Erythroplasia of Queyrat (EQ) is Squamous cell carcinoma in situ of penis usually involving glans and prepuce, commonly found in uncircumcised men with progression into invasive carcinoma in about 30% of cases. We pre...Erythroplasia of Queyrat (EQ) is Squamous cell carcinoma in situ of penis usually involving glans and prepuce, commonly found in uncircumcised men with progression into invasive carcinoma in about 30% of cases. We present a case of 50 yrs, male with reddish, Irritative rash on glans penis;HPE confirms the case of EQ with acanthosis, derangement of stratum spinosum and basement membrane integrity. It successfully treated with two cycle of Photo Dynamic Therapy (PDT). If conservative approach with immquimod, fluorouracil fails then invasive approach should be adopted.展开更多
Mucinous metaplasia of the squamous epithelium of the glans penis is very rarely seen in the setting of Zoon’s balanitis. We report a case of 40 year old male with a past medical history of paroxysmal nocturnal hemog...Mucinous metaplasia of the squamous epithelium of the glans penis is very rarely seen in the setting of Zoon’s balanitis. We report a case of 40 year old male with a past medical history of paroxysmal nocturnal hemoglobinuria, status-post allogeneic hematopoietic cell transplantation from an HLA-matched sibling 6 years prior to evaluation, complicated by oral and cutaneous chronic graft-versus-host disease. Mucinous metaplasia was confirmed by PAS and Mucin stains, and plasmacytosis was confirmed by immunohistochemistry for CD138 and MUM1 markers. Kappa and Lambda immunostains revealed a polyclonal pattern. The etiology of zoon’s balanitis as well as the significance of mucinous metaplasia in these setting are unclear and need to be further investigated.展开更多
文摘Erythroplasia of Queyrat (EQ) is Squamous cell carcinoma in situ of penis usually involving glans and prepuce, commonly found in uncircumcised men with progression into invasive carcinoma in about 30% of cases. We present a case of 50 yrs, male with reddish, Irritative rash on glans penis;HPE confirms the case of EQ with acanthosis, derangement of stratum spinosum and basement membrane integrity. It successfully treated with two cycle of Photo Dynamic Therapy (PDT). If conservative approach with immquimod, fluorouracil fails then invasive approach should be adopted.
文摘Mucinous metaplasia of the squamous epithelium of the glans penis is very rarely seen in the setting of Zoon’s balanitis. We report a case of 40 year old male with a past medical history of paroxysmal nocturnal hemoglobinuria, status-post allogeneic hematopoietic cell transplantation from an HLA-matched sibling 6 years prior to evaluation, complicated by oral and cutaneous chronic graft-versus-host disease. Mucinous metaplasia was confirmed by PAS and Mucin stains, and plasmacytosis was confirmed by immunohistochemistry for CD138 and MUM1 markers. Kappa and Lambda immunostains revealed a polyclonal pattern. The etiology of zoon’s balanitis as well as the significance of mucinous metaplasia in these setting are unclear and need to be further investigated.
