In this study, we investigated whether increases in hippocampal blood flow (HBF) by tooth pulp stimulation (TPS) are mediated via the activation of cyclooxygenase-2 (COX-2). We measured mean arterial blood pressure (M...In this study, we investigated whether increases in hippocampal blood flow (HBF) by tooth pulp stimulation (TPS) are mediated via the activation of cyclooxygenase-2 (COX-2). We measured mean arterial blood pressure (MABP) and HBF in urethane-anesthetized rats using laser Doppler flowmetry and examined the effects of etodolac, a specific COX-2 inhibitor, on TPS-induced MABP and HBF responses. The MABP response was not attenuated by the intraperitoneal (i.p.) administration of etodolac (10 mg/kg);however, the HBF response was significantly attenuated by etodolac administration. These results suggest that COX-2 may be involved in the mechanisms regulating TPS-induced HBF responses.展开更多
制备了依托度酸和哌嗪的有机盐,并得到了其晶体结构。结构解析结果表明,依托度酸羧基上的氢转移到哌嗪的氮原子上,N H O氢键是维持结构稳定的主要分子间相互作用。与原药相比,新合成的盐的本征溶出速率和平衡溶解度分别提高了2.1倍和4....制备了依托度酸和哌嗪的有机盐,并得到了其晶体结构。结构解析结果表明,依托度酸羧基上的氢转移到哌嗪的氮原子上,N H O氢键是维持结构稳定的主要分子间相互作用。与原药相比,新合成的盐的本征溶出速率和平衡溶解度分别提高了2.1倍和4.8倍。此外,新合成的盐具有良好的水合稳定性,在25℃,相对湿度95%的条件下暴露28 d未发生相变。作为依托度酸的第一个有机盐,该盐是依托度酸有前景的固体存在形式。展开更多
文摘In this study, we investigated whether increases in hippocampal blood flow (HBF) by tooth pulp stimulation (TPS) are mediated via the activation of cyclooxygenase-2 (COX-2). We measured mean arterial blood pressure (MABP) and HBF in urethane-anesthetized rats using laser Doppler flowmetry and examined the effects of etodolac, a specific COX-2 inhibitor, on TPS-induced MABP and HBF responses. The MABP response was not attenuated by the intraperitoneal (i.p.) administration of etodolac (10 mg/kg);however, the HBF response was significantly attenuated by etodolac administration. These results suggest that COX-2 may be involved in the mechanisms regulating TPS-induced HBF responses.
文摘制备了依托度酸和哌嗪的有机盐,并得到了其晶体结构。结构解析结果表明,依托度酸羧基上的氢转移到哌嗪的氮原子上,N H O氢键是维持结构稳定的主要分子间相互作用。与原药相比,新合成的盐的本征溶出速率和平衡溶解度分别提高了2.1倍和4.8倍。此外,新合成的盐具有良好的水合稳定性,在25℃,相对湿度95%的条件下暴露28 d未发生相变。作为依托度酸的第一个有机盐,该盐是依托度酸有前景的固体存在形式。
