Early brain development after birth is extremely dynamic,suggest!ng that potential functional changes occur during this period.In this study,the maximal electroshock seizure threshold(MEST)was used to explore the elec...Early brain development after birth is extremely dynamic,suggest!ng that potential functional changes occur during this period.In this study,the maximal electroshock seizure threshold(MEST)was used to explore the electrophysiological variation among three developmental stages in young mice(no more than 5 weeks old).The induced electroshock seizure(ES)behavior of early post natal mice(1-2-weeks old)differed from that during weaning(3 weeks old)and early puberty(4-5-weeks old).Thus,we further explored their respective characteristic responses to the ES parameters.When the stimulation current(SC)was limited to 4.0 mA,only the 1-2-week-old mice were induced to exhibit ES behavior at voltages of 30 V and 40 V,indicating they were more sensitive to maximal electroshock seizure(MES)(response to lower voltage).展开更多
In order to improve the properties of titanium alloys manufactured by laser melting deposition(LMD),the electroshocking treatment(EST)was proposed in this work.The effects of EST on microstructure and mechanical prope...In order to improve the properties of titanium alloys manufactured by laser melting deposition(LMD),the electroshocking treatment(EST)was proposed in this work.The effects of EST on microstructure and mechanical properties of LMD Ti-6.5Al-3.5Mo-1.5Zr-0.3Si were investigated.The results showed that the width of the heat affected band decreased and disappeared under the thermal and athermal effects of EST,resulting in the uniform microstructure.In the microstructure,theαlaths became coarser gradually,and the quantity ofα/βinterface was reduced.The reduction of the quantity ofα/βinterface leads to make less resistant to dislocation,resulting in the reduction in hardness and strength.The discontinuous grain boundaryαphase and nucleationαcolony near grain boundary inhibited the crack propagation and improved the ductility.Summary,EST can manipulate the microstructure and improve the mechanical properties of LMD titanium alloys.展开更多
In this article,in-situ scanning electron microscope characterization of the tensile properties of TiB/Ti-2Al-6Sn titanium matrix composite(TMC)was conducted before and after electroshocking treatment(EST).After EST,t...In this article,in-situ scanning electron microscope characterization of the tensile properties of TiB/Ti-2Al-6Sn titanium matrix composite(TMC)was conducted before and after electroshocking treatment(EST).After EST,the tensile strength increased by 113.2 MPa.The effect of EST on the tensile strength and fracture behavior of TiB was investigated using in-situ characterization of the fracture morphology and crack propagation path of the matrix and TiB.Before EST,TiB fracture introduced cracks that extended into the matrix,resulting in material failure.After EST,the refined TiB improved the bearing capacity of the matrix,thereby improving TMC strength.Moreover,after EST,the cracks were introduced into the matrix,and resulting the fracture of matrix first.With an increase in the external load,cracks in the matrix were observed to propagate to TiB,and the refined TiB was fractured,detached,and pulled out,resulting in the formation of pores.Analyzing the propagation path of the main crack after EST showed that the deflection angle of the main crack increased.The micro structure of the fracture surface indicated that the fracture of the matrix was plastic,whereas that of TiB was brittle.After EST,the size and area of the dimples increased,confirming the increase in plasticity.The results revealed that the comprehensive mechanical properties of TiB/Ti-2Al-6Sn improved after EST.Hence,EST is an efficient method for tailoring the micro structures and mechanical properties of TMCs.展开更多
在司法鉴定领域,涉及电击死亡的案件多发,鉴别死者是生前还是死后受到电击仍是法医病理学鉴定的难点问题之一。为此通过傅里叶变换红外光谱融合机器学习模型对心脏组织视角下的电击死和死后电击两种情况开展分类识别研究。将30只大鼠进...在司法鉴定领域,涉及电击死亡的案件多发,鉴别死者是生前还是死后受到电击仍是法医病理学鉴定的难点问题之一。为此通过傅里叶变换红外光谱融合机器学习模型对心脏组织视角下的电击死和死后电击两种情况开展分类识别研究。将30只大鼠进行电击死、死后电击和对照处理,通过光谱仪扫描得到其心脏组织光谱,采用竞争性自适应重加权算法共提取到70个光谱特征波长,建立随机森林模型对特征波长提取前后的心脏组织光谱进行模式识别;结果表明,特征波长提取前后模型分类识别的准确率分别为34.9%和73.7%,验证了特征波长提取方法的有效性和必要性。同时建立偏最小二乘模型、传统支持向量机以及粒子群算法和灰狼算法优化的支持向量机模型进行分类识别,结果表明,模型分类识别的准确率分别为61.07%、34.48%、100%和98.46%,对比发现经特征提取后的粒子群优化支持向量机模型分类识别效果最好。为排除“生物学死亡期”的干扰,又取60只大鼠按同种方式对其处理,每组又分死后0.5 h和死后1 h 2个亚组,再次通过傅里叶变换红外光谱仪扫描得到光谱数据,数据预处理后将其与之前得到的数据进行一并处理并结合粒子群优化支持向量机模型分析,结果表明,该方法分类识别的准确率可达到80.85%。这为电击死领域的法医学鉴定提供了新的研究思路和方法,说明傅里叶红外变换红外光谱结合机器学习模型可以作为一种补充工具来提供相对客观的判断,具有重要的研究意义。展开更多
目的观察氨磺必利辅以无抽搐电休克治疗精神分裂症的疗效。方法我院2018年5月-2019年5月收治的74例精神分裂症患者为本次研究对象,按照是否行氨磺必利辅以无抽搐电休克治疗将所有患者分为对照组(37例:未辅以无抽搐电休克治疗)与试验组(3...目的观察氨磺必利辅以无抽搐电休克治疗精神分裂症的疗效。方法我院2018年5月-2019年5月收治的74例精神分裂症患者为本次研究对象,按照是否行氨磺必利辅以无抽搐电休克治疗将所有患者分为对照组(37例:未辅以无抽搐电休克治疗)与试验组(37例:辅以无抽搐电休克治疗),比较两组患者预后。结果试验组患者治疗3个疗程后总有效率(75.68%)、神经元特异性烯醇化酶(neuron specific enolase,NSE)、髓鞘碱性蛋白(myelin basic protein,MBP)、泌乳素等相关数值均优于对照组(P<0.05)。结论精神分裂症患者氨磺必利辅以无抽搐电休克治疗效果明显优于单一氨磺必利治疗。展开更多
基金supported by the National Natural Science Foundation of China(81403191)Yunnan Provincial Natural Science Foundation(2018FB118,2015FA004,and KKSY201626001)
文摘Early brain development after birth is extremely dynamic,suggest!ng that potential functional changes occur during this period.In this study,the maximal electroshock seizure threshold(MEST)was used to explore the electrophysiological variation among three developmental stages in young mice(no more than 5 weeks old).The induced electroshock seizure(ES)behavior of early post natal mice(1-2-weeks old)differed from that during weaning(3 weeks old)and early puberty(4-5-weeks old).Thus,we further explored their respective characteristic responses to the ES parameters.When the stimulation current(SC)was limited to 4.0 mA,only the 1-2-week-old mice were induced to exhibit ES behavior at voltages of 30 V and 40 V,indicating they were more sensitive to maximal electroshock seizure(MES)(response to lower voltage).
基金This work was financially supported by the National Natural Science Foundation of China(Grant Nos.51975441 and 52271135)the Innovation Funding Project of National Engineering and Research Center for Commercial Aircraft Manufacturing(No.COMAC-SFGS-2022-1871)+6 种基金the Major Research Plan of the National Natural Science Foundation of China(Grant No.92266102)the Natural Science Foundation of Hubei Province(Grant No.2022CFB492)the Knowledge Innovation Program of Wuhan-Basic Research(No.2022010801010174)the Application Foundation Frontier Project of Wuhan(No.2020010601012171)the“Chu Tian Scholar”project of Hubei Province(No.CTXZ2017-05)the Overseas Expertise Introduction Project for Discipline Innovation(No.B17034)Innovative Research Team Development Program of Ministry of Education of China(No.IRT_17R83).
文摘In order to improve the properties of titanium alloys manufactured by laser melting deposition(LMD),the electroshocking treatment(EST)was proposed in this work.The effects of EST on microstructure and mechanical properties of LMD Ti-6.5Al-3.5Mo-1.5Zr-0.3Si were investigated.The results showed that the width of the heat affected band decreased and disappeared under the thermal and athermal effects of EST,resulting in the uniform microstructure.In the microstructure,theαlaths became coarser gradually,and the quantity ofα/βinterface was reduced.The reduction of the quantity ofα/βinterface leads to make less resistant to dislocation,resulting in the reduction in hardness and strength.The discontinuous grain boundaryαphase and nucleationαcolony near grain boundary inhibited the crack propagation and improved the ductility.Summary,EST can manipulate the microstructure and improve the mechanical properties of LMD titanium alloys.
基金financially supported by the National Natural Science Foundation of China(No.52271135)the Major Research Plan of the National Natural Science Foundation of China(No.92266102)+5 种基金the Natural Science Foundation of Hubei Province(No.2022CFB492)the Knowledge Innovation Program of Wuhan-Basic Research(No.2022010801010174)the Application Foundation Frontier Project of Wuhan(No.2020010601012171)"Chu Tian Scholar"Project of Hubei Province(No.CTXZ2017-05)the Overseas Expertise Introduction Project for Discipline Innovation(No.B17034)the Innovative Research Team Development Program of Ministry of Education of China(No.IRT_17R83)。
文摘In this article,in-situ scanning electron microscope characterization of the tensile properties of TiB/Ti-2Al-6Sn titanium matrix composite(TMC)was conducted before and after electroshocking treatment(EST).After EST,the tensile strength increased by 113.2 MPa.The effect of EST on the tensile strength and fracture behavior of TiB was investigated using in-situ characterization of the fracture morphology and crack propagation path of the matrix and TiB.Before EST,TiB fracture introduced cracks that extended into the matrix,resulting in material failure.After EST,the refined TiB improved the bearing capacity of the matrix,thereby improving TMC strength.Moreover,after EST,the cracks were introduced into the matrix,and resulting the fracture of matrix first.With an increase in the external load,cracks in the matrix were observed to propagate to TiB,and the refined TiB was fractured,detached,and pulled out,resulting in the formation of pores.Analyzing the propagation path of the main crack after EST showed that the deflection angle of the main crack increased.The micro structure of the fracture surface indicated that the fracture of the matrix was plastic,whereas that of TiB was brittle.After EST,the size and area of the dimples increased,confirming the increase in plasticity.The results revealed that the comprehensive mechanical properties of TiB/Ti-2Al-6Sn improved after EST.Hence,EST is an efficient method for tailoring the micro structures and mechanical properties of TMCs.
文摘在司法鉴定领域,涉及电击死亡的案件多发,鉴别死者是生前还是死后受到电击仍是法医病理学鉴定的难点问题之一。为此通过傅里叶变换红外光谱融合机器学习模型对心脏组织视角下的电击死和死后电击两种情况开展分类识别研究。将30只大鼠进行电击死、死后电击和对照处理,通过光谱仪扫描得到其心脏组织光谱,采用竞争性自适应重加权算法共提取到70个光谱特征波长,建立随机森林模型对特征波长提取前后的心脏组织光谱进行模式识别;结果表明,特征波长提取前后模型分类识别的准确率分别为34.9%和73.7%,验证了特征波长提取方法的有效性和必要性。同时建立偏最小二乘模型、传统支持向量机以及粒子群算法和灰狼算法优化的支持向量机模型进行分类识别,结果表明,模型分类识别的准确率分别为61.07%、34.48%、100%和98.46%,对比发现经特征提取后的粒子群优化支持向量机模型分类识别效果最好。为排除“生物学死亡期”的干扰,又取60只大鼠按同种方式对其处理,每组又分死后0.5 h和死后1 h 2个亚组,再次通过傅里叶变换红外光谱仪扫描得到光谱数据,数据预处理后将其与之前得到的数据进行一并处理并结合粒子群优化支持向量机模型分析,结果表明,该方法分类识别的准确率可达到80.85%。这为电击死领域的法医学鉴定提供了新的研究思路和方法,说明傅里叶红外变换红外光谱结合机器学习模型可以作为一种补充工具来提供相对客观的判断,具有重要的研究意义。
文摘目的观察氨磺必利辅以无抽搐电休克治疗精神分裂症的疗效。方法我院2018年5月-2019年5月收治的74例精神分裂症患者为本次研究对象,按照是否行氨磺必利辅以无抽搐电休克治疗将所有患者分为对照组(37例:未辅以无抽搐电休克治疗)与试验组(37例:辅以无抽搐电休克治疗),比较两组患者预后。结果试验组患者治疗3个疗程后总有效率(75.68%)、神经元特异性烯醇化酶(neuron specific enolase,NSE)、髓鞘碱性蛋白(myelin basic protein,MBP)、泌乳素等相关数值均优于对照组(P<0.05)。结论精神分裂症患者氨磺必利辅以无抽搐电休克治疗效果明显优于单一氨磺必利治疗。
