Objective:To investigate the relationship between the changes of electroencephalogram(EEG)power spectrum,P300 latency and amplitude at different frequency bands and the severity of depressive episode in adolescents wh...Objective:To investigate the relationship between the changes of electroencephalogram(EEG)power spectrum,P300 latency and amplitude at different frequency bands and the severity of depressive episode in adolescents who were hospitalized for the first time.Methods:A retrospective study was conducted on 126 adolescent patients with depressive episodes who were hospitalized for the first time in the Department of Children and Adolescents of Yunnan Psychiatric Hospital from January 2022 to August 2023.According to Hamilton Depression Rating Scale(HAMD),the patients were divided into three groups:mild depression group(43 cases),moderate depression group(42 cases)and severe depression group(41 cases).The distribution of the 16-lead power spectrum of α,θ,and δ waves in EEG,as well as the latency and amplitude of P300,were compared among the three groups.The association between adolescent depression and its severity was analyzed.Results:(1)The EEG power distribution of the three groups was different in the frequency bands of α,θ and δ(P<0.05).There were differences in the α,θ,and δ frequency bands between mild and moderate as well as severe depressive episodes,and between moderate and severe depressive episodes in the θ and δ frequency bands.(2)P300,N2 latency and P300 amplitude:There were significant differences among the three groups(P<0.05).(3)δFP1,θF3,θC4,P300 latency and N2 latency were positively correlated with the degree of depression;P300 amplitude andα02 were negatively correlated with the degree of depression.(4)The receiver operating characteristic curve(ROC)area of P300 amplitude was 0.932,and the area under the curve ofα02 was 0.776.Conclusion:The combination of resting EEG power and P300 can be used as a biomarker to assess the severity of a depressive episode in adolescents who are hospitalized for the first time and provide a new strategy for treatment.展开更多
Anatomical functionality is a major topic in brain research. Numerous investigations have shown task dependent activation of focal brain areas, with most information based on time-averaged data due to methodological l...Anatomical functionality is a major topic in brain research. Numerous investigations have shown task dependent activation of focal brain areas, with most information based on time-averaged data due to methodological limitations. Ultra-fast quantitative EEG, especially in the newly developed combination with eye tracking (EnkephaloVision), is very suitable to follow activities of local electric circuits. This investigation in 57 subjects revealed transient focal frequency changes reaching up to more than 6000% of global median spectra power during cognitive and emotional challenges at frontal electrode positions. Recording epochs of 364 ms uncovered coherences with respect to focal brain areas and single frequencies, which are typically lost during averaged calculations. When averaging data over a whole scene, a least demanding challenge like viewing a boring animal video only activated the lateral frontal lobe, whereas solving brain-teasers and performance of mathematical calculations led to delta (modulated by acetylcholine) and theta (modulated by norepinephrine) increases in all brain regions in a statistically significant manner. In addition to delta and theta increases, performance of the Stroop test led to beta2 (related to GABA-ergic transmission) increases in the temporal lobe. The higher the mental demand the more brain regions were involved during 10 different challenges. There was no challenge which did not activate the lateral frontal brain in terms of increases of delta and theta spectral power. The results are in line with the view that the lateral frontal lobe is involved primarily during cognitive and emotional behavior related to activity changes of acetylcholine and norepinephrine.展开更多
The relationship between hippocampal electroencephalogram(EEG)power spectrum and the extinction of addiction memory was investigated.Forty KM mice(Kunming mice)that had successfully established morphine(MOR)-condition...The relationship between hippocampal electroencephalogram(EEG)power spectrum and the extinction of addiction memory was investigated.Forty KM mice(Kunming mice)that had successfully established morphine(MOR)-conditioned place preference(CPP)were divided into four groups:saline-training extinction(SAL-TE),SAL-natural extinction(SAL-NE),MORTE,MOR-NE,for extinction treatment and EEG recording in the dorsal and ventral hippocampus(DH/VH).Results show that the CPP score of MOR-TE significantly decreased and the total,βandγbands power spectrum of MOR-TE was suppressed.Notably,the total power from the VH was more correlated with the extinction method,and the TE total power was always lower than NE in SAL or MOR group.Naloxone enhanced the EEG total power and all bands(DH)orβandγbands(VH)power in the SAL group.However,in the MOR-TE group,onlyβandγbands power in VH increased(P<0.05).The results suggest that TE can promote the extinction of opiate addictive memory more effectively than NE,and the extinction of MOR-CPP may have a stronger correlation with changes of VH-EEG power spectrum.展开更多
A test group consisting of 104 healthy men from the ages of 19 to 21 was divided into two groups according to the magnitude of their IAF （individual EEG Gt-ffequency） median--groups with high （n = 53, IA 〉 10.04 H...A test group consisting of 104 healthy men from the ages of 19 to 21 was divided into two groups according to the magnitude of their IAF （individual EEG Gt-ffequency） median--groups with high （n = 53, IA 〉 10.04 Hz） and low （n = 51, IAF 〈 10.03 Hz） levels of IAF. Differences between the groups in terms of the power and coherence of EEG oscillations and the EMG signal average amplitude at rest were estimated. It was found that the dominant role of the thalamocortical interactions （thalamus and cortex） in the group of testees having a high IAF causes the greater differentiation and rationality of the downstream effects on muscles and provides more economic baselines and contractile capabilities of the leading hand flexor muscles. Increased non-specific influences of the limbic system and reticular formation in providing the testees＇ cortical activity under conditions of a low frequency are accompanied by a smaller lateral and reciprocal specificity in the downstream impacts, and by a lower performance of supraspinal irmervations.展开更多
文摘Objective:To investigate the relationship between the changes of electroencephalogram(EEG)power spectrum,P300 latency and amplitude at different frequency bands and the severity of depressive episode in adolescents who were hospitalized for the first time.Methods:A retrospective study was conducted on 126 adolescent patients with depressive episodes who were hospitalized for the first time in the Department of Children and Adolescents of Yunnan Psychiatric Hospital from January 2022 to August 2023.According to Hamilton Depression Rating Scale(HAMD),the patients were divided into three groups:mild depression group(43 cases),moderate depression group(42 cases)and severe depression group(41 cases).The distribution of the 16-lead power spectrum of α,θ,and δ waves in EEG,as well as the latency and amplitude of P300,were compared among the three groups.The association between adolescent depression and its severity was analyzed.Results:(1)The EEG power distribution of the three groups was different in the frequency bands of α,θ and δ(P<0.05).There were differences in the α,θ,and δ frequency bands between mild and moderate as well as severe depressive episodes,and between moderate and severe depressive episodes in the θ and δ frequency bands.(2)P300,N2 latency and P300 amplitude:There were significant differences among the three groups(P<0.05).(3)δFP1,θF3,θC4,P300 latency and N2 latency were positively correlated with the degree of depression;P300 amplitude andα02 were negatively correlated with the degree of depression.(4)The receiver operating characteristic curve(ROC)area of P300 amplitude was 0.932,and the area under the curve ofα02 was 0.776.Conclusion:The combination of resting EEG power and P300 can be used as a biomarker to assess the severity of a depressive episode in adolescents who are hospitalized for the first time and provide a new strategy for treatment.
文摘Anatomical functionality is a major topic in brain research. Numerous investigations have shown task dependent activation of focal brain areas, with most information based on time-averaged data due to methodological limitations. Ultra-fast quantitative EEG, especially in the newly developed combination with eye tracking (EnkephaloVision), is very suitable to follow activities of local electric circuits. This investigation in 57 subjects revealed transient focal frequency changes reaching up to more than 6000% of global median spectra power during cognitive and emotional challenges at frontal electrode positions. Recording epochs of 364 ms uncovered coherences with respect to focal brain areas and single frequencies, which are typically lost during averaged calculations. When averaging data over a whole scene, a least demanding challenge like viewing a boring animal video only activated the lateral frontal lobe, whereas solving brain-teasers and performance of mathematical calculations led to delta (modulated by acetylcholine) and theta (modulated by norepinephrine) increases in all brain regions in a statistically significant manner. In addition to delta and theta increases, performance of the Stroop test led to beta2 (related to GABA-ergic transmission) increases in the temporal lobe. The higher the mental demand the more brain regions were involved during 10 different challenges. There was no challenge which did not activate the lateral frontal brain in terms of increases of delta and theta spectral power. The results are in line with the view that the lateral frontal lobe is involved primarily during cognitive and emotional behavior related to activity changes of acetylcholine and norepinephrine.
基金the National Natural Science Foundation of China(31760278)NHC Key Laboratory of Drug Addiction Medicine of Kunming Medical University(2020DAMOP-002)。
文摘The relationship between hippocampal electroencephalogram(EEG)power spectrum and the extinction of addiction memory was investigated.Forty KM mice(Kunming mice)that had successfully established morphine(MOR)-conditioned place preference(CPP)were divided into four groups:saline-training extinction(SAL-TE),SAL-natural extinction(SAL-NE),MORTE,MOR-NE,for extinction treatment and EEG recording in the dorsal and ventral hippocampus(DH/VH).Results show that the CPP score of MOR-TE significantly decreased and the total,βandγbands power spectrum of MOR-TE was suppressed.Notably,the total power from the VH was more correlated with the extinction method,and the TE total power was always lower than NE in SAL or MOR group.Naloxone enhanced the EEG total power and all bands(DH)orβandγbands(VH)power in the SAL group.However,in the MOR-TE group,onlyβandγbands power in VH increased(P<0.05).The results suggest that TE can promote the extinction of opiate addictive memory more effectively than NE,and the extinction of MOR-CPP may have a stronger correlation with changes of VH-EEG power spectrum.
文摘A test group consisting of 104 healthy men from the ages of 19 to 21 was divided into two groups according to the magnitude of their IAF （individual EEG Gt-ffequency） median--groups with high （n = 53, IA 〉 10.04 Hz） and low （n = 51, IAF 〈 10.03 Hz） levels of IAF. Differences between the groups in terms of the power and coherence of EEG oscillations and the EMG signal average amplitude at rest were estimated. It was found that the dominant role of the thalamocortical interactions （thalamus and cortex） in the group of testees having a high IAF causes the greater differentiation and rationality of the downstream effects on muscles and provides more economic baselines and contractile capabilities of the leading hand flexor muscles. Increased non-specific influences of the limbic system and reticular formation in providing the testees＇ cortical activity under conditions of a low frequency are accompanied by a smaller lateral and reciprocal specificity in the downstream impacts, and by a lower performance of supraspinal irmervations.
