Analysis of Imaging Characteristics and Dynamic Changes of 3 Cases of Severe Novel Coronavirus Pneumonia in Qinghai Province

Objective:To analyze the characteristics,dynamic changes,and outcomes of the first imaging manifestations of 3 patients with severe COVID-19 in our hospital.Methods:Computed tomography(CT)findings of 3 patients with severe COVID-19 who tested positive by the nucleic acid test in our hospital were selected,mainly focusing on the morphology,distribution characteristics,and dynamic changes of the first CT findings.Results:3 patients with severe pneumonia were older,with one aged 80.The first chest CT examination for all 3 patients differed.Imaging showed a leafy distribution of consolidation,primarily affecting the lower lobes of both lungs and extending subpleurally.A grid-like pattern was observed,along with changes in the consolidation and air bronchogram.These changes had slower absorption,especially in patients with underlying diseases.Conclusion:CT manifestations of severe COVID-19 have specific characteristics and the analysis of their characteristics and dynamic changes provide valuable insights for clinical treatment.

Dynamic changes of ocular biometric parameters:a modified form-deprivation myopia model of young guinea pigs

AIM: To evaluate the dynamic ocular biometric changes of a modified form-deprivation myopia model in young guinea pigs. METHODS: The animals were randomly assigned to two groups: the monocularly deprived facemask group (MDF, with all the right eyes covered, n=24) and the normal control group(free of facemask, n=24). Each group was then equally divided into four subgroups which were followed up for 2, 4, 6 and 8 weeks, respectively. Parameters measured from every eye included refraction, corneal curvature, axial length and the dry weight of sclera at the posterior pole. RESULTS: All the facemasks remained in place during the follow-up. The covered eyes developed myopia with the vitreous chamber lengthening and the dry weight of posterior sclera reduced at each time point compared with the contralateral uncovered (P<0.05 at all time points). The changes had a linear correlation with the deprivation time (P<0.05). There were no significant differences in all the parameters between the uncovered eyes of MDF group and the normal control group (P>0.05 at all time points). CONCLUSION: Monocular form deprivation with the facemask is highly effective and non-invasive in inducing axial myopia in guinea pigs. The axial myopia is mainly caused by the increased vitreous chamber length and the weakened posterior sclera rigidity. The form-deprivation eye didn't interfere with the natural development of the contralateral eye.

Quantitative analysis of the dynamic change and spatial differences of the ecological security: a case study of Loess Plateau in northern Shaanxi Province

Using the theory and method of the ecological footprint, and combining the changes of regional land use, resource environment, population, society and economy, this paper calculated the ecological footprint, ecological carrying capacity and ecological surplus/loss in 1986-2002 on the Loess Plateau in northern Shaanxi Province. What is more, this paper has put forward the concept of ecological pressure index, set up ecological pressure index models, and ecological security grading systems, and the prediction models of different ecological footprints, ecological carrying capacity, ecological surplus and ecological safety change, and also has assessed the ecological footprint demands of 10,000 yuan GDE The results of this study are as follows： （1） the ecological carrying capacity in northern Shaanxi shows a decreasing trend, the difference of reducing range is the fastest; （2） the ecological footprint appears an increasing trend; （3） ecological pressure index rose to 0.91 from 0.44 during 1986-2002 on the Loess Plateau of northern Shaanxi with an increase of 47%; and （4） the ecological security in the study area is in a critical state, and the ecological oressure index has been increasing rapidlv.

Comparison of performance between rescaled range analysis and rescaled variance analysis in detecting abrupt dynamic change

In the present paper, a comparison of the performance between moving cutting data-rescaled range analysis （MC- R/S） and moving cutting data-rescaled variance analysis （MC-V/S） is made. The results clearly indicate that the operating efficiency of the MC-R/S algorithm is higher than that of the MC-V/S algorithm. In our numerical test, the computer time consumed by MC-V/S is approximately 25 times that by MC-R/S for an identical window size in artificial data. Except for the difference in operating efficiency, there are no significant differences in performance between MC-R/S and MC-V/S for the abrupt dynamic change detection. Mc-R/s and MC-V/S both display some degree of anti-noise ability. However, it is important to consider the influences of strong noise on the detection results of MC-R/S and MC-V/S in practical application

Dynamic Changes in DNA Damage and Repair Biomarkers with Employment Length among Nickel Smelting Workers

Our study explored the dynamic changes in andthe relationship between the DNA damage marker8-hydroxy-2＇-deoxyguanosine （8-OHdG） and theDNA repair marker 8-hydroxyguanine DNAglycosidase 1 （hOGG1） according to the length ofoccupational employment in nickel smeltingworkers. One hundred forty nickel-exposedsmelting workers and 140 age-matched unexposedoffice workers were selected from the Jinchangcohort. The 8-OHdG levels in smelting workers wassignificantly higher than in office workers （Z=-8.688,P〈0.05） and the 8-OHdG levels among nickelsmelting workers in the 10-14 y employment lengthcategory was significantly higher than among allpeers. The hOGG1 levels among smelting workerswere significantly lower than those of non-exposedworkers （Z=-8.948, P〈0.05）. There were significantdifferences between employment length andhOGG1 levels, with subjects employed in nickelsmelting for 10-14 y showing the highest levels ofhOGG1. Correlation analysis showed positivecorrelations between 8-OHdG and hOGG1 levels（r=0.413; P〈0.01）. DNA damage was increased withemployment length among nickel smelting workersand was related to the inhibition of hOGG1 repaircapacity.

Dynamic Change Analysis of Urban Green Land in Jinan City Based RS and Geo-information Tupu

The three-period (1995, 1998 and 2003) remote sensing images in Jinan City, China are selected. And the information of green land, construction land, woodland and water body is extracted by using the image processing module of remote-sensing software and computerized interpretation module. Both the change table and transfer matrix table of land use area are analyzed by modeling module of remote-sensing software. Then, the Geo-information Tupu is obtained; and the temporal and spatial variation of land use in Jinan City is monitored and analyzed by Geo-information Tupu and transfer matrix. Result shows that land use structure change of Jinan City in the years 1995-1998 shows a transformation from green land to construction land. Area of green land circulating into construction land reaches 62.27 square kilometers, accounting for 25.84% of the initial green land. In the year 1998, areas of woodland and green land are reduced due to the urban expansion of Jinan City. However, with the enhancement of people's awareness of environmental protection, areas of woodland and green land gradually increase in the year 2003, which are still less than those in the year 1995.

Spectral-domain optical coherence tomography dynamic changes and steroid response in multiple evanescent white dot syndrome

Dear Editor,Multiple evanescent white dot syndrome （MEWDS） was first described in 1984 as a rare, acute, unilateral,multifocal retinochoroidal disorder, typically affecting young myopic women. Previous studies with fluorescein angiography （FA） and electrophysiology suggested that MEWDS to be a disease in the retinal pigment epithelium （RPE） or outer retina, while recent studies with spectral- domain optical coherence tomography （SD-OCT） suggested it may be an outer retinal disease due to observation of hyperreflective material in outer retina and subtle disruptionsof the ellipsoid zone without RPE disruption.

Dynamic changes of gravity fields before and after the 2008 Wenchuan earthquake(Ms8.0)

The pattern evolution and dynamic mechanism of the dynamic changes of regional gravity fields occurring before and after the Wenchuan Ms8.0 earthquake are analyzed, based on five epochs of 1998 -2007 mobile gravity data from the middle-south section of the north-south seismic belt, and two epochs of field research data collected after the 2008 Wenchuan earthquake in combination with GPS data, leveling observations, and geotectonic environment data. The regional dynamic gravity changes demonstrate the effects of the eastward flow of solid matter in the Qinghai-Tibetan plateau and the preparation of the 2008 Wenchuan earthquake （2- 10 yr）. The two most meaningful gravity indicators of the Wcnchuan earthquake preparation are the positive （increasing） gravity changes occurring over many years in the southwest epicenter and the largescale gradient zone of gravity variation, with the cumulative difference between the two sides of the gradient zone of gravity exceeding 200 μGal. The positive gravity changes may facilitate a constant energy accumulation and the gradient belt may support seismic shear breakage. Overall, the gravity changes associated with the earthquake preparation indicate a pattern of accelerating increase-decelerating increase-earthquake occurrence. The Songpan-Ganzi block generally displays a negative gravity change, providing evidence for a local upwarp- ing of the deep crust-mantle and an interior expansion of the deep crust attributable to high temperatures. The viewpoint is consistent with the dilatant mechanism for earthquake preparation.

Dynamic changes of a typical linear dune in the Tengger Desert

The dynamical processes of a typical linear dune including morphological features, dune ridge swing range and crest height were investigated at different monitoring periods in the hinterland of Tengger Desert. The results indicated that the development of linear dune depends on not only the northwesterly prevailing wind, but also the winds from northeast and southwest. The dune ridge swayed along its fundamental strike and took on an eastward movement gradually. The original dune strike was NW70° on August 3, 1994, and then changed to NE15° on April 21, 2001. The dune crest increased by 1.8 m longitudinally, which manifested strong wind-blown sand activities in this region. Wind erosion frequently occured at the bottom of sand dune, while sand accumulation appeared on its mid-upper section. The mean wind erosion depth was 25 cm on the bottom of linear dune and the height difference of the control points on the dune’s ridge was 1.13 m. Although the linear dune swayed laterally, the horizontal displacement of its ridge moved eastward 5.8 m averagely. The swing range of the dune crest line is very distinct, with a maximum value of 13.2 m. The highest site on the K-profile swayed on both sides of the dune ridge and the heights were 19.88 m at the control point K5, 19.61 m at K6 and 19.05 m at K7, respectively. The results indicated that the lateral swing of the linear dune was distinct under the northwesterly wind and it moved toward east gradually.

The impact of dynamic change of cropland on grain production in Jilin

The quantity and quality changes of cropland in Jilin province are analyzed by combining the statistics from 1949 to 1999 and land-use maps interpreted from TM images in 1986 and in 2000. In general, the decreasing trend of the cropland in Jilin province was derived from the statistic data in 1949-1999. While since 1983, the cropland area has increased slightly, because of the conversion from other land-use types to cropland. It is showed that the net increase of cropland was about 43.40×10 4 ha. While the quality change of the cropland can be seen from that mainly caused by the conversion from forestland, grassland to cropland and the change mainly took place in the west, where it is ecologically fragile. According to the spatial distribution model, the centroids' move of the cropland and the grain production are calculated, whose directions are not consistent. The impact of the dynamic change of the cropland on food security is further analyzed.

Dynamic Changes of Lakes in Tibet Plateau and the Climate Interaction in the Past Forty Years

Lake change,as a mirror of climate change,has obvious indication and warning effect on climate.By extracting information of all lakes in Tibet Plateau from Landsat of the 1970’s,the 1990’s,around 2000 and 2010 based on RS and GIS,and,in combination with on-the-spot investigations to a few representative lakes,the authors

Dynamic change of agricultural energy efficiency and its influencing factors in China

In order to practice the concept of‘lucid waters and lush mountains are invaluable assets’and promote the green development of agriculture,it is necessary to improve the efficiency of agricultural energy utilization.Based on the panel data of 28 provinces from 1995 to 2018,this paper calculated China’s agricultural energy input from two categories of direct energy and indirect energy,and used EBM(Epsilon-based Measure)mixed distance function model to measure the energy efficiency of agriculture in China.The nuclear density function and spatial autocorrelation were used to analyze the dynamic evolution of agricultural energy efficiency,and the dynamic panel model was used to analyze the influencing factors of agricultural energy efficiency.The results showed that:①From 1995 to 2018,the total agricultural energy input had increased year by year in China,with an average annual growth rate of 2%.Energy input structure changed from indirect energy-based to direct energy-based.Agricultural energy efficiency showed an evolutionary trend of‘rising-stagnating-rising rapidly’in China.The agricultural energy efficiency was generally low in China,and there was a large space for improvement in agricultural energy efficiency.②From 1995 to 2018,the average annual growth rate of agricultural energy efficiency in the eastern,central and western regions was 2.7%,1.9%and 1.4%respectively.In 2018,the agricultural energy efficiency in the eastern,central and western regions was 0.81,0.71 and 0.59 respectively.The gap between regions was expanding rapidly,and the agricultural energy efficiency in the central and western regions needed to be improved.③From 1995 to 2018,the agricultural energy efficiency of each province was polarized and the absolute gap was widened.There was obvious improvement in agricultural energy efficiency in Guangdong,Shandong,Jiangxi,Jiangsu,Liaoning and Tianjin,while the agricultural energy efficiency of Xinjiang,Guizhou,Zhejiang,Shanghai,and Inner Mongolia deteriorated.④From 1995 to 2018,there was no global spatial correlation of China’s agricultural energy efficiency.However,local‘high-high’concentration gradually appeared in the eastern region since 2010.⑤The first lag of energy efficiency had a significant positive impact on agricultural energy efficiency,and agricultural energy efficiency improvement had a time lag.The level of human capital,per capita net income of farmers and the level of urbanizaton had a significant positive impact on agricultural energy efficiency.The disaster rate,the level of development of secondary and tertiary industries,and the level of opening up had a significant negative impact on agricultural energy efficiency.In the implementation of the strategy of rural revitalization,we should focus on the central and western regions,take the cultivation of professional farmers as the key,focus on improving agricultural production conditions,enhance the level of cooperation between regions,exert the leading role of the secondary and tertiary industries,and enhance the ability of agricultural disaster prevention and mitigation.

Study on dynamic changes of land desertification in the circum-lake zone of the Qinghai Lake in the past 30 years supported by Remote Sensing and Geographical Information System

The circum-lake zone of the Qinghai Lake is one of the most serious regions of desertification on the Qinghai-Tibetan Plateau. Based on Remote Sensing （RS） and Geographical Information System （GIS） techniques, the four sets of remote sensing images acquired in 1976, 1987, 1995, and 2006 were selected to conduct thematic information extraction in 14,300 km2 of land in the circum-lake zone using the Earth Resource Data Analysis System （ERDAS） image and information processing function. In the meantime the off-site interpretation and filed check-correction methods were used to recon- struct the temporal-spatial dynamic changes and differentiation patterns of land desertification in the circum-lake zone in the past 30 years, and based on this, the developmental trend of land desertification in the next 20 years was predicted. The results of the study show that in the past 30 years land desertification in the region experienced a continuous fluctuation between rapid- and slow-development processes in time, while in space it exhibited a few small patchy distributions or sporadic distributions in many places while at the same time, four large sand-dominated distributions stood out and evolved into a circum-lake belt differentiation pattern with a lakeside dike as the connecting line. Due to the integrated effects of climate changes, human activities and artificial rehabilitation, land desertification area in the region in the next 20 years will exhibit an increasing trend in the first 15 years and then increase at a slower rate, and afterward occur in a reverse, decreasing trend.

Dynamic Changes of the CT Perfusion Parameters in the Embolic Model of Cerebral Ischemia

Summary: To study the dynamic changes of CT perfusion parameters during the first 12 h in the embolic cerebral ischemia models. Local cerebral ischemia model were established in 7 New Zealand white rabbits. All CT scans were performed with a GE Lightspeed 16 multislice CT. Following the baseline scan, further CT perfusion scans were performed at the same locations 20 min, 1-6 h and 8, 10 and 12 h after the embolus delivery. Maps of all parameters were obtained by CT perfusion software at each time point. The brains, taken 12 h after the scan, were sliced corresponding to the positions of the CT slices and stained by 2,3,5-triphenyltetrazolium chloride (TTC). On the basis of the TTC results, the ischemic sides were divided into 3 regions: core, penumbra and the relatively normal region. The changes of all parameters were then divided into 3 stages. In the first two hours (the first stage), the CBV dropped more remarkably in the core than in the penumbra but rose slightly in the relatively normal region while the CBF decreased and MTT, TTP extended in all regions to varying degrees. In the 2nd-5th h (the second stage), all the parameters fluctuated slightly around a certain level. In the 5th-12th h (the third stage), the CBV and CBF dropped, and MTT and TTP were prolonged or shortened slightly in the core and penumbra though much notably in the former while the CBV, CBF rose and MTT, TTP were shortened remarkably in the relatively normal region. We experimentally demonstrated that the location and extent of cerebral ischemia could be accurately assessed by CT perfusion imaging. The pathophysiology of the ischemia could be reflected by the CT perfusion to varying degrees.

Dynamic Changes of Microbial Community for Degradation of Lignocellulose

Dynamic changes of a microbial community for lignocellulose degradation were explored in details. Community composition and development were investigated by the means of denaturing gradient gel electrophoresis （DGGE）, and results showed that the microbial community was constituted of 14 kinds of bacteria and presented the fluctuation in some degrees with fermentation. Furthmore, the result of cluster analysis of DGGE pattern was accordant with growth curve, and the degradation process was divided into three stages： initial stage （0-12 h）, intermediate stage （24-144 h） and end stage （144-216 h）.

Dynamic Changes in Per Capita Net Income of Rural Residents in Nyingchi City of Tibet

Through an in-depth analysis of the per capita net income of rural residents in Nyingchi City,it was known that the per capita net income of rural residents in Nyingchi City was increasing at high speed in recent 10 years. However,the wage income,household operating income,and agricultural income gap constitute the major factors influencing the gap of the per capita net income of rural residents in Nyingchi City. Finally,it came up with recommendations including promoting the reasonable flow of labor to the secondary and tertiary industries,increasing the wage income and transfer income of rural residents,accelerating the construction of small towns in rural areas,promoting the development of rural cooperatives,implementing the strategy of " benefiting farmers and strengthening tourism",promoting integration of agriculture and eco-tourism,promoting the development of modern agriculture,and expanding diversified production income of farmers.

Dynamic changes of cellular immune function and individualized adjustments of immunosup-pressant for the management of severe infection after liver transplantation

Objective To explore the dynamic changes of the cellular immune function in severe infection after liver transplantation,and to guide the individualized immunology adjustment. Methods 378 cases of liver transplantation were analyzed retrospectively. Seventy - four cases ( infection group) suffered serious infection,including 54 cases cured ( cure group) ,20 cases died (

Localization and Dynamic Change of Saikosaponin in Root of Bupleurum chinense

Anatomical, histochemical and phytochemical methods were used to investigate the structure, the localization and content changes of total saikosaponin and saikosaponin-a of the roots of Bupleurum chinense DC. at different developmental stages. Results showed that saikosaponin was mainly distributed in pericycle and primary phloem in the young root; but in the mature root, it was mainly distributed in vascular cambium and secondary phloem. During the whole growth period from the pre-blossom, blossom, fruit, and fruit mature periods until the pre-withering period, it was in the fruit mature period that both the total saikosaponin content and the saikosaponin-a content reached the highest level. So the last 20 d of October was considered as the right collecting season for the drug of B. chinense. In addition, the quality of 1-year-old drug was better than that of 2-year-old drug due to its higher saikosaponin content. On the other hand, judging from the external characteristics of the drug, the one with an acerose taproot and more lateral roots was of better quality. The results offered theoretical bases for selecting medicinal material of high quality and determining the most appropriate harvesting stage and part of B. chinense.

Localization and Dynamic Change of Saponin in Vegetative Organs of Polygala tenuifolia

Anatomical, histochemical and phytochemical methods were used to investigate the structure, localization and dynamic changes of total saponin and senegenin of vegetative organs in Polygala tenuifolia Willd. Histochemical localization results showed that saponin accumulated mainly in parenchyma cells of vegetative organs. The phytochemical results also showed that the saponin accumulated in the vegetative organs of P. tenuifolia, with higher content in roots and lower content in the aerial parts that included stems and leaves. The saponin content and dry weight of the vegetative organs of P. tenuifolia had dynamic variance at the developmental stages and all reached the highest level in the post-fruit period. Hence, the roots and aerial parts should be gathered in August to make full use of the plant. As the root is the main medicinal organ of P. tenuifolia, the content of total saponin and senegenin of different aged and different parts of the root were determined. The content of total saponin and senegenin exhibited a sustained decreasing trend with increasing root age; therefore, the annual roots had high quality. The content of total saponin and senegenin in different parts of the root showed obvious variation. The content in the ＂skin areas＂ was much higher than that of xylem. The results offer a theoretical basis for determining the appropriate harvesting stage and a reasonable harvest of P. tenuifolia.