Background:This study explores the relationship between endoplasmic reticulum(ER)stress and diabetes,particularly focusing on the impact of physical exercise on ER stress mechanisms and identifying potential therapeut...Background:This study explores the relationship between endoplasmic reticulum(ER)stress and diabetes,particularly focusing on the impact of physical exercise on ER stress mechanisms and identifying potential therapeutic drugs and targets for diabetes-related sepsis.The research also incorporates traditional physical therapy perspectives,emphasizing the genomic insights gained from exercise therapy in disease management and prevention.Methods:Gene analysis was conducted on the GSE168796 and GSE94717 datasets to identify ER stress-related genes.Gene interactions and immune cell correlations were mapped using GeneCard and STRING databases.A screening of 2,456 compounds from the TCMSP database was performed to identify potential therapeutic agents,with a focus on their docking potential.Techniques such as luciferase reporter gene assay and RNA interference were used to examine the interactions between microRNA-149-5p and MMP9.Results:The study identified 2,006 differentially expressed genes and 616 miRNAs.Key genes like MMP9,TNF-α,and IL1B were linked to an immunosuppressive state.Licorice glycoside E demonstrated high affinity for MMP9,suggesting its potential effectiveness in treating diabetes.The constructed miRNA network highlighted the regulatory roles of MMP9,IL1B,IFNG,and TNF-α.Experimental evidence confirmed the binding of microRNA-149-5p to MMP9,impacting apoptosis in diabetic cells.Conclusion:The findings highlight the regulatory role of microRNA-149-5p in managing MMP9,a crucial gene in diabetes pathophysiology.Licorice glycoside E emerges as a promising treatment option for diabetes,especially targeting MMP9 affected by ER stress.The study also underscores the significance of physical exercise in modulating ER stress pathways in diabetes management,bridging traditional physical therapy and modern scientific understanding.Our study has limitations.It focuses on the microRNA-149-5p-MMP9 network in sepsis,using cell-based methods without animal or clinical trials.Despite strong in vitro findings,in vivo studies are needed to confirm licorice glycoside E’s therapeutic potential and understand the microRNA-149-5p-MMP9 dynamics in real conditions.展开更多
Tt-phase electron-doped superconductor Pr1-xLaCexCuO4-δ（PLCCO） thin films are successfully prepared on SrTiOs （100） substrates by using the dc magnetron sputtering method. It is found that the films each have a h...Tt-phase electron-doped superconductor Pr1-xLaCexCuO4-δ（PLCCO） thin films are successfully prepared on SrTiOs （100） substrates by using the dc magnetron sputtering method. It is found that the films each have a highly oriented structure along the c-axis. For optimally doped films with x ≈ 0.10, the superconducting transition temperature Tc is 25.5 K, which is similar to that of a single crystal. The quadratic temperature dependence of the resistivity is observed when T 〉 To, which can be attributed to the two-dimensional Fermi liquid behaviour. Besides, the optimal conditions for preparing the T1-phase PLCCO thin films are also discussed in detail.展开更多
The improvement on the calculation of anti-Stokes energy transfer rate is studied in the present work. The additional proportion coefficient between Stokes and anti-Stokes light intensities of quantum Raman scattering...The improvement on the calculation of anti-Stokes energy transfer rate is studied in the present work. The additional proportion coefficient between Stokes and anti-Stokes light intensities of quantum Raman scattering theory as compared with the classical Raman theory is introduced to successfully describe the anti-Stokes energy transfer. The theoretical formula for the improvement on the calculation of anti-Stokes energy transfer rate is derived for the first time in this study. The correctness of introducing coefficient exp{△E/kT} from well-known Raman scatter theory is demonstrated also. Moreover, the experimental lifetime measurement in Er0.01YbxY1-0.01-xVO4 crystal is performed to justify the validity of our important improvement in the original phonon-assisted energy transfer theory for the first time.展开更多
With the largest population in the world,the Asia-Pacific area is in a great need for the fundamentalresearch of visual sciences,the protection of vision and the prevention and treatment of visual diseases.The Symposi...With the largest population in the world,the Asia-Pacific area is in a great need for the fundamentalresearch of visual sciences,the protection of vision and the prevention and treatment of visual diseases.The Symposium will open a new era of the academic exchanges in the field of visual sciences in thisarea.It also will enhance the academic exchanges of visual sciences worldwide.展开更多
文摘Background:This study explores the relationship between endoplasmic reticulum(ER)stress and diabetes,particularly focusing on the impact of physical exercise on ER stress mechanisms and identifying potential therapeutic drugs and targets for diabetes-related sepsis.The research also incorporates traditional physical therapy perspectives,emphasizing the genomic insights gained from exercise therapy in disease management and prevention.Methods:Gene analysis was conducted on the GSE168796 and GSE94717 datasets to identify ER stress-related genes.Gene interactions and immune cell correlations were mapped using GeneCard and STRING databases.A screening of 2,456 compounds from the TCMSP database was performed to identify potential therapeutic agents,with a focus on their docking potential.Techniques such as luciferase reporter gene assay and RNA interference were used to examine the interactions between microRNA-149-5p and MMP9.Results:The study identified 2,006 differentially expressed genes and 616 miRNAs.Key genes like MMP9,TNF-α,and IL1B were linked to an immunosuppressive state.Licorice glycoside E demonstrated high affinity for MMP9,suggesting its potential effectiveness in treating diabetes.The constructed miRNA network highlighted the regulatory roles of MMP9,IL1B,IFNG,and TNF-α.Experimental evidence confirmed the binding of microRNA-149-5p to MMP9,impacting apoptosis in diabetic cells.Conclusion:The findings highlight the regulatory role of microRNA-149-5p in managing MMP9,a crucial gene in diabetes pathophysiology.Licorice glycoside E emerges as a promising treatment option for diabetes,especially targeting MMP9 affected by ER stress.The study also underscores the significance of physical exercise in modulating ER stress pathways in diabetes management,bridging traditional physical therapy and modern scientific understanding.Our study has limitations.It focuses on the microRNA-149-5p-MMP9 network in sepsis,using cell-based methods without animal or clinical trials.Despite strong in vitro findings,in vivo studies are needed to confirm licorice glycoside E’s therapeutic potential and understand the microRNA-149-5p-MMP9 dynamics in real conditions.
基金This work was supported by the National Natural Science Foundation of China （No.20771079） and the Natural Science Foundation of Education Department of Jiangsu Province （No.07KJB150126）.
文摘BaCe0.8Pr0.2O3- 陶器被高温度综合固态反应。结构的特征和水晶的阶段纯净用粉末 X 光检查衍射分析被决定。由使用交流阻抗光谱学，煤气的集中房间并且氢的电气化学的抽的方法，传导性和 BaCe0.8Pr0.2O3- 的离子的运输数字被测量，并且材料的电的传导行为在 500-900
基金supported by the State Key Program for Basic Research of China(Grant No 2004CB619004-1)the National Natural Science Foundation of China(Grant No 10474121)
文摘Tt-phase electron-doped superconductor Pr1-xLaCexCuO4-δ（PLCCO） thin films are successfully prepared on SrTiOs （100） substrates by using the dc magnetron sputtering method. It is found that the films each have a highly oriented structure along the c-axis. For optimally doped films with x ≈ 0.10, the superconducting transition temperature Tc is 25.5 K, which is similar to that of a single crystal. The quadratic temperature dependence of the resistivity is observed when T 〉 To, which can be attributed to the two-dimensional Fermi liquid behaviour. Besides, the optimal conditions for preparing the T1-phase PLCCO thin films are also discussed in detail.
基金supported by the National Natural Science Foundation of China (Grant No.10674019)
文摘The improvement on the calculation of anti-Stokes energy transfer rate is studied in the present work. The additional proportion coefficient between Stokes and anti-Stokes light intensities of quantum Raman scattering theory as compared with the classical Raman theory is introduced to successfully describe the anti-Stokes energy transfer. The theoretical formula for the improvement on the calculation of anti-Stokes energy transfer rate is derived for the first time in this study. The correctness of introducing coefficient exp{△E/kT} from well-known Raman scatter theory is demonstrated also. Moreover, the experimental lifetime measurement in Er0.01YbxY1-0.01-xVO4 crystal is performed to justify the validity of our important improvement in the original phonon-assisted energy transfer theory for the first time.
文摘With the largest population in the world,the Asia-Pacific area is in a great need for the fundamentalresearch of visual sciences,the protection of vision and the prevention and treatment of visual diseases.The Symposium will open a new era of the academic exchanges in the field of visual sciences in thisarea.It also will enhance the academic exchanges of visual sciences worldwide.
