EARS计划在结直肠癌外科患者中的应用效果分析

目的对结直肠癌外科患者治疗过程中,快速康复(enhanced recovery after surgery,ERAS)计划的应用价值进行分析。方法选择2020年7月1日—2022年3月1日常德市第一人民医院普通外科结直肠癌患者150例,按随机数字表法分为研究组与对照组,每组各75例,分别对患者进行传统开腹手术+EARS计划与传统开腹手术治疗,分析两组并发症、炎症因子水平、首次下床活动时间、进食时间、术后住院天数、排气时间、排便时间、满意度。结果研究组术后住院天数、排便、首次下床活动、进食、排气时间等指标均短于对照组,差异有统计学意义(P<0.05)。治疗有效率比较,研究组高于对照组,差异有统计学意义(P<0.05)。对照组并发症发生率高于研究组,差异有统计学意义(P<0.05)。研究组炎症因子水平均低于对照组,差异有统计学意义(P<0.05)。结论EARS计划推广价值较高,可以抑制炎症因子水平,提升治疗效果,预后效果显著。

Hyaluronic acid injection in the auricular base for the aesthetic correction of lying ears:A retrospective study

Background Ears play an important role in facial profiles.Lying ears are not perceived favorably in Asian cultures;therefore,surgical procedures are implemented to adjust this defect.However,surgery has complications and requires recovery time.We introduced a hyaluronic acid(HA)injection technique to aesthetically improve ear prominence.Methods This retrospective study examined 25 Chinese patients aged 20-47 years with congenital lying ears who received HA injections in the auricular base at Shanghai Ninth People’s Hospital and Hangzhou Yijie Medical Cosmetology Clinic between November 2019 and December 2022.The average injection volume was 6.32​±​1.22 mL in the auricular base unilaterally,and the follow-up time ranged from 6 to 24 months.Morphological measurement data were recorded.Two-dimensional(2D)and three-dimensional(3D)images were obtained to evaluate the effects.Results All patients showed improvements in ear prominence.The cranioauricular angle(CAA)increased from 22.24°​±​4.53°to 65.90°​±​5.38°immediately post-injection and was maintained at 49.18°​±​4.74°6 months later.The ear projection(EP)increased from 14.75​±​2.72 mm to 26.26​±​2.94 mm immediately post-injection and was 22.51​±​2.68 mm after 6 months.No serious complications were noted.Conclusion HA injection in the auricular base effectively corrected the lying ears and aesthetically optimized the facial profile.It also had a face-lift effect that made the face look younger and more compact.The injection procedure was minimally invasive and required no recovery period.The effect was maintained for a long time and was satisfactory.

基于EARS理念下联合延续性护理干预对泌尿外科微创术后患者下肢深静脉血栓形成的应用价值分析

探讨基于加速康复外科(EARS)理念下的联合延续性护理干预对泌尿外科微创术后患者住院期间及出院后下肢深静脉血栓形成的应用价值。方法 选取2021年8月至2022年8月于济南市第八人民医院泌尿外科病区就治的泌尿外科微创术后患者100例,根据随机数字表法将其分为对照组和观察组两组。比较两组患者临床情况。结果 干预一个月后,观察组FBG、PLT、D-二聚体低于对照组,差异具有统计学意义(P值均<0.05)。干预一个月后观察组的疼痛程度评分低于对照组,日常生活活动能力评分高于对照组,差异有统计学意义(P值均<0.05)。干预一个月后,两组生理舒适度评分、心理精神舒适度评分、GCQ总分均高于干预前(P值均<0.05),且观察组显著高于对照组(P值均<0.05)干预一个月后,观察组患者的霍曼斯征阳性、下肢深静脉血栓发生率显著低于对照组,差异有统计学意义(P值均<0.05)。结论 基于EARS理念下的联合延续性护理干预有助于维持患者的凝血稳定性,缓解患者疼痛。此外,该干预能够有效降低医院相关性血栓形成的风险,并提高患者的舒适度和日常生活活动能力。

EARS2基因突变致丘脑脑干受累性脑白质病伴高乳酸血症1例并文献复习

目的探讨EARS2基因突变致丘脑脑干受累性脑白质病伴高乳酸血症(LTBL)的临床特征、实验室检查特点及基因型,提高对该病的认识和管理水平。方法总结和分析1例以肝功能衰竭为首发表现的LTBL病例的临床特点、实验室检查、基因检测结果及随访,并行文献复习。结果男,45 d,因"皮肤黄染43 d"就诊。患儿生后2 d发现皮肤、巩膜黄染,42 d后发现肝功能衰竭(严重胆汁淤积、低血糖、凝血功能异常)、四肢肌张力减低,高乳酸性酸中毒;颅脑MR提示多发脑损伤;外显子捕获与高通量测序检测线粒体基因未见异常,检测核基因发现16号染色体上EARS2基因存在2个致病性复合杂合突变[c.1355T>G(p.L452R),c.813C>A(p.F271L)],确诊为LTBL。随访中黄疸逐渐消退,15月龄时肝功能检查恢复正常,血乳酸水平降至正常;精神运动发育明显落后,颅脑MR提示严重脑积水,予以行脑室-腹腔引流术,术后半年脑积水好转,精神运动发育较前改善。结论肝功能衰竭可以是EARS2基因突变所致的LTBL早期主要发现之一,随着年龄增长,肝功能可逐渐好转,精神运动发育落后及脑积水逐渐成为本病较为显著的临床特点,LTBL表型和基因型的关系还需要进一步研究。

EARS2基因变异致新生儿丘脑脑干受累性脑白质病伴高乳酸血症1例报告并文献复习

目的探讨丘脑脑干受累性脑白质病伴高乳酸血症的临床表型及基因型。方法回顾分析1例新生儿丘脑脑干受累性脑白质病伴高乳酸血症患儿的临床资料并复习相关文献。结果女性患儿,出生26小时,临床表现为反应差、抽搐及顽固性高乳酸血症。患儿于妊娠期时头颅MRI示胼胝体缺如。全外显子测序发现患儿EARS 2核基因第7号外显子c.1294C>T杂合无义变异和第5号外显子c.971G>T杂合错义变异,分别来自父亲和母亲;线粒体基因二代测序未发现患儿线粒体基因变异,但MLPA检测发现患儿及其母亲线粒体基因MTND 1-1*异质性缺失变异。结论发现导致丘脑脑干受累性脑白质病伴高乳酸血症新的EARS 2核基因外显子c.1294C>T无义变异和c.971G>T错义变异。

Clinical Comparison and Analysis of Decoction of Traditional Chinese Medicine Combined with Ear Acupoint Application and Simple Artificial Tears in the Treatment of Dry Eye Syndrome

OBJECTIVE: To study the clinical comparison and analysis of decoction of Traditional Chinese Medicine(TCM) combined with ear acupoint application and simple artificial tears in the treatment of dry eye syndrome. METHODS:A total of 62 patients(124 eyes) with dry eye syndrome treated in the Department of Ophthalmology of The 4th People's Hospital of Shenyang from July 2017 to March 2018 were selected and equally divided into 2 groups according to the admission order. The observation group received the combination therapy of TCM decoction and ear acupoint application, while the control group was given the simple artificial tears. The symptom score after 2 weeks, 4 weeks, and 8 weeks as well as the indicators including break-up time(BUT), Schirmer I test(SIT) and fluorescein(FL) were recorded and compared between groups. RESULTS: The symptom scores had no difference before treatment(P > 0.05), and were better in the observation group than those in the control group after treatment(P < 0.05). At 2 weeks, 4 weeks, and 8 weeks after the treatment, the amelioration level of BUT, SIT, and FL indicators in the observation group was better than that of the control group(P < 0.05). CONCLUSION: Compared with the artificial tears treatment method, the TCM decoction combined with ear acupoint application can significantly ameliorate the tear film stability, tear secretion, and reduce ocular surface damage for dry eye patients.

Contribution of ear photosynthesis to grain yield under rainfed and irrigation conditions for winter wheat cultivars released in the past 30 years in North China Plain

To understand the contribution of ear photosynthesis to grain yield and its response to water supply in the improvement of winter wheat, 15 cultivars released from 1980 to 2012 in North China Plain（NCP） were planted under rainfed and irrigated conditions from 2011 to 2013, and the ear photosynthesis was tested by ear shading. During the past 30 years, grain yield significantly increased, the flag leaf area slightly increased under irrigated condition but decreased significantly under rainfed condition, the ratio of grain weight：leaf area significantly increased, and the contribution of ear photosynthesis to grain yield changed from 33.6 to 64.5% and from 32.2 to 57.2% under rainfed and irrigated conditions, respectively. Grain yield, yield components, and ratio of grain weight：leaf area were positively related with contribution of ear photosynthesis. The increase in grain yield in winter wheat was related with improvement in ear photosynthesis contribution in NCP, especially under rainfed condition.

Postaurical injection is a systemic delivery supported by symmetric distribution of Gd-DOTA in both the ipsilateral and contralateral ears

Postaurical injection of therapeutics was recently applied in clinical practice to treat inner ear diseases based on supposed existence of a direct channel from the postaurical area to the inner ear. Doubting on the associated reports and aiming to provide evidence on the inner ear uptake mechanism, the present study tracked the dynamic distribution of gadolinium-tetra-azacyclo-dodecane-tetra-acetic acid (Gd-DOTA) in rat inner ears after postaurical injection using MRI. A targeted tympanic medial wall delivery was utilized as control. The results showed that, at the early time points after postaurical injection, Gd-DOTA distributed mainly in tissues surrounding the bulla, temporal bone and skull and neck space. In the inner ear, there was gradual uptake of Gd-DOTA on both the ipsilateral and contralateral sides with equal signal intensities. There was no sign of direct channel carrying the agent from the postaurical area to the inner ear. Targeted tympanic medial wall delivery induced significantly greater uptake of Gd-DOTA in the inner ear than did postaurical injection. At 30 min post-administration, targeted tympanic medial wall delivery yielded 4.6-folds higher signal intensity than did postaurical injection. The total dose of Gd-DOTA delivered by the targeted tympanic medial wall approach was only 0.1% of that delivered by postaurical injection. In conclusion, postaurical injection is a systemic administration, which is similar to hypodermic injection, rather than a focal delivery method. By contraries, targeted tympanic medial wall delivery induces fast and abundant uptake of Gd-DOTA in the ipsilateral inner ear without significant distribution in unwanted areas.

Quantifying.Associations among Dimensions of Ears and Their Form Factors in Maize(Zea Mays)Using Dimensional Analysis

Ear morphological traits such as volume and shape are important features of maize and the quantitative associations among them can help understand kernel yield determination. 150 mature ears each of 4 maize cultivars were collected from field experiments, and ear length(L), diameter(D), area(S) and volume(V) were recorded for individual ears, kernel weight per ear also recorded for a portion of the examined ears. Following principles of dimensional analysis, 8 theoretical equations of 3 sets,which relate ear higher dimensions to its length and diameter, were developed and parameterized and validated with the field observations. The 3 optimized equations showed that the shape of ears in maize can be featured with 3 dimensionless form factors, namely diameter-to-length ratio(c=D/L), areal form factor(b=S/L/D), and volumetric form factor(a=V/L/D/D). Statistically,all of them were significantly different among cultivars, and a's values varied from 0.582 to 0.612, and b's 0.839-0.868, and c's 0.242-0.308. Volumetric form factor and areal form factor could estimate precisely ear volume and area respectively, but diameter-to-length ratio was not suitable to estimate ear diameter by its length. Ear volume explained almost all variation of ear kernel weight and product L*D*D did the same substantially. Dimensional analysis proved to be promising in understanding relationship among morphological traits of ears in maize. Its application in crop researches should improve our knowledge of the physical properties of crop plants.

Chong-Chet Anterior Scoring Technique for the Correction of Prominent Ears: Results in 30 Patients

A lot ofotoplasty techniques have been developed during the past years. However, there is no single perfect technique which is worldwide accepted. We present our assessment of a Chong-Chet anterior scoring technique for the correction of prominent ears which we applied in 30 patients between 2005 and 2010. This study is a report of creating a natural fold of cartilage using Chong-Chet anterior scoring technique by cartilage incision at the border between the antihelix and scapha, with medial scoring of the scapha and lateral scoring of the antihelix. Sutures were used to maintain the created fold. There were no major complications at the 1-year follow-up evaluation. None of the patients developed a recurrence, or retro protrusion of the helix which required a second operation for correction. The procedure is a simple surgical technique. The reconstructed ear shows reliable results in stability, size and normal convolutions. Furthermore, sharp cartilaginous ridges and hidden helix are avoided.

Genetically modified pigs:Emerging animal models for hereditary hearing loss

Hereditary hearing loss(HHL),a genetic disorder that impairs auditory function,significantly affects quality of life and incurs substantial economic losses for society.To investigate the underlying causes of HHL and evaluate therapeutic outcomes,appropriate animal models are necessary.Pigs have been extensively used as valuable large animal models in biomedical research.In this review,we highlight the advantages of pig models in terms of ear anatomy,inner ear morphology,and electrophysiological characteristics,as well as recent advancements in the development of distinct genetically modified porcine models of hearing loss.Additionally,we discuss the prospects,challenges,and recommendations regarding the use pig models in HHL research.Overall,this review provides insights and perspectives for future studies on HHL using porcine models.

Study of the Constraints of Millet Production (Pennisetum glaucum (L.) R. Br.) and the Peasant Perception of Biological Control in the Tahoua Region

Millet (Pennisetum glaucum (L.) R. Br.) is the Sahelian crop par excellence due to its adaptation to the particular production conditions in this region. Unfortunately, in recent years this crop has been threatened by very strong parasitic pressure and drought during the production period. The objective of this study is to analyze the main constraints of millet production and the solutions known to producers. A survey was carried out in November 2022 with a sample of 298 producers in five municipalities in the Tahoua region. The main constraints are drought and pressure from crop pests (locust, millet ear miner, floricultural insects) according to 57.9% of respondents. The millet ear miner is the most formidable pest according to 55% of respondents. Thus, the average yield obtained in a year of good production without the leafminer is 194 kg/ha and that obtained in a year of millet ear leafminer is around 27 kg to 43 kg/ha depending on the municipality. The yield obtained this last campaign after the attack of this leafminer varies from 64 to 77 kg/ha depending on the municipalities compared to a potential yield of over 1000 kg/ha. More than half of producers (58.1%) are unaware of the existence of biological control compared to only 12.5% who are aware of this alternative method. Work to popularize this technology is necessary in the five municipalities and the entire region in general.

基于Dlib的疲劳驾驶远程监测系统设计

阐述设计疲劳驾驶远程监测系统,利用Dlib人脸检测模型,通过计算EAR与MAR参数值来判断驾驶员是否闭眼或打哈欠,并通过HPE算法判断驾驶员头部姿态。若发现疲劳驾驶,系统会进行警告提示,并通过云端发送到监测平台进行人为干预,实现“双重保险”。经实验测试,此系统可以准确判定货车驾驶员的疲劳状态,降低事故风险。

Expression and Clinical Significance of Various Cytokines in Otitis Media

The expression and clinical significance of relevant cytokines in otitis media (OM) are discussed, and the alterations to the pathological state of the otitis media mucosa are further understood through the study of cytokine transduction pathways. More and more studies have shown that relevant cell proliferation and inflammation progression pathways play a role in the development of otitis media, such as the Jun amino-terminal protein kinase (JNK) mitogen-activated protein kinase (MAPK) signaling pathway, the NF-κB signaling pathway, and the PI3K/AKT/PTEN pathway, which are involved in the proliferation of the middle ear mucosa during otitis media, which affects the mucosal cilia, motor function, Eustachian tube function, and the mucosal ciliary function. These studies provide new ideas for the treatment of otitis media and further explore the feasibility of immunotherapy in the future treatment of otitis media. In this paper, we present a review of the latest research progress on the expression of various cytokines in otitis media.

Evaluation of the Effect and Efficiency of Ear Tip Bloodletting Combined with Xianfang Huoming Yin in the Treatment of Early-Stage Wheals

Objective:To evaluate the effect and efficiency of ear tip bloodletting combined with Xianfang Huoming Yin(XFH)in the treatment of early-stage wheals.Methods:70 patients with early-stage wheals admitted from September 2020 to September 2022 were divided into two groups by randomized numerical table method,with 35 cases/group.Both groups received conventional treatment,the control group combined with XFH,and the observation group combined with ear tip bloodletting therapy and XFH.Conscious symptom scores,ocular indexes,therapeutic effects,and sleep quality between the two groups were compared.Results:After the treatment,the patients in the observation group had lower self-awareness symptom scores and sleep quality scores as compared to those in the control group;the diameter of the mass in the observation group was smaller than that of the control group after treatment;the average tear film rupture time and the time taken for the first non-contact tear film to rupture were longer in the observation group than those in the control group;the total effective rate of the treatment in the observation group was higher than that of the control group(P<0.05).Conclusion:Ear tip bloodletting combined with XFH was ideal for the treatment of early-stage wheals and has a high effective rate.

Effects of Drilling in Mastoid Cavity over Hearing in the Contralateral Ear

In advanced otological surgeries, powered instruments form an indispensable part. The risk of deterioration to hearing in the operated ear is a commonly discussed issue, however, there remains a possibility of affecting the hearing in the contralateral ear due to transcranial vibration. So in this study we aimed to assess the possibility of the non-operated ear being affected by the noise generated during ear surgeries and whether it is temporary or permanent in nature. Methodology: This study included 63 patients diagnosed with unilateral disease who underwent mastoid surgery. Preoperatively all the patients were subjected to Pure tone audiometry (PTA), Transient evoked otoacoustic emission (TEOAE) and Distortion product otoacoustic emission (DPOAE). Patients were operated using both cutting and diamond burrs of ranging from sizes 1 - 6 mm. Total drilling time was recorded. Results: Post-operative hearing evaluation was done at 1 week, 4 weeks and 12 weeks. The sound emitted by various burrs was recorded by Sound Level Meter. Out of the total 58 patients that followed up, 46 showed change in at least one of the hearing parameters. Patients showing changes had a higher drilling time as compared to those with no changes. Of these, the changes associated with the total drilling time and with cutting burr time were found to be significant. The hearing changes seen on PTA, TEOAE and DPOAE were transient in nature with only one patient having a persistent decreased high frequency threshold at the end of 12 weeks. It was also found that cutting burrs produce more sound as compared to diamond burrs and a larger size burr of a type produces more sound than a smaller one of its type. Conclusion: The drilling of mastoid bone during ear surgeries can transiently impair the hearing in the contralateral ear which is of great significance in patients with only one hearing ear.

SONY IN EARS在你耳边轻轻唱

那些戴着耳机摇头晃脑的年轻人都有不同程度上的自闭症。在walkman诞生之初就有心理学家提出了这个说法,那时候是1982年。而现实证明,正是这些患有自闭症的家伙发明了电脑、互联网和数字音乐,从而改变了整个世界沟通的方式。扯远了,戴耳机的人确实喜欢沉浸在自己的小天地里,因为外面有太多他们不喜欢的声音,那些劣质的、沉闷的、毫无质感的高中低频。所以把耳朵堵起来是个好办法,这样音乐就可以直接钻进你的身体里,嘘……

The Eyes and Ears of War

位于波斯湾附近的“美国空军联合空战中心”的一整面墙就是一个巨大的、不断闪烁、不断变幻画面的屏幕,这面屏幕显示伊拉克上空每架美军战机的准确位置。

Direct differentiation of ears and tassels from cultured shoot apices of maize

In vitro morphogenesis of inflorescences from the cultured corn seedling shoot tips was obtained on modified Murashige and Skoog (MS) medium in complete darkness. Some shoot tip meristems excised from seedlings of inbred line 515, inbred line 8112 and their filial generations would directly give rise to florets on modified MS medium supplemented with 2.0 mg/L N6-bezyladenine (6-BA) in five or six weeks. On the medium with 1.0 mg/L 6-BA and 0. 2 mg/L 2, 4-dichlorophenoxy acetic acid (2, 4-D), the explants swelled first, and produced multiple shoot clumps, then the culture of the shoot tips from all of the six inbred lines in experiment would ultimately initiate to develop ears and tassels accompanied by multiple shoot clumps developing on the medium with 1.0 mg/L 6-BA and 0. 2 mg/Lin-dole-3-butyric acid (IBA). The developmental patterns of the corn inflorescences were similar to the controls of normal plants in the field, but the number of the ears was much more than that of the tassels in vitro. It