An SPECT system dedicated to small animal imaging shall be of a millimeter spatial resolution or even better.This study was aimed at achieving 0.5-mm spatial resolution for a small animal SPECT system at low cost.It w...An SPECT system dedicated to small animal imaging shall be of a millimeter spatial resolution or even better.This study was aimed at achieving 0.5-mm spatial resolution for a small animal SPECT system at low cost.It was developed from a single-head clinical SPECT scanner,with a seven-pinhole collimator and a four-degree-offreedom motion control stage.Several key techniques were developed,including high-resolution image reconstruction algorithm,high accuracy geometrical calibration method,and optimized system matrix derivation scheme.The system matrix was derived from Monte-Carlo simulation and de-noised by fitting each point spread function to a two dimensional Gaussian function.Experiments of point source and ultra micro hot rod phantom were conducted.With a spatial resolution of 0.5-0.6 mm,this system provides a practical way for low-cost high-resolution animal imaging on a clinic SPECT system.展开更多
The recalibration of electrical capacitance tomography (ECT) system is one of the key problems in keeping the system running steadily.However, for engineering application in solids/gas transport,online calibration can...The recalibration of electrical capacitance tomography (ECT) system is one of the key problems in keeping the system running steadily.However, for engineering application in solids/gas transport,online calibration can not be implemented and the data from this sensor may be unreliable due to the sensor pipe interior wall abrasion during pneumatic transport,so the solids concentration calculated from the reconstructed image based on these data will be highly inaccurate.The simulations show that, the inter-electrode relative capacitance variation of electrode pair spacing 1 is the most sensitive to the abrasion of sensor pipe interior wall, so this relative capacitance variation when the sensor is filled with air can be used as an indicator demanding offline system recalibration when the wall abrasion goes significant.Furthermore, while the pipe interior wall abrasion is not very serious, online correcting measured inter-electrode capacitance with wall capacitance variation can improve the accuracy of concentration calculation.展开更多
基金Supported by Specialized Research Fund for the Doctoral Program of Higher Education(SRFDP200800031071)National Natural Science Foundation of China (No.10975086)the National High Technology Research and Development Program of China(No.2006AA020802)
文摘An SPECT system dedicated to small animal imaging shall be of a millimeter spatial resolution or even better.This study was aimed at achieving 0.5-mm spatial resolution for a small animal SPECT system at low cost.It was developed from a single-head clinical SPECT scanner,with a seven-pinhole collimator and a four-degree-offreedom motion control stage.Several key techniques were developed,including high-resolution image reconstruction algorithm,high accuracy geometrical calibration method,and optimized system matrix derivation scheme.The system matrix was derived from Monte-Carlo simulation and de-noised by fitting each point spread function to a two dimensional Gaussian function.Experiments of point source and ultra micro hot rod phantom were conducted.With a spatial resolution of 0.5-0.6 mm,this system provides a practical way for low-cost high-resolution animal imaging on a clinic SPECT system.
文摘The recalibration of electrical capacitance tomography (ECT) system is one of the key problems in keeping the system running steadily.However, for engineering application in solids/gas transport,online calibration can not be implemented and the data from this sensor may be unreliable due to the sensor pipe interior wall abrasion during pneumatic transport,so the solids concentration calculated from the reconstructed image based on these data will be highly inaccurate.The simulations show that, the inter-electrode relative capacitance variation of electrode pair spacing 1 is the most sensitive to the abrasion of sensor pipe interior wall, so this relative capacitance variation when the sensor is filled with air can be used as an indicator demanding offline system recalibration when the wall abrasion goes significant.Furthermore, while the pipe interior wall abrasion is not very serious, online correcting measured inter-electrode capacitance with wall capacitance variation can improve the accuracy of concentration calculation.
