Dysosma versipellis is the rhizome of Bajiaolian in Berberaceae.It is a unique medicinal plant in China and it was the first to be recorded in Shennong’s Classic of Materia Medica(unknown author,25–220 C.E.).It has ...Dysosma versipellis is the rhizome of Bajiaolian in Berberaceae.It is a unique medicinal plant in China and it was the first to be recorded in Shennong’s Classic of Materia Medica(unknown author,25–220 C.E.).It has complex chemical components as well as complex,pharmacological and toxicological effects are extensive.Based on the recent research progress,the chemical constituents,pharmacological activities and toxicological effects of Dysosma versipellis were summarized.Combined with the core concept of quality markers of traditional Chinese medicine,the prediction and analysis were carried out from the aspects of phytogenetics and the source pathway of specific chemical constituents,traditional medicinal properties,traditional efficacy,chemical composition measurability,blood components,and pharmacokinetics,in order to provide reference for further study of Dysosma versipellis.展开更多
Two new anthraquinones,dysoanthraquinone and 2-demethyldysoanthraquinone,were separated from Dysosma majoense.Both compounds contain methylendioxy at 6—C,7—C.It is very interesting in terms of biogenetic pathway tha...Two new anthraquinones,dysoanthraquinone and 2-demethyldysoanthraquinone,were separated from Dysosma majoense.Both compounds contain methylendioxy at 6—C,7—C.It is very interesting in terms of biogenetic pathway that they may have been transformed from aryltetralin lignans by means of oxidative cleavage followed by ring closure.展开更多
Dysosma versipellis (Hance) M. Cheng ex Ying (Berberidaceae) is a rare and vulnerable, perennial herb endemic to China with pharmaceutical significance. Increasing habitat loss and over-exploitation of the plant has s...Dysosma versipellis (Hance) M. Cheng ex Ying (Berberidaceae) is a rare and vulnerable, perennial herb endemic to China with pharmaceutical significance. Increasing habitat loss and over-exploitation of the plant has severely affected the plant's in situ conservation, necessitating ex situ conservation and commercial cultivation. The light regime is a critical environmental factor contributing to successful ex situ conservation via efficient production of biomass and secondary metabolites. We investigated the responses of 2-year-old D. versipellis plants to a light gradient in terms of leaf morphology, growth, biomass production, photo- synthesis and podophyllotoxin (PTOX) accumulation. D. versipellis responded to the light gradient in terms of plant height, leaf size, leaf photosynthesis and PTOX accumulation. Plants demonstrated optimal vegetative growth, photosynthetic capability, and PTOX production, under a light intensity equal to 30% full sunlight. Half full sunlight led to the lowest production of PTOX despite having no obviously different effects on growth. Full sunlight was able to cause leaf death in mid-summer (July), although these plantlets did not significantly differ in growth or biomass production before July and new leaves emerged in August. D. versipellis is therefore proposed to be a shade-tolerant plant, well adapted to variations in irradiance. Irradiance of 10%-50%, particularly ca. 30% full sunlight is strongly recommended for ex situ conservation and commercial cultivation.展开更多
Nine podophyllum lignans and one flavonol were isolated from the rhizomes of Dysosma tsayuensis Ying. On the basis of physical and chemical data,IR,UV,MS, 1HNMR, 13C NMR spectra, they are identified as deoxypodophyllo...Nine podophyllum lignans and one flavonol were isolated from the rhizomes of Dysosma tsayuensis Ying. On the basis of physical and chemical data,IR,UV,MS, 1HNMR, 13C NMR spectra, they are identified as deoxypodophyllotoxin(DT-Ⅰ),podophyllotoxin(DT-Ⅱ), isopicropodo- phyllone(DT-Ⅲ),dehydropodophyllotoxin(DT-Ⅳ),β-peltatin(DT-Ⅴ),diphyllin(DT-Ⅵ), picropodophyllin(DT-Ⅶ),podophyllotoxone(DT-Ⅷ),4’-demethypodophyllotoxin(DT-Ⅸ), kaempferol. Podophyllotoxin yields 1 5%.展开更多
基金the National Natural Science foundation of China(No.82204938).
文摘Dysosma versipellis is the rhizome of Bajiaolian in Berberaceae.It is a unique medicinal plant in China and it was the first to be recorded in Shennong’s Classic of Materia Medica(unknown author,25–220 C.E.).It has complex chemical components as well as complex,pharmacological and toxicological effects are extensive.Based on the recent research progress,the chemical constituents,pharmacological activities and toxicological effects of Dysosma versipellis were summarized.Combined with the core concept of quality markers of traditional Chinese medicine,the prediction and analysis were carried out from the aspects of phytogenetics and the source pathway of specific chemical constituents,traditional medicinal properties,traditional efficacy,chemical composition measurability,blood components,and pharmacokinetics,in order to provide reference for further study of Dysosma versipellis.
文摘Two new anthraquinones,dysoanthraquinone and 2-demethyldysoanthraquinone,were separated from Dysosma majoense.Both compounds contain methylendioxy at 6—C,7—C.It is very interesting in terms of biogenetic pathway that they may have been transformed from aryltetralin lignans by means of oxidative cleavage followed by ring closure.
基金supported by the National Key Project of Scientific and Technical Supporting Programs of China (2008BAC39B05)the National Basic Research Program of China (2007CB411600)the Zhejiang Provincial Major Project of Science and Technology (2006C13077)
文摘Dysosma versipellis (Hance) M. Cheng ex Ying (Berberidaceae) is a rare and vulnerable, perennial herb endemic to China with pharmaceutical significance. Increasing habitat loss and over-exploitation of the plant has severely affected the plant's in situ conservation, necessitating ex situ conservation and commercial cultivation. The light regime is a critical environmental factor contributing to successful ex situ conservation via efficient production of biomass and secondary metabolites. We investigated the responses of 2-year-old D. versipellis plants to a light gradient in terms of leaf morphology, growth, biomass production, photo- synthesis and podophyllotoxin (PTOX) accumulation. D. versipellis responded to the light gradient in terms of plant height, leaf size, leaf photosynthesis and PTOX accumulation. Plants demonstrated optimal vegetative growth, photosynthetic capability, and PTOX production, under a light intensity equal to 30% full sunlight. Half full sunlight led to the lowest production of PTOX despite having no obviously different effects on growth. Full sunlight was able to cause leaf death in mid-summer (July), although these plantlets did not significantly differ in growth or biomass production before July and new leaves emerged in August. D. versipellis is therefore proposed to be a shade-tolerant plant, well adapted to variations in irradiance. Irradiance of 10%-50%, particularly ca. 30% full sunlight is strongly recommended for ex situ conservation and commercial cultivation.
文摘Nine podophyllum lignans and one flavonol were isolated from the rhizomes of Dysosma tsayuensis Ying. On the basis of physical and chemical data,IR,UV,MS, 1HNMR, 13C NMR spectra, they are identified as deoxypodophyllotoxin(DT-Ⅰ),podophyllotoxin(DT-Ⅱ), isopicropodo- phyllone(DT-Ⅲ),dehydropodophyllotoxin(DT-Ⅳ),β-peltatin(DT-Ⅴ),diphyllin(DT-Ⅵ), picropodophyllin(DT-Ⅶ),podophyllotoxone(DT-Ⅷ),4’-demethypodophyllotoxin(DT-Ⅸ), kaempferol. Podophyllotoxin yields 1 5%.
