Epoxy resin systems (ERSs) are a frequent cause of occupational allergic conta ct dermatitis. Sensitization occurs not only to the resins, but also to hardener s and reactive diluents. However, only a fraction of the ...Epoxy resin systems (ERSs) are a frequent cause of occupational allergic conta ct dermatitis. Sensitization occurs not only to the resins, but also to hardener s and reactive diluents. However, only a fraction of the ERS components currentl y in use are available for patch testing. With the multicentre study EPOX 2002, we attempted to improve diagnostics in this field by patch testing with componen ts currently used in ERSs. During the first study period (October 2002 to July 2 003), in addition to commercially available ERS patch test substances, 16 study substances (1 resin, 9 hardeners and 6 reactive diluents) were patch tested in 7 0 patients with suspected contact allergy due to ERSs and 22 patients with a pri or positive patch test reaction to epoxy resin (ER) in the standard series. Most frequently, allergic reactions to ER based on diglycidyl ether of bisphenol A a nd F were observed (55.2%and 43.7%, respectively). Agreement between positive reactions to both resins, which can be explained by immunological cross-sensiti zation and/or coexposure, was substantial [Cohen’s kappa 0.65 (95%CI:0.49-0 . 80)]. Among the reactive diluents, 1,6-hexanediol diglycidyl ether (1,6-HDDGE ) and 1,4-butanediol diglycidyl ether (1,4-BDDGE) were the most frequent allerg ens, with 19.5%and 18.4%positive reactions, respectively. Although agreement b etween positive reactions to 1,6-HDDGE and 1,4BDDGE was even better than with t he 2 resins, the sample size is considered too small to decide reliably whether 1,6-HDDGE alone could serve as a marker allergen for both. Allergic reactions t o p-tert-butylphenyl glycidyl ether and to phenyl glycidyl ether (PGE) occurre d in 11.5%of the patients tested, with only moderate agreement. All patients po sitive to cresyl glycidyl ether (6.8%) also reacted to PGE. Of the hardeners te sted, m-xylylene diamine was the most frequent allergen (13.8%), followed by i sophorone diamine (5.7%). No reactions were observed to several substances, the test concentration of which may have been too low and will be increased in the future.展开更多
文摘Epoxy resin systems (ERSs) are a frequent cause of occupational allergic conta ct dermatitis. Sensitization occurs not only to the resins, but also to hardener s and reactive diluents. However, only a fraction of the ERS components currentl y in use are available for patch testing. With the multicentre study EPOX 2002, we attempted to improve diagnostics in this field by patch testing with componen ts currently used in ERSs. During the first study period (October 2002 to July 2 003), in addition to commercially available ERS patch test substances, 16 study substances (1 resin, 9 hardeners and 6 reactive diluents) were patch tested in 7 0 patients with suspected contact allergy due to ERSs and 22 patients with a pri or positive patch test reaction to epoxy resin (ER) in the standard series. Most frequently, allergic reactions to ER based on diglycidyl ether of bisphenol A a nd F were observed (55.2%and 43.7%, respectively). Agreement between positive reactions to both resins, which can be explained by immunological cross-sensiti zation and/or coexposure, was substantial [Cohen’s kappa 0.65 (95%CI:0.49-0 . 80)]. Among the reactive diluents, 1,6-hexanediol diglycidyl ether (1,6-HDDGE ) and 1,4-butanediol diglycidyl ether (1,4-BDDGE) were the most frequent allerg ens, with 19.5%and 18.4%positive reactions, respectively. Although agreement b etween positive reactions to 1,6-HDDGE and 1,4BDDGE was even better than with t he 2 resins, the sample size is considered too small to decide reliably whether 1,6-HDDGE alone could serve as a marker allergen for both. Allergic reactions t o p-tert-butylphenyl glycidyl ether and to phenyl glycidyl ether (PGE) occurre d in 11.5%of the patients tested, with only moderate agreement. All patients po sitive to cresyl glycidyl ether (6.8%) also reacted to PGE. Of the hardeners te sted, m-xylylene diamine was the most frequent allergen (13.8%), followed by i sophorone diamine (5.7%). No reactions were observed to several substances, the test concentration of which may have been too low and will be increased in the future.
