The pattern evolution and dynamic mechanism of the dynamic changes of regional gravity fields occurring before and after the Wenchuan Ms8.0 earthquake are analyzed, based on five epochs of 1998 -2007 mobile gravity da...The pattern evolution and dynamic mechanism of the dynamic changes of regional gravity fields occurring before and after the Wenchuan Ms8.0 earthquake are analyzed, based on five epochs of 1998 -2007 mobile gravity data from the middle-south section of the north-south seismic belt, and two epochs of field research data collected after the 2008 Wenchuan earthquake in combination with GPS data, leveling observations, and geotectonic environment data. The regional dynamic gravity changes demonstrate the effects of the eastward flow of solid matter in the Qinghai-Tibetan plateau and the preparation of the 2008 Wenchuan earthquake (2- 10 yr). The two most meaningful gravity indicators of the Wcnchuan earthquake preparation are the positive (increasing) gravity changes occurring over many years in the southwest epicenter and the largescale gradient zone of gravity variation, with the cumulative difference between the two sides of the gradient zone of gravity exceeding 200 μGal. The positive gravity changes may facilitate a constant energy accumulation and the gradient belt may support seismic shear breakage. Overall, the gravity changes associated with the earthquake preparation indicate a pattern of accelerating increase-decelerating increase-earthquake occurrence. The Songpan-Ganzi block generally displays a negative gravity change, providing evidence for a local upwarp- ing of the deep crust-mantle and an interior expansion of the deep crust attributable to high temperatures. The viewpoint is consistent with the dilatant mechanism for earthquake preparation.展开更多
In view of the three-dimensional dynamic abutment pressure,the influence of the far-field hard stratum(FHS)in deep,thick coal seams is indeterminant.Based on elastic foundation theory,a three-dimensional dynamic predi...In view of the three-dimensional dynamic abutment pressure,the influence of the far-field hard stratum(FHS)in deep,thick coal seams is indeterminant.Based on elastic foundation theory,a three-dimensional dynamic prediction model of the abutment pressure was established.Using this model,the dynamic change in the coal seam abutment pressure caused by the movement of the FHS was studied,and a method for determining the dynamic change range of the abutment pressure was developed.The results of the new prediction model of the abutment pressure are slightly higher than the measured values,with an error of 0.51%,which avoids the shortcomings of the results because the Winkler foundation model results are lower than the measured values and have an error of 9.98%.As time progresses,the abutment pressure and its distribution range are affected by the FHS movement,which has the characteristics of gradually increasing dynamic change until the FHS fractures.The peak value of the abutment pressure increases linearly with time,and the influence range increases with time following a power function with an exponent of less than 1.The influence range of the FHS movement on the abutment pressure ahead of the working face,behind the working face,and along the working face is 10 times,25 times,and 17 times the mining thickness,respectively.According to the actual geological parameters,the dynamic change range of the coal seam abutment pressure was determined by drawing an additional stress curve and by determining the threshold value.These research results are of great significance to the partition optimization of the roadway support design of deep,thick coal seams.展开更多
The aim of this paper is to investigate how the corporate characteristics and contextual factors influence the choice of managers in initiating the sustainability report/reporting (SR) and to understand the role of ...The aim of this paper is to investigate how the corporate characteristics and contextual factors influence the choice of managers in initiating the sustainability report/reporting (SR) and to understand the role of organisational dynamics. The research design develops through a deductive and inductive approach. The deductive approach is based on an analysis of the Social and Environmental Accounting Research (SEAR) strands which use the theoretical framework of (neo-) institutional theory to inquire the adoption and diffusion of SR. The inductive method is based on a research case that focuses on the SGR Group. "How can the rico-institutional theory help explain the process of SGR's SR implementation in Italian and Bulgarian companies"? The study identifies both the internal and contextual factors associated with the SR development and the regulative, normative, and cognitive dimensions/factors that affect the implementation and institutionalisation of SR in Italy and Bulgaria, in accordance with the different institutional environments in which the social and sustainability accounting projects are developed.展开更多
DNMT1 is a DNA methyltransferase that catalyzes and maintains methylation in CpG dinucleotides.It blocks the entrance of DNA into the catalytic pocket via the replication foci targeting sequence(RFTS)domain.Recent stu...DNMT1 is a DNA methyltransferase that catalyzes and maintains methylation in CpG dinucleotides.It blocks the entrance of DNA into the catalytic pocket via the replication foci targeting sequence(RFTS)domain.Recent studies have shown that an H3-tail-conjugated two-mono-ubiquitin mark(H3Ub2)activates DNMT1 by binding to the RFTS domain.However,the activation mechanism of DNMT1 remains unclear.In this work,we combine various sampling methods of extensive simulations,including conventional molecular dynamics,Gaussian-accelerated molecular dynamics,and coarse-grained molecular dynamics,to elucidate the activation mechanism of DNMT1.Geometric and energy analyses show that binding of H3Ub2 to the RFTS domain of DNMT1 results in the bending of theα4-helix in the RFTS domain at approximately 30°–35°,and the RFTS domain rotates~20°anti-clockwise and moves~3?away from the target recognition domain(TRD).The hydrogen-bonding network at the RFTSTRD interface is significantly disrupted,implying that the RFTS domain is dissociated from the catalytic core,which contributes to activating the auto-inhibited conformation of DNMT1.These results provide structural and dynamic evidence for the role of H3Ub2 in regulating the catalytic activity of DNMT1.展开更多
According to dimensionless analysis of the coalbed methane (CBM) production data of Fanzhuang block in southern Qinshui basin, the dimensionless gas production rate is calculated to quantitatively divide the CBM wel...According to dimensionless analysis of the coalbed methane (CBM) production data of Fanzhuang block in southern Qinshui basin, the dimensionless gas production rate is calculated to quantitatively divide the CBM well production process into four stages, i.e., drai- nage stage, unstable gas production stage, stable gas pro- duction stage, and gas production decline stage. By the material balance method, the coal reservoir permeability change in different stages is quantitatively characterized. The characteristics and control mechanisms of change in coalbed permeability (CICP) during different production stages are concluded on five aspects, i.e., permeability trend variation, controlling mechanism, system energy, phase state compositions, and production performance. The study reveals that CICP is characterized by first decline, then recovery, and finally by increase and is controlled directly by effective stress and matrix shrinkage effects. Further, the duration and intensity of the matrix shrinkage effect are inherently controlled by adsorption and desorp- tion features.展开更多
基金financially supported by the National Natural Science Foundation of China (40574012,40374031)Key Project of the National Science & Technology Pillar Program in the Eleventh Five-year Plan(2006BAC01B02-02)Monitoring Project of China Earthquake Administration (201210)
文摘The pattern evolution and dynamic mechanism of the dynamic changes of regional gravity fields occurring before and after the Wenchuan Ms8.0 earthquake are analyzed, based on five epochs of 1998 -2007 mobile gravity data from the middle-south section of the north-south seismic belt, and two epochs of field research data collected after the 2008 Wenchuan earthquake in combination with GPS data, leveling observations, and geotectonic environment data. The regional dynamic gravity changes demonstrate the effects of the eastward flow of solid matter in the Qinghai-Tibetan plateau and the preparation of the 2008 Wenchuan earthquake (2- 10 yr). The two most meaningful gravity indicators of the Wcnchuan earthquake preparation are the positive (increasing) gravity changes occurring over many years in the southwest epicenter and the largescale gradient zone of gravity variation, with the cumulative difference between the two sides of the gradient zone of gravity exceeding 200 μGal. The positive gravity changes may facilitate a constant energy accumulation and the gradient belt may support seismic shear breakage. Overall, the gravity changes associated with the earthquake preparation indicate a pattern of accelerating increase-decelerating increase-earthquake occurrence. The Songpan-Ganzi block generally displays a negative gravity change, providing evidence for a local upwarp- ing of the deep crust-mantle and an interior expansion of the deep crust attributable to high temperatures. The viewpoint is consistent with the dilatant mechanism for earthquake preparation.
基金the National Natural Science Foundation of China[Grant No.U1810102].
文摘In view of the three-dimensional dynamic abutment pressure,the influence of the far-field hard stratum(FHS)in deep,thick coal seams is indeterminant.Based on elastic foundation theory,a three-dimensional dynamic prediction model of the abutment pressure was established.Using this model,the dynamic change in the coal seam abutment pressure caused by the movement of the FHS was studied,and a method for determining the dynamic change range of the abutment pressure was developed.The results of the new prediction model of the abutment pressure are slightly higher than the measured values,with an error of 0.51%,which avoids the shortcomings of the results because the Winkler foundation model results are lower than the measured values and have an error of 9.98%.As time progresses,the abutment pressure and its distribution range are affected by the FHS movement,which has the characteristics of gradually increasing dynamic change until the FHS fractures.The peak value of the abutment pressure increases linearly with time,and the influence range increases with time following a power function with an exponent of less than 1.The influence range of the FHS movement on the abutment pressure ahead of the working face,behind the working face,and along the working face is 10 times,25 times,and 17 times the mining thickness,respectively.According to the actual geological parameters,the dynamic change range of the coal seam abutment pressure was determined by drawing an additional stress curve and by determining the threshold value.These research results are of great significance to the partition optimization of the roadway support design of deep,thick coal seams.
文摘The aim of this paper is to investigate how the corporate characteristics and contextual factors influence the choice of managers in initiating the sustainability report/reporting (SR) and to understand the role of organisational dynamics. The research design develops through a deductive and inductive approach. The deductive approach is based on an analysis of the Social and Environmental Accounting Research (SEAR) strands which use the theoretical framework of (neo-) institutional theory to inquire the adoption and diffusion of SR. The inductive method is based on a research case that focuses on the SGR Group. "How can the rico-institutional theory help explain the process of SGR's SR implementation in Italian and Bulgarian companies"? The study identifies both the internal and contextual factors associated with the SR development and the regulative, normative, and cognitive dimensions/factors that affect the implementation and institutionalisation of SR in Italy and Bulgaria, in accordance with the different institutional environments in which the social and sustainability accounting projects are developed.
基金supported by the Chinese Ministry of Science and Technology and National Natural Science Foundation of China(2019YFA0508902,2018YFA0107004,32170549,31870737,22103040)the National Laboratory of Biomacromolecules(2021kf05)the Fundamental Research Funds for the Central Universities and Tianjin Funds for Distinguished Young Scientists(17JCJQJC45900)。
文摘DNMT1 is a DNA methyltransferase that catalyzes and maintains methylation in CpG dinucleotides.It blocks the entrance of DNA into the catalytic pocket via the replication foci targeting sequence(RFTS)domain.Recent studies have shown that an H3-tail-conjugated two-mono-ubiquitin mark(H3Ub2)activates DNMT1 by binding to the RFTS domain.However,the activation mechanism of DNMT1 remains unclear.In this work,we combine various sampling methods of extensive simulations,including conventional molecular dynamics,Gaussian-accelerated molecular dynamics,and coarse-grained molecular dynamics,to elucidate the activation mechanism of DNMT1.Geometric and energy analyses show that binding of H3Ub2 to the RFTS domain of DNMT1 results in the bending of theα4-helix in the RFTS domain at approximately 30°–35°,and the RFTS domain rotates~20°anti-clockwise and moves~3?away from the target recognition domain(TRD).The hydrogen-bonding network at the RFTSTRD interface is significantly disrupted,implying that the RFTS domain is dissociated from the catalytic core,which contributes to activating the auto-inhibited conformation of DNMT1.These results provide structural and dynamic evidence for the role of H3Ub2 in regulating the catalytic activity of DNMT1.
基金financial support from the various funding agencies including the Major State Basic Research Development Program of China (973 Program, 2009CB219604)the National Natural Science Foundation of China (41272175)+1 种基金the Key Project of the National Science & Technology (2011ZX05034-001)the China Scholarship Council
文摘According to dimensionless analysis of the coalbed methane (CBM) production data of Fanzhuang block in southern Qinshui basin, the dimensionless gas production rate is calculated to quantitatively divide the CBM well production process into four stages, i.e., drai- nage stage, unstable gas production stage, stable gas pro- duction stage, and gas production decline stage. By the material balance method, the coal reservoir permeability change in different stages is quantitatively characterized. The characteristics and control mechanisms of change in coalbed permeability (CICP) during different production stages are concluded on five aspects, i.e., permeability trend variation, controlling mechanism, system energy, phase state compositions, and production performance. The study reveals that CICP is characterized by first decline, then recovery, and finally by increase and is controlled directly by effective stress and matrix shrinkage effects. Further, the duration and intensity of the matrix shrinkage effect are inherently controlled by adsorption and desorp- tion features.