孕妇血清E-selection、LRRFIP、Hcy水平与妊娠期高血压的相关性研究

目的探讨孕妇血清E-选择素(E-selection)、富亮氨酸重复序列相互作用蛋白(leucine-rich repeat containing protein,LRRFIP)、同型半胱氨酸(homocysteine,Hcy)水平与妊娠期高血压的相关性。方法选取漳州市妇幼保健院门诊2019年6月—2020年10月收治的80例妊娠期高血压孕妇为观察组,同期80名正常妊娠孕妇为对照组,根据妊娠结局将妊娠期高血压患者分为不良妊娠(26例)和良好妊娠(54例)两个亚组。比较两组临床资料、入院时血清E-selection、LRRFIP、Hcy水平,比较不同妊娠结局患者入院时血清E-selection、LRRFIP、Hcy水平,分析入院时血清E-selection、LRRFIP、Hcy水平与临床资料、妊娠期高血压发生及不良妊娠结局的相关性,受试者工作特征曲线(receiver operating characteristic,ROC)分析入院时血清E-selection、LRRFIP、Hcy水平联合检测对妊娠期高血压患者不良妊娠结局的预测价值。结果观察组收缩压(systolic blood pressure,SBP)、舒张压(diastolic blood pressure,DBP)高于对照组(P<0.05);入院时,观察组血清E-selection、LRRFIP、Hcy水平高于对照组(P<0.05);入院时,不良妊娠结局患者血清E-selection、LRRFIP、Hcy水平高于良好妊娠结局患者(P<0.05);入院时,血清E-selection、LRRFIP、Hcy水平与SBP、DBP、妊娠期高血压、不良妊娠结局呈正相关(P<0.05);入院时血清E-selection、LRRFIP、Hcy水平联合预测妊娠期高血压患者发生不良妊娠结局的AUC为0.786,最佳敏感度、特异度分别为92.31%、64.81%。结论妊娠期高血压患者血清E-selection、LRRFIP、Hcy水平呈异常表达,并与妊娠结局具有密切联系。

Copper-Catalyzed Hydrosulfonylation of Alkynes Employing Sulfonohydrazides toward the Synthesis of Vinyl Sulfones

The hydrosulfonylation of terminal alkynes employing sulfonohydrazides has been accomplished with cop- per-catalysis in the presence of BPO （benzoic peroxyanhydride）. Generally, excellent yield of the vinyl sulfone products has been acquired by heating the reaction at 70℃ in DMSO.