A bone cell population dynamics model for cor- tical bone remodeling under mechanical stimulus is devel- oped in this paper. The external experiments extracted from the literature which have not been used in the creat...A bone cell population dynamics model for cor- tical bone remodeling under mechanical stimulus is devel- oped in this paper. The external experiments extracted from the literature which have not been used in the creation of the model are used to test the validity of the model. Not only can the model compare reasonably well with these ex- perimental results such as the increase percentage of final values of bone mineral content （BMC） and bone fracture en- ergy （BFE） among different loading schemes （which proves the validity of the model）, but also predict the realtime devel- opment pattern of BMC and BFE, as well as the dynamics of osteoblasts （OBA）, osteoclasts （OCA）, nitric oxide （NO） and prostaglandin E2 （PGE2） for each loading scheme, which can hardly be monitored through experiment. In conclusion, the model is the first of its kind that is able to provide an in- sight into the quantitative mechanism of bone remodeling at cellular level by which bone cells are activated by mechan- ical stimulus in order to start resorption/formation of bone mass. More importantly, this model has laid a solid foun- dation based on which future work such as systemic control theory analysis of bone remodeling under mechanical stimu- lus can be investigated. The to-be identified control mecha- nism will help to develop effective drugs and combined non- pharmacological therapies to combat bone loss pathologies. Also this deeper understanding of how mechanical forces quantitatively interact with skeletal tissue is essential for the generation of bone tissue for tissue replacement purposes in tissue engineering.展开更多
对含有0~4.00%（质量分数）不等量Dy的钕铁硼基体进行了Dy晶界扩散,并分析比较其磁性能、成分以及微观结构。研究发现,所有样品在经过Dy扩散后均提升263.4~316.7 k A/m的矫顽力,且Dy质量分数均增加了0.30%~0.35%左右,与基体初始Dy含量...对含有0~4.00%（质量分数）不等量Dy的钕铁硼基体进行了Dy晶界扩散,并分析比较其磁性能、成分以及微观结构。研究发现,所有样品在经过Dy扩散后均提升263.4~316.7 k A/m的矫顽力,且Dy质量分数均增加了0.30%~0.35%左右,与基体初始Dy含量并没有明显关联性。进一步分析发现,不同样品的矫顽力提高幅度并不正比于Dy增加量,基体Dy含量越高,单位量Dy元素的矫顽力提高效率越低。结合EPMA面分布图分析后认为,在不含Dy的基体中进行扩散的过程是晶界区域中Dy从无到有的过程,这时的矫顽力提高效率最高。展开更多
文摘A bone cell population dynamics model for cor- tical bone remodeling under mechanical stimulus is devel- oped in this paper. The external experiments extracted from the literature which have not been used in the creation of the model are used to test the validity of the model. Not only can the model compare reasonably well with these ex- perimental results such as the increase percentage of final values of bone mineral content （BMC） and bone fracture en- ergy （BFE） among different loading schemes （which proves the validity of the model）, but also predict the realtime devel- opment pattern of BMC and BFE, as well as the dynamics of osteoblasts （OBA）, osteoclasts （OCA）, nitric oxide （NO） and prostaglandin E2 （PGE2） for each loading scheme, which can hardly be monitored through experiment. In conclusion, the model is the first of its kind that is able to provide an in- sight into the quantitative mechanism of bone remodeling at cellular level by which bone cells are activated by mechan- ical stimulus in order to start resorption/formation of bone mass. More importantly, this model has laid a solid foun- dation based on which future work such as systemic control theory analysis of bone remodeling under mechanical stimu- lus can be investigated. The to-be identified control mecha- nism will help to develop effective drugs and combined non- pharmacological therapies to combat bone loss pathologies. Also this deeper understanding of how mechanical forces quantitatively interact with skeletal tissue is essential for the generation of bone tissue for tissue replacement purposes in tissue engineering.
文摘对含有0~4.00%（质量分数）不等量Dy的钕铁硼基体进行了Dy晶界扩散,并分析比较其磁性能、成分以及微观结构。研究发现,所有样品在经过Dy扩散后均提升263.4~316.7 k A/m的矫顽力,且Dy质量分数均增加了0.30%~0.35%左右,与基体初始Dy含量并没有明显关联性。进一步分析发现,不同样品的矫顽力提高幅度并不正比于Dy增加量,基体Dy含量越高,单位量Dy元素的矫顽力提高效率越低。结合EPMA面分布图分析后认为,在不含Dy的基体中进行扩散的过程是晶界区域中Dy从无到有的过程,这时的矫顽力提高效率最高。
