Sphincter of Oddi dysfunction Type Ⅲ: New studies suggest new approaches are needed

Sphincter of Oddi dysfunction(SOD) has been classified into three types based upon the presence or absence of objective findings including liver test abnormalities and bile duct dilatation. Type Ⅲ is the most controversial and is classified as biliary type pain in the absence ofany these objective findings. Many prior studies have shown that the clinical response to endoscopic therapy is higher based upon the presence of these objective criteria. However, there has been variable correlation of the manometry findings to outcome after endoscopic therapy. Nevertheless, manometry and sphincterotomy has been recommended for Type Ⅲ patients given the overall response rate of 33%, although the reported response rates are highly variable. However, all of the prior data was non-blinded and non-randomized with variable follow-up. The evaluating predictors in SOD study- a prospective randomized blinded sham controlled one year outcome study showed no correlation between manometric findings and outcome after sphincterotomy. Furthermore, patients receiving sham therapy had a statistically significantly better outcome than those undergoing biliary or dual sphincterotomy. This study calls into question the whole concept of SOD Type Ⅲ and, based upon prior physiologic studies, one can suggest that SOD Type Ⅲ likely represents a right upper quadrant functional abdominal pain syndrome and should be treated as such.

Sphincter of Oddi dysfunction and bile duct microlithiasis in acute idiopathic pancreatitis

Although there are numerous causes of acute panc-reatitis, an etiology cannot always be found. Two potential etiologies, microlithiasis and sphincter of Oddi dysfunction, are discussed in this review. Gallbladder microlithiasis, missed on transcutaneous ultrasound, is reported as the cause of idiopathic acute pancreatitis in a wide frequency range of 6%-80%. The best diagnostic technique for gallbladder microlithiasis is endoscopic ultrasound although biliary crystal analysis and empiric cholecystectomy remain as reasonable options. In contrast, in patients who are post-cholecystectomy, bile duct microlithiasis does not appear to have a role in the pathogenesis of acute pancreatitis. Sphincter of Oddi dysfunction is present in 30%-65% of patients with idiopathic acute recurrent pancreatitis in whom other diagnoses have been excluded. It is unclear if this sphincter dysfunction was the original etiology of the first episode of pancreatitis although it appears to have a causative role in recurring episodes since sphincter ablation decreases the frequency of recurrent attacks. Unfortunately, this conclusion is primarily based on small retrospective case series; larger prospective studies of the outcome of pancreatic sphincterotomy for SOD-associated acute pancreatitis are sorely needed. Another problem with this diagnosis and its treatment is the concern over potential procedure related complications from endoscopic retrograde cholangiopancreatography (ERCP), manometry and pancreatic sphincterotomy. For these reasons, patients should have recurrent acute pancreatitis, not a single episode, and have a careful informed consent before assessment of the sphincter of Oddi is undertaken.

Sphincter of Oddi dysfunction: Managing the patient with chronic biliary pain

Oddi 机能障碍(草皮) 的括约肌由于在 Oddi 的括约肌的水平的 pancreaticobiliary 流动的功能的阻塞是长期的胆汁的疼痛或周期性的胰腺炎的症候群。Milwaukee 分类成层病人根据他们的临床的图画基于腹的疼痛的提高的肝酶，扩大胆总管和存在。类型我病人们象反常的肝酶和扩大胆总管一样有疼痛。类型 II 草皮由疼痛和仅仅发现的一个目的组成，并且类型 III 仅仅由胆汁的疼痛组成。这个分类是有用的指导 Oddi 机能障碍的括约肌的诊断和管理。为诊断的当前的标准答案是测压法检测提高的括约肌压力，它与结果相关到括约肌切开术。然而，测压法不是广泛地可得到的并且是有胰腺炎的风险的一个侵略过程。包括丰满的饭 ultrasonography 和 scintigraphy，非侵略的测试方法与压力计的调查结果显示出有限关联，但是可能在预言结果到括约肌切开术有用。波特淋毒素的内视镜的注射嗯毒素出现到预言随后的结果到括约肌切开术，并且能在为治疗的病人的选择有用，特别在测压法是无法获得的背景。

Sphincter of Oddi dysfunction and pancreatitis

Sphincter of Oddi dysfunction (SOD) is a term used to describe a group of heterogenous pain syndromes caused by abnormalities in sphincter contractility. Biliary and pancreatic SOD are each sub-classified as typeⅠ,Ⅱ or Ⅲ,according to the Milwaukee classification. SOD appears to carry an increased risk of acute pancreatitis as well as rates of post ERCP pancreatitis of over 30%. Various mechanisms have been postulated but the exact role of SOD in the pathophysiology of acute pancreatitis is unknown. There is also an association between SOD and chronic pancreatitis but it is still unclear if this is a cause or effect relationship. Management of SOD is aimed at sphincter ablation,usually by endoscopic sphincterotomy (ES). Patients with typeⅠSOD will benefit from ES in 55%-95% of cases. Sphincter of Oddi manometry is not necessary before ES in typeⅠ SOD. For patients with types Ⅱ and Ⅲ the benefit of ES is lower. These patients should be more thoroughly evaluated before performing ES. Some researchers have found that manometry and ablation of both the biliary and pancreatic sphincters is required to adequately assess and treat SOD. In pancreatic SOD up to 88% of patients will benefit from sphincterotomy. Therefore,there have been calls from some quarters for the current classification system to be scrapped in favour of an overall system encompassing both biliary and pancreatic types. Future work should be aimed at understanding the mechanisms underlying the relationship between SOD and pancreatitis and identifying patient factors that will help predict benefit from endoscopic therapy.

Medical treatment for sphincter of oddi dysfunction:Can it replace endoscopic sphincterotomy?

AIM:To report the results of a medical management of sphincter of oddi dysfunction(SOD) after an intermediate follow-up period.METHODS:A total of 59 patients with SOD(2 men and 57 women,mean age 51 years old) were included in this prospective study.After medical treatment for one year,the patients were clinically re-evaluated after an average period of 30 mo.RESULTS:The distribution of the patients according to the Milwaukee's classification was the following:11 patients were type 1,34 were type 2 and 14 were type 3.Fourteen patients underwent an endoscopic sphincterotomy(ES) after one year of medical treatment.The median intermediate follow-up period was 29.8 ± 3 mo(3-72 mo).The initial effectiveness of the medical treatment was complete,partial and poor among 50.8%,13.5% and 35%,respectively,of the patients.At the end of the follow-up period,37 patients(62.7%) showed more than 50% improvement.The rate of improvement in patients who required ES was not significantly different compared with the patients treated conservatively(64.2% vs 62.2%,respectively).CONCLUSION:Our study confirms that conservative medical treatment could be an alternative to endoscopic sphincterotomy because,after an intermediate follow-up period,the two treatments show the same success rates.

Characterization of functional biliary pain and dyspeptic symptoms in patients with sphincter of Oddi dysfunction:Effect of papillotomy

AIM: To characterize functional biliary pain and other gastrointestinal (GI) symptoms in postcholecystectomy syndrome (PCS) patients with and without sphincter of Oddi dysfunction (SOD) proved by endoscopic sphincter of Oddi manometry (ESOM), and to assess the post- endoscopic sphincterotomy (EST) outcome. METHODS: We prospectively investigated 85 cholecystectomized patients referred for ERCP because of PCS and suspected SOD. On admission, all patients completed our questionnaire. Physical examination, laboratory tests, abdominal ultrasound, quantitative hepatobiliary scintigraphy (QHBS), and ERCP were performed in all patients. Based on clinical and ERCP findings 15 patients had unexpected bile duct stone disease and 15 patients had SOD biliary typeⅠ. ESOM demonstrated an elevated basal pressure in 25 patients with SOD biliary-type Ⅲ. In the remaining 30 cholecystectomized patients without SOD, the liver function tests, ERCP, QHBS and ESOM were all normal. As a control group, 30 ‘asymptomatic’ cholecystectomized volunteers (attended to our hospital for general cardiovascular screening) completed our questionnaire, which is consisted of 50 separate questions on GI symptoms and abdominal pain characteristics. Severity of the abdominal pain (frequency and intensity) was assessed with a visual analogue scale (VAS). In 40 of 80 patients having definite SOD (i.e. patients with SOD biliary typeⅠand those with elevated SO basal pressure on ESOM), an EST was performed just after ERCP. In these patients repeated questionnaires were filled at each follow-up visit (at 3 and 6 mo) and a second lookQHBS was performed 3 mo after the EST to assess the functional response to EST. RESULTS: The analysis of characteristics of the abdominal pain demonstrated that patients with common bile duct stone and definite SOD had a significantly higher score of symptomatic agreement with previously determined biliary-like pain features than patient groups of PCS without SOD and controls. In contrary, no significant differences were found when the pain severity scores were compared in different groups of PCS patients. In patients with definite SOD, EST induced a significant acceleration of the transpapillary bile flow; and based on the comparison of VASs obtained from the pre- and post-EST questionnaires, the severity scores of abdominal pain were significantly improved, however, only 15 of 35 (43%) patients became completely pain free. Post-EST severity of abdominal pain by VASs was significantly higher in patients with predominant dyspepsia at initial presentation as compared to those without dyspeptic symptoms. CONCLUSION: Persistent GI symptoms and general patient dissatisfaction is a rather common finding after EST in patients with SOD, and correlated with the presence of predominant dyspeptic symptoms at the initial presentation, but does not depend on the technical and functional success of EST.

Management of patients with sphincter of Oddi dysfunction based on a new classification

AIM: To propose a new classif ication system for sphincter of Oddi dysfunction (SOD) based on clinical data of patients. METHODS: The clinical data of 305 SOD patients documented over the past decade at our center were analyzed retrospectively, and typical cases were reported. RESULTS: The new classification with two more types (double-duct, biliary-pancreatic reflux) were set up on the basis of the Milwaukee criteria. There were 229 cases of biliary-type SOD, including 192 (83.8%) cases cured endoscopically, and 29 (12.7%) cured by open abdominal surgery, and the remaining 8 (3.5%) cases observed with unstable outcomes. Eight (50%) patients with pancreatic-type SOD were cured by endoscopic treatment, and the remaining 8 patients were cured after open abdominal surgery. There were 19 cases of double-duct-type SOD, which consisted of 7 (36.8%) patients who were cured endoscopically and 12 (63.2%) who were cured surgically. A total of 41 cases were diagnosed as biliary-pancreatic-reflux-type SOD. Twenty (48.8%) of them were treated endoscopically, 16 (39.0%) were treated by open abdominal surgery, and 5 (12.2%) were under observation. CONCLUSION: The newly proposed SOD classification system introduced in this study better explains the clinical symptoms of SOD from the anatomical perspective and can guide clinical treatment of this disease.

Evaluating the efficacy of endoscopic sphincterotomy on biliary-type sphincter of Oddi dysfunction: A retrospective clinical trial

BACKGROUND Although endoscopic sphincterotomy(EST)has a positive therapeutic effect on biliary-type sphincter of Oddi dysfunction(SOD),some patients still have little relief after EST,which implies that other functional abdominal pain may also be present with biliary-type SOD and interfere with the diagnosis and treatment of it.AIM To retrospectively assess EST as a treatment for biliary-type SOD and analyze the importance of functional gastrointestinal disorder(FGID)in guiding endoscopic treatment of SOD.METHODS Clinical data of 79 patients with biliary-type SOD(type I and type II)treated with EST at Affiliated Hospital of Guizhou Medical University from January 2014 to January 2019 were retrospectively collected to evaluate the clinical therapeutic effect of EST.The significance of relationship between FGID and biliary-type SOD was analyzed.RESULTS Seventy-nine patients with biliary-type SOD received EST,including 29 type 1 patients and 50 type 2 patients.The verbal rating scale-5(VRS-5)scores before EST were all 3 or 4 points,and the scores decreased after EST;the difference was statistically significant(P<0.05).After EST,the serum indexes of alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase and total bilirubin in biliary-type SOD were significantly lower than before(P<0.05).After EST,67(84.8%)and 8(10.1%)of the 79 patients with biliary-type SOD had obviously effective(VRS-5=0 points)and effective treatment(VRS-5=1-2 points),with an overall effectiveness rate of 94.9%(75/79).There was no difference in VRS-5 scores between biliary-type SOD patients with or without FGID before EST(P>0.05).Of 12 biliary-type SOD(with FGID)patients,11 had abdominal pain after EST;of 67 biliary-type SOD(without FGID)patients,0 had abdominal pain after EST.The difference was statistically significant(P<0.05).The 11 biliary-type SOD(with FGID)patients with recurrence of symptoms,the recurrence time was about half a year after the EST,and the symptoms were significantly relieved after regular medical treatment.There were 4 cases of postendoscopic retrograde cholangiopancreatography pancreatitis(5.1%),and no cholangitis,bleeding or perforation occurred.Patients were followed up for 1 year to 5 years after EST,with an average follow-up time of 2.34 years,and there were no long-term adverse events such as sphincter of Oddi restenosis or cholangitis caused by intestinal bile reflux during the follow-up.CONCLUSION EST is a safe and effective treatment for SOD.For patients with type I and II SOD combined with FGID,single EST or medical treatment has limited efficacy.It is recommended that EST and medicine be combined to improve the cure rate of such patients.

“陆氏针灸”以“俞募配穴”为主治疗Oddi括约肌功能障碍的经验浅析

陆师临证重视整体治疗和全面切诊,注重固护胃、肾二气,强调针刺补泻手法和针感,重用温针、善用水针。陆师在传承和发展“陆氏针灸”之精髓的基础上运用“俞募配穴”为主治疗Oddi括约肌功能障碍,以疏肝健脾、理气止痛为治疗原则,辨证取穴,疗效显著。

Oddi括约肌测压对胆囊切除术后腹痛患者的诊断价值

目的：探讨Ｏｄｄｉ括约肌测压对胆囊切除术后复发腹痛患者的诊断意义。方法：用低顺应性水灌注系统，三通道测压导管，观察Ｏｄｄｉ括约肌基础压、Ｏｄｄｉ括约肌基础收缩幅度、频率、传播方式和胆管内压。结果：胆囊切除术后患者，胆总管内压无明显差异（Ｐ＞０．０５），但Ｏｄｄｉ括约肌基础压力、Ｏｄｄｉ括约肌基础收缩频率及幅度均明显增高（Ｐ＜０．０１），Ｏｄｄｉ括约肌逆向性收缩的比例亦升高（Ｐ＜０．０５）。Ｏｄｄｉ括约肌测压异常发生率为４６．７％，其中Ⅰ型患者测压异常发生率为９０％，８０％表现为Ｏｄｄｉ括约肌狭窄，１０％为Ｏｄｄｉ括约肌运动功能紊乱；Ⅱ型患者测压异常发生率为３１．８％，Ｏｄｄｉ括约肌狭窄占１３．７％，功能紊乱占１８．１％；Ⅲ型患者测压异常发生率为６．７％，均表现为Ｏｄｄｉ括约肌运动功能紊乱。Ⅰ型患者测压异常发生率明显高于Ⅱ型及Ⅲ型患者。结论：Ｏｄｄｉ括约肌测压对研究Ｏｄｄｉ括约肌运动功能具有较高价值。

Oddi括约肌功能障碍的ERCP研究

目的 探讨内镜逆行胰胆管造影 (ERCP)对Oddi括约肌功能障碍的诊断价值。方法 对 2 1例Oddi括约肌功能障碍患者进行各种检查 ,重点分析ERCP在Oddi括约肌功能障碍的内镜诊断特点及X线表现 ,并将ERCP诊断方法与实验室检查、B超等检查方法进行比较。结果 ERCP能直观显示十二指肠乳头的位置、形状、大小、开口的形态及狭窄程度和胰胆管扩张 ,特别是对胆总管下端、乏特氏壶腹部的形态、边缘的显示。结论 ERCP是目前诊断Oddi括约肌功能障碍的最佳方法。

胆管结石患者术后经“T”管窦道胆道镜Oddi括约肌测压的表现及意义

目的:对胆管结石患者术后经“T”管窦道行胆道镜测压,研究胆管结石患者术后Oddi括约肌(SO)功能,探讨结石与SO功能变化的关系．方法:共对216例患者测量十二指肠压、Oddi 括约肌基础压、收缩幅度、收缩频率、收缩间期、胆总管压以及顺蠕动、逆蠕动及同时收缩所占百分比．对患者根据SO基础压分为4 组:A组(SO运动功能不足组)、B组(SO压力正常组)、C组(SO压力略升高组)和D组(SO功能障碍组),比较各组各测压指标之间差别．结果:A组SO收缩幅度均值为62．32± 32．13 mmHg,较其他三组明显降低(P<0．01); SO收缩间期较B,C组明显缩短(P<0．01);收缩频率与B,C组的差异无统计学意义,但明显小于D组(P<0．05);胆总管压均值为3．89± 8．10 mmHg,较B,C组差异无统计学意义,但是明显低于D组(P<0．01),而且大于SO基础压． D组SO收缩幅度均值为97．02±51．76 mmHg, 与B,C组差异虽无统计学意义,但呈升高趋势,而且明显高于A组(P<0．01);SO收缩间期较C组短(P<0．05),与另外两组差异无统计学意义;SO收缩频率较前三组则明显增快 (P<0．01vsA,B组,P<0．05vsC组);胆总管压均值为10．41±12．37 mmHg,较A,B组明显升高(P<0．01),与C组差别无统计学意义;逆蠕动所占百分比与A,B组相比明显增加(35．73％± 26．38％vs20.31％±21．96％,22．71％±23．86％, P<0．05),与C组差别无统计学意义．结论:胆管结石患者术后存在SO功能障碍及 SO运动功能不足两种病理状况,而且SO的这些异常改变可能与胆管结石的形成和／或复发有关．经T型管窦道胆道镜测压可以作为诊断 SO功能障碍及SO运动功能不足的有效手段．

Oddi括约肌异常在胆石形成中的作用

Oddi括约肌的功能异常在胆胰疾病的发生发展中具有重要的作用。Oddi括约肌功能的异常可分为解剖形态异常和机能失调,研究发现其与肠胆反流的发生以及胆道结石的形成密切相关。回顾总结了Oddi括约肌异常的分类及其与胆石形成的关系,认为对Oddi括约肌功能障碍的干预和调节可望在指导胆石症的治疗和预防方面产生深远影响。

EST对胆囊切除术后Oddi括约肌功能障碍胆道型的治疗价值

目的 :探讨内镜下十二指肠乳头切开术 (EST)对胆囊切除术后Oddi括约肌功能障碍 (SphincterofOddiDysfunction ,SOD)胆道型的治疗价值。方法 :参考SOD国际诊断标准 (罗马Ⅱ ) ,拟定关于胆道型SOD的标准选择 72例SOD患者 ,经ERCP确诊后 ,及时进行EST治疗 ,采用Pull式十二指肠乳头切开刀进行切开 ,切口长度约 1～ 1 .5cm ,其中 1 2例狭窄型患者应用针型切开刀开窗后 ,再行ERCP成功。术后观察疗效 ,以显效、有效和无效来评价 ,并观察分析并发症情况。结果 :72例患者经EST治疗后 ,显效 58例 (80 .6 % ) ,有效 9例(1 2 .5 % ) ,总有效率为 93 .1 % :无效 5例 (6 .9% )。EST术中及术后出现并发症 9例 (1 2 .5 % ) ,其中出血 4例 ,急性胰腺炎 3例 ,胆系感染 2例。结论 :EST对SOD患者具有非常确切的疗效 ,且患者痛苦小 ,住院时间短。

十二指肠镜下诊断和治疗胆囊切除术后胆道型Oddi括约肌功能障碍

目的探讨十二指肠镜技术对胆囊切除术后胆道型Oddi括约肌功能障碍（sphincter of Oddi dysfunction,SOD）的诊断和治疗价值。方法参考SOD国际诊断标准（罗马Ⅱ）,选择符合胆道型SOD标准的46例行内镜逆行胰胆管造影（endoscopic retrograde cholangiopancreatography,ERCP）,其内镜诊断特点和X线影像表现符合胆道型SOD诊断标准的病例,直接行内镜下乳头括约肌切开术（endoscopic sphincterotomy,EST）或内镜下乳头气囊扩张术（endoscopic papillary ballooncatheterdilatation,EPBD）治疗。结果ERCP显示46例胆总管直径1.3～2.5cm,胆管无结石及其他器质性病变,下端呈鸟嘴状狭窄或渐进性狭窄28例。39例行EST,7例行EPBD。34例（73.9%）腹痛基本消失,8例（17.4%）明显缓解,4例（8.7%）无明显改善,总有效率91.3%（42/46）。术后1～14d发热及黄疸者症状完全消失,术后7～14d肝功能酶学异常指标均恢复正常。2例术后发生急性胰腺炎,经禁食、抗炎治疗后治愈,无其他严重并发症发生。46例随访1～36个月,平均10.8月,治疗后症状改善或消失,未见复发及其他异常。结论对于胆囊切除术后胆道型SOD,内镜下诊断和治疗技术是一种微创、安全、有效的措施。

内镜下十二指肠乳头括约肌切开术治疗Oddi括约肌功能失调(附69例报告)

目的观察内镜下十二指肠乳头括约肌切开术(EST)对胆囊切除术后Oddi括约肌功能失调(SOD)的疗效。方法根据患者病史、临床症状、ERCP检查及肝功能改能变等进行综合诊断,对诊断为SOD的92例患者先行内科药物治疗,有69例接受EST治疗。结果药物治疗总有效率为20.7%(19/92),EST治疗总有效率为92.8%(64/69),明显优于药物治疗(P<0.01)。结论对早期的轻症SOD患者,药物治疗是首选;对药物治疗失败者或中晚期的狭窄型SOD患者,EST是一种微创、安全和有效的治疗手段。

芍药甘草汤治疗Ⅱ型胆管Oddi括约肌功能障碍的临床研究

【目的】观察芍药甘草汤治疗Ⅱ型胆管Oddi括约肌功能障碍的临床疗效。【方法】选取37例Ⅱ型胆管Oddi括约肌功能障碍患者,以芍药甘草汤治疗8周,观察治疗前后腹痛视觉模拟量表(VAS)评分和分级评分、肝功能指标[谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(ALP)、总胆红素(TBil)、直接胆红素(DBil)]、胆总管直径及肝胆十二指肠核素显影时间,并评价其疗效和安全性。【结果】(1)疗效方面,经治疗8周后,临床治愈11例,显效16例,有效6例,无效4例,总有效率为89.19%。(2)治疗后,患者的VAS评分和腹痛总评分均较治疗前明显降低,差异均有统计学意义(P<0.05)。(3)治疗后,患者的ALT、AST、ALP水平均较治疗前明显降低,差异均有统计学意义(P<0.05),而TBil、DBil治疗前后变化不明显,差异均无统计学意义(P>0.05)。(4)治疗后,患者的肝胆十二指肠核素显影时间明显缩短,差异有统计学意义(P<0.05),而治疗后的平均胆总管直径略有缩小,但差异无统计学意义(P>0.05)。【结论】芍药甘草汤治疗Ⅱ型胆管Oddi括约肌功能障碍患者疗效确切,能有效缓解患者腹痛症状,改善患者肝功能,减少胆汁排泄时间。

Oddi括约肌:从切开到修复

Oddi括约肌是控制胆胰管通道的阀门,对于维护胆胰管正常生理功能具有不可替代的作用。无论是括约肌成形还是切开术,均可不同程度的破坏Oddi括约肌的功能,造成术后十二指肠液的反流和胆汁细菌污染,增加复发性胆总管结石、反流性胆管炎甚至胆管癌的风险。因此,临床医师应重视保护Oddi括约肌的结构和功能。基于笔者的经验,对于括约肌已被医源性损伤的患者,在肝外胆道可保留的前提下,均应联合经十二指肠括约肌修复术以恢复Oddi括约肌结构的完整性,减少其功能缺失继发的胆胰管并发症。

Oddi括约肌功能失调的药物与内镜治疗的作用

了解药物与内镜下十二指肠乳头括约肌切开术(EST)对胆囊切除术后Odd i括约肌功能失调(SOD)的疗效。以临床诊断的SOD患者先行药物治疗一周,无效者再行EST治疗,观察其疗效。在45例药物治疗的患者中,有效者仅11例,其有效率为24.4%;而在34例药物治疗无效后经EST治疗的患者中,有效者为31例,其有效率为91.2%,明显优于药物治疗(P<0.005)。EST术中和术后出现并发症4例,其发生率为11.8%。EST是药物治疗SOD无效时的最佳手段。

袖套式Oddi括约肌压力测定法在Oddi括约肌功能紊乱中的应用

目的 探讨袖套式Oddi括约肌压力测定法（Sleeve type Oddi sphincter pressure measurement,SOM）在Oddi括约肌功能紊乱诊疗中的作用。方法 纳入拟诊为Oddi括约肌功能紊乱患者共26例及对照组患者2例,进行SOM,测定项目包括SO基础压、收缩压、收缩振幅及收缩频率。术后监测各时间点患者的疼痛评分、血清淀粉酶的变化,及术后24 h检查上腹部CT。结果 全部患者均耐受操作,平均操作时间（16.5±0.4）min,与传统的压力检测结果比较,所有患者两次检测的SO基础压、收缩压、收缩振幅及收缩频率差异均无统计学意义（P〉0.05）,其中基础压基本一致。术后1例患者出现轻型胰腺炎,其余27例患者术后48 h内疼痛评分为0~2分,血清淀粉酶及上腹部CT均正常。全部患者未出现其他并发症发生。结论 新型SOM法操作简单,结果可靠,监测时间可控,术后并发症少,并可进行胰管括约肌检测,适合在临床开展。此方法可取代传统灌注式多极压力测定法,用于Oddi括约肌功能紊乱的诊断。