Viral gastric cancer,called Epstein Barr virus associated gastric cancer(EBVaGC),refers to a special subtype of gastric cancer in which the expression of Epstein Barr virus encoded small RNA(EBER)in gastric cancer cel...Viral gastric cancer,called Epstein Barr virus associated gastric cancer(EBVaGC),refers to a special subtype of gastric cancer in which the expression of Epstein Barr virus encoded small RNA(EBER)in gastric cancer cells.It accounts for about 10%of the total number of patients with gastric cancer.The pathogenesis is not yet clear.Compared with other types of gastric cancer,EBVaGC has a relatively good prognosis,which is closely related to its unique immune microenvironment.The research shows that the intense immune response and immune escape coexist in the tumor microenvironment of EBVaGC.So its research results in immunotherapy are worth looking forward to.This paper aims to review the research progress about tumor immune microenvironment and hot spot immunotherapy of EBVaGC,in order to provide theoretical support for basic research of clinical application.展开更多
文摘Viral gastric cancer,called Epstein Barr virus associated gastric cancer(EBVaGC),refers to a special subtype of gastric cancer in which the expression of Epstein Barr virus encoded small RNA(EBER)in gastric cancer cells.It accounts for about 10%of the total number of patients with gastric cancer.The pathogenesis is not yet clear.Compared with other types of gastric cancer,EBVaGC has a relatively good prognosis,which is closely related to its unique immune microenvironment.The research shows that the intense immune response and immune escape coexist in the tumor microenvironment of EBVaGC.So its research results in immunotherapy are worth looking forward to.This paper aims to review the research progress about tumor immune microenvironment and hot spot immunotherapy of EBVaGC,in order to provide theoretical support for basic research of clinical application.
