雷公藤生物碱合成物EUONINE的质谱鉴定

本文阐述了具有免疫活性的雷公藤生物碱euonine的高分辨质谱特性,精确测定了分子量,并推演了裂解机理。

Partial Synthesis of Macrolide Alkaloid Euonine

The macrolide alkaloid euonine 1 with pharmacologic activity was prepared from the alkaloid wilforgine 2. Their structures were confirmed by IR, NMR, MS and optical rotation.

THE CRYSTAL AND MOLECULAR STRUCTURE OF EUONINE

I. INTRODUCTIONTwo sesquiterpene alkaloids were isolated from the root skin of Tripterygium Wilfordii Hook. f. by Deng Fu-xiao et al., and named euonine (Ⅰ) and wilfomine (Ⅱ), respectively. They show immunosuppressives after their pharmacological activities were studied by Zheng You-lan et al. The other alkaloids, from Tripterygium Wilfordii Hook.

雷公藤倍半萜生物碱的研究

目的 研究雷公藤 (TripterygiumwilfordiiHook .f .)的化学成分。 方法 应用各种色谱技术进行分离纯化 ,用UV ,IR ,MS ,HRMS ,1HNMR ,13CNMR(COM和OFR) ,1H 1HCOSY ,1H 13CCOSY ,2D NOESY ,1H 13CCOLOC鉴定化合物。并进行初步的药理实验。结果 分离并鉴定了 2个生物碱 :euonine (I)和雷公藤康碱 (IIwilfordconine)。结论 II为一种新的倍半萜生物碱 ,药理实验证明该生物碱有免疫抑制活性 。