目的通过连续监测神经重症监护病房(neurological intensive care unit,N-ICU)患者的EEG变化,探讨急性幕上大面积脑梗死脑电图波段功率(band power)的改变及意义。方法急性幕上大面积脑梗死患者20例(梗死组),脑电正常的同期N-ICU患者20...目的通过连续监测神经重症监护病房(neurological intensive care unit,N-ICU)患者的EEG变化,探讨急性幕上大面积脑梗死脑电图波段功率(band power)的改变及意义。方法急性幕上大面积脑梗死患者20例(梗死组),脑电正常的同期N-ICU患者20例(对照组),采用10～20标准电极安装法,8导参考电极导联进行脑电监护。观察梗死组两侧波段功率的改变,比较梗死组和对照组两侧波段功率差值的不同。结果急性幕上大面积脑梗死双侧大脑半球各波段功率均表现为不对称性,病灶侧δ波的绝对波段功率(absolute band power,ABP)和相对波段功率(relative band power,RBP)较健侧显著增大(t值分别为3.649和5.286,均P<0.01),α和β波的RBP均显著减小(t值分别为-4.586和-3.006,均P<0.01),θ波的RBP也显著减小(t=-2.243,P<0.05)。与对照组比较,梗死组左右半球δ波的ABP差值和各波段的RBP差值均有显著性意义(P<0.05)。结论脑缺血时波段功率能早期、定量、直观的反映病情变化,为缺血的发现、病情的评估和疗效的判断提供了一种较好的方法。展开更多
The brain regions associated with binge-eating disorder (BED) and those targeted by Lisdexamfetamine (LDX) overlap. The present paper reviews the psychobehavioural and neuropharmacological mechanisms at play in BED an...The brain regions associated with binge-eating disorder (BED) and those targeted by Lisdexamfetamine (LDX) overlap. The present paper reviews the psychobehavioural and neuropharmacological mechanisms at play in BED and compulsive eating behaviours, along with the mechanisms of action LDX is thought to play. We present one case of chronic BED and highlight the EEG scans pre- and post-LDX treatment. The normalization of the patient’s electroencephalogy (EEG) activity associated with BED after LDX supports theorized mechanisms of LDX action, further explaining its efficacy in treatment. A significant decrease in theta band power was observed in the patient after treatment with LDX. Specifically, this decrease was modulated by changes in the F8 electrode corresponding to the orbitofrontal cortex (OFC)—An area associated with deficits in inhibitory function, seen in addictions and BED. A better understanding of the psychobehavioural and neuropharmacological mechanisms involved in BED and LDX treatment has the potential to significantly enhance our knowledge of the underlying pathogenesis, potential prevention, and optimal treatment options for patients.展开更多
文摘目的通过连续监测神经重症监护病房(neurological intensive care unit,N-ICU)患者的EEG变化,探讨急性幕上大面积脑梗死脑电图波段功率(band power)的改变及意义。方法急性幕上大面积脑梗死患者20例(梗死组),脑电正常的同期N-ICU患者20例(对照组),采用10～20标准电极安装法,8导参考电极导联进行脑电监护。观察梗死组两侧波段功率的改变,比较梗死组和对照组两侧波段功率差值的不同。结果急性幕上大面积脑梗死双侧大脑半球各波段功率均表现为不对称性,病灶侧δ波的绝对波段功率(absolute band power,ABP)和相对波段功率(relative band power,RBP)较健侧显著增大(t值分别为3.649和5.286,均P<0.01),α和β波的RBP均显著减小(t值分别为-4.586和-3.006,均P<0.01),θ波的RBP也显著减小(t=-2.243,P<0.05)。与对照组比较,梗死组左右半球δ波的ABP差值和各波段的RBP差值均有显著性意义(P<0.05)。结论脑缺血时波段功率能早期、定量、直观的反映病情变化,为缺血的发现、病情的评估和疗效的判断提供了一种较好的方法。
文摘The brain regions associated with binge-eating disorder (BED) and those targeted by Lisdexamfetamine (LDX) overlap. The present paper reviews the psychobehavioural and neuropharmacological mechanisms at play in BED and compulsive eating behaviours, along with the mechanisms of action LDX is thought to play. We present one case of chronic BED and highlight the EEG scans pre- and post-LDX treatment. The normalization of the patient’s electroencephalogy (EEG) activity associated with BED after LDX supports theorized mechanisms of LDX action, further explaining its efficacy in treatment. A significant decrease in theta band power was observed in the patient after treatment with LDX. Specifically, this decrease was modulated by changes in the F8 electrode corresponding to the orbitofrontal cortex (OFC)—An area associated with deficits in inhibitory function, seen in addictions and BED. A better understanding of the psychobehavioural and neuropharmacological mechanisms involved in BED and LDX treatment has the potential to significantly enhance our knowledge of the underlying pathogenesis, potential prevention, and optimal treatment options for patients.
