This study concentrates of the new generation of the agile （AEOS）. AEOS is a key study object on management problems earth observation satellite in many countries because of its many advantages over non-agile satell...This study concentrates of the new generation of the agile （AEOS）. AEOS is a key study object on management problems earth observation satellite in many countries because of its many advantages over non-agile satellites. Hence, the mission planning and scheduling of AEOS is a popular research problem. This research investigates AEOS characteristics and establishes a mission planning model based on the working principle and constraints of AEOS as per analysis. To solve the scheduling issue of AEOS, several improved algorithms are developed. Simulation results suggest that these algorithms are effective.展开更多
Preservation of low-frequency residual hearing is very important for combined electro-acoustic stimulation after cochlear implantation.However,in clinical practice,loss of low-frequency residual hearing often occurs a...Preservation of low-frequency residual hearing is very important for combined electro-acoustic stimulation after cochlear implantation.However,in clinical practice,loss of low-frequency residual hearing often occurs after cochlear implantation and its mechanisms remain unclear.Factors affecting lowfrequency residual hearing after cochlear implantation are one of the hot spots in current research.Inflammation induced by injury associated with cochlear implantation is deemed to be significant,as it may give rise to low-frequency residual hearing loss by interfering with the blood labyrinth barrier and neural synapses.Pathological changes along the pathway for low-frequency auditory signals transmission may include latent factors such as damage to neuroepithelial structures,synapses,stria vascularis and other ultrastructures.In this review,current research on mechanisms of low-frequency residual hearing loss after cochlear implantation and possible roles of inflammatory responses are summarized.展开更多
Cancer is a leading cause of death worldwide. Cancer treatments by chemotherapeutic agents, surgery, and radiation have not been highly effective in reducing the incidence of cancers and increasing the survival rate o...Cancer is a leading cause of death worldwide. Cancer treatments by chemotherapeutic agents, surgery, and radiation have not been highly effective in reducing the incidence of cancers and increasing the survival rate of cancer patients. In recent years, plant-derived compounds have attracted considerable attention as alternative cancer remedies for enhancing cancer prevention and treatment because of their low toxicities, low costs, and low side effects. Ellagic acid(EA) is a natural phenolic constituent. Recent in vitro and in vivo experiments have revealed that EA elicits anticarcinogenic effects by inhibiting tumor cell proliferation, inducing apoptosis, breaking DNA binding to carcinogens, blocking virus infection, and disturbing inflammation, angiogenesis, and drug-resistance processes required for tumor growth and metastasis. This review enumerates the anticarcinogenic actions and mechanisms of EA. It also discusses future directions on the applications of EA.展开更多
Nonlinear equations systems(NESs)are widely used in real-world problems and they are difficult to solve due to their nonlinearity and multiple roots.Evolutionary algorithms(EAs)are one of the methods for solving NESs,...Nonlinear equations systems(NESs)are widely used in real-world problems and they are difficult to solve due to their nonlinearity and multiple roots.Evolutionary algorithms(EAs)are one of the methods for solving NESs,given their global search capabilities and ability to locate multiple roots of a NES simultaneously within one run.Currently,the majority of research on using EAs to solve NESs focuses on transformation techniques and improving the performance of the used EAs.By contrast,problem domain knowledge of NESs is investigated in this study,where we propose the incorporation of a variable reduction strategy(VRS)into EAs to solve NESs.The VRS makes full use of the systems of expressing a NES and uses some variables(i.e.,core variable)to represent other variables(i.e.,reduced variables)through variable relationships that exist in the equation systems.It enables the reduction of partial variables and equations and shrinks the decision space,thereby reducing the complexity of the problem and improving the search efficiency of the EAs.To test the effectiveness of VRS in dealing with NESs,this paper mainly integrates the VRS into two existing state-of-the-art EA methods(i.e.,MONES and DR-JADE)according to the integration framework of the VRS and EA,respectively.Experimental results show that,with the assistance of the VRS,the EA methods can produce better results than the original methods and other compared methods.Furthermore,extensive experiments regarding the influence of different reduction schemes and EAs substantiate that a better EA for solving a NES with more reduced variables tends to provide better performance.展开更多
Elaidic acid(EA)stimulation can lead to endoplasmic reticulum stress(ERS),accompanied by a large release of Ca^(2+),and ultimately the activation of NLRP3 inflammasome in Kupffer cells(KCs).Mitochondrial instability o...Elaidic acid(EA)stimulation can lead to endoplasmic reticulum stress(ERS),accompanied by a large release of Ca^(2+),and ultimately the activation of NLRP3 inflammasome in Kupffer cells(KCs).Mitochondrial instability or dysfunction may be the key stimulating factors to activate NLRP3 inflammasome,and sustained Ca^(2+)transfer can result in mitochondrial dysfunction.We focused on KCs to explore the damage to mitochondria by EA.After EA stimulation,cells produced an oxidative stress(OS)response with a significant increase in ROS release.Immunoprecipitation experiments and the addition of inhibitors revealed that the increase in the level of intracellular Ca^(2+)led to Ca^(2+)accumulation in the mitochondrial matrix via mitochondria-associated membranes(MAMs).This was accompanied by a significant release of m ROS,loss of MMP and ATP,and a significant increase in mitochondrial permeability transition pore opening,ultimately leading to mitochondrial instability.These findings confirmed the mechanism that EA induced mitochondrial Ca^(2+)imbalance in KCs via MAM,ultimately leading to mitochondrial dysfunction.Meanwhile,EA induced OS and the decrease of MMP and ATP in rat liver,and significant lesions were found in liver mitochondria.Swelling of the inner mitochondrial cristae and mitochondrial vacuolization occurred,with a marked increase in lipid droplets.展开更多
基金supported by the National Natural Science Foundation of China(7127106671171065+1 种基金71202168)the Natural Science Foundation of Heilongjiang Province(GC13D506)
文摘This study concentrates of the new generation of the agile （AEOS）. AEOS is a key study object on management problems earth observation satellite in many countries because of its many advantages over non-agile satellites. Hence, the mission planning and scheduling of AEOS is a popular research problem. This research investigates AEOS characteristics and establishes a mission planning model based on the working principle and constraints of AEOS as per analysis. To solve the scheduling issue of AEOS, several improved algorithms are developed. Simulation results suggest that these algorithms are effective.
文摘Preservation of low-frequency residual hearing is very important for combined electro-acoustic stimulation after cochlear implantation.However,in clinical practice,loss of low-frequency residual hearing often occurs after cochlear implantation and its mechanisms remain unclear.Factors affecting lowfrequency residual hearing after cochlear implantation are one of the hot spots in current research.Inflammation induced by injury associated with cochlear implantation is deemed to be significant,as it may give rise to low-frequency residual hearing loss by interfering with the blood labyrinth barrier and neural synapses.Pathological changes along the pathway for low-frequency auditory signals transmission may include latent factors such as damage to neuroepithelial structures,synapses,stria vascularis and other ultrastructures.In this review,current research on mechanisms of low-frequency residual hearing loss after cochlear implantation and possible roles of inflammatory responses are summarized.
基金supported in part by grants from The National Science and Technology Foundation for Rural Development in China during the "12th Five-Year-Plan" (Grant No. 2011BAD33B02)The National Natural Science Foundation of China (Grant No. 81300323)
文摘Cancer is a leading cause of death worldwide. Cancer treatments by chemotherapeutic agents, surgery, and radiation have not been highly effective in reducing the incidence of cancers and increasing the survival rate of cancer patients. In recent years, plant-derived compounds have attracted considerable attention as alternative cancer remedies for enhancing cancer prevention and treatment because of their low toxicities, low costs, and low side effects. Ellagic acid(EA) is a natural phenolic constituent. Recent in vitro and in vivo experiments have revealed that EA elicits anticarcinogenic effects by inhibiting tumor cell proliferation, inducing apoptosis, breaking DNA binding to carcinogens, blocking virus infection, and disturbing inflammation, angiogenesis, and drug-resistance processes required for tumor growth and metastasis. This review enumerates the anticarcinogenic actions and mechanisms of EA. It also discusses future directions on the applications of EA.
基金This work was supported by the National Natural Science Foundation of China(62073341)in part by the Natural Science Fund for Distinguished Young Scholars of Hunan Province(2019JJ20026).
文摘Nonlinear equations systems(NESs)are widely used in real-world problems and they are difficult to solve due to their nonlinearity and multiple roots.Evolutionary algorithms(EAs)are one of the methods for solving NESs,given their global search capabilities and ability to locate multiple roots of a NES simultaneously within one run.Currently,the majority of research on using EAs to solve NESs focuses on transformation techniques and improving the performance of the used EAs.By contrast,problem domain knowledge of NESs is investigated in this study,where we propose the incorporation of a variable reduction strategy(VRS)into EAs to solve NESs.The VRS makes full use of the systems of expressing a NES and uses some variables(i.e.,core variable)to represent other variables(i.e.,reduced variables)through variable relationships that exist in the equation systems.It enables the reduction of partial variables and equations and shrinks the decision space,thereby reducing the complexity of the problem and improving the search efficiency of the EAs.To test the effectiveness of VRS in dealing with NESs,this paper mainly integrates the VRS into two existing state-of-the-art EA methods(i.e.,MONES and DR-JADE)according to the integration framework of the VRS and EA,respectively.Experimental results show that,with the assistance of the VRS,the EA methods can produce better results than the original methods and other compared methods.Furthermore,extensive experiments regarding the influence of different reduction schemes and EAs substantiate that a better EA for solving a NES with more reduced variables tends to provide better performance.
基金supported by fund from the National Natural Science Foundation of China(32172322)。
文摘Elaidic acid(EA)stimulation can lead to endoplasmic reticulum stress(ERS),accompanied by a large release of Ca^(2+),and ultimately the activation of NLRP3 inflammasome in Kupffer cells(KCs).Mitochondrial instability or dysfunction may be the key stimulating factors to activate NLRP3 inflammasome,and sustained Ca^(2+)transfer can result in mitochondrial dysfunction.We focused on KCs to explore the damage to mitochondria by EA.After EA stimulation,cells produced an oxidative stress(OS)response with a significant increase in ROS release.Immunoprecipitation experiments and the addition of inhibitors revealed that the increase in the level of intracellular Ca^(2+)led to Ca^(2+)accumulation in the mitochondrial matrix via mitochondria-associated membranes(MAMs).This was accompanied by a significant release of m ROS,loss of MMP and ATP,and a significant increase in mitochondrial permeability transition pore opening,ultimately leading to mitochondrial instability.These findings confirmed the mechanism that EA induced mitochondrial Ca^(2+)imbalance in KCs via MAM,ultimately leading to mitochondrial dysfunction.Meanwhile,EA induced OS and the decrease of MMP and ATP in rat liver,and significant lesions were found in liver mitochondria.Swelling of the inner mitochondrial cristae and mitochondrial vacuolization occurred,with a marked increase in lipid droplets.
