降压药能与抗ED药物同服吗

高血压作为一种最常见的心血管疾病,与勃起功能障碍(ED)有着密切的联系。根据美国马萨诸塞州男性老年化研究资料显示,在40~70岁男性当中有超过一半的人受到不同程度ED的困扰,年发病率为124/1000。同时据流行病学研究发现,ED在非高血压人群中发生率为16%;在高血压人群中,发病率则高达32.1%,远高于正常血压人群。那为什么高血压容易并发ED呢?原因主要有以下3点。

A dual-RPA based lateral flow strip for sensitive,on-site detection of CP4-EPSPS and Cry1Ab/Ac genes in genetically modified crops

Traditional transgenic detection methods require high test conditions and struggle to be both sensitive and efficient.In this study,a one-tube dual recombinase polymerase amplification(RPA)reaction system for CP4-EPSPS and Cry1Ab/Ac was proposed and combined with a lateral flow immunochromatographic assay,named“Dual-RPA-LFD”,to visualize the dual detection of genetically modified(GM)crops.In which,the herbicide tolerance gene CP4-EPSPS and the insect resistance gene Cry1Ab/Ac were selected as targets taking into account the current status of the most widespread application of insect resistance and herbicide tolerance traits and their stacked traits.Gradient diluted plasmids,transgenic standards,and actual samples were used as templates to conduct sensitivity,specificity,and practicality assays,respectively.The constructed method achieved the visual detection of plasmid at levels as low as 100 copies,demonstrating its high sensitivity.In addition,good applicability to transgenic samples was observed,with no cross-interference between two test lines and no influence from other genes.In conclusion,this strategy achieved the expected purpose of simultaneous detection of the two popular targets in GM crops within 20 min at 37°C in a rapid,equipmentfree field manner,providing a new alternative for rapid screening for transgenic assays in the field.

给定控制数的连通图的最大EDS极图

图G的偏心距离和(EDS)定义为ξ^(d)(G)=∑_(v∈V)ε_(G)(v)D_(G)(v),其中ε_(G)(v)是顶点v的偏心率,D_(G)(v)是顶点v到G中其它所有顶点的距离之和.通过研究图的EDS,给出了Miao等猜想的一个更简单的证明,确定了给定控制数的连通图的最大EDS极图.

EDS成分分析法在电气熔痕鉴定中的应用

EDS成分分析法是微量物证鉴定的常用方法,具有灵敏度高、操作简单快速等特点,在纤维、金属、玻璃、油漆及纸张等各类微量物证的鉴定中有着广泛的应用。在火灾痕迹物证鉴定领域,EDS成分分析法已成为重要方法之一。通过探讨三起采用EDS成分分析法对电气熔痕进行鉴定的实例,提出在火灾现场物证取样、熔痕鉴定和鉴定意见运用等方面的注意事项。

Performance evaluation of laterite soil embankment stabilized with bottom ash,coir fiber,and lime

In tropical regions,heavy rainfall induces erosion and shallow landslides on road embankments.Cement-based stabilization methods,common in these regions,contribute to climate change due to their high carbon footprint.This study explored the potential application of coir fiber-reinforced laterite soil-bottom ash mixtures as embankment materials in the tropics.The objective is to enhance engineered embankment slopes'erosion resistance and stability while offering reuse options for industrial byproducts.This study examined various mix designs for unconfined compressive strength(UCS)and permeability,utilizing 30%bottom ash(BA)and 1%coir fiber(CF)with varying sizes ranging from 10 to 40 mm,6%lime,and laterite soil(LS),followed by microstructural analyses.The results demonstrate that the compressive strength increases as the CF length increases to 25 mm.In contrast,permeability increases continuously with increasing CF length.Lime-treated mixtures exhibit superior short-and long-term strength and reduce permeability owing to the formation of cementitious materials,as confirmed by microstructural analyses.A lab-scale slope box was constructed to evaluate the surface erosion of the stabilized laterite soil embankment.Based on the rainfall simulation results,the LS-BA-CF mixtures show better resistance to erosion and deformation compared to untreated LS,especially when lime is added to the top layer.This study provides insights into a sustainable and cost-effective approach for slope stabilization using BA and CF,offering a promising solution for tropical regions susceptible to surface erosion and landslides.

Outstanding proton conductivity over wide temperature and humidity ranges and enhanced mechanical, thermal stabilities for surface-modified MIL-101-Cr-NH_(2)/Nafion composite membranes

High-performance proton exchange membranes are of great importance for fuel cells.Here,we have synthesized polycarboxylate plasticizer modified MIL-101-Cr-NH_(2)(PCP-MCN),a kind of hybrid metal-organic framework,which exhibits a superior proton conductivity.PCP-MCN nanoparticles are used as additives to fabricate PCP-MCN/Nafion composite membranes.Microstructures and characteristics of PCP-MCN and these membranes have been extensively investigated.Significant enhancement in proton conduction for PCP-MCN around 55℃ is interestingly found due to the thermal motion of the PCP molecular chains.Robust mechanical properties and higher thermal decomposition temperature of the composite membranes are directly ascribed to strong intermolecular interactions between PCP-MCN and Nafion side chains,i.e.,the formation of substantial acid–base pairs(-SO_(3)^(-)…^(+)H–NH-),which further improves compatibility between additive and Nafion matrix.At the same humidity and temperature condition,the water uptake of composite membranes significantly increases due to the incorporation of porous additives with abundant functional groups and thus less crystallinity degree in comparison to pristine Nafion.Proton conductivity(σ)over wide ranges of humidities(30-100%RH at 25℃)and temperatures(30-98℃ at 100%RH)for prepared membranes is measured.The s in PCPMCN/Nafion composite membranes is remarkably enhanced,i.e.0.245 S/cm for PCP-MCN-3wt.%/Nafion is twice that of Nafion membrane at 98℃ and 100%RH,because of the establishment of well-interconnected proton transport ionic water channels and perhaps faster protonation–deprotonation processes.The composite membranes possess weak humidity-dependence of proton transport and higher water uptake due to excellent water retention ability of PCP-MCN.In particular,when 3 wt.%PCP-MCN was added to Nafion,the power density of a single-cell fabricated with this composite membrane reaches impressively 0.480,1.098 W/cm^(2) under 40%RH,100%RH at 60℃,respectively,guaranteeing it to be a promising proton exchange membrane.

Thermo-Mechanical, Physico-Chemical, Morphological, and Fire Characteristics of Eco-Friendly Particleboard Manufactured with Phosphorylated Lignin Addition

Lignin,lignosulfonate,and synthesized phosphorylated lignosulfonate were introduced as greenfillers in citric acid-sucrose adhesives for bonding particleboard fabricated from areca leaf sheath(ALS).The characteristics of particleboards were compared to that of ultralow emitting formaldehyde(ULEF-UF).Thefillers derived from Eucalyptus spp.kraft-lignin were added forflame retardancy enhancement.10%of each lignin and modified lig-nin was added into the ULEF-UF and citric acid-sucrose bonded particleboards.Analyses applied to particle-boards included thermal characteristics,X-ray diffraction analysis(XRD),morphological properties,Fourier transform infrared spectroscopy(FTIR),as well as physical,mechanical,andfire resistance characteristics of the laboratory-fabricated particleboards.Lignin and modified lignin resulted in improved thermal stability of the composites bonded with ULEF-UF while the improvement in the particleboard bonded with citric acid-sucrose was not significant.The introduction offiller exerted a higher influence on the UF-bonded particleboards compared to composites fabricated with citric acid-sucrose.Generally,the presence of lignin,lignosulfonate,and phosphorylated lignosulfonate enhanced the mechanical strength of the ULEF-bonded particleboards,although their dimensional stability has deteriorated.Markedly,the use of lignin and lignosulfonate enhanced thefire resis-tance of the particleboards produced with lower observed weight loss.All laboratory particleboards exhibited satisfactoryfire resistance,attaining a V-0 rating in according to the UL-94 standard.

Pathogenesis and treatment of diabetes mellitus-related erectile dysfunction: current therapies and potential challenges

Erectile dysfunction(ED)is one of the important complications of diabetes,which is very common in diabetic patients,affecting more than half of male patients,and the incidence of the disease is about 3.5 times that of the normal population.The pathogenesis of diabetic erectile dysfunction(DMED)is complex,involving nerve,vascular,endocrine,muscular and psychological aspects.At present,the therapeutic approaches of DMED include drug therapy,surgery,physical therapy and so on.This article provides a review of current research on the pathogenesis and treatment of DMED.Further elucidation of the pathogenesis of DMED and the development of new therapeutic approaches are of great significance for the prevention and treatment of DMED.

System View在EDA实验中的应用

在电子线路和通信课程的实验教学中，往往因为条件的限制而无法开设许多实验，本文推荐Ｓｙｓｔｅｍ Ｖｉｅｗ作为实验教学软件，它有强大的动态系统的模拟仿真功能，并适用于滤波器设计、信号处理、完整通信系统的设计与仿真等实验，可以构建一个良好的实验教学平台。

Evaluation of modifi ed Alvarado scoring system and RIPASA scoring system as diagnostic tools of acute appendicitis

BACKGROUND: Acute appendicitis is the most common surgical condition presented in emergency departments worldwide. Clinical scoring systems, such as the Alvarado and modified Alvarado scoring systems, were developed with the goal of reducing the negative appendectomy rate to 5%–10%. The Raja Isteri Pengiran Anak Saleha Appendicitis(RIPASA) scoring system was established in 2008 specif ically for Asian populations. The aim of this study was to compare the modif ied Alvarado with the RIPASA scoring system in Kuwait population.METHODS: This study included 180 patients who underwent appendectomies and were documented as having "acute appendicitis" or "abdominal pain" in the operating theatre logbook(unit B) from November 2014 to March 2016. The sensitivity, specificity, positive predictive value(PPV), negative predictive value(NPV), diagnostic accuracy, predicted negative appendectomy and receiver operating characteristic(ROC) curve of the modified Alvarado and RIPASA scoring systems were derived using SPSS statistical software.RESULTS: A total of 136 patients were included in this study according to our criteria. The cut-off threshold point of the modif ied Alvarado score was set at 7.0, which yielded a sensitivity of 82.8% and a specif icity of 56%. The PPV was 89.3% and the NPV was 42.4%. The cut-off threshold point of the RIPASA score was set at 7.5, which yielded a 94.5% sensitivity and an 88% specif icity. The PPV was 97.2% and the NPV was 78.5%. The predicted negative appendectomy rates were 10.7% and 2.2% for the modif ied Alvarado and RIPASA scoring systems, respectively. The negative appendectomy rate decreased significantly, from 18.4% to 10.7% for the modified Alvarado, and to 2.2% for the RIPASA scoring system, which was a signif icant difference(P<0.001) for both scoring systems.CONCLUSION: Based on the results of this study, the RIPASA score is a simple scoring system with better sensitivity and specif icity than the modif ied Alvarado scoring system in Asian populations. It consists of 14 clinical parameters that can be obtained from a good patient history, clinical examination and laboratory investigations. The RIPASA scoring system is more accurate and specific than the modif ied Alvarado scoring system for Kuwait population.

Systematic mutational analysis of epitope-grafted ED3 immunogenicity reveals a DENV3-DENV4 bi-serospecific ED3 mutant

Objective:To identify the residue determinants of the serospecificity and sero-cross-reactivity of dengue virus(DENV)envelope protein domain 3(ED3),which contains two major putative epitopes of DENV.Methods:We constructed ED3 from DENV3(3ED3)and DENV4(4ED3),and six epitope-grafted variants,where we transferred epitope 1(L304I,K305D,V309M,and S310A)and/or epitope 2(D383N,K384S,K387T,and N389H)of 4ED3 onto 3ED3 and vice-versa.Swiss albino mice aged 3-4 weeks were immunized against wildtype and epitope-grafted ED3 variants and anti-ED3 IgG antibody responses were determined using ELISA.Results:Mouse immunization using 3ED3 and 4ED3 generated serotype-specific antisera,as expected.Similarly,most epitope-grafted ED3s produced antisera serospecific to the template ED3 with little or no cross-recognition of ED3 of the serotype from which the epitopes were taken.These indicated that a mere grafting of the epitope was not sufficient to transfer serospecificity,contrary to our expectations.However,one epitope-grafted ED3 mutant,where epitope 1 of 3ED3 was grafted onto 4ED3(4ED3^(epi1)),generated antisera that was serospecific to both 4ED3 and 3ED3.Conclusions:The 4ED3^(epi1)is a chimeric ED3 that produces antisera possessing serospecificity to both 3ED3 and 4ED3 onto a common 4ED3 scaffold.The 4ED3^(epi1),therefore,provides a unique tool for analyzing serospecificity and sero-cross-reactivity in dengue.We believe that chimeric ED3 may provide a template for future recombinant ED3 possessing serospecificity of multiple DENVs onto a single scaffold and may pave a way developing tri-and/or tetravalent anti-DENV antisera.

Spectra of seismic force reduction factors of MDOF systems normalized by two characteristic periods

Seismic force reduction factor(SFRF) spectra of shear-type multi-degree-of-freedom(MDOF) structures are investigated. The modified Clough model, capable of considering the strength-degradation/hardening and stiffnessdegradation, is adopted. The SFRF mean spectra using 102 earthquake records on a typical site soil type(type C) are constructed with the period abscissa being divided into three period ranges to maintain the peak features at the two sitespecific characteristic periods. Based on a large number of results, it is found that the peak value of SFRF spectra may also exist for MDOF, induced by large high-mode contributions to elastic base shear, besides the mentioned two peak values. The variations of the stiffness ratio λk and the strength ratio λF of the top to bottom story are both considered. It is found that the SFRFs for λF ≤λk are smaller than those for λF > λk. A SFRF modification factor for MDOF systems is proposed with respect to SDOF. It is found that this factor is significantly affected by the story number and ductility. With a specific λF(= λk0.75), SFRF mean spectra are constructed and simple solutions are presented for MDOF systems. For frames satisfying the strong column/weak beam requirement, an approximate treatment in the MDOF shear-beam model is to assign a post-limit stiffness 15%-35% of the initial stiffness to the hysteretic curve. SFRF spectra for MDOF systems with 0.2 and 0.3 times the post-limit stiffness are remarkably larger than those without post-limit stiffness. Thus, the findings that frames with beam hinges have smaller ductility demand are explained through the large post-limit stiffness.

The effect of slow shot speed and casting pressure on the 3D microstructure of high pressure die casting AE44 magnesium alloy

3D reconstruction and 2D observation were conducted to characterize the microstructure of the castings produced through high pressure die casting with different parameters.Our results indicate that shrinkage pores generally co-existed with externally solidified crystals(ESCs).In specimen produced without fast slow shot speed,big net-shrinkage pores accompanied with ESCs were found in the center of the specimen.When the casting pressurization was introduced,the shrinkage pores gathered to the specimen center and became much less due to the optimization of melt feeding.Much more porosity was found near the gate rather than in the middle of the rod bar,especially gas pores.Thefilling process simulation reveals that the middle position of the bars wasfirstlyfilled and followed by the near gate position accompanied with one intense turbulentflow.

甲苯磺酸瑞马唑仑全身麻醉诱导ED50及ED95的测定

目的 观察不同剂量甲苯磺酸瑞马唑仑对喉罩插管全身麻醉诱导期患者镇静效能及起效时间的变化,确定其诱导的药物ED50及ED95值.方法 选择全身麻醉手术的可喉罩插管全身麻醉的患者27例,采用改良序贯(Dixon)法测定甲苯磺酸瑞马唑仑用药效果.设定起始诱导剂量为0.1mg/kg,下一例患者的剂量根据上一例患者诱导出现的结果而定,阴性反应标准,患者诱导后改良警觉/镇静评分(MOAA/S评分)≤1分,BIS≤60时间均<1min.如患者出现阴性反应,下一例患者的诱导剂量下降一个浓度梯度,浓度梯度差值为0.025mg/kg,直至患者出现阳性反应.以此类推,出现6次阴性与阳性交叉后终止研究.结果 甲苯磺酸瑞马唑仑ED50为0.168mg/kg(95%CI:0.137~0.216),ED95为0.297mg/kg(95%CI:0.226~0.828),全身麻醉诱导成功的12例患者中SBP、MAP、DBP呈下降趋势,麻醉诱导前5min(T0)高于其他各时点,在诱导后3min血压降至低点,差异有统计学意义(P<0.05),但血压下降程度均≤30%.诱导后MOAA/S评分≤1分时间为(33.08±9.18)s,BIS≤60时间为(37.42±10.97)s,BIS在1min内降至最低值,随后上升,但插管期间均BIS<60.HR随时间推移呈上升趋势,在用药后2min升至高点,与T0比较,差异有统计学意义(P<0.05).结论 甲苯磺酸瑞马唑仑ED50为0.168mg/kg、ED95为0.297mg/kg,可以安全应用于麻醉诱导期,达到类似丙泊酚起效时间,对循环、心率影响小,能提供足够的镇静时间,减少副作用.

Novel Membranes Regenerated from Blends of Cellulose/Gluten Using Ethylenediamine/Potassium Thiocyanate Solvent System

Current industrial methods for dissolution of cellulose in making regenerated cellulose products are relatively expensive,toxic and dangerous and have environmental problems coming with the hazard chemical wastes.To solve these problems,a novel ethylenediamine and potassium thiocyanate(ED/KSCN)solvent system was developed,that is economical,ecofriendly,and highly efficient.The ED/KSCN solvent system was proven to be a suitable solvent for fabricating cellulose(blended with other polymers)membranes.In this study,gluten was used to develop nonporous membranes with cellulose.The method of casting these membranes provided better ones than the former researchers’techniques.These composite membranes’physical and mechanical properties were studied by analysis of morphology,viscosity,crystallinity,thermal behaviors,tensile properties and water absorption of membranes.Results showed that membranes are nonporous,uniform,strong,flexible,ecofriendly and renewable.Mechanical and physical properties were influenced by the ratio of cellulose/gluten.By blending 40% gluten,the tensile strength of cellulose membrane dropped to 15.89 MPa from 35.11 MPa.However,its elongation at break increased from 35.3% to 57.02% accordingly.

An Intelligent Intrusion Detection System in Smart Grid Using PRNN Classifier

Typically,smart grid systems enhance the ability of conventional power system networks as it is vulnerable to several kinds of attacks.These vulnerabil-ities might cause the attackers or intruders to collapse the entire network system thus breaching the confidentiality and integrity of smart grid systems.Thus,for this purpose,Intrusion detection system(IDS)plays a pivotal part in offering a reliable and secured range of services in the smart grid framework.Several exist-ing approaches are there to detect the intrusions in smart grid framework,however they are utilizing an old dataset to detect anomaly thus resulting in reduced rate of detection accuracy in real-time and huge data sources.So as to overcome these limitations,the proposed technique is presented which employs both real-time raw data from the smart grid network and KDD99 dataset thus detecting anoma-lies in the smart grid network.In the grid side data acquisition,the power trans-mitted to the grid is checked and enhanced in terms of power quality by eradicating distortion in transmission lines.In this approach,power quality in the smart grid network is enhanced by rectifying the fault using a FACT device termed UPQC(Unified Power Quality Controller)and thereby storing the data in cloud storage.The data from smart grid cloud storage and KDD99 are pre-pro-cessed and are optimized using Improved Aquila Swarm Optimization(IASO)to extract optimal features.The probabilistic Recurrent Neural Network(PRNN)classifier is then employed for the prediction and classification of intrusions.At last,the performance is estimated and the outcomes are projected in terms of grid voltage,grid current,Total Harmonic Distortion(THD),voltage sag/swell,accu-racy,precision,recall,F-score,false acceptance rate(FAR),and detection rate of the classifier.The analysis is compared with existing techniques to validate the proposed model efficiency.

A Secure IoT-Cloud Based Healthcare System for Disease Classification Using Neural Network

The integration of the Internet of Things(IoT)and cloud computing is the most popular growing technology in the IT world.IoT integrated cloud com-puting technology can be used in smart cities,health care,smart homes,environ-mental monitoring,etc.In recent days,IoT integrated cloud can be used in the health care system for remote patient care,emergency care,disease prediction,pharmacy management,etc.but,still,security of patient data and disease predic-tion accuracy is a major concern.Numerous machine learning approaches were used for effective early disease prediction.However,machine learning takes more time and less performance while classification.In this research work,the Attribute based Searchable Honey Encryption with Functional Neural Network(ABSHE-FNN)framework is proposed to analyze the disease and provide stronger security in IoT-cloud healthcare data.In this work,the Cardiovascular Disease and Pima Indians diabetes dataset are used for heart and diabetic disease classification.Initi-ally,means-mode normalization removes the noise and normalizes the IoT data,which helps to enhance the quality of data.Rectified Linear Unit(RLU)was applied to adjust the feature weight to reduce the training cost and error classifi-cation.This proposed ABSHE-FNN technique provides better security and achieves 92.79%disease classification accuracy compared to existing techniques.

Engine Performance Using Blended Fuels of Biodiesel and Eco Diesel

Diesel engines is an internal combustion engine with high thermal efficiency,which also uses biodiesel fuel,an environmentally friendly,non-toxic,and low sulfur content.Biodiesel has been around for a long time due to its similar characteristics to diesel fuels which has limited availability.However,several disadvantages are associated with biodiesel,such as poor volatility and high viscosity,which reduces engine performance.Therefore,this study was carried out to improve the diesel engine performance by mixing biodiesel with ecodiesel(ED),an additive produced from natural ingredients that is dissolvable in biodiesel.The biodiesel fuel properties used are density 860 kg/m3,dynamic viscosity 4.50E-06 m2/s,cetane number 45,and flashpoint 52°C.The results showed that biodiesel-ED mixture could improve engine performance and the optimum performance was at a speed of 3000 rpm on 43.30(kW),124.93(N.m)of the engine torque,and 2.45E–5(kg/kW.s)of the specific fuel consumption.According to paired sample t-test,the difference in the engine performance is only experienced in the torque,which has a significant increase in the composition of the biodiesel+ED by 0.07 gr mixture.

Investigating the Effects of Eichhornia Crassipes Biodiesel and Liquefied Petroleum Gas on the Performance and Emissions of a Dual-Fuel Engine

This study considers the effect of Eichhornia Crassipes Biodiesel(ECB)blends on the performances,combustion,and emission characteristics of a direct injection compression ignition engine operated in a dual-fuel mode(DFM)and equipped with an Exhaust gas recirculation technique(EGR).In particular,a single-cylinder,four-stroke,water-cooled diesel engine was utilized and four modes of fuel operation were considered:mode I,the engine operated with an ordinary diesel fuel;mode II,the engine operated with the addition of 2.4 L/min of lique-fied petroleum gas(LPG)and 20%EGR;mode III,20%ECB with 2.4 L/min LPG and 20%EGR;mode IV,40%ECB with 2.4 L/min LPG and 20%EGR.The operation conditions were constant engine speed(1500 rpm),var-iation of load(25%,50%,75%,and 100%),full load,with a compression ratio of 18,and a time injection of 23°BTDC(Before top died center).With regard to engine emissions,carbon dioxide(CO_(2)),carbon monoxide(CO),hydrocarbons(UHC),and nitrogen oxide(NOX)were measured using a gas analyzer.The smoke opacity was measured using an OPABOX smoke meter.By comparing the results related to the different modes with mode I at full load,the BTE(Brake thermal efficiency)increased by 20.17%,11.45%,and 12.66%with modes II,III,and IV,respectively.In comparison to the results for mode II,the BTE decreased due to the combustion of ECB blends by 7.26%and 6.24%for mode III and mode IV,respectively,at full load.In comparison to mode II,the Brake specific energy consumption(BSEC)increased with the ECB substitution.With ECB blends,there is a noticeable decrease in the CO,CO_(2),and UHC emissions at a partial load.Furthermore,the 20%ECB has no effect on CO emissions at full load.For modes II and IV,the CO_(2)increased by 33.33%and 19%,respectively,while the UHC emissions were reduced by 14.49%for mode III and 26.08%for mode IV.The smoke of mode III was lower by 7.21%,but for mode IV,it was higher by 12.37%.In addition,with mode III and mode IV,the NOx emissions increased by 30.50%and 18.80%,respectively.