探讨在急性非穿孔阑尾炎治疗中采用内镜逆行阑尾炎治疗术(ERAT)的临床疗效

目的内镜逆行阑尾炎治疗术(ERAT)在急性非穿孔阑尾炎治疗中的应用。方法 按照研究的安排,要选择50名患有急性非穿孔阑尾炎的病患,再将他们等分为两组。实验组接受ERAT的治疗,对照组进行传统手术治疗。结果 两组患者的治疗有效率、手术指标、并发症率以及促炎因子水平比对结果(P<0.05)。结论 ERAT能在急性非穿孔阑尾炎患者治疗中发挥积极作用。

Study on Matching a 300 MVA Motor Generator with an Ohmic Heating Power Supply in HL-2M

A new 300 MVA/1350 MJ motor generator （MG） will be built to feed all of the poloidal field power supplies （PFPS） and auxiliary heating power supplies of the HL-2M tokamak. The MG has a vertical-shaft salient pole 6-phase synchronous generator and a coaxial 8500 kW induction motor. The Ohmic heating power supply （OHPS） consisting of 4-quadrant DC pulsed convertor is the one with the highest parameters among the PFPS. Therefore, the match between the generator and the OHPS is very important. The matching study with Matlab/Simulink is described in this paper. The simulation results show that the subtransient reactance of the generator is closely related to the inversion operation of the OHPS. By setting various subtransient reactance in the simulation generator model and considering the cost reduction, the optimized parameters are obtained as xd＂ = 0.405 p.u. at 100 Hz for the generator. The models built in the simulation can be used as an important tool for studying the dynamic characteristics and the control strategy of other HL-2M PFPSes.

Multilinear Commutators of Sublinear Operators on Triebel-Lizorkin Spaces

In this sublinear operators paper, the boundedness of multilinear commutators related to with Lipschitz function on Triebel-Lizorkin spaces is given. As an application, we prove that the multilinear commutators of Littlewood-Paley operator and Bochner-Riesz operator are bounded on Triebel-Lizorkin spaces.

New 3-mode bosonic operator realization of SU(2) Lie algebra:From the point of view of squeezing

We consider the quantum mechanical SU（2） transformation e^2λJzJ±e^-2λJz = e^±2λJ±as if the meaning of squeezing with e^±2λ being squeezing parameter. By studying SU（2） operators （J±, Jz） from the point of view of squeezing we find that （J±,Jz） can also be realized in terms of 3-mode bosonic operators. Employing this realization, we find the natural representation （the eigenvectors of J＋ or J-） of the 3-mode squeezing operator e^2λJz. The idea of considering quantum SU（2） transformation as if squeezing is liable for us to obtain the new bosonic operator realization of SU（2） and new squeezing operators.

Extended optimal guidance law with impact angle and acceleration constriants

The extended optima straints of miss distance and Schwartz inequality. To reduce guidance law with terminal conmpact angle is derived by the terminal acceleration and eliminate gravity disturbance absolutely, the object function, which designs the weight of control command to be the power function of time-to-go＇s reciprocal, is given. And the gravity is considered when building the state equation. Based on the parsing express of the guidance command change with varying time and adjoint system analysis method, the command characteristics and the non-dimensional miss distance of the guidance law are analyzed, a design principle of guidance order coefficients is discussed. Finally, based on the requirement of engineering, the method to calculate the guidance condition and maximal required acceleration of the guidance law is given. The simulation demonstrates that not only the guidance law can satisfy the terminal position and impact angle constraints, but also the terminal acceleration can be converged toward zero, which will support a good situation for the terminal angle of attacking control.

Structure and regeneration status of Komto Afromontane moist forest, East Wollega Zone, west Ethiopia

We conducted a study in Komto Forest in East WoUega Zone, Oromia National Regional State, West Ethiopia for determining vegetation structure and regeneration status in this forest. We systematically sampled 53 quadrats （20 m ×20 m） along line transects radiating from the peak of Komto Mountain in eight directions. Vegetation parameters such as DBH, height, seedling and sapling density of woody species, and location and altitude of each quadrat were recorded. In total, 103 woody plant species of 87 genera and 45 families were identified. Analysis of selected tree species revealed different population structures. Generally, the forest was dominated by small trees and shrubs characteristic of secondary regeneration. Observations on the regeneration of the forest indicated that there are woody species that require urgent conservation measures. Based on the results of this study, we recommend detailed ecological studies of various environmental factors such as soil type and properties, and ethnobotanical studies to explore indigenous knowledge on uses of plants.

Synergistic Suppressive Effect of PARP-1 Inhibitor PJ34 and HDAC Inhibitor SAHA on Proliferation of Liver Cancer Cells

Summary： Poly （ADP-ribose） polymerase-1 （PARP-1） inhibitors and histone deacetylase （HDAC） in- hibitors have recently emerged as promising anticancer drugs. The aim of this study was to investigate the effect of combination treatment with the PARP inhibitor P J34 and HDAC inhibitor SAHA on the proliferation of liver cancer cells. Cell proliferation and apoptosis were assessed in three human liver cancer cell lines （HepG2, Hep3B and HCC-LM3） treated with PJ34 （8 μmol/L） and SAHA （1 panol/L）, alone or combined, by Cell Counting Kit-8 assay and flow cytometry, respectively. The nude mice bear- ing subcutaneous HepG2 tumors were administered different groups of drugs （10 mg/kg PJ34, 25 mg/kg SAHA, 10 mg/kg PJ34＋25 mg/kg SAHA）, and the inhibition rates of tumor growth were compared between groups. The results showed that combined use of P J34 and SAHA could synergistically inhibit the proliferation of liver cancer cell lines HepG2, Hep3B and HCC-LM3. The apoptosis rate of HepG2 cells treated with PJ34＋SAHA was significantly higher than that of HepG2 cells treated with PJ34 or SAHA alone （P〈0.05）. In vivo, the tumor inhibition rates were 53.5%, 61.4% and 82.6% in PJ34, SAHA and PJ34＋SAHA groups, respectively. The combined use of PJ34 and SAHA could significantly inhibit the xenograft tumor growth when compared with use of P J34 or SAHA alone （P〈0.05）. It was led to conclude that P J34 and SAHA can synergistically suppress the proliferation of liver cancer cells.

WEIGHTED COMPOSITION OPERATORS BETWEEN DIRICHLET SPACES

In this article, we study the boundedness of weighted composition operators between different vector-valued Dirichlet spaces. Some sufficient and necessary conditions for such operators to be bounded are obtained exactly, which are different completely from the scalar-valued case. As applications, we show that these vector-valued Dirichlet spaces are different counterparts of the classical scalar-valued Dirichlet space and characterize the boundedness of multiplication operators between these different spaces.

Regulatory Effects of AT1R-TRAF6-MAPKs Signaling on Proliferation of Intermittent Hypoxia-induced Human Umbilical Vein Endothelial Cells

Summary： Endothelial dysfunction induced by intermittent hypoxia （IH） participates in obstructive sleep apnea syndrome （OSAS）-associated cardiovascular disorders. Myeloid differentiation primary response 88 （MyD88） and tumor necrosis factor receptor-associated factor 6 （TRAF6） regulate nu- merous downstream adaptors like mitogen-activated protein kinases （MAPKs） and the subsequent oxidative stress and inflammatory responses. This study aimed to characterize the role of MyD88/TRAF6 in IH-treated cell function and its associated signaling. Human umbilical vein endo- thelial cells （HUVECs） were randomly exposed to IH or normoxia for 0, 2, 4 and 6 h. Western blot- ting was used to detect the expression pattern of target gene proteins [angiotensin 1 receptor （AT1R）, p-ERK1/2, p-p38MAPK, MyD88 and TRAF6], and the relationships among these target genes down-regulated by the corresponding inhibitors were studied. Finally, the influence of these target genes on proliferation of HUVECs was also assessed by EdU analysis. Protein levels of AT1R, TRAF6 and p-ERK1/2 were increased after IH exposure, with a slight rise in MyD88 and a dynamic change in p-p38MAPK. The down-regulation of TRAF6 by siRNA reduced ERK1/2 phosphorylation during IH without any effects on ATIR. Blockade of AT1R with valsartan decreased TRAF6 and p-ERK1/2 protein expression after IH exposure. ERK1/2 inhibition with PD98059 suppressed only AT1R expression. IH promoted HUVECs proliferation, which was significantly suppressed by the in- hibition of TRAF6, AT1R and ERK1/2. The findings demonstrate that TRAF6 regulates the prolifera- tion of HUVECs exposed to short-term IH by modulating cell signaling involving ERK1/2 down- stream of AT1R. Targeting the AT1R-TRAF6-p-ERK1/2 signaling pathway might be helpful in re- storing endothelial function.

CERTAIN SUBCLASS OF p-VALENT MEROMORPHIC ANALYTIC FUNCTIONS INVOLVING CERTAIN INTEGRAL OPERATOR

The purpose of the present paper is to introduce a new subclass of p-valent meromorphic functions by using certain integral operator and to investigate various properties for this subclass.

Boundedness of Commutators Generated by Campanato-type Functions and Riesz Transforms Associated with Schrdinger Operators

Abstract： Let L=-△＋V be a SchrSdinger operator on Rn, n 〉 3, where △ is the Laplacian on Rn and V ≠ 0 is a nonnegative function satisfying the reverse HSlder＇s inequality. Let [b, T] be the commutator generated by the Campanatotype function b ∈∧Lβ and the Riesz transform associated with SchrSdinger operator T =△↓（-△ ＋ V）-1/2. In the paper, we establish the boundedness of [b, T] on Lebesgue spaces and Campanato-type spaces.

POTENTIAL OPERATORS AND LAPLACE TYPE MULTIPLIERS ASSOCIATED WITH THE TWISTED LAPLACIAN

We study potential operators and,more generally,Laplace-Stieltjes and Laplace type multipliers associated with the twisted Laplacian.We characterize those 1 ≤ p,q ≤ ∞,for which the potential operators are Lp—Lq bounded.This result is a sharp analogue of the classical Hardy-Littlewood-Sobolev fractional integration theorem in the context of special Hermite expansions.We also investigate Lp mapping properties of the Laplace-Stieltjes and Laplace type multipliers.

China,America Have Coo[erated in Micro Biological Production Test

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Synthetically engineered microbes reveal interesting principles of cooperation

Cooperation is ubiquitous in biological sys- tems. However, if natural selection favors traits that confer an advantage to one individual over another, then helping others would be paradoxical. Nevertheless, cooperation persists and is critical in maintaining homeostasis in systems ranging from populations of bacteria to groupings of mammals. Developing an understanding of the dynamics and mechanisms by which cooperation operates is critical in understanding ecological and evolutionary relationships. Over the past decade, synthetic biology has emerged as a powerful tool to study social dynamics. By engineering rationally controlled and modulatable beha- vior into microbes, we have increased our overall under- standing of how cooperation enhances, or conversely constrains, populations. Furthermore, it has increased our understanding of how cooperation is maintained within populations, which may provide a useful framework to influence populations by altering cooperation. As many bacterial pathogens require cooperation to infect the host and survive, the principles developed using synthetic biology offer promise of developing novel tools and strategies to treat infections, which may reduce the use of antimicrobial agents. Overall, the use of engineered cooperative microbes has allowed the field to verify existing, and develop novel, theories that may govern cooperative behaviors at all levels of biology.

Regeneration of critical-sized defects, in a goat model, using a dextrin-based hydrogel associated with granular synthetic bone substitute

The development of injectable bone substitutes(IBS)have obtained great importance in the bone re-generation field,as a strategy to reach hardly accessible defects using minimally invasive techniques and able to fit to irregular topographies.In this scenario,the association of injectable hydrogels and bone graft granules is emerging as a well-established trend.Particularly,in situ forming hydrogels have arisen as a new IBS generation.An in situ forming and injectable dextrin-based hydrogel(HG)was developed,aiming to act as a carrier of granular bone substitutes and bioactive agents.In this work,the HG was associated to a granular bone substitute(Bonelike)and implanted in goat critical-sized calvarial defects(14mm)for 3,6 and 12weeks.The results showed that HG improved the han-dling properties of the Bonelike granules and did not affect its osteoconductive features,neither impairing the bone regener ation process.Human multipotent mesenchymal stromal cells from the umbilical cord,extracellular matrix hydrolysates and the pro-angiogenic peptide LLKKK18 were also combined with the IBS.These bioactive agents did not enhance the new bone formation significantly under the conditions tested,according to micro-computed tomography and histological analysis.

内镜下逆行阑尾治疗术(ERAT)治疗单纯性阑尾炎的疗效及安全性

目的探究与分析内镜下逆行阑尾治疗术(ERAT)治疗单纯性阑尾炎的疗效及安全性.方法选取江油市第二人民医院自2017年4月-2019年4月收治的单纯性阑尾炎患者40例,采取随机数字表法分为内镜组与腹腔镜组,每组各20例,内镜组行内镜下逆行阑尾治疗术,腹腔镜组行腹腔镜阑尾切除术,对比两组围术期指标及并发症、手术前后炎症因子水平、随访1年复发率.结果内镜组与腹腔镜组相比,手术时间短、住院天数短、下床活动时间短、体温恢复正常时间短、白细胞恢复正常时间短,组间差异具有统计学意义(P<0.05).两组手术后与手术前相比,血清IL-6、PCT、TNF-α、CRP水平均较高,内镜组手术后与腹腔镜组手术后相比,血清IL-6、PCT、TNF-α、CRP水平均较低,组间差异具有统计学意义(P<0.05).内镜组与腹腔镜组相比,并发症发生率及随访1年复发率无明显差异(P>0.05).结论ERAT治疗单纯性阑尾炎的围术期指标更好,不容易引起严重的炎症反应,未增加并发症发生率及复发率,安全性有保证.

两种内镜逆行阑尾炎治疗术的临床应用效果比较

目的比较两种内镜逆行阑尾炎治疗术(ERAT)在急性非复杂性阑尾炎治疗中的应用效果。方法选取2021年1月-2023年6月该院收治的急性非复杂性阑尾炎患者100例,随机分为直视组(50例)和对照组(50例)。对照组采用常规ERAT,直视组采用EyeMax洞察胆胰成像系统辅助ERAT,比较两组患者手术时间、阑尾插管时间、阑尾插管成功率、腹痛缓解时间、体温恢复正常时间、白细胞恢复正常时间、住院时间和手术并发症发生率。结果直视组阑尾插管时间为(5.43±3.51)min,短于对照组的(8.76±5.43)min,直视组手术时间为(45.50±10.65)min,短于对照组的(54.32±13.45)min,差异均有统计学意义(P=0.000);两组患者插管成功率、复发率、腹痛缓解时间、体温恢复正常时间、白细胞恢复正常时间、住院天数和并发症发生率比较,差异均无统计学意义(P>0.05)。结论EyeMax洞察胆胰成像系统辅助ERAT,能缩短阑尾插管时间和手术时间,且不增加手术并发症,避免了患者和医护人员受到辐射,安全有效,值得临床推广。

内镜逆行阑尾炎治疗术治疗急性阑尾炎的研究现状及进展

内镜逆行阑尾炎治疗术(endoscopic retrograde appendicitis therapy,ERAT)是由我国刘冰熔教授于2012年首次在国际上提出。ERAT治疗急性阑尾炎同时保留了完整的阑尾,是一种简便、无创的内镜下治疗急性阑尾炎的新技术。本文主要阐述ERAT发展至今的研究现状以及进展。

军用作战软件敏捷研发模式与启示

军事软件敏捷能力交付将成为未来体系对抗博弈的新战场。首先,归纳了军用作战软件研发特点,提出了军用作战软件敏捷研发的3种参考模型以及能力评估框架;然后,分析了美军军用作战软件敏捷研发模式的发展情况与趋势;最后,将软件工厂视为敏捷研发模式的落地实践,提出了相关参考架构、敏捷研发能力评估和启示,并对军用软件敏捷研发关键技术进行了总结。