Integral thin shells made of high strength aluminum alloys are urgently needed in new generation transportation equipment. There are challenges to overcoming the co-existing problems of wrinkling and splitting by the ...Integral thin shells made of high strength aluminum alloys are urgently needed in new generation transportation equipment. There are challenges to overcoming the co-existing problems of wrinkling and splitting by the cold forming and hot forming processes. An innovative technology of ultra-low temperature forming has been invented for aluminum alloy thin shells by the new phenomenon of ‘dual enhancement effect’. That means plasticity and hardening are enhanced simultaneously at ultra-low temperatures. In this perspective, the dual enhancement effect is described, and the development, current state and prospects of this new forming method are introduced. This innovative method can provide a new approach for integral aluminum alloy components with large size, ultra-thin thickness, and high strength. An integral tank dome of rocket with 2 m in diameter was formed by using a blank sheet with the same thickness as the final component, breaking through the limit value of thickness-diameter ratio.展开更多
Ethylene was found to alter the shoot gravitropic response a century ago. However, its actual effects remained controversial over the century. In the present study, we investigated the effects of ethylene on the gravi...Ethylene was found to alter the shoot gravitropic response a century ago. However, its actual effects remained controversial over the century. In the present study, we investigated the effects of ethylene on the gravitropic response of Arabidopsis inflorescence and discovered that although the intact Arabidopsis inflorescence bent upward at the rate of 43° ±3°/h in the first 1.5 h under the given control growth conditions, it bent upward at a rate of 20°±3° and 64°±14°/h in the presence of exogenous ethylene if the plants were pretreated for 0.5 and 12 h, respectively, before the initiation of gravistimulation. The increase in gravicur-vature rate is proportional to the length of ethylene pre-treatment. The minimum ethylene pretreatment time required for achieving the maximum curvature rate is 10 -11 h with removal of exogenous ethylene. The stimulatory effect of ethylene on the inflorescence gravicurvature requires a latent period of time (1h) to become measurable. In contrast, the inhibitory展开更多
In the symplectic space composed of the original variables,displacements,and their dual variables,stresses,the symplectic solution for the composite laminates based on the Pipes-Pagano model is established in this pap...In the symplectic space composed of the original variables,displacements,and their dual variables,stresses,the symplectic solution for the composite laminates based on the Pipes-Pagano model is established in this paper.In contrast to the traditional technique using only one kind of variables,the symplectic dual variables include displacement components as well as stress components.Therefore,the compatibility conditions of displacement and stress at interfaces can be formulated simultaneously.After being introduced into the symplectic dual system,the uniform schemes,such as the separation of variables and symplectic eigenfunction expansion method,can be implemented conveniently to analyze composite laminate problems.An analytical solution for the free edge effect of composite laminates is obtained,showing the effectiveness of the symplectic dual method in analyzing composite laminates.展开更多
To overcome the problems of natural decreases in power quality,and to eliminate wind speed fluctuation due to wind shear and tower shadow effect arising from wind turbine structural parameters,an improved prediction m...To overcome the problems of natural decreases in power quality,and to eliminate wind speed fluctuation due to wind shear and tower shadow effect arising from wind turbine structural parameters,an improved prediction model accounting for the dual effect of wind shear and tower shadow is,in this paper,built.Compared to the conventional prediction model,the proposed model contains a new constraint condition,which makes the disturbance term caused by the tower shadow effect always negative so that the prediction result is closer to the actual situation.Furthermore,wind turbine structural parameters such as hub height,rotor diameter,the diameter of the tower top,and rotor overhang on wind shear and tower shadow effect are also explored in detail.The results show that the wind shear effect became weaker with the increase in hub height.The hub height is independent of the tower shadow effect.The rotor diameter is positively correlated with the wind shear and tower shadow effect.The tower shadow effect is positively correlated with the diameter of the tower top and negatively correlated with the rotor overhang.展开更多
We propose a periodic structure as an extra absorption layer(i.e., absorber) based on surface plasmon resonance effects, enhancing dual-band absorption in both middle wavelength infrared(MWIR) and long wavelength ...We propose a periodic structure as an extra absorption layer(i.e., absorber) based on surface plasmon resonance effects, enhancing dual-band absorption in both middle wavelength infrared(MWIR) and long wavelength infrared(LWIR)regions. Periodic gold disks are selectively patterned onto the top layer of suspended SiN/VO_2/SiN sandwich-structure.We employ the finite element method to model this structure in COMSOL Multiphysics including a proposed method of modulating the absorption peak. Simulation results show that the absorber has two absorption peaks at wavelengths λ =4.8 μm and λ = 9 μm with the absorption magnitudes more than 0.98 and 0.94 in MWIR and LWIR regions, respectively. In addition, the absorber achieves broad spectrum absorption in LWIR region, in the meanwhile, tunable dual-band absorption peaks can be achieved by variable heights of cavity as well as diameters and periodicity of disk. Thus, this designed absorber can be a good candidate for enhancing the performance of dual band uncooled infrared detector, furthermore, the manufacturing process of cavity can be easily simplified so that the reliability of such devices can be improved.展开更多
The difference-frequency (DF) ultrasound generated by using parametric effect promises to improve detection depth owing to its low attenuation, which is beneficial for deep tissue imaging. With ultrasound contrast a...The difference-frequency (DF) ultrasound generated by using parametric effect promises to improve detection depth owing to its low attenuation, which is beneficial for deep tissue imaging. With ultrasound contrast agents infusion, the harmonic components scattered from the microbubbles, including DF, can be generated due to the nonlinear vibration. A theoretical study on the DF generation from microbubbles under the dual-frequency excitation is proposed in formula based on the solution of the RPNNP equation. The optimisation of the DF generation is discussed associated with the applied acoustic pressure, frequency, and the microbubble size. Experiments are performed to validate the theoretical predictions by using a dual-frequency signal to excite microbubbles. Both the numerical and experimental results demonstrate that the optimised DF ultrasound can be achieved as the difference frequency is close to the resonance frequency of the microbubble and improve the contrast-to-tissue ratio in imaging.展开更多
The dual-frequency(DF)IP is a new kind of frequency domain IP method.Not only is thedual-frequency current transmitted simultaneously but the electric potential difference due to dualfrequency current is measured sync...The dual-frequency(DF)IP is a new kind of frequency domain IP method.Not only is thedual-frequency current transmitted simultaneously but the electric potential difference due to dualfrequency current is measured synchronously.This paper discusses the principle and charateristicof DF current, DF current can be formed by two rectangular currents which must be coherent orelse false Percent Frequency Effect(PEE)will occur.DF currents with different waveforms areequivalent in the ability of detecting IP anomalies.Unstable current has much less effect of DFIP than on conventional variable frequency method;in fact,there is no need to stabilize currentin DF IP method.There are many differences between harmonic contents of DF current and thatof rectangular wave used in variable frequency method,but theoretical analysis,labaratory mod-eling and field data all show that the anomalies of both DF and variable frequency method are sim-liar in character and close in value.DF IP can match variable frequeney IP and time domain IPin the ability of detecting IP anomaly,furthermore,dual-frequency IP measurements are morerapid,more accurate and more simple in operation.展开更多
在理想环境下,双双曲调频(dual hyperbolic frequency modulation,Dual-HFM)速度谱估计方法可得到高分辨率的连续多普勒估计结果。然而由多径、双目标环境引起的旁瓣干扰,削弱了速度谱方法抑制噪声的能力,影响目标参数估计。针对该方法...在理想环境下,双双曲调频(dual hyperbolic frequency modulation,Dual-HFM)速度谱估计方法可得到高分辨率的连续多普勒估计结果。然而由多径、双目标环境引起的旁瓣干扰,削弱了速度谱方法抑制噪声的能力,影响目标参数估计。针对该方法在多径、双目标等各种复杂水声环境中的应用,进行了深入的讨论,推导了多径、双目标造成的速度谱旁瓣位置,并提出了基于多帧信号的速度谱旁瓣抑制方法,利用另一维度信号空间中目标回波信息与多径杂波旁瓣的差异性,抑制了复杂水下环境中的速度谱旁瓣,并保留了速度谱计算量低的优点。通过数值仿真验证了所提方法的适用性,为低信噪比、多径、双目标环境下的多普勒估计提供了理论依据。展开更多
In order to study the interaction between two independent jets, a three-dimensional(3D) transient mathematical model is developed to investigate the flow field and acoustic properties of the two-stream jets. The res...In order to study the interaction between two independent jets, a three-dimensional(3D) transient mathematical model is developed to investigate the flow field and acoustic properties of the two-stream jets. The results are compared with those of the single-stream jet at Mach number 0.9 and Reynolds number 3600. The large eddy simulation(LES) with dynamic Smagorinsky sub-grid scale(SGS) approach is used to simulate the turbulent jet flow structure. The acoustic field is evaluated by the Ffowcs Williams–Hawkings(FW-H) integral equation. Considering the compressibility of high-speed gas jets, the density-based explicit formulation is adopted to solve the governing equations. Meanwhile, the viscosity is approximated by using the Sutherland kinetic theory. The predicted flow characteristics as well as the acoustic properties show that they are in good agreement with the existing experimental and numerical results under the same flow conditions available in the literature. The results indicate that the merging phenomenon of the dual-jet is triggered by the deflection mechanism of the Coanda effect, which sequentially introduces additional complexity and instability of flow structure. One of the main factors affecting the dual-jet merging is the aperture ratio, which has a direct influence on the potential core and surrounding flow fluctuation. The analysis on the noise pollution reveals that the potential core plays a fundamental role in noise emission while the additional mixing noise makes less contribution than the single jet noise. The overall sound pressure level(OASPL) profiles have a directive property, suggesting an approximate 25° deflection from the streamwise direction, however, shifting toward lateral direction of about 10° to 15° in the dual-jet. The conclusion obtained in this study can provide valuable data to guide the development of manufacturing-green technology in the multi-jet applications.展开更多
Dual band bandpass filter is designed and optimized for RF wireless applications. The performances of that RF dual band filter are improved especially parameters describing the insertion loss, return losses and reject...Dual band bandpass filter is designed and optimized for RF wireless applications. The performances of that RF dual band filter are improved especially parameters describing the insertion loss, return losses and rejection. Dual-band bandpass filter using stub loaded resonators is designed and characterized. Theoretical results are compared with experimental data. This comparison shows that the magnitude of reflection coefficient S11 from ADSTM simulation is better than 28.0 dB, and the insertion loss S21 is less than 0.5 dB. The two rejections are also better than 32.0 dB. The simulated results also show that two central frequencies are located at desired 1.82 and 2.95 GHz. Comparison of measured and simulated results shows frequency drift. The main reason for this frequency shifting is due to some uncertainties. These are obviously due to geometrical and physical parameters H and εr respectively of Duroid substrate used during design and measurements.展开更多
The effect of α phase on CuZnAl shape memo- ry alloy(SMA)has been systematically studied by electrical resistance method,quantitative measure- ment of micrography and transmission electron microscopy(TEM).It is found...The effect of α phase on CuZnAl shape memo- ry alloy(SMA)has been systematically studied by electrical resistance method,quantitative measure- ment of micrography and transmission electron microscopy(TEM).It is found that,by controlling the amount of α phase in(α+β)-CuZnAl alloy, phase transformation temperatures can be adjusted precisely in a wide range,while the good shape memory effect of CuZnAl is kept.In a word, quenching from(α+β)dual phase region is a rea- sonable method of adjusting phase transformation temperatures for CuZnAl alloy.展开更多
The emergence and spread of the mobile colistin-resistance gene,mcr-1,and its variants pose achallenge to the use of colistin,a last-resort antibiotic used to treat severe infections caused by extensively drug-resista...The emergence and spread of the mobile colistin-resistance gene,mcr-1,and its variants pose achallenge to the use of colistin,a last-resort antibiotic used to treat severe infections caused by extensively drug-resistant(XDR)Gram-negative pathogens.Antibiotic adjuvants are a promising strategy to enhance the efficacy of colistin against colistin-resistant pathogens;however,few studies have considered the effects of adjuvants on limiting resistance-gene transmission.We found that chelerythrine(4 mg·L^(-1))derived from Macleaya cordata extract,which is used as an animal feed additive,reduced the minimal inhibitory concentration(MIC)of colistin against an mcr-1 positive Escherichia coli(E.coli)strain by 16-fold(from 2.000 to 0.125 mg·L^(-1)).eliminated approximately 10^(4) colony-forming units(CFUs)of an mcr-1-carrying strain in a murine intestinal infection model,and inhibited the conjugation of an mcr-1-bearing plasmid in vitro(by>100-fold)and in a mouse model(by up to 5-fold).A detailed analysis revealed that chelery-thrine binds to phospholipids on bacterial membranes and increases cytoplasmic membrane fluidity,thereby impairing respiration,disrupting proton motive force(PMF),generating reactive oxygen species(ROS),and decreasing intracellular adenosine triphosphate(ATP)levels,which subsequently downregu-lates mcr-1 and conjugation-associated genes.These dual effects of chelerythrine can expand the use of antibiotic adjuvants and may provide a new strategy for circumventing mobile colistin resistance.展开更多
Based on the analysis of vertical electric potential distribution across the dual-channel strained p-type Si/strained Si1-xGex/relaxd Si1-yGey(s-Si/s-SiGe/Si1-yGey) metal-oxide-semiconductor field-effect transistor ...Based on the analysis of vertical electric potential distribution across the dual-channel strained p-type Si/strained Si1-xGex/relaxd Si1-yGey(s-Si/s-SiGe/Si1-yGey) metal-oxide-semiconductor field-effect transistor (PMOSFET), analytical expressions of the threshold voltages for buried channel and surface channel are presented. And the maximum allowed thickness of s-Si is given, which can ensure that the strong inversion appears earlier in the buried channel (compressive strained SiGe) than in the surface channel (tensile strained Si), because the hole mobility in the buried channel is higher than that in the surface channel. Thus they offer a good accuracy as compared with the results of device simulator ISE. With this model, the variations of threshold voltage and maximum allowed thickness of s-Si with design parameters can be predicted, such as Ge fraction, layer thickness, and doping concentration. This model can serve as a useful tool for p-channel s-Si/s-SiGe/Si1-yGey metal-oxide-semiconductor field-effect transistor (MOSFET) designs.展开更多
The optimal magnetizing fields of the variable polarization effects of ferrite are studied by using thecoupling-wave(cw)theory,vaiational principle and optimization techniques.Several kinds of shapes of themagnetic li...The optimal magnetizing fields of the variable polarization effects of ferrite are studied by using thecoupling-wave(cw)theory,vaiational principle and optimization techniques.Several kinds of shapes of themagnetic line of force and some valuable results of the optimal magnetizing field are given.The theoretical cal-culations are in good agreement with the experimental results.展开更多
基金supported by the National Key Research and Development Program of China (No.2019YFA0708800)the Fundamental Research Funds for the Central Universities (No.DUT20ZD101)。
文摘Integral thin shells made of high strength aluminum alloys are urgently needed in new generation transportation equipment. There are challenges to overcoming the co-existing problems of wrinkling and splitting by the cold forming and hot forming processes. An innovative technology of ultra-low temperature forming has been invented for aluminum alloy thin shells by the new phenomenon of ‘dual enhancement effect’. That means plasticity and hardening are enhanced simultaneously at ultra-low temperatures. In this perspective, the dual enhancement effect is described, and the development, current state and prospects of this new forming method are introduced. This innovative method can provide a new approach for integral aluminum alloy components with large size, ultra-thin thickness, and high strength. An integral tank dome of rocket with 2 m in diameter was formed by using a blank sheet with the same thickness as the final component, breaking through the limit value of thickness-diameter ratio.
文摘Ethylene was found to alter the shoot gravitropic response a century ago. However, its actual effects remained controversial over the century. In the present study, we investigated the effects of ethylene on the gravitropic response of Arabidopsis inflorescence and discovered that although the intact Arabidopsis inflorescence bent upward at the rate of 43° ±3°/h in the first 1.5 h under the given control growth conditions, it bent upward at a rate of 20°±3° and 64°±14°/h in the presence of exogenous ethylene if the plants were pretreated for 0.5 and 12 h, respectively, before the initiation of gravistimulation. The increase in gravicur-vature rate is proportional to the length of ethylene pre-treatment. The minimum ethylene pretreatment time required for achieving the maximum curvature rate is 10 -11 h with removal of exogenous ethylene. The stimulatory effect of ethylene on the inflorescence gravicurvature requires a latent period of time (1h) to become measurable. In contrast, the inhibitory
基金supported by the National Basic Research Program of China (No. 2010CB832704)the National Natural Science Foundation of China (No. 10772039)
文摘In the symplectic space composed of the original variables,displacements,and their dual variables,stresses,the symplectic solution for the composite laminates based on the Pipes-Pagano model is established in this paper.In contrast to the traditional technique using only one kind of variables,the symplectic dual variables include displacement components as well as stress components.Therefore,the compatibility conditions of displacement and stress at interfaces can be formulated simultaneously.After being introduced into the symplectic dual system,the uniform schemes,such as the separation of variables and symplectic eigenfunction expansion method,can be implemented conveniently to analyze composite laminate problems.An analytical solution for the free edge effect of composite laminates is obtained,showing the effectiveness of the symplectic dual method in analyzing composite laminates.
基金funded by the National Natural Science Foundation of China(51866012).
文摘To overcome the problems of natural decreases in power quality,and to eliminate wind speed fluctuation due to wind shear and tower shadow effect arising from wind turbine structural parameters,an improved prediction model accounting for the dual effect of wind shear and tower shadow is,in this paper,built.Compared to the conventional prediction model,the proposed model contains a new constraint condition,which makes the disturbance term caused by the tower shadow effect always negative so that the prediction result is closer to the actual situation.Furthermore,wind turbine structural parameters such as hub height,rotor diameter,the diameter of the tower top,and rotor overhang on wind shear and tower shadow effect are also explored in detail.The results show that the wind shear effect became weaker with the increase in hub height.The hub height is independent of the tower shadow effect.The rotor diameter is positively correlated with the wind shear and tower shadow effect.The tower shadow effect is positively correlated with the diameter of the tower top and negatively correlated with the rotor overhang.
基金supported by the One Hundred Talents Program of the Chinese Academy of Sciencesthe National Natural Science Foundation of China(Grant Nos.61376083 and 61307077)+1 种基金the China Postdoctoral Science Foundation(Grant Nos.2013M530613 and 2015T80080)the Guangxi Key Laboratory of Precision Navigation Technology and Application(Grant Nos.DH201505,DH201510,and DH201511)
文摘We propose a periodic structure as an extra absorption layer(i.e., absorber) based on surface plasmon resonance effects, enhancing dual-band absorption in both middle wavelength infrared(MWIR) and long wavelength infrared(LWIR)regions. Periodic gold disks are selectively patterned onto the top layer of suspended SiN/VO_2/SiN sandwich-structure.We employ the finite element method to model this structure in COMSOL Multiphysics including a proposed method of modulating the absorption peak. Simulation results show that the absorber has two absorption peaks at wavelengths λ =4.8 μm and λ = 9 μm with the absorption magnitudes more than 0.98 and 0.94 in MWIR and LWIR regions, respectively. In addition, the absorber achieves broad spectrum absorption in LWIR region, in the meanwhile, tunable dual-band absorption peaks can be achieved by variable heights of cavity as well as diameters and periodicity of disk. Thus, this designed absorber can be a good candidate for enhancing the performance of dual band uncooled infrared detector, furthermore, the manufacturing process of cavity can be easily simplified so that the reliability of such devices can be improved.
基金supported by the National Natural Science Foundation of China (Grant Nos.10974098 and 10774071)the Natural Science Foundation of Jiangsu Province,China (Grant No.BK2009407)+1 种基金the Doctoral Foundation of Ministry of Education of China (Grant No.20093207120003)the National Basic Research Program of China (Grant No.2010CB732600)
文摘The difference-frequency (DF) ultrasound generated by using parametric effect promises to improve detection depth owing to its low attenuation, which is beneficial for deep tissue imaging. With ultrasound contrast agents infusion, the harmonic components scattered from the microbubbles, including DF, can be generated due to the nonlinear vibration. A theoretical study on the DF generation from microbubbles under the dual-frequency excitation is proposed in formula based on the solution of the RPNNP equation. The optimisation of the DF generation is discussed associated with the applied acoustic pressure, frequency, and the microbubble size. Experiments are performed to validate the theoretical predictions by using a dual-frequency signal to excite microbubbles. Both the numerical and experimental results demonstrate that the optimised DF ultrasound can be achieved as the difference frequency is close to the resonance frequency of the microbubble and improve the contrast-to-tissue ratio in imaging.
文摘The dual-frequency(DF)IP is a new kind of frequency domain IP method.Not only is thedual-frequency current transmitted simultaneously but the electric potential difference due to dualfrequency current is measured synchronously.This paper discusses the principle and charateristicof DF current, DF current can be formed by two rectangular currents which must be coherent orelse false Percent Frequency Effect(PEE)will occur.DF currents with different waveforms areequivalent in the ability of detecting IP anomalies.Unstable current has much less effect of DFIP than on conventional variable frequency method;in fact,there is no need to stabilize currentin DF IP method.There are many differences between harmonic contents of DF current and thatof rectangular wave used in variable frequency method,but theoretical analysis,labaratory mod-eling and field data all show that the anomalies of both DF and variable frequency method are sim-liar in character and close in value.DF IP can match variable frequeney IP and time domain IPin the ability of detecting IP anomaly,furthermore,dual-frequency IP measurements are morerapid,more accurate and more simple in operation.
文摘在理想环境下,双双曲调频(dual hyperbolic frequency modulation,Dual-HFM)速度谱估计方法可得到高分辨率的连续多普勒估计结果。然而由多径、双目标环境引起的旁瓣干扰,削弱了速度谱方法抑制噪声的能力,影响目标参数估计。针对该方法在多径、双目标等各种复杂水声环境中的应用,进行了深入的讨论,推导了多径、双目标造成的速度谱旁瓣位置,并提出了基于多帧信号的速度谱旁瓣抑制方法,利用另一维度信号空间中目标回波信息与多径杂波旁瓣的差异性,抑制了复杂水下环境中的速度谱旁瓣,并保留了速度谱计算量低的优点。通过数值仿真验证了所提方法的适用性,为低信噪比、多径、双目标环境下的多普勒估计提供了理论依据。
基金Project supported by the Fundamental Research Funds for the Central Universities,China(Grant No.N150204003)
文摘In order to study the interaction between two independent jets, a three-dimensional(3D) transient mathematical model is developed to investigate the flow field and acoustic properties of the two-stream jets. The results are compared with those of the single-stream jet at Mach number 0.9 and Reynolds number 3600. The large eddy simulation(LES) with dynamic Smagorinsky sub-grid scale(SGS) approach is used to simulate the turbulent jet flow structure. The acoustic field is evaluated by the Ffowcs Williams–Hawkings(FW-H) integral equation. Considering the compressibility of high-speed gas jets, the density-based explicit formulation is adopted to solve the governing equations. Meanwhile, the viscosity is approximated by using the Sutherland kinetic theory. The predicted flow characteristics as well as the acoustic properties show that they are in good agreement with the existing experimental and numerical results under the same flow conditions available in the literature. The results indicate that the merging phenomenon of the dual-jet is triggered by the deflection mechanism of the Coanda effect, which sequentially introduces additional complexity and instability of flow structure. One of the main factors affecting the dual-jet merging is the aperture ratio, which has a direct influence on the potential core and surrounding flow fluctuation. The analysis on the noise pollution reveals that the potential core plays a fundamental role in noise emission while the additional mixing noise makes less contribution than the single jet noise. The overall sound pressure level(OASPL) profiles have a directive property, suggesting an approximate 25° deflection from the streamwise direction, however, shifting toward lateral direction of about 10° to 15° in the dual-jet. The conclusion obtained in this study can provide valuable data to guide the development of manufacturing-green technology in the multi-jet applications.
文摘Dual band bandpass filter is designed and optimized for RF wireless applications. The performances of that RF dual band filter are improved especially parameters describing the insertion loss, return losses and rejection. Dual-band bandpass filter using stub loaded resonators is designed and characterized. Theoretical results are compared with experimental data. This comparison shows that the magnitude of reflection coefficient S11 from ADSTM simulation is better than 28.0 dB, and the insertion loss S21 is less than 0.5 dB. The two rejections are also better than 32.0 dB. The simulated results also show that two central frequencies are located at desired 1.82 and 2.95 GHz. Comparison of measured and simulated results shows frequency drift. The main reason for this frequency shifting is due to some uncertainties. These are obviously due to geometrical and physical parameters H and εr respectively of Duroid substrate used during design and measurements.
文摘The effect of α phase on CuZnAl shape memo- ry alloy(SMA)has been systematically studied by electrical resistance method,quantitative measure- ment of micrography and transmission electron microscopy(TEM).It is found that,by controlling the amount of α phase in(α+β)-CuZnAl alloy, phase transformation temperatures can be adjusted precisely in a wide range,while the good shape memory effect of CuZnAl is kept.In a word, quenching from(α+β)dual phase region is a rea- sonable method of adjusting phase transformation temperatures for CuZnAl alloy.
基金grants from the Laboratory of Lingnan Modern Agriculture Project(NT2021006 to Yang Wang and Jianzhong Shen)the National Natural Science Foundation of China(81861138051 and 81991535 to Yang Wang and Congming Wu).
文摘The emergence and spread of the mobile colistin-resistance gene,mcr-1,and its variants pose achallenge to the use of colistin,a last-resort antibiotic used to treat severe infections caused by extensively drug-resistant(XDR)Gram-negative pathogens.Antibiotic adjuvants are a promising strategy to enhance the efficacy of colistin against colistin-resistant pathogens;however,few studies have considered the effects of adjuvants on limiting resistance-gene transmission.We found that chelerythrine(4 mg·L^(-1))derived from Macleaya cordata extract,which is used as an animal feed additive,reduced the minimal inhibitory concentration(MIC)of colistin against an mcr-1 positive Escherichia coli(E.coli)strain by 16-fold(from 2.000 to 0.125 mg·L^(-1)).eliminated approximately 10^(4) colony-forming units(CFUs)of an mcr-1-carrying strain in a murine intestinal infection model,and inhibited the conjugation of an mcr-1-bearing plasmid in vitro(by>100-fold)and in a mouse model(by up to 5-fold).A detailed analysis revealed that chelery-thrine binds to phospholipids on bacterial membranes and increases cytoplasmic membrane fluidity,thereby impairing respiration,disrupting proton motive force(PMF),generating reactive oxygen species(ROS),and decreasing intracellular adenosine triphosphate(ATP)levels,which subsequently downregu-lates mcr-1 and conjugation-associated genes.These dual effects of chelerythrine can expand the use of antibiotic adjuvants and may provide a new strategy for circumventing mobile colistin resistance.
基金Project supported by the National Defence Pre-research Foundation of China (Grant Nos. 51308040203,9140A08060407DZ0103,and 6139801)
文摘Based on the analysis of vertical electric potential distribution across the dual-channel strained p-type Si/strained Si1-xGex/relaxd Si1-yGey(s-Si/s-SiGe/Si1-yGey) metal-oxide-semiconductor field-effect transistor (PMOSFET), analytical expressions of the threshold voltages for buried channel and surface channel are presented. And the maximum allowed thickness of s-Si is given, which can ensure that the strong inversion appears earlier in the buried channel (compressive strained SiGe) than in the surface channel (tensile strained Si), because the hole mobility in the buried channel is higher than that in the surface channel. Thus they offer a good accuracy as compared with the results of device simulator ISE. With this model, the variations of threshold voltage and maximum allowed thickness of s-Si with design parameters can be predicted, such as Ge fraction, layer thickness, and doping concentration. This model can serve as a useful tool for p-channel s-Si/s-SiGe/Si1-yGey metal-oxide-semiconductor field-effect transistor (MOSFET) designs.
文摘The optimal magnetizing fields of the variable polarization effects of ferrite are studied by using thecoupling-wave(cw)theory,vaiational principle and optimization techniques.Several kinds of shapes of themagnetic line of force and some valuable results of the optimal magnetizing field are given.The theoretical cal-culations are in good agreement with the experimental results.