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Platelet indices as predictors of poor glucoregulation in type 2 diabetes mellitus adults at Bishoftu General Hospital,Ethiopia
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作者 Dereje Abebe Regassa Gebeyaw Arega Berihun +3 位作者 Bisrat Fikadu Habtu Woyesa Beyene Haile Rahel Shumi Nagaash Girum Tesfaye Kiya 《World Journal of Diabetes》 SCIE 2024年第9期1889-1902,共14页
BACKGROUND Diabetes is a chronic metabolic syndrome that has become a global public health problem with significant morbidity and mortality.It is a pro-inflammatory and pro-thrombotic condition characterized by increa... BACKGROUND Diabetes is a chronic metabolic syndrome that has become a global public health problem with significant morbidity and mortality.It is a pro-inflammatory and pro-thrombotic condition characterized by increased platelet activation and alterations in platelet indices.However,the use of platelet indices as predictors of poor glucoregulation has not been fully evaluated in this context,and evidence for their role as predictors of poor glycemic status in diabetic patients is limited.AIM To evaluate platelet indices and determine their prognostic significance in relation to inadequate glucoregulation among individuals diagnosed with type 2 diabetes at Bishoftu General Hospital in Ethiopia,from June 15 to August 12,2022.METHODS A comparative cross-sectional study was conducted in 261 participants including 174 individuals with type 2 diabetes mellitus(T2DM)and 87 non-diabetic controls.The systematic random sampling technique was used to select participants.Data were collected using structured questionnaires,physical measurements,checklists,and laboratory tests.Platelet parameters and fasting blood glucose levels were determined from blood samples using Sysmex-XN550 and CobasC311 analyzers,respectively.The hematology analyzer output was checked and participants were also screened for malaria parasites using a prepared blood smear.Collected data were entered into Epi-data version 3.1 and exported to SPSS version 25 for analysis.Theχ^(2) test,Mann-Whitney U test,Kruskal-Wallis test,post hoc test,Spearman correlation,and receiver operating characteristic curve were used for analysis.A P value<0.05 was considered statistically significant.RESULTS The results of our study indicate that diabetic patients have significantly higher levels of platelet distribution width(PDW),mean platelet volume(MPV),platelet large cell ratio(PLCR),and plateletcrit(PCT)compared to healthy individuals(P<0.001).Furthermore,these indices were found to be significantly elevated in individuals with poor glycemic control in T2DM compared to those with good glycemic control and healthy controls.We also observed significant correlations between these indices and various anthropometric and clinical variables.Our findings suggest that PDW,with a cut-off value of 15.75 fL and an area under the curve(AUC)of 0.803,MPV,with a cut-off value of 12.25 fL and an AUC of 0.774,PLCR,with a cut-off value of 36.3%and an AUC of 0.775,and PCT,with a cut-off value of 0.24%and an AUC of 0.761,can serve as predictors of poor glycemic control in patients with diabetes mellitus.CONCLUSION The observed correlation between diabetic patients and a significant increase in platelet indices has highlighted their potential as predictors of poor glycemic control in diabetes.Therefore,regular screening and profiling of platelet indices is recommended as part of the follow-up process for individuals with diabetes mellitus. 展开更多
关键词 Platelet indices Type 2 diabetes mellitus CONTROLS ADULT ethiopia
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Does community-based health insurance affect lifestyle and timing of treatment seeking behavior?Evidence from Ethiopia
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作者 Zecharias Fetene Anteneh Anagaw D.Mebratie +2 位作者 Zemzem Shigute Getnet Alemu Arjun S.Bedi 《Global Health Journal》 2024年第2期83-90,共8页
Objectives This paper aims to investigate the effects of enrollment in the Ethiopian community-based health insurance(CBHI)scheme on household preventive care activities and the timing of treatment-seeking behavior fo... Objectives This paper aims to investigate the effects of enrollment in the Ethiopian community-based health insurance(CBHI)scheme on household preventive care activities and the timing of treatment-seeking behavior for illness symptoms.There is growing concern about the financial sustainability of CBHI schemes in developing countries.However,few empirical studies have identified potential contributors,including ex-ante and ex-post moral hazards.Methods We implement a household fixed-effect panel data regression model,drawing on three rounds of household survey data collected face to face in districts where CBHI scheme is operational and in districts where it is not operational in Ethiopia.Results The findings show that enrolment in CBHI does not significantly influence household behaviour regarding preventive care activities such as water treatment before drinking and handwashing before meals.However,CBHI significantly increases delay in treatment-seeking behaviour for diseases symptoms.Particularly,on average,we estimate about 4-6 h delay for malaria symptoms,a little above 4 h for tetanus,and 10-11 h for tuberculosis among the insured households.Conclusions While there is evidence that CBHI improve the utilization of outpatient or primary care services,our study suggests that insured members may wait longer before visiting health facilities.This delay could be partly due to moral hazard problems,as insured households,particularly those from rural areas,may consider the opportunity costs associated with visiting health facilities for minor symptoms.Overall,it is essential to identify the primary causes of delays in seeking medical services and implement appropriate interventions to encourage insured individuals to seek early medical attention. 展开更多
关键词 Community-based health insurance Financial sustainability Preventive care Treatment-seeking behavior Household fixed effect ethiopia
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Diagnostic significance of complete blood cell count and hemogramderived markers for neonatal sepsis at Southwest Public Hospitals,Ethiopia
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作者 Dereje Abebe Regassa Rahel Shumi Nagaash +1 位作者 Bisirat Fikadu Habtu Woyesa Beyene Haile 《World Journal of Clinical Pediatrics》 2024年第2期114-126,共13页
BACKGROUND Neonatal sepsis is defined as an infection-related condition characterized by signs and symptoms of bacteremia within the first month of life.It is the leading cause of mortality and morbidity among newborn... BACKGROUND Neonatal sepsis is defined as an infection-related condition characterized by signs and symptoms of bacteremia within the first month of life.It is the leading cause of mortality and morbidity among newborns.While several studies have been conducted in other parts of world to assess the usefulness of complete blood count parameters and hemogram-derived markers as early screening tools for neonatal sepsis,the associations between sepsis and its complications with these blood parameters are still being investigated in our setting and are not yet part of routine practice.AIM To evaluate the diagnostic significance of complete blood cell count hemogramderived novel markers for neonatal sepsis among neonates attending public hospitals in the southwest region of Oromia,Ethiopia,through a case control study.METHODS A case control study was conducted from October 2021 to October 2023 Sociodemographic,clinical history,and laboratory test results data were collected using structured questionnaires.The collected data were entered into Epi-data 3.1 version and exported to SPSS-25 for analysis.Chi-square,independent sample ttest,and receiver operator characteristics curve of curve were used for analysis.A P-value of less than 0.05 was considered statistically significant.RESULTS In this study,significant increases were observed in the following values in the case group compared to the control group:In white blood cell(WBC)count,neutrophils,monocyte,mean platelet volume(MPV),neutrophils to lymphocyte ratio,monocyte to lymphocyte ratio(MLR),red blood cell width to platelet count ratio(RPR),red blood width coefficient variation,MPV to RPR,and platelet to lymphocyte ratio.Regarding MLR,a cut-off value of≥0.26 was found,with a sensitivity of 68%,a specificity of 95%,a positive predictive value(PPV)of 93.2%,and a negative predictive value(NPV)of 74.8%.The area under the curve(AUC)was 0.828(P<0.001).For WBC,a cutoff value of≥11.42 was identified,with a sensitivity of 55%,a specificity of 89%,a PPV of 83.3%,and a NPV of 66.4%.The AUC was 0.81(P<0.001).Neutrophils had a sensitivity of 67%,a specificity of 81%,a PPV of 77.9%,and a NPV of 71.1%.The AUC was 0.801,with a cut-off value of≥6.76(P=0.001).These results indicate that they were excellent predictors of neonatal sepsis diagnosis.CONCLUSION The findings of our study suggest that certain hematological parameters and hemogram-derived markers may have a potential role in the diagnosis of neonatal sepsis. 展开更多
关键词 Complete blood count Hemogram-derived marker NEONATE SEPSIS ethiopia
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Time to recovery from severe pneumonia and its predictors among pediatric patients admitted in Mizan-Tepi University Teaching Hospital,South West Ethiopia,2022
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作者 Belete Fenta Kebede Aynalem Yetwale Hiwot +2 位作者 Tsegaw Biyazin Tesfa Yalemtsehay Dagnaw Genie Nigatu Dessalegn Mulu 《Frontiers of Nursing》 2024年第3期343-353,共11页
Objective:Despite trials and programs for the prevention of childhood mortality due to pneumonia,Ethiopia is among the top five countries with the highest number of deaths due to pneumonia.Although the prevalence of p... Objective:Despite trials and programs for the prevention of childhood mortality due to pneumonia,Ethiopia is among the top five countries with the highest number of deaths due to pneumonia.Although the prevalence of pneumonia has increased in the abovementioned trials,little is known about the recovery time from severe pneumonia and its predictors in the study area.Therefore,this study aimed to assess the time to recovery from severe pneumonia and its predictors among pediatric patients admitted to Mizan-Tepi University Teaching Hospital,Ethiopia,in 2022.Methods:A total of 591 children admitted for severe pneumonia were selected using simple random sampling.Data were entered into Epi-data version 4.4.2.1 and expor ted to STATA version 14 for analysis,and the assumptions of Cox propor tional hazard models and goodness of fit were assessed through Shoenfeld residual and Cox-Snell residual,respectively.Bivariate and multivariable Cox regression models were used to identify the predictors of mor tality.Results:This study revealed that 91.54%(95%confidence interval[CI]:89.00–93.53)of participants recovered with an incidence rate of 24.10(95%CI:22.15–26.21)per 100 person-day–observations.The hmedian recovery time of children was 4 days(95%CI:2–6).Children who were not exclusively breastfed(AHR=1.3;95%CI:1.03–1.66),who had a history of inability to suck/feed(AHR=0.81;95%CI:0.65–0.99)were independent predictors of the time to recovery.Conclusions:Children with severe pneumonia who had not exclusively breastfed and who had a history of inability to suck/feed were independent predictors of time to recovery.Therefore,all stakeholders and concerned health care providers should focus more on early diagnosis and management and hasten early recovery based on the identified factors. 展开更多
关键词 Mizan-Tepi University Teaching Hospital pediatric patients PREDICTORS severe pneumonia Southwest ethiopia time to recovery
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Antibacterial activities of selected medicinal plants in traditional treatment of human wounds in Ethiopia 被引量:13
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作者 Biruhalem Taye Mirutse Giday +1 位作者 Abebe Animut Jemal Seid 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2011年第5期370-375,共6页
Objective:To evaluate the activity of selected Ethiopian medicinal plants traditionally used for wound treatment against wound-causing bacteria.Methods:Samples of medicinal plants(Achyranthes aspera,Brucea antidysente... Objective:To evaluate the activity of selected Ethiopian medicinal plants traditionally used for wound treatment against wound-causing bacteria.Methods:Samples of medicinal plants(Achyranthes aspera,Brucea antidysenteriea,Datura stramonium,Croton macrostachyus,Acokanthera xchimperi.,Phytolacca dodecandra,Milhttia ferruginea,and Solanum incanum)were extracted using absolute methanol and water and tested for their antimicrobial activities against clinical isolates and standard strains of wound-causing bacteria using agar well diffusion and micro titer plate methods.Results:Most of the plant extracts had antibacterial activities,among which Acokanthera schimperi and Brucea antidysenteriea inhibited growth of 100%and 35%of the test organisms,respectively.Methanolic extracts had higher activities compared with their corresponding aqueous extracts.The most susceptible organism to the extracts was Streptococcus pyogens while the most resistant were Escherichia coli and Proteus vulgaris.Conclusions:This finding justifies the use of the plants in wound healing and their potential activity against woundcausing bacteria.Their toxicity level and antimicrobial activity with different extraction solvents should further be studied to use them as sources and templates for the synthesis of drugs to control wound and other disease-causing bacteria. 展开更多
关键词 Antibacterial activity MEDICINAL plants HUMAN WOUNDS ethiopia AGAR well diffusion Micro TITER plate Plant EXTRACTS
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Mineralogical and petrographic analysis on the flake graphite ore from Saba Boru area in Ethiopia 被引量:16
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作者 Allah D.Jara Girma Woldetinsae +1 位作者 Amha Betemariam Jung Yong Kim 《International Journal of Mining Science and Technology》 SCIE EI CSCD 2020年第5期715-721,共7页
The mineralogy and petrography of natural graphite in Saba Boru of Ethiopia indicate that there exists flake graphite with a slightly oval structured fine size according to our study on thin and polished sections.Here... The mineralogy and petrography of natural graphite in Saba Boru of Ethiopia indicate that there exists flake graphite with a slightly oval structured fine size according to our study on thin and polished sections.Herein,for estimating the carbon content in graphite,the ASTM-C561,the test method for ash in a graphite sample,was used.For characterizing graphite,x-ray diffraction,x-ray fluorescence,inductively coupled plasma mass spectroscopy,and scanning electron microscopy were also used.Chemical analysis of ore samples determined that the average compositions are 63.35%SiO2,15.45%Al2O3,2.36%Fe2O3,2.07%K2O,less than1%others,and loss-on-ignition(LOI)in the range of^4.74%–37.42%.The total carbon content of graphitic ore ranged from 4.11%to 33.14%.Importantly,when graphite is concentrated through floatation,its average purity and recovery are 92.97%and 90.82%,respectively.Furthermore,once the graphite concentrates are treated with hydrofluoric acid,the average value attains a high grade of 96.48%C.Moreover,the average ash content is 81.93%(pre-flotation)and 3.1%(post-flotation),respectively.Finally,after beneficiation,a silica is identified as a major gangue(85.88%),usable as a raw material for other purposes such as cement.Hence,these graphite-bearing rocks seem to be worth exploring for commercialization opportunities. 展开更多
关键词 MINERALOGY PETROGRAPHY Flake graphite FLOTATION Saba Boru ethiopia
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Opportunistic and other intestinal parasites among HIV/AIDS patients attending Gambi higher clinic in Bahir Dar city,North West Ethiopia 被引量:5
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作者 Abebe Alemu Yitayal Shiferaw +2 位作者 Gebeyaw Getnet Aregaw Yalew Zelalem Addis 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2011年第8期661-665,共5页
Objective:To determine the magnitude of opportunistic and non-opportunistic intestinal parasitic infections among HTV/AIDS patients in Bahir Dar.Methods:Cross-sectional study was conducted among HIV/ AIDS patients att... Objective:To determine the magnitude of opportunistic and non-opportunistic intestinal parasitic infections among HTV/AIDS patients in Bahir Dar.Methods:Cross-sectional study was conducted among HIV/ AIDS patients attending Gambi higher clinic from Aprill- May 30,2009. Convenient sampling technique was employed to identify the study subjects and hence a total of 248 subjects were included.A pre-tested structured questionnaire was used to collect sociodemographic data of patients.Stool samples were examined by direct saline,iodine wet mount, formol-ether sedimentation concentration and modified Ziehl-Neelsen staining technique. Results:Out of 248 enrolled in the study,171(69.0%)(90 males and 81 females) were infected with one or more intestinal parasites.The highest rate of intestinal parasites were observed among HIV/AIDS patients(80.3%,151/188),and the infection rate of HIV negative individuals was 33.3%(20/60).Cryptosporidum parvum(43.6%),Isospora belli(15.5%) and Blastocystis hominis (10.5%) were opportunistic parasites that were found only in HIV/AIDS patients.Conclusions: Opportunistic parasite infections are common health problem among HIV/ AIDS patients in the study area.Therefore,early detection and treatment of these parasites are important to improve the quality of life of HIV/AIDS patients. 展开更多
关键词 OPPORTUNISTIC parasites Non-opportunistic parasites HIV/AIDS ethiopia
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Influence of topographic aspect on floristic diversity, structure and treeline of afromontane cloud forests in the Bale Mountains,Ethiopia 被引量:4
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作者 Eshetu Yirdaw Mike Starr +1 位作者 Mesele Negash Fantaw Yimer 《Journal of Forestry Research》 SCIE CAS CSCD 2015年第4期919-931,共13页
We studied the influence of east and west aspects on floristic composition, diversity, structure and treeline of afromontane cloud forests at Rira in the Bale Mountains, southeast Ethiopia. In addition, we studied how... We studied the influence of east and west aspects on floristic composition, diversity, structure and treeline of afromontane cloud forests at Rira in the Bale Mountains, southeast Ethiopia. In addition, we studied how aspect relates to and/or interacts with other topographic and edaphic factors in influencing vegetation diversity. Strati- fied systematic plot sampling was used to survey the floristic composition, diversity and structure of forests on east- and west-facing slopes. The sample plot size was 20 x 20 m and a total of 36 plots were inventoried. A total of 72 composite soil samples were collected and analysed. Woody species richness of the forest on the east-facing slope was 1.7 times higher than on the west-facing slope. Shannon, Simpson and Log-series alpha diversity indices and evenness of forests on the east-facing slope were sig- nificantly higher than on the west-facing slope. NMDS ordination indicated that the east- and west-facing slopes formed two clusters of species and aspect explained 55.2 % and 10.4 % of the variation in species richness and abun- dance, respectively. There was no significant difference between aspects in stand structure except in dominantheight, which was higher on the east-facing slopes. There was significant interaction between aspect and elevation in influencing woody species diversity. The four plant com- munity groups, which were identified using cluster and indicator species analysis were represented differently on the east and west aspects. The treeline on the east-facing slope (3352 m) was located about 110 m higher than on the west-facing slope (3240 m). Soil moisture deficiency was unlikely to be a limiting factor on either site. Near the equator, east-west aspect was shown to have considerable impact on floristic composition, diversity, structure, and treeline position of montane forests. Diurnal cloud move- ment patterns and its impact on microclimate of slope aspect should be taken into account in future studies of cloud forest diversity, structure, and treeline position. 展开更多
关键词 AFROMONTANE ASPECT Cloud forests ethiopia Floristic diversity
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Optimal parameter selection for qualitative regional erosion risk monitoring:A remote sensing study of SE Ethiopia 被引量:4
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作者 Moncef Bouaziz Mathias Leidig Richard Gloaguen 《Geoscience Frontiers》 SCIE CAS 2011年第2期237-245,共9页
Arid and semi-arid regions are susceptible to high levels of erosion. A rapid and cost effective methodological erosion assessment for these regions is required to describe and monitor the processes that control erosi... Arid and semi-arid regions are susceptible to high levels of erosion. A rapid and cost effective methodological erosion assessment for these regions is required to describe and monitor the processes that control erosion. This study uses remote sensing to describe the contribution of several factors that control erosion. Topography, land use, vegetation density, soil properties and climatic proxies are used to determine erosion risk and to provide basic maps of water and soil conservation practices. A hierarchical decision tree is used to sum and combine the weight of parameters controlling the erosion. The assigned weights of each spatial unit express the susceptibility to erosion. We focus on the catchment basin of the Maleka Wakena reservoir, located in the southeastern portion of the main Ethiopian Rift, where erosion is the major environmental problem. Three different combinations of the dominant controlling factors are yielded in this study. In order to optimize the qualitative erosion risk assessment, each combination is discussed and evaluated depending on the contribution of parameters involved in the erosion process. 展开更多
关键词 Erosion risk Remote sensing MODELING Geographic informationsystem (GIS) ethiopia
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Antimicrobial susceptibility patterns of Streptococcus pneumoniae over 6 years at Gondar University Hospital, Northwest Ethiopia 被引量:3
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作者 Belay Anagaw Mucheye Gezachew +7 位作者 Fantahun Biadgelgene Berhanu Anagaw Tariku Geleshe Birke Taddese Birhanu Getie Mengistu Endris Andargachew Mulu Chandrashekhar Unakal 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2013年第7期536-541,共6页
Objective:To assess the magnitude and antimicrobial susceptibility patterns ofStreptococcus pneumoniaeisolates from various clinical specimens.Methods:A record based on retrospectivestudy was conducted at Gondar Unive... Objective:To assess the magnitude and antimicrobial susceptibility patterns ofStreptococcus pneumoniaeisolates from various clinical specimens.Methods:A record based on retrospectivestudy was conducted at Gondar University Teaching Hospital from September 2007 to January 2012.All patients who visited Gondar University Hospital and provided clinical specimens(body fluids,discharge,swab and blood)for routine bacteriological culturing and antimicrobial susceptibilitytesting were taken for analysis.Clinical specimens were processed for bacterial culture accordingto the standard procedures.Antimicrobial susceptibility test for isolated organisms was doneusing agar disk diffusion method.The data were entered and analyzed using SPSS software version16 package.Results:One hundred and fifty threeStreptococcus pneumoniaewere isolated frompatients who visited Gondar University Teaching Hospital bacteriology laboratory for culture.Majority of the pneumococcal isolates were from inpatients[111(72.5%)],and 74(48.4%)were frombody fluids.Out of the total isolates,93(61%)were found to be resistant to at least one antibioticused for susceptibility testing.Forty eight(43.2%)of the isolates were multi-drug resistant(resistantto two or more drugs).The resistance rate noted for both ciprofloxacin 17(11.1%)and ceftriaxone15(9.8%)were alarming.Conclusions:High proportions of the isolates tend to be increasinglyresistant to the commonly prescribed drugs.The recommended drug of choice like ciprofloxacinand ceftriaxone were found to be less susceptible in the study area.Based on the findings,wetherefore recommend that antimicrobial agents should be inspected for acceptable activity beforethey are prescribed and administered empirically.Further study with a better design and surveyof antimicrobial susceptibility at large scale shoule be performed to draw advanced information. 展开更多
关键词 STREPTOCOCCUS PNEUMONIAE ANTIMICROBIAL agents SUSCEPTIBILITY PATTERNS Gondar ethiopia
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Phenotypic diversity in Ethiopian durum wheat(Triticum turgidum var.durum)landraces 被引量:3
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作者 Dejene K.Mengistu Afeworki Y.Kiros Mario E.Pè 《The Crop Journal》 SCIE CAS CSCD 2015年第3期190-199,共10页
The phenotypic diversity of 274 Ethiopian durum wheat accessions was analyzed, taking their geographic origins into account. The aim was to assess the extent and patterns of agronomically important phenotypic variatio... The phenotypic diversity of 274 Ethiopian durum wheat accessions was analyzed, taking their geographic origins into account. The aim was to assess the extent and patterns of agronomically important phenotypic variation across districts of origin and altitude classes for major qualitative traits using diversity index and multivariate methods. Eight qualitative and three quantitative traits were scored for 2740 plants and analyzed for diversity. The Shannon–Weaver diversity(H′) index was used to estimate phenotypic diversity. The estimated H′ ranged from monomorphic for glume hairiness to highly polymorphic for other traits. The highest(0.86) H′ was obtained for seed degree of shriveling, possibly indicating the differential responses of the genotypes to water deficit during later growth stages. With respect to district of origin, the highest(0.72) and lowest(0.44) H′ values were obtained for the Bale and SNNP districts, respectively. With respect to altitude, the highest(0.76) and lowest(0.62) H′ values were recorded for altitudes 1600–2000and > 3000 m above sea levels, respectively. Principal components analysis explained substantial variation contributed by district of origin and altitude range. Genotypes were clustered into three groups by districts of origin and altitude class, with relatively strong bootstrap values of 57 and 62 for the former and latter, respectively. It could be concluded that Ethiopian durum wheat landraces are very diverse both within and among districts of origin and altitude classes. This wealth of genetic diversity should be exploited for wheat improvement of yield and for resistance to biotic and abiotic stresses, particularly terminal drought. 展开更多
关键词 PHENOTYPIC DIVERSITY DIVERSITY index LANDRACES DISTRICTS of origin Altitude ethiopia
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Efficacy and side effects of praziquantel in the treatment of Schistosomiasis mansoni in schoolchildren in Shesha Kekele Elementary School,Wondo Genet,Southern Ethiopia 被引量:3
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作者 Berhanu Erko Abraham Degarege +2 位作者 Konjit Tadesse Asnake Mathiwos Mengistu Legesse 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2012年第3期235-239,共5页
Objective:To evaluate the efficacy and side effects of praziquantel(PZQ) in the treatment of schistosomiasis in Ethiopia.Methods:In a cross-sectional study,stool specimens were collected from randomly selected 299 sch... Objective:To evaluate the efficacy and side effects of praziquantel(PZQ) in the treatment of schistosomiasis in Ethiopia.Methods:In a cross-sectional study,stool specimens were collected from randomly selected 299 school children in Shesha Kekele Elementary School,Wondo Genet, Southern Ethiopia,in April 2010.Stool specimens were examined using a single Kato-Katz thick smear for Schistosoma mansoni(5.mansoni) ova.Children who were found positive for S.mansoni were treated with a single oral dose of PZQ at 40 mg/kg bw and interviewed for treatment-related symptoms 24 hours after drug administration.Four weeks post-treatment,stool specimens were collected from the same children and examined following the same procedure as in the pretreatment.Drug efficacy was determined based on cure and egg reduction rates.Results:Pretreatment prevalence of S.mansoni infection was 74.9%with geometric mean egg count of 268. The evaluated generic PZQ produced an overall cure rate of 73.6%(P<0.000 1,OR:8.33,CI:5.3-13.1) and egg reduction rate of 68.2%(P=0.03,F=0.64).The cure rate showed significant association with age(x^2=H,P=0.004),the highest rate being observed in the 15-22 age group.83%of S. mansoni infected children showed various treatment-related symptoms,the most frerjiient being headache,nausea,and abdominal pain.These symptoms were associated with age(P<0.001) and pre-treatment intensity of infection(P<0.05).Conclusions:The present observations revealed relatively lower cure and egg reduction rates of the PZQ evaluated as compared to previous reports for other PZQ brands in Ethiopia.Hence,in depth studies are recommended to clarify whether the present relatively lower cure rate is the actual cure rate of the praziquantel evaluated,treatment failure,or reduced susceptibility of the parasite.Treatment-related side effects observed were transient and tolerable. 展开更多
关键词 EFFICACY PRAZIQUANTEL SCHISTOSOMA MANSONI ethiopia Schistosomiasis Thick smear Prevalence Infection Susceptibility Parasite SCHOOLCHILDREN Side effect Drug EFFICACY Egg reduction
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Impact of exclosures on wood biomass production and fuelwood supply in northern Ethiopia 被引量:2
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作者 Wolde Mekuria Mastewal Yami +2 位作者 Mitiku Haile Kindeya Gebrehiwot Emiru Birhane 《Journal of Forestry Research》 SCIE CAS CSCD 2019年第2期629-637,共9页
In the Ethiopian highlands, communal grazing lands are one of the major land uses, and are source of livelihood for the rural people. Free and uncontrolled grazing in the communal grazing lands is the dominant grazing... In the Ethiopian highlands, communal grazing lands are one of the major land uses, and are source of livelihood for the rural people. Free and uncontrolled grazing in the communal grazing lands is the dominant grazing system. The traditional uncontrolled and free grazing system has caused severe degradation of the grazing lands. As a result, communities have started to establish exclosures and support the restoration of degraded communal grazing lands. Studies have shown that exclosures are effective to restoring degraded communal grazing lands and improving ecosystem services. However, studies that investigate the changes in aboveground biomass following the establishment of exclosures and compare it with fuelwood demand of the beneficiaries in our study area is lacking. Therefore, our study aimed at:(1) quantifying yearly biomass accumulation in exclosures and compare it to fuelwood demand of households that manage the exclosures;(2) assessing household energy sources and their consumption levels. To monitor changes in biomass production with over time, replicated(n = 3) 5 and10 year-old exclosures were sampled. To investigate fuelwood sources and consumption patterns, household surveys, key informant interviews and focus group discussion were conducted. Our results demonstrated that total biomass production increased with exclosure age. In both exclosure, biomass production from Vachellia etbaica was significantly(p \ 0.05) greater than that from Euclea.racemosa. Average daily fuelwood consumption per person was(0.63 ± 0.2) kg day^(-1). This means that the total biomass(27.5 Mg year^(-1)) obtained from 114.6 ha of exclosures covers only 9.4% of yearly fuelwood demand of the residents who manage the sampled exclosures. Nearly all respondents(95%) confirmed that they travel more than10 km day^(-1) to gather fuelwood from surrounding degraded forest patches. We recommend plantings of fast growing native tree species within exclosures and around homesteads to provide a sustainable fuelwood supply and using improved stoves to address the problem of fuelwood shortage. District agricultural offices could provide seedlings of native plant species, while communities provide unpaid labour for planting and managing plantations. 展开更多
关键词 BIOMASS ethiopia EXCLOSURES Fuel WOOD Tigray WOODY SPECIES
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Association of ABO blood group and Plasmodium falciparum malaria in Dore Bafeno Area,Southern Ethiopia 被引量:10
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作者 Tewodros Zerihun Abraham Degarege Berhanu Erko 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2011年第4期289-294,共6页
Objective:To assess the distribution of ABO blood group and their relationship with Plasmodium falciparum(P.falciparum) malaria among febrile outpatients who sought medical attention at Dore Bafeno Health Center,South... Objective:To assess the distribution of ABO blood group and their relationship with Plasmodium falciparum(P.falciparum) malaria among febrile outpatients who sought medical attention at Dore Bafeno Health Center,Southern Ethiopia.Methods:A total of 269 febrile outpatients who visited Dore Bafeno Health Center,Southern Ethiopia,were examined for malaria and also tested for ABO blood groups in January 2010.The blood specimens were collected by finger pricking,stained with Geimsa,and examined microscopically.Positive cases of the parasitemia were counted.CareStart^(TM) Malaria PflPv Combo was also used to test the blood specimens for malaria.ABO blood groups were determined by agglutination test using ERYCLONE antisera.Data on socio-demographic characteristics and treatment status of the participants were also collected.Chi-square and ANOVA tests were used to assess the difference between frequencies and means,respectively.Results:Out of a total of 269 participants,178(66.2%) febrile patients were found to be infected with Plasmodium parasites,among which 146(54.3%),28(10.4%),and 4(1.5%) belonged to P.falciparum,P.vivax,and mixed infections,respectively.All febrile patients were also tested for ABO blood groups and 51.3%,23.5%,21.9%and 3.3%were found to be blood types of 0,A,B and AB,respectively.Both total malaria infection and P.falciparum infection showed significant association with blood types(P<0.05).The proportion of A or B but not 0 phenotypes was higher(P<0.05) in individuals with P.falciparum as compared with non-infected individuals.The chance of having P.falciparum infection in patients with blood groups A,B and AB was 2.5,2.5 and 3.3times more than individuals showing blood 0 phenotypes,respectively.The mean P.falciparum malaria parasitemia for blood groups A,B,AB,and 0 were 3 744/μ L,1 805/ μ L,5 331/μ L,and1 515/μ L,respectively(P<0.01).Conclusions:The present findings indicate that individuals of blood groups A,B and AB are more susceptible to P.falciparum infection as compared with individuals of blood group O.Nevertheless,further in depth studies are required to clearly establish the role that ABO blood group plays in P.falciparum malaria. 展开更多
关键词 Plasmodium falciparum malaria ABO blood groups ethiopia Febrile outpatient PARASITEMIA ASSOCIATION Blood specimen Geimsa CareStart^(TM) Malaria Pf/Pv Combo ERYCLONE antisera Plasmodium parasite Malaria infection Distribution Agglutination test Plasmodium vivax
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Ethiopian vegetation types,climate and topography 被引量:3
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作者 Mengesha Asefa Min Cao +3 位作者 Yunyun He Ewuketu Mekonnen Xiaoyang Song Jie Yang 《Plant Diversity》 SCIE CAS CSCD 2020年第4期302-311,共10页
Ethiopia is land of geographical contrasts with elevations that range from 125 m below sea level in the Danakil Depression to 4533 m above sea level in the Semien Mountains,a world heritage site.The diverse climate of... Ethiopia is land of geographical contrasts with elevations that range from 125 m below sea level in the Danakil Depression to 4533 m above sea level in the Semien Mountains,a world heritage site.The diverse climate of various ecological regions of the country has driven the establishment of diverse vegetation,which range from Afroalpine vegetation in the mountains to the arid and semi-arid vegetation type in the lowlands.The formation of Ethiopian vegetation is highly connected to the climate and geological history of the country.Highland uplift and rift formation due to volcanic forces formed novel habitats with different topography and climatic conditions that have ultimately become drivers for vegetation diversification.Due to Ethiopia's connection with the temperate biome in the north and the Arabian Peninsula during the dry glacial period,the biotic assemblage of Ethiopian highlands consists of both Afrotropical and palearctic biota.In general,eight distinct vegetation types have been identified in Ethiopia,based mainly on elevation and climate gradients.These vegetation types host their own unique species,but also share several common species.Some of the vegetation types are identified as centers of endemism and have subsequently been identified globally as the East African Afromontane hotspot.Ethiopia is biologically rich,with more than 6500 vascular plant species.Of these species,12%are endemic mainly due to geographical isolation and unique climatic conditions.However,researchers have yet to extensively investigate the ecology,phenology,as well as the evolutionary,genetics,and conservation status of Ethiopian vegetations at community and species level over space and time.This lack of research is a barrier to achieving the goal of zero global plant extinctions.Taxa extinction risk assessment has not been extensively carried out for majority of Ethiopian species.Detailed research is needed to explore how vegetation and species respond to rapidly growing environmental change.Currently,human-induced climate change and habitat fragmentation are severely threatening the country's biodiversity,and the consequences of these effects have not been studied at large.Furthermore,we still lack scientific evidence on how micro-and macro-ecological and evolutionary processes have been shaping vegetation structures in this climatically,topographically,and geologically diverse country.These gaps in our knowledge represent an opportunity for ecologists,geneticists,evolutionary biologists,conservation biologists,and other experts to investigate the biodiversity status and the complex ecological processes involved in structuring vegetation dynamics so as to help take effective conservation actions. 展开更多
关键词 ELEVATION BIODIVERSITY CLIMATE ethiopia Vegetation types TOPOGRAPHY
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Analysis of vulnerability and resilience to climate change induced shocks in North Shewa, Ethiopia 被引量:5
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作者 Gutu Tesso Bezabih Emana Mengistu Ketema 《Agricultural Sciences》 2012年第6期871-888,共18页
This article analyzes the vulnerability and resilience levels of farm households in North Shewa, Ethiopia, using a survey of 452 households. Agro ecological based classification was done to analyze vulnerability to cl... This article analyzes the vulnerability and resilience levels of farm households in North Shewa, Ethiopia, using a survey of 452 households. Agro ecological based classification was done to analyze vulnerability to climate change induced shocks. Integrated vulnerability analysis approach was employed to develop indexes for socioeconomic and biophysical indicators. The indicators have been classified into adaptive capacity, exposure and sensitivity to climate change impact. Then Principal Component Analysis was used to compute vulnerability index of each agro ecological zone. The result shows that farmers living in the highland areas were very much vulnerable to natural shocks compared to those living in the lowland area. In order to identify and analyse the determinants of resilience to climate change impacts, ordered probit model was used. Households were classified into three categories based on the time they take to bounce back after natural shocks. The model outputs indicate that farmers with better investment on natural resource management, access to market, better social network, access to credit, preparedness, saving liquid assets, access to irrigation and better level of education exhibited greater level of resilience during and after climate change induced shocks. 展开更多
关键词 Climate change VULNERABILITY RESILIENCE Principal Component ANALYSIS ORDERED PROBIT ethiopia
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Efficiency of soil and water conservation practices in different agro-ecological environments in the Upper Blue Nile Basin of Ethiopia 被引量:2
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作者 Dagnenet SULTAN Atsushi TSUNEKAWA +7 位作者 Nigussie HAREGEWEYN Enyew ADGO Mitsuru TSUBO Derege T MESHESHA Tsugiyuki MASUNAGA Dagnachew AKLOG Ayele A FENTA Kindiye EBABU 《Journal of Arid Land》 SCIE CSCD 2018年第2期249-263,共15页
In developing countries such as Ethiopia, research to develop and promote soil and water conservation practices rarely addressed regional diversity. Using a water-balance approach in this study, we used runoff plots f... In developing countries such as Ethiopia, research to develop and promote soil and water conservation practices rarely addressed regional diversity. Using a water-balance approach in this study, we used runoff plots from three sites, each representing a different agro-ecological environment, e.g., high, mid and low in both elevation and rainfall, in the Upper Blue Nile Basin of Ethiopia to examine the runoff response and runoff conservation efficiency of a range of different soil and water conservation measures and their impacts on soil moisture. The plots at each site represented common land use types(cultivated vs. non-agricultural land use types) and slopes(gentle and steep). Seasonal runoff from control plots in the highlands ranged 214–560 versus 253–475 mm at midlands and 119–200 mm at lowlands. The three soil and water conservation techniques applied in cultivated land increased runoff conservation efficiency by 32% to 51%, depending on the site. At the moist subtropical site in a highland region, soil and water conservation increased soil moisture enough to potentially cause waterlogging, which was absent at the lowrainfall sites. Soil bunds combined with Vetiveria zizanioides grass in cultivated land and short trenches in grassland conserved the most runoff(51% and 55%, respectively). Runoff responses showed high spatial variation within and between land use types, causing high variation in soil and water conservation efficiency. Our results highlight the need to understand the role of the agro-ecological environment in the success of soil and water conservation measures to control runoff and hydrological dynamics. This understanding will support policy development to promote the adoption of suitable techniques that can be tested at other locations with similar soil, climatic, and topographic conditions. 展开更多
关键词 AGRO-ECOLOGY drought-prone runoff coefficient runoff conservation efficiency ethiopia
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Impact of climate-smart agricultural technology on multidimensional poverty in rural Ethiopia 被引量:3
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作者 Tsegaye Mulugeta HABTEWOLD 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2021年第4期1021-1041,共21页
A large body of empirical literature showed that the adoption of agricultural technologies reduces poverty. However, dominants of those studies so far used one-dimensional income or expenditure-based measures of pover... A large body of empirical literature showed that the adoption of agricultural technologies reduces poverty. However, dominants of those studies so far used one-dimensional income or expenditure-based measures of poverty which may not reflect other types of deprivations. Therefore, the major objective of this study is to examine the impact of adopting climate-smart agricultural technology, which refers to a joint application of row planting methods and the use of chemical fertilizers, on the multidimensional poverty status of rural households in Ethiopia. To estimate the impact of the stated technologies, this study employs propensity score matching and endogenous switching regression methods. To measure the multidimensional poverty index, the study also uses the Alkire and Foster counting approach. Using the Ethiopian Socioeconomic Survey(ESS), collected in 2015-Wave 3, the results of the study show that the adoption of these technologies reduces deprivation score and one of its component, the standard of living part. Regionally, a high reduction in deprivation is observed in Amhara and Oromiya regions. The results also show that the impact is significantly higher in severely deprived households. It is also observed that the reduction in multidimensional poverty due to the technology is through an increase in income/consumption via improvement in production gain. The impact channels more through the non-food expenditure pathway. Finally, this study also sheds light on the effects that technology adoption has on multidimensional poverty reduction. 展开更多
关键词 multidimensional poverty rural poverty technology adoption poverty reduction poverty pathways ethiopia
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Characterizing Vulnerability of Crop-Based Rural Systems to Climate Change and Variability: Agro-Ecology Specific Empirical Evidence from the Dabus Watershed, North-West Ethiopia 被引量:3
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作者 Paulos Asrat Belay Simane 《American Journal of Climate Change》 2017年第4期643-667,共25页
Climate change is impacting climate sensitive rural livelihood systems. Exposure, sensitivity, and adaptive capacity of agricultural livelihoods to climate variability and change differ across agro-ecologies and these... Climate change is impacting climate sensitive rural livelihood systems. Exposure, sensitivity, and adaptive capacity of agricultural livelihoods to climate variability and change differ across agro-ecologies and these pose a challenge to climate resilient development strategy. This study assesses agro-ecology specific vulnerability of smallholder farmers to climate change and variability in the Dabus Watershed (North-west Ethiopia), based on a survey of 734 farm households complemented with focus group discussion and key informant interviews. Recognizing the physiographic and climatic diversity that exists across agro-ecologies in the study area, Livelihood Vulnerability Index (LVI) framed within the United Nations Intergovernmental Panel on Climate Change (IPCC) vulnerability framework (LVI-IPCC) is adapted to assess agro-ecology specific vulnerability in two local agro-ecologies, namely wet lowland and dry lowland. For each agro-ecology, exposure, sensitivity and adaptive capacity indices as well as LVI-IPCC vulnerability score was calculated. The result shows that the dry lowland agro-ecology has a relatively higher exposure and sensitivity to climate stresses with a comparatively limited adaptive capability. On the other hand, the wet lowland agro-ecology exhibits intermediate vulnerability with a relatively lower perceived exposure and higher adaptive capacity. Higher exposure relative to adaptive capacity resulted in a positive LVI-IPCC score in the dry lowland agro-ecology and positioned it in more vulnerable level than the wet lowland. A higher adaptive capacity relative to exposure unveils a negative LVI-IPCC score for the wet lowland agro-ecology and positioned it in a moderate vulnerability category. In line with the findings, there is a need to set agro-ecology specific priorities for intervention that is most needed to cop up with the effects of climate variability and change in each agro-ecology. Climate risk exposure levels can be reduced through timely provision of climate specific information and early warning systems aimed at enhancing preparedness of farm households to extreme events. It is also crucial to expand availability of infrastructural facilities such as market, health services, and veterinary services so as to enhance adaptive capacity. Supporting alternative livelihood options and enhancing water harvesting practices for supplementary irrigation also call policy attention. 展开更多
关键词 ethiopia Climate Change Exposure Sensitivity Adaptive Capacity VULNERABILITY AGRO-ECOLOGY
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Prevalence of diarrhea and associated risk factors among children under-five years of age in Eastern Ethiopia: A cross-sectional study 被引量:2
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作者 Bezatu Mengistie Yemane Berhane Alemayehu Worku 《Open Journal of Preventive Medicine》 2013年第7期446-453,共8页
Diarrhea remains a major cause of mortality in children under 5 years of age in Sub-Saharan countries in Africa. Risk factors for diarrhea vary by context and have important implications for developing appropriate str... Diarrhea remains a major cause of mortality in children under 5 years of age in Sub-Saharan countries in Africa. Risk factors for diarrhea vary by context and have important implications for developing appropriate strategies to reduce the burden of the disease. The objective of this study was to assess the prevalence of diarrhea and associated risk factors among children un-der 5 years of age in Kersa district, located in Eastern Ethiopia. A community-based cross-sectional study was conducted among 1456 randomly selected households with at least one child under 5 years of age. A questionnaire and an observational check list were used for col-lecting information on socio-economic charac-teristics, environmental hygiene and behavioral practices, and occurrence of diarrhea among children under 5 years of age. Logistic regres-sion was used to calculate the adjusted odds ratio of 95% confidence interval. The two-week prevalence of diarrhea among children under 5 years of age was 22.5% (95% CI: 20.3-24.6). Improper refuse disposal practices (OR = 2.22, 95% CI: 1.20-4.03), lack of hand washing facilities (OR = 1.92, 95%CI: 1.29-2.86), living in rural area (OR = 1.81, 95% CI: 1.12-3.31), the presence of two or more siblings in a household (OR = 1.74, 95% CI: 1.33-2.28), and age of the child (OR= 2.25, 95% CI;1.5-3.36) were the major risk factors for diarrhea. This study demonstrated that diarrhea morbidity was relatively high among children under 5 years of age residing in Eastern Ethiopia. Efforts to reduce childhood diarrhea should focus on improving household sanitation, personal hygiene, and child birth spacing. 展开更多
关键词 DIARRHEA Risk Factor CHILDREN under 5 YEARS ethiopia CROSS-SECTIONAL Study HYGIENE
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