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Rational design and crystallographic analysis of novel isoform-selective TRKA inhibitors for cancer therapy
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作者 Guan Wang Yongya Wu +6 位作者 Chengyong Wu Wen Shuai Tingting Jiang Aoxue Wang Faqian Bu Qiu Sun Liang Ouyang 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2023年第1期440-443,共4页
To the Editor:Tropomyosin receptor kinase A/B/C(TRKA/B/C)are encoded by neurotrophic tyrosine receptor kinase 1/2/3(NTRK1/2/3),respectively.NTRK gene fusions are the most common drivers of malignancies.Additionally,TR... To the Editor:Tropomyosin receptor kinase A/B/C(TRKA/B/C)are encoded by neurotrophic tyrosine receptor kinase 1/2/3(NTRK1/2/3),respectively.NTRK gene fusions are the most common drivers of malignancies.Additionally,TRKA is the most common oncogene in TRK family,which is detected in 7.4%of human tumors. 展开更多
关键词 Cancer therapy Co-crystal structure drugdiscovery Selective inhibitor TRKA
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