AIM: To investigate the loci of adefovir dipivoxil (ADV)-induced resistance in hepatitis B virus (HBV) isolates and optimize the management of ADV-treated patients.
从发病的养殖水样及鳗鲡体表溃烂处组织分离出一株M-1菌株,经16S r RNA测序鉴定为嗜水气单胞菌。对该菌进行溶血性、药物敏感性试验,结果表明:该菌株具有溶血性,并对链霉素、庆大霉素表现敏感,而对四环素、青霉素G、左氟沙星、诺氟沙星...从发病的养殖水样及鳗鲡体表溃烂处组织分离出一株M-1菌株,经16S r RNA测序鉴定为嗜水气单胞菌。对该菌进行溶血性、药物敏感性试验,结果表明:该菌株具有溶血性,并对链霉素、庆大霉素表现敏感,而对四环素、青霉素G、左氟沙星、诺氟沙星等6种抗生素表现出耐药性。在鳗鲡感染试验中,表现出具有较强的致病性,注射约107CFU/mL病原菌液0.5 mL,72 h内致死率达100%。在养殖防治模拟试验中,20%戊二醛溶液和10%聚维酮碘溶液的防治效果与庆大霉素接近,可大幅度杀灭水体中的嗜水气单胞菌,从而降低鳗鲡死亡率。从健康、绿色养殖长远角度来看,建议采用20%戊二醛溶液、10%聚维酮碘溶液不易导致增强耐药性的杀菌药物。展开更多
Despite major advances in the knowledge and management of liver diseases achieved in recent decades,decompensation of cirrhosis still carries a high burden of morbidity and mortality.Bacterial infections are one of th...Despite major advances in the knowledge and management of liver diseases achieved in recent decades,decompensation of cirrhosis still carries a high burden of morbidity and mortality.Bacterial infections are one of the main causes of decompensation.It is very important for clinical management to be aware of the population with the highest risk of poor outcome.This review deals with the new determinants of prognosis in patients with cirrhosis and bacterial infections reported recently.Emergence of multiresistant bacteria has led to an increasing failure rate of the standard empirical antibiotic therapy recommended by international guidelines.Moreover,it has been recently reported that endothelial dysfunction is associated with the degree of liver dysfunction and,in infected patients,with the degree of sepsis.It has also been reported that relative adrenal insufficiency is frequent in the non-critically ill cirrhotic population and it is associated with a higher risk of developing infection,severe sepsis,hepatorenal syndrome and death.We advise a change in the standard empirical antibiotic therapy in patients with high risk for multiresistant infections and also to take into account endothelial and adrenal dysfunction in prognostic models in hospitalized patients with decompensated cirrhosis.展开更多
基金Supported by BaoenWang Liver Fibrosis Research Fund of the Chinese Foundation for Hepatitis Prevention and Control,No.20100009Zhejiang Medicine and Health Sciences Research Fund,No.2008B167 and No.2014PYA018+3 种基金Nanjing Military Area Command of the PLA Medical Technology Innovation,No.11MA019Ningbo Health Technology Project for Excellent Young and Middle-aged Talent,No.2011-145Ningbo Leader and Top Notch Person Training Project,No.2012-131Zhejiang Medicine and Health Project for Excellent Young Talent,No.2013-245
文摘AIM: To investigate the loci of adefovir dipivoxil (ADV)-induced resistance in hepatitis B virus (HBV) isolates and optimize the management of ADV-treated patients.
文摘从发病的养殖水样及鳗鲡体表溃烂处组织分离出一株M-1菌株,经16S r RNA测序鉴定为嗜水气单胞菌。对该菌进行溶血性、药物敏感性试验,结果表明:该菌株具有溶血性,并对链霉素、庆大霉素表现敏感,而对四环素、青霉素G、左氟沙星、诺氟沙星等6种抗生素表现出耐药性。在鳗鲡感染试验中,表现出具有较强的致病性,注射约107CFU/mL病原菌液0.5 mL,72 h内致死率达100%。在养殖防治模拟试验中,20%戊二醛溶液和10%聚维酮碘溶液的防治效果与庆大霉素接近,可大幅度杀灭水体中的嗜水气单胞菌,从而降低鳗鲡死亡率。从健康、绿色养殖长远角度来看,建议采用20%戊二醛溶液、10%聚维酮碘溶液不易导致增强耐药性的杀菌药物。
文摘Despite major advances in the knowledge and management of liver diseases achieved in recent decades,decompensation of cirrhosis still carries a high burden of morbidity and mortality.Bacterial infections are one of the main causes of decompensation.It is very important for clinical management to be aware of the population with the highest risk of poor outcome.This review deals with the new determinants of prognosis in patients with cirrhosis and bacterial infections reported recently.Emergence of multiresistant bacteria has led to an increasing failure rate of the standard empirical antibiotic therapy recommended by international guidelines.Moreover,it has been recently reported that endothelial dysfunction is associated with the degree of liver dysfunction and,in infected patients,with the degree of sepsis.It has also been reported that relative adrenal insufficiency is frequent in the non-critically ill cirrhotic population and it is associated with a higher risk of developing infection,severe sepsis,hepatorenal syndrome and death.We advise a change in the standard empirical antibiotic therapy in patients with high risk for multiresistant infections and also to take into account endothelial and adrenal dysfunction in prognostic models in hospitalized patients with decompensated cirrhosis.
