After the spread of COVID-19,e-learning systems have become crucial tools in educational systems worldwide,spanning all levels of education.This widespread use of e-learning platforms has resulted in the accumulation ...After the spread of COVID-19,e-learning systems have become crucial tools in educational systems worldwide,spanning all levels of education.This widespread use of e-learning platforms has resulted in the accumulation of vast amounts of valuable data,making it an attractive resource for predicting student performance.In this study,we aimed to predict student performance based on the analysis of data collected from the OULAD and Deeds datasets.The stacking method was employed for modeling in this research.The proposed model utilized weak learners,including nearest neighbor,decision tree,random forest,enhanced gradient,simple Bayes,and logistic regression algorithms.After a trial-and-error process,the logistic regression algorithm was selected as the final learner for the proposed model.The results of experiments with the above algorithms are reported separately for the pass and fail classes.The findings indicate that the accuracy of the proposed model on the OULAD dataset reached 98%.Overall,the proposed method improved accuracy by 4%on the OULAD dataset.展开更多
E-learning behavior data indicates several students’activities on the e-learning platform such as the number of accesses to a set of resources and number of participants in lectures.This article proposes a new analyt...E-learning behavior data indicates several students’activities on the e-learning platform such as the number of accesses to a set of resources and number of participants in lectures.This article proposes a new analytics systemto support academic evaluation for students via e-learning activities to overcome the challenges faced by traditional learning environments.The proposed e-learning analytics system includes a new deep forest model.It consists of multistage cascade random forests with minimal hyperparameters compared to traditional deep neural networks.The developed forest model can analyze each student’s activities during the use of an e-learning platform to give accurate expectations of the student’s performance before ending the semester and/or the final exam.Experiments have been conducted on the Open University Learning Analytics Dataset(OULAD)of 32,593 students.Our proposed deep model showed a competitive accuracy score of 98.0%compared to artificial intelligence-based models,such as ConvolutionalNeuralNetwork(CNN)and Long Short-TermMemory(LSTM)in previous studies.That allows academic advisors to support expected failed students significantly and improve their academic level at the right time.Consequently,the proposed analytics system can enhance the quality of educational services for students in an innovative e-learning framework.展开更多
Cells undergo metabolic reprogramming to adapt to changes in nutrient availability, cellular activity, and transitions in cell states. The balance between glycolysis and mitochondrial respiration is crucial for energy...Cells undergo metabolic reprogramming to adapt to changes in nutrient availability, cellular activity, and transitions in cell states. The balance between glycolysis and mitochondrial respiration is crucial for energy production, and metabolic reprogramming stipulates a shift in such balance to optimize both bioenergetic efficiency and anabolic requirements. Failure in switching bioenergetic dependence can lead to maladaptation and pathogenesis. While cellular degradation is known to recycle precursor molecules for anabolism, its potential role in regulating energy production remains less explored. The bioenergetic switch between glycolysis and mitochondrial respiration involves transcription factors and organelle homeostasis, which are both regulated by the cellular degradation pathways. A growing body of studies has demonstrated that both stem cells and differentiated cells exhibit bioenergetic switch upon perturbations of autophagic activity or endolysosomal processes. Here, we highlighted the current understanding of the interplay between degradation processes, specifically autophagy and endolysosomes, transcription factors, endolysosomal signaling, and mitochondrial homeostasis in shaping cellular bioenergetics. This review aims to summarize the relationship between degradation processes and bioenergetics, providing a foundation for future research to unveil deeper mechanistic insights into bioenergetic regulation.展开更多
Production optimization is of significance for carbonate reservoirs,directly affecting the sustainability and profitability of reservoir development.Traditional physics-based numerical simulations suffer from insuffic...Production optimization is of significance for carbonate reservoirs,directly affecting the sustainability and profitability of reservoir development.Traditional physics-based numerical simulations suffer from insufficient calculation accuracy and excessive time consumption when performing production optimization.We establish an ensemble proxy-model-assisted optimization framework combining the Bayesian random forest(BRF)with the particle swarm optimization algorithm(PSO).The BRF method is implemented to construct a proxy model of the injectioneproduction system that can accurately predict the dynamic parameters of producers based on injection data and production measures.With the help of proxy model,PSO is applied to search the optimal injection pattern integrating Pareto front analysis.After experimental testing,the proxy model not only boasts higher prediction accuracy compared to deep learning,but it also requires 8 times less time for training.In addition,the injection mode adjusted by the PSO algorithm can effectively reduce the gaseoil ratio and increase the oil production by more than 10% for carbonate reservoirs.The proposed proxy-model-assisted optimization protocol brings new perspectives on the multi-objective optimization problems in the petroleum industry,which can provide more options for the project decision-makers to balance the oil production and the gaseoil ratio considering physical and operational constraints.展开更多
文摘After the spread of COVID-19,e-learning systems have become crucial tools in educational systems worldwide,spanning all levels of education.This widespread use of e-learning platforms has resulted in the accumulation of vast amounts of valuable data,making it an attractive resource for predicting student performance.In this study,we aimed to predict student performance based on the analysis of data collected from the OULAD and Deeds datasets.The stacking method was employed for modeling in this research.The proposed model utilized weak learners,including nearest neighbor,decision tree,random forest,enhanced gradient,simple Bayes,and logistic regression algorithms.After a trial-and-error process,the logistic regression algorithm was selected as the final learner for the proposed model.The results of experiments with the above algorithms are reported separately for the pass and fail classes.The findings indicate that the accuracy of the proposed model on the OULAD dataset reached 98%.Overall,the proposed method improved accuracy by 4%on the OULAD dataset.
基金The authors thank to the deanship of scientific research at Shaqra University for funding this research work through the Project Number(SU-ANN-2023017).
文摘E-learning behavior data indicates several students’activities on the e-learning platform such as the number of accesses to a set of resources and number of participants in lectures.This article proposes a new analytics systemto support academic evaluation for students via e-learning activities to overcome the challenges faced by traditional learning environments.The proposed e-learning analytics system includes a new deep forest model.It consists of multistage cascade random forests with minimal hyperparameters compared to traditional deep neural networks.The developed forest model can analyze each student’s activities during the use of an e-learning platform to give accurate expectations of the student’s performance before ending the semester and/or the final exam.Experiments have been conducted on the Open University Learning Analytics Dataset(OULAD)of 32,593 students.Our proposed deep model showed a competitive accuracy score of 98.0%compared to artificial intelligence-based models,such as ConvolutionalNeuralNetwork(CNN)and Long Short-TermMemory(LSTM)in previous studies.That allows academic advisors to support expected failed students significantly and improve their academic level at the right time.Consequently,the proposed analytics system can enhance the quality of educational services for students in an innovative e-learning framework.
文摘Cells undergo metabolic reprogramming to adapt to changes in nutrient availability, cellular activity, and transitions in cell states. The balance between glycolysis and mitochondrial respiration is crucial for energy production, and metabolic reprogramming stipulates a shift in such balance to optimize both bioenergetic efficiency and anabolic requirements. Failure in switching bioenergetic dependence can lead to maladaptation and pathogenesis. While cellular degradation is known to recycle precursor molecules for anabolism, its potential role in regulating energy production remains less explored. The bioenergetic switch between glycolysis and mitochondrial respiration involves transcription factors and organelle homeostasis, which are both regulated by the cellular degradation pathways. A growing body of studies has demonstrated that both stem cells and differentiated cells exhibit bioenergetic switch upon perturbations of autophagic activity or endolysosomal processes. Here, we highlighted the current understanding of the interplay between degradation processes, specifically autophagy and endolysosomes, transcription factors, endolysosomal signaling, and mitochondrial homeostasis in shaping cellular bioenergetics. This review aims to summarize the relationship between degradation processes and bioenergetics, providing a foundation for future research to unveil deeper mechanistic insights into bioenergetic regulation.
基金the financial support of this work from the National Natural Science Foundation of China(Grant No.11972073,Grant No.51974357,and Grant No.52274027)supported by China Postdoctoral Science Foundation(Grant No.2022M713204)Scientific Research and Technology Development Project of China National Petroleum Corporation(Grant No.2121DJ2301).
文摘Production optimization is of significance for carbonate reservoirs,directly affecting the sustainability and profitability of reservoir development.Traditional physics-based numerical simulations suffer from insufficient calculation accuracy and excessive time consumption when performing production optimization.We establish an ensemble proxy-model-assisted optimization framework combining the Bayesian random forest(BRF)with the particle swarm optimization algorithm(PSO).The BRF method is implemented to construct a proxy model of the injectioneproduction system that can accurately predict the dynamic parameters of producers based on injection data and production measures.With the help of proxy model,PSO is applied to search the optimal injection pattern integrating Pareto front analysis.After experimental testing,the proxy model not only boasts higher prediction accuracy compared to deep learning,but it also requires 8 times less time for training.In addition,the injection mode adjusted by the PSO algorithm can effectively reduce the gaseoil ratio and increase the oil production by more than 10% for carbonate reservoirs.The proposed proxy-model-assisted optimization protocol brings new perspectives on the multi-objective optimization problems in the petroleum industry,which can provide more options for the project decision-makers to balance the oil production and the gaseoil ratio considering physical and operational constraints.
