The current study was designed to investigate the mechanisms by which ropivacaine may act within the central nervous system (CNS) to produce cardiotoxicity.Eighty New Zealand rabbits were divided into four groups rand...The current study was designed to investigate the mechanisms by which ropivacaine may act within the central nervous system (CNS) to produce cardiotoxicity.Eighty New Zealand rabbits were divided into four groups randomly.In Group 1,20 rabbits received intracerebroventricular (icv) saline,and then received icv ropivacaine 30 min later.In Group 2,20 rabbits received icv ropivacaine.Whenever dysrhythmias continued for more than 5 min,0.1 ml saline was administered into the left cerebral ventricle.Ten minutes later,0.1 ml midazolam was given into the left lateral ventricle.In Group 3,20 rabbits received icv ropivacaine,and once the dysrhythmias developed,the inspired isoflurane concentration was increased from 0.75% to 1.50%.In Group 4,20 animals received an intravenous (iv) phenylephrine infusion until dysrhythmias occurred.In Group 1,the rabbits did not develop dysrhythmias in response to icv saline,whereas dysrhythmias did develop in these animals after icv ropivacaine.In Group 2,icv saline had no effect on the dysrhythmias;however,icv midazolam terminated cardiac dysrhythmias.In Group 3,an increase in the concentration of the inspired isoflurane had no effect on dysrhythmias.In Group 4,icv midazolam had no effect on dysrhythmias in response to iv phenylephrine.Ropivacaine administered directly into the CNS is capable of producing cardiac dysrhythmias;midazolam terminated dysrhythmias presumably by potentiation of γ-aminobutyric acid (GABA) receptor activity.Our results suggest that ropivacaine produces some of its cardiotoxicity not only by the direct cardiotoxicity of the drug,but also by the CNS effects of ropivacaine.展开更多
In present work,EEG and BP were used as the indexes to observe the relationbetween the change of EEG and the change of BP in the endotoxic shocked rats。At maintainingshock for 1 hr,dysrhythmia of EEG appeared in 38/4...In present work,EEG and BP were used as the indexes to observe the relationbetween the change of EEG and the change of BP in the endotoxic shocked rats。At maintainingshock for 1 hr,dysrhythmia of EEG appeared in 38/46 cases.Simultaneously,there was a markeddrop in Bp,P【0.05.Following the shocked time prolonged,dysrhythmia was getting severe。AfterEA”Rengzhong"(n=14)or“Zusanli”(n=12),BP was significantly increased(P【0.05),anddysrhythmia of EEG showed clear improvement in most of the rats。There was a close relation be-tween the changes of EEG and BP,the change of EEG had a direct bearing on the change of BP.展开更多
Due to recent population emigration movements,an epidemic of Chagas disease is currently menacing most developed countries.The authors report the case of a 53-year-old Brazilian woman living in Europe for the last 10 ...Due to recent population emigration movements,an epidemic of Chagas disease is currently menacing most developed countries.The authors report the case of a 53-year-old Brazilian woman living in Europe for the last 10 years who developed heart failure symptoms,having a previous symptomatic sinus node disease with a pacemaker implant at age of 40 years.The diagnosis was based on serology and myocardial biopsy and the patient was treated with nifurtimox.The authors emphasize the need of a high level of suspicion in patients with suggestive epidemiology and the needof populational screening of specific high risk groups.New treatment options are also discussed.展开更多
基金Project (No. 2006K13-G7-4) supported by the Key Sci-Tech Research Project of Shaanxi Province,China
文摘The current study was designed to investigate the mechanisms by which ropivacaine may act within the central nervous system (CNS) to produce cardiotoxicity.Eighty New Zealand rabbits were divided into four groups randomly.In Group 1,20 rabbits received intracerebroventricular (icv) saline,and then received icv ropivacaine 30 min later.In Group 2,20 rabbits received icv ropivacaine.Whenever dysrhythmias continued for more than 5 min,0.1 ml saline was administered into the left cerebral ventricle.Ten minutes later,0.1 ml midazolam was given into the left lateral ventricle.In Group 3,20 rabbits received icv ropivacaine,and once the dysrhythmias developed,the inspired isoflurane concentration was increased from 0.75% to 1.50%.In Group 4,20 animals received an intravenous (iv) phenylephrine infusion until dysrhythmias occurred.In Group 1,the rabbits did not develop dysrhythmias in response to icv saline,whereas dysrhythmias did develop in these animals after icv ropivacaine.In Group 2,icv saline had no effect on the dysrhythmias;however,icv midazolam terminated cardiac dysrhythmias.In Group 3,an increase in the concentration of the inspired isoflurane had no effect on dysrhythmias.In Group 4,icv midazolam had no effect on dysrhythmias in response to iv phenylephrine.Ropivacaine administered directly into the CNS is capable of producing cardiac dysrhythmias;midazolam terminated dysrhythmias presumably by potentiation of γ-aminobutyric acid (GABA) receptor activity.Our results suggest that ropivacaine produces some of its cardiotoxicity not only by the direct cardiotoxicity of the drug,but also by the CNS effects of ropivacaine.
基金The Project Supported by National Natural Science Foundation of China
文摘In present work,EEG and BP were used as the indexes to observe the relationbetween the change of EEG and the change of BP in the endotoxic shocked rats。At maintainingshock for 1 hr,dysrhythmia of EEG appeared in 38/46 cases.Simultaneously,there was a markeddrop in Bp,P【0.05.Following the shocked time prolonged,dysrhythmia was getting severe。AfterEA”Rengzhong"(n=14)or“Zusanli”(n=12),BP was significantly increased(P【0.05),anddysrhythmia of EEG showed clear improvement in most of the rats。There was a close relation be-tween the changes of EEG and BP,the change of EEG had a direct bearing on the change of BP.
文摘Due to recent population emigration movements,an epidemic of Chagas disease is currently menacing most developed countries.The authors report the case of a 53-year-old Brazilian woman living in Europe for the last 10 years who developed heart failure symptoms,having a previous symptomatic sinus node disease with a pacemaker implant at age of 40 years.The diagnosis was based on serology and myocardial biopsy and the patient was treated with nifurtimox.The authors emphasize the need of a high level of suspicion in patients with suggestive epidemiology and the needof populational screening of specific high risk groups.New treatment options are also discussed.
