阶段干预后较干预前明显降低,差异有统计学意义(P=0.013)。结论:在医院中药注射剂管理中运用多学科协作管理模式结合PDCA质量管理工具,可使管理质量显著提高,该方法值得在医院药事管理中推广。 展开更多
关键词 中药注射剂 多学科协作管理 PDCA 合理用药
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中成药治疗复发性流产的临床研究概况性综述 被引量:1
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作者 余馨 贡磊磊 +2 位作者 姚伟洁 袁偲偲 冯欣 《中国药物警戒》 2024年第4期361-365,385,共6页
目的系统梳理中成药治疗复发性流产(RSA)的药品信息和临床研究现状,为临床合理用药提供参考证据,为临床实践和医疗卫生决策提供依据。方法检索中英文数据库中对中成药治疗RSA的临床文献进行系统回顾,利用相关软件进行文献管理,并对药品... 目的系统梳理中成药治疗复发性流产(RSA)的药品信息和临床研究现状,为临床合理用药提供参考证据,为临床实践和医疗卫生决策提供依据。方法检索中英文数据库中对中成药治疗RSA的临床文献进行系统回顾,利用相关软件进行文献管理,并对药品及研究的基本信息进行提取,以文字描述和图表的形式开展可视化对比分析。结果共纳入95篇文献,包括系统评价和Meta分析2篇,临床研究93篇;涉及11种中成药,包括1种中药注射剂。临床研究数量较多的药品是滋肾育胎丸、固肾安胎丸和保胎灵制剂;2005年起相关研究数量整体呈升高趋势,已在全国24个地区开展;样本量为51~100例的研究最多,包括67项(72.04%);研究数量最多的比较类型是中成药联合西药与西药比较,研究总量达75项(80.65%)。目前临床无统一的治疗方案及疗效判断标准,部分研究(43.01%)记录了患者用药过程中不良反应发生情况。结论临床上中成药治疗RSA具有较好的适宜性,其与西药联用的效果明确。但存在药品说明书内容缺乏、用药时机疗程和结局评价指标未标准化、用药安全的重视程度不够、中医特色体现度不足等问题有待未来改善。 展开更多
关键词 复发性流产 习惯性流产 滋肾育胎丸 固肾安胎丸 保胎灵制剂 中成药 合理用药
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人血白蛋白心外科围手术期应用合理性多中心回顾性调查分析
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作者 潘文斐 于欢 +7 位作者 党大胜 陈丽娟 李特 史天陆 黄帮华 李波霞 弓小雪 王莹 《药物流行病学杂志》 CAS 2024年第2期176-183,共8页
目的调查国内多地区心外科围手术期人血白蛋白(HSA)临床应用情况,结合临床指南评价其应用合理性,为促进HSA的合理应用提供参考。方法回顾性收集2019年4—6月全国8家医院行心外科手术患者的病历资料,统计患者一般资料、HSA的用法用量、... 目的调查国内多地区心外科围手术期人血白蛋白(HSA)临床应用情况,结合临床指南评价其应用合理性,为促进HSA的合理应用提供参考。方法回顾性收集2019年4—6月全国8家医院行心外科手术患者的病历资料,统计患者一般资料、HSA的用法用量、疗程、费用,用药前后血清白蛋白水平等信息,分析HSA的使用情况,建立相关评价标准对其应用的合理性进行评价。结果共纳入患者449例,HSA用药合理率为81.1%。用药疗程>2~5 d居多,HSA应用总量在50~99 g居多,用药目的主要为提高胶体渗透压、减轻渗出以改善间质水肿和术后扩充血容量。结论保证心外科围手术期HSA的合理应用,防止血液制品滥用需要引起临床的高度重视。 展开更多
关键词 人血白蛋白 临床应用 回顾性调查 合理用药
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银杏及其制剂药用发展及毒性评价研究述评 被引量:5
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作者 赵一懿 郭洪祝 《上海中医药杂志》 CSCD 2024年第1期16-22,共7页
基于我国古代银杏药用历史和近现代国内外银杏产业发展史对银杏药用发展概况进行述评,并针对银杏制剂毒副作用及不良反应方面所关注的成分组成、药理活性及检测方法等进行归纳总结,借古论今,以期正确看待联合用药、合理用药及银杏制剂... 基于我国古代银杏药用历史和近现代国内外银杏产业发展史对银杏药用发展概况进行述评,并针对银杏制剂毒副作用及不良反应方面所关注的成分组成、药理活性及检测方法等进行归纳总结,借古论今,以期正确看待联合用药、合理用药及银杏制剂毒性评价研究,为后续进一步开发银杏药用价值提供参考依据。 展开更多
关键词 银杏 中药制剂 药理作用 生物活性 银杏酸 中药毒性 合理用药 述评
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抗免疫球蛋白E药物在儿童哮喘中的合理应用
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作者 陈静 向莉 《中国合理用药探索》 CAS 2024年第8期60-64,共5页
儿童哮喘作为一种常见的慢性呼吸道疾病,对患儿的生活质量及家庭负担造成了严重影响。近年来,抗免疫球蛋白E(IgE)药物作为治疗儿童哮喘的新型生物制剂,其疗效和安全性得到了广泛关注。本文综述了抗IgE药物在儿童哮喘治疗中的研究进展,... 儿童哮喘作为一种常见的慢性呼吸道疾病,对患儿的生活质量及家庭负担造成了严重影响。近年来,抗免疫球蛋白E(IgE)药物作为治疗儿童哮喘的新型生物制剂,其疗效和安全性得到了广泛关注。本文综述了抗IgE药物在儿童哮喘治疗中的研究进展,包括作用机制、药物特性、临床应用及与其他治疗药物的联合应用等,旨在探讨抗IgE药物在儿童哮喘中的合理应用策略及治疗展望,以期为临床实践提供参考。 展开更多
关键词 儿童哮喘 治疗 生物制剂 抗IgE药物 合理应用
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奥氮平治疗精神分裂症血药浓度监测及影响因素分析
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作者 路淑淑 张贝贝 +3 位作者 张巍献 裴可灵 王海鹏 杨楹 《医学检验与临床》 2024年第6期6-10,共5页
目的:了解奥氮平治疗精神分裂症患者的血药浓度情况及其影响因素,为临床个体化用药提供参考。方法:收集2022年度山东省精神卫生中心精神分裂症住院患者服用奥氮平治疗进行血药浓度监测的临床资料,采用卡方检验和logistic回归分析年龄、... 目的:了解奥氮平治疗精神分裂症患者的血药浓度情况及其影响因素,为临床个体化用药提供参考。方法:收集2022年度山东省精神卫生中心精神分裂症住院患者服用奥氮平治疗进行血药浓度监测的临床资料,采用卡方检验和logistic回归分析年龄、性别、服药剂量、是否首发等因素对患者血药浓度是否达标的影响。结果:纳入分析的539例患者共计监测1593例次血药浓度,其中1250例次(78.47%)血药浓度达标。19~40岁和41~59岁年龄组患者血药浓度达标率分别是≤18岁年龄组患者的1.838倍(P=0.044)和1.946倍(P=0.038)。女性患者血药浓度达标率是男性患者的0.460倍(P<0.000)。服用剂量为5~10mg和10~30mg的患者血药浓度达标率分别是服用剂量≤5mg患者的9.252倍(P<0.001)和11.117倍(P<0.001)。结论:服用剂量对奥氮平血药浓度达标具有正向作用,且存在个体差异,应常规进行奥氮平血药浓度监测,提高精神分裂症治疗的有效性和安全性。 展开更多
关键词 奥氮平 血药浓度 治疗药物监测 合理用药
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《国家基本药物临床应用指南(2018版)》孕妇禁用中成药收载情况分析
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作者 王娇 马彦江 刘前进 《亚太传统医药》 2024年第6期243-246,共4页
目的:了解《国家基本药物临床应用指南(2018版)》中孕妇禁用中成药的情况,为进一步完善基本药物目录品种及促进临床合理用药提供参考。方法:对《国家基本药物临床应用指南(2018版)》含孕妇禁用中成药的收载情况进行汇总和分析。结果:书... 目的:了解《国家基本药物临床应用指南(2018版)》中孕妇禁用中成药的情况,为进一步完善基本药物目录品种及促进临床合理用药提供参考。方法:对《国家基本药物临床应用指南(2018版)》含孕妇禁用中成药的收载情况进行汇总和分析。结果:书中共收载孕妇禁用中成药112种,其中内科、外科、妇科、眼科、耳鼻喉科、骨伤科类分别有64、12、14、2、5、15种;含土鳖虫成药10种(占8.92%);含麝香(人工麝香)成药8种(占7.14%);含朱砂、雄黄成药7种(占6.25%);含附子、制川乌、制草乌成药5种(占4.46%);含马钱子、细辛成药9种(8.04%);含罂粟壳成药2种(占1.79%);其他饮片成药71种(65.19%);按剂型分类注射剂、口服剂、外用剂、其他剂型分别有5、98、8、1种。结论:孕妇禁用中成药品种、剂型分布合理,但存在剂量、标注不规范等问题,仍需进一步完善。研究结果可为下一步整理其他特殊人群用药提供借鉴,为临床合理用药提供更加准确的理论指导。 展开更多
关键词 2018版《国家基本药物临床应用指南》 孕妇禁用 中成药 合理用药
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基于不同年龄段人群的金莲清热制剂不良反应报告分析
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作者 张纾 林翼旻 +1 位作者 张玲萍 黄榕珍 《中南药学》 CAS 2024年第7期1929-1933,共5页
目的探讨不同年龄段人群使用金莲清热制剂的相关安全性风险,为临床合理用药提供参考。方法结合福建省药品不良反应监测数据库(2004年1月—2023年6月)、国内文献报道及药品监管机构采取的风险管理等资料,分析不同年龄段人群使用金莲清热... 目的探讨不同年龄段人群使用金莲清热制剂的相关安全性风险,为临床合理用药提供参考。方法结合福建省药品不良反应监测数据库(2004年1月—2023年6月)、国内文献报道及药品监管机构采取的风险管理等资料,分析不同年龄段人群使用金莲清热制剂的不良反应情况,分析其可能存在的风险。结果金莲清热制剂药品不良反应主要涉及15岁以下的儿童,多在用药当日发生,最突出的是以腹泻为主的胃肠道反应和以皮疹、瘙痒为主的过敏反应。结论金莲清热制剂不良反应一般较轻,大多数不需要特殊处理,但需关注儿童用药安全。根据药品安全性评价结果,国家药品监督管理局已发布对金莲清热制剂药品说明书的修订要求,药品上市许可持有人按要求修订说明书的同时还应积极开展与医务人员和患者的沟通和宣贯教育,保障患者用药安全。 展开更多
关键词 金莲清热制剂 不良反应 合理用药
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84例接骨七厘制剂不良反应分析与管理建议
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作者 龙慧玲 贺先琳 《中国合理用药探索》 CAS 2024年第7期99-103,共5页
目的:分析接骨七厘制剂的药品不良反应(ADR)发生特征,为其安全合理用药提供参考。方法:收集2010年1月1日~2022年12月6日期间国家药品不良反应监测系统中有关接骨七厘制剂的ADR报告,采用回顾性研究方法对患者性别、年龄、用药原因、严重... 目的:分析接骨七厘制剂的药品不良反应(ADR)发生特征,为其安全合理用药提供参考。方法:收集2010年1月1日~2022年12月6日期间国家药品不良反应监测系统中有关接骨七厘制剂的ADR报告,采用回顾性研究方法对患者性别、年龄、用药原因、严重ADR报告、ADR累及系统/器官及主要临床表现、合并用药进行统计分析。结果:共收集了84例ADR报告,其中男性患者略多于女性患者,患者年龄多分布在45~64岁(36.90%),主要用药原因为骨折(51.19%),有11例严重ADR报告,ADR累及系统/器官主要为胃肠系统疾病(61.15%),与活血止痛胶囊联用时出现的ADR较多。结论:在临床使用中应当加强接骨七厘制剂ADR监测,确保患者用药合理安全。 展开更多
关键词 接骨七厘制剂 药品不良反应 合理用药 不良反应监测 分析
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上饶市眼科医院2021至2022年滴眼剂使用分析
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作者 张传林 童雪燕 徐小婷 《当代医学》 2024年第12期78-81,共4页
目的分析上饶市眼科医院眼用制剂临床使用情况,为眼用制剂的供应管理提供参考。方法回顾性分析2021年1月至2022年12月上饶市眼科医院眼用制剂用药金额、门诊及住院患者均次费用、医保及基本药物目录内用药金额、不同类别和不同制剂药物... 目的分析上饶市眼科医院眼用制剂临床使用情况,为眼用制剂的供应管理提供参考。方法回顾性分析2021年1月至2022年12月上饶市眼科医院眼用制剂用药金额、门诊及住院患者均次费用、医保及基本药物目录内用药金额、不同类别和不同制剂药物使用情况。结果2022年,上饶市眼科医院眼用制剂使用金额较2021年下降13.89%,门诊患者眼用制剂用药金额和均次费用分别下降21.86%和19.13%,住院患者眼用制剂用药金额和均次费用分别上升10.21%和5.10%。2022年,国家医保药物金额和国家基本药物使用金额较2021年分别下降9.14%和33.63%,但国家医保药物金额占比上升5.51%,国家基本药物金额占比下降22.92%。2021和2022年感染炎症治疗药物、干眼与视力疲劳治疗药物、青光眼治疗药物一直位于使用金额的前三位,其使用金额占比分别达到了56.76%、24.22%、9.08%和59.70%、19.06%、11.51%。用于感染炎症、干眼、青光眼治疗药物用量及金额位于前三位。结论上饶市眼科医院眼用制剂种类丰富,部分临床监测指标趋于合理,但仍需提高基本药物和医保品种的配备使用,降低住院患者药品费用。 展开更多
关键词 眼用制剂 用药分析 次均费用 合理用药
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医院地佐辛注射液临床应用情况调查与合理用药分析
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作者 宋盛瀛 葛俊 吕剑涛 《医学综述》 CAS 2024年第15期1915-1920,共6页
目的调查医院地佐辛注射液的临床应用情况,分析其用药合理性。方法回顾性分析2020年1月1日至12月31日滨州医学院烟台附属医院应用地佐辛注射液治疗的7768例患者的临床资料及用药情况,在适应证、用法用量、用药天数等方面进行用药合理性... 目的调查医院地佐辛注射液的临床应用情况,分析其用药合理性。方法回顾性分析2020年1月1日至12月31日滨州医学院烟台附属医院应用地佐辛注射液治疗的7768例患者的临床资料及用药情况,在适应证、用法用量、用药天数等方面进行用药合理性评价。结果对地佐辛注射液使用患者多次入院产生的年龄增长进行全面统计显示,总例数7868例(总入院8336例次),其中男3598例、女4270例,年龄3~96岁,平均(51±17)岁。全院共有49个科室使用地佐辛注射液,总计149.5 g,其中使用量前十的科室的地佐辛注射液使总量为108.882 g,占全年使用量的72.83%。7768例使用地佐辛注射液的患者中,诊断排名前五的是肿瘤(1632例,21.01%)、外伤(1316例,16.94%)、炎症性疾病(935例,12.04%)、剖宫产(865例,11.14%)、腰椎间盘突出症(293例,3.77%)。7768例患者中,需谨慎用药的患者538例(6.93%)。7768例(总入院8336例次)患者每次入院的首次使用地佐辛注射液,术中用、肌内注射为主要用法,分别占入院总例次的54.98%、39.13%。其中不合理的用法有领药、局部麻醉、外用和嚼服。用药1~7 d的患者共8149例次,占总入院例次的97.76%;用药时间>7 d的为187例次,占比2.24%,主要为胃肠外科(28例次)、肿瘤科(42例次)、神经外科(25例次),主要临床诊断为恶性肿瘤。结论医院地佐辛注射液的临床应用基本合理,但存在给药方式不合理、用法不规范、慎用人群用药和用药时间过长的问题,可使用审方软件进行前置审核措施,提高药师审方能力。 展开更多
关键词 地佐辛 临床应用 合理用药
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