Prevalence and Factors Associated with Dry Eyes Syndrome in Glaucomatous Patients on Anti-Glaucoma Eye Drops Followed up at the Garoua Regional Hospital-Northern Cameroon

Background: Dry eye and glaucoma are two common pathologies in the elderly, and are very often associated. This association suggests a link between them and between their treatments. Our purpose for this study is to determine the prevalence of dry eye in our glaucoma patients treated with eye drops and deduce the factors associated with it. Patients and Methods: We conducted a cross-sectional, analytical study from October 2022 to September 2023 in the ophthalmology department of Garoua Regional Hospital in glaucoma patients aged over 15 years able to answer the Ocular Surface Disease Index (OSDI) questionnaires and treated with antiglaucoma eye drops for more than 3 months. These patients underwent a complete ophthalmological examination and a tear film break-up time test. Results: A total of 73 patients (146 eyes) were examined. The average age of the patients was 47.2 ± 16.5 years, with a male predominance of 54.8%. The prevalence of dry eye syndrome in our patients according to the OSDI score was 56.2% (95% CI) (44.8;67.6). The prevalence of dry eye syndrome on clinical examination of the BUT in the right eye was 83.7% (95% CI) (75.1;92.1) and 79.4% (70.2;88.7) in the left eye. The duration of antiglaucoma treatment was the factor associated with dry eye syndrome (p < 0.05) in glaucoma patients in our setting. Conclusion: Dry Eye Syndrome is common in glaucoma patients on drops in our setting. Treatment duration of more than 1 year seems to be associated with dry eyes.

Knowledge, Attitude, and Practices Regarding Diabetic Eye Disease among General Population in Medina City, Saudi Arabia

Background: Diabetic eye disease is known as a group of eye problems that diabetic patients may develop as a complication of diabetes and can lead to blindness. They may include Diabetic retinopathy (DR), Cataracts, and Glaucoma. Objectives: This study aims to assess the knowledge, attitude, and practices (KAP) around diabetic eye disease in the general population including patients with DM and non-diabetic people in Medina City, Saudi Arabia. Methods: This is a cross-sectional study involving 385 participants via a self-administered online Questionnaire started in January 2023 in Medina, Saudi Arabia. Results: In total, 339 participants with ages ranged from 18 to more than 60 years with a mean age of 26.8 ± 12.6 years old completed the questionnaire. The majority were females (74.6%), singles (67.8%), and had a university level of education (54.6%). Most of the study participants were found to have poor knowledge levels (67%) in comparison to 33% who had an overall good knowledge of diabetic eye diseases. Knowledge level was found to be higher among old-aged participants and those with a family history of DM (P = 0.001, P = 0.049) respectively. Regarding participants’ attitudes and practices, the study showed good attitudes toward eye care practice for diabetics with half of the participants (50%) reporting self-awareness as a reason that made them undergo the first eye screening. Conclusion: Participants in the present study have poor knowledge and awareness level of diabetic eye disease. Furthermore, positive attitudes and perceptions have been revealed by the participants toward the practice of providing eye care for diabetics. .

Pattern of Eye Diseases among Tea Workers

Background: Bangladesh’s tea industry is essential to the country’s economic expansion. Since tea workers in Bangladesh are marginalized within our community, they have limited access to comprehensive eye care services. Productivity and well-being are cornerstones of comprehensive health care strategy. Ocular disorders are influenced by life expectancy, sociodemographic status, and the epidemiological transition. In this context, the state of ocular health and the many eye illnesses remain to be significantly addressed. Purpose: To evaluate the pattern of eye diseases among tea workers in a tea estate of Bangladesh. Methods: This cross-sectional observational study was carried out in Halda Valley Tea Estate, Nazirhat, Fatickchari, Chattogram, Bangladesh, under the supervision of the Department of Community Ophthalmology, BSMMU, following ethical clearance and approval by the IRB board of BSMMU. With informed written consent and approval from the authority of the tea estate, a total of 110 tea workers were recruited. Socio-demographic characteristics, ocular findings, and patterns of eye diseases were determined and recorded. Results: The mean age of the study participants was 39.60 ± 11.63 years. The maximum (58.1%) study participants were 31 - 50 years old, female (64.5%), illiterate (82.7%), and tribal (71.8%) indigenes. Eye diseases were found in 94.5% of workers. Presbyopia (28.2%), cataracts (27.3%), and refractive error (26.4%) were the most common. Tea workers with eye diseases were significantly older than those who did not have any eye diseases (40.20 ± 11.57 vs. 29.17 ± 7.31 years, p Conclusion: A significant number of tea workers had eye diseases, of which presbyopia, cataracts, and refractive error were the most common.

Bilateral Retinal Nerve Fiber Layer Loss and Recovery with Teprotumumab in Thyroid Eye Disease

Background: Thyroid Eye Disease (TED) is known to alter tissues of the orbital cavity, including the optic nerve. However, its effect on measured global Retinal Nerve Fiber Layer (gRNFL) is not well elucidated. This case evaluates the effect of teprotumumab on gRNFL in a patient with moderate TED. Observations: A 60-year-old female with controlled ocular hypertension and moderate TED received 8 standard IV teprotumumab infusions. Comprehensive ocular evaluations were performed pre-, during-, and post-treatment. Bilateral gRNFL thickness decreased (10 m OD;12 m OS) at 4 months post-treatment start, persisting at 8 months, but recovered at 20 months. Conclusions and Importance: Teprotumumab treatment in patients with TED led to a transient bilateral decrease in gRNFL thickness, which was restored to baseline levels with no adverse events reported. Monitoring gRNFL changes in teprotumumab-treated patients is crucial as gRNFL thinning indicates retinal ganglion cell damage. Teprotumumabs ability to dampen the IGF-IR inflammatory cascade may have reduced retinal inflammation, leading to recovery.

基于光学相干断层扫描血管成像术探讨Eye-TEAS防治儿童近视疗效及作用机制

目的:基于光学相干断层扫描血管成像术(OCTA)探讨眼周经皮穴位电刺激仪(Eye-TEAS)防治儿童近视的疗效和机制。方法:纳入60名近视儿童,记录黄斑中心凹下脉络膜厚度(SFCT)等眼部各参数水平,并对各参数进行相关性分析;采用Eye-TEAS对受试者进行3个月的干预治疗,每天30 min,每周使用不低于5次。检测Eye-TEAS干预前、干预1次后、干预1个月后、干预3个月后受试者等效屈光度(SER)、眼轴长度(AL)、SFCT及黄斑区3 mm×3 mm面积内的脉络膜中大血管密度(CVD)、脉络膜毛细血管密度(CCVD)的变化情况。结果:58名近视儿童完成了干预及随访,在基线数据观察中,SER与SFCT、CCVD均呈显著正相关(P<0.01),AL与SER、SFCT、CVD、CCVD呈显著负相关(P<0.05或P<0.01)。相较于干预前,干预第1次后、1个月后、3个月后SER、AL均未发生显著变化(P>0.05)。干预第1次后SFCT与基线水平比较,差异无统计学意义(P>0.05)。干预1个月、3个月后SFCT与基线水平比较,差异均有统计学意义(P<0.05),其中干预1个月后SER变化和SFCT变化呈显著正相关(P<0.05)。在干预第1次、干预1个月后CVD较基线水平增加(P<0.05),但干预3个月后CVD与基线水平比较,差异无统计学意义(P>0.05)。相较于基线数据,干预1个月后和干预3个月后CCVD均显著升高(P<0.01)。结论:近视儿童SFCT、眼底微循环情况与AL、SER具有高度相关性;Eye-TEAS干预后SFCT显著增厚,CVD、CCVD也显著增加,这可能与Eye-TEAS通过影响脉络膜血流的变化减缓近视的进展有关。

Eye Movement Modeling Examples as a Teaching Tool for Epidural Block

Introduction: Video examples with task demonstrations by experts, with the expert’s eye movements superimposed on the task, are known as “eye movement modeling examples” (EMME). We performed this study to evaluate if there were improvements in the performance of anesthesia novice trainees when executing the epidural technique after an EMME of epidural block procedure. Methods: We developed an eye movement modeling example (EMME) from eye tracking recordings made by experienced anesthesiologists with more than 20 years of experience. Forty-two PGY3 anesthesia trainees who had never previously performed an epidural block were randomized to receive (study group) or not receive (control group) the EMME video before their institutional training. All the trainees were evaluated every 10 epidural blocks until the end of the rotation period, by an independent, blinded observer using the Global Rating Scale for Epidural Anesthesia (GRS). Results: Trainees who received the EMME training exhibited more respect for the patient’s tissues (P Discussion: This is the first study that has used the EMME for a practical, clinical teaching purpose on real patients and that has used it as an aid in teaching epidural anesthesia. We demonstrated that inexperienced trainees who received the EMME training improved their proficiency at epidural blocks as compared to those who had no EMME training beforehand. Given this result, we welcome further studies to investigate the impact and the role of EMME on clinical teaching in the field of anesthesia.

基于双目eye in hand系统的多角度树干位姿估计方法

针对采摘机器人自主行走导航过程中,难以准确定位其与果树之间的相对位置,难以准确估计果树树干姿态的问题,提出基于双目eye in hand系统的多角度树干位姿估计方法。利用YOLOv5深度学习方法与半全局块匹配算法识别树干并生成局部点云;利用半径滤波和体素滤波减少树干点云数据;利用闭环式手眼标定方法对双目eye in hand系统进行标定,并对同一树干多角度相机位置的点云数据进行拼接;利用随机抽样一致(RANSAC)算法与无约束最小二乘法估计并优化树干的位置和姿态,获取树干的圆柱体参数。通过对30幅标定板图像进行实验,闭环式手眼标定方法的平均欧式误差为3.7177 mm;采用半径滤波和体素滤波可减少98.470%的点云数据;采用RANSAC算法、圆柱体估计算法拟合树干点云数据,得到圆柱体的半径r=41.2771 mm,R_(MAE)=2.57156 mm,R_(RMSE)=2.98936 mm;无约束最小二乘法优化后r=39.4028 mm,R_(MAE)=1.98955 mm,R_(RMSE)=2.46588 mm。该文通过对双目eye in hand系统进行标定,建立坐标系转换关系,多角度采集环境信息,准确定位机器人与果树之间的相对位置,估计果树树干的姿态。

Effect of Cadmium on the Developmental Instability of Anabas testudineus through Evaluation of Fluctuating Asymmetry of Eye Diameter

Biomonitoring using fish has been a popular method of assessing the toxic effects of cadmium concentrations of cadmium in water bodies and has led to bioaccumulation in fish contributing to various morphological alterations. Among the known effects of these alterations is developmental instability via fluctuating asymmetry (FA). The utilization of FA data is a simple yet effective method to evaluate the toxic effects of cadmium on the stability of development. This study used climbing perch (Anabas testudieneus) to assess the FA in the diameter of the eye because of low-level cadmium exposure. The left and right sides of the traits were measured once every four weeks for 16 weeks. The average measurements from both sides of the traits were used to calculate the FA value. Results found that the highest mean FA for the diameter of the eye was obtained in the highest treatment group, 0.015 mg/L. The results also indicate that increasing concentrations of cadmium exposure had a statistically significant effect on the FA of eye diameter. There was also a statistically significant interaction between the duration of exposure and treatment groups in FA of the diameter of the eye. The results from the study indicate that prolonged exposure to sub-lethal concentrations of cadmium can cause significant effects on the normal development of eyes in Anabas testudineus. This study can add to the body of research regarding fluctuating asymmetry as a tool to study developmental toxicants and assess other bilateral organs.

双发射EY@MIL-100(Sc)荧光传感器的制备及对硝基芳香化合物的检测性能研究

通过溶剂热法合成了均苯三甲酸钪配位聚合物[MIL-100(Sc)],并将染料曙红Y负载框架物成功构筑荧光传感器EY@MIL-100(Sc)。采用PXRD、红外表征了产物结构,研究了EY@MIL-100(Sc)的荧光性质,并识别检测水中硝基芳香化合物。结果表明:EY@MIL-100(Sc)对4-硝基苯酚(4-NP)的检测表现出高灵敏度和选择性,KSV为2.78×10^(4)L/mol,检测限为0.42μmol/L,且有良好的可回收性能。EY@MIL-100(Sc)荧光识别硝基芳香化合物的机理归属于光诱导电子转移和共振能量转移共同作用。

Self-Medication during Eye Affections among Consultant Patients at Chu-Iota

Introduction: According to the World Health Organization (WHO), self-medication consists in the fact that an individual resorts to a drug, on his own initiative or that of a loved one, with the aim of treating an ailment or a symptom that he identified himself without having recourse to a health professional. Self-medication involves the use of medicinal products by the consumer to treat self-recognized disorders or symptoms, or the intermittent or continued use of a medication prescribed by a physician for chronic or recurring diseases or symptoms. The aim of this study is to determine the different characteristics of ophthalmic self-medication at the CHU-IOTA. Patients and Method: We conducted a prospective study in patients of any age who resorted to ophthalmological self-medication before the first consultation or during the ophthalmological care of consulting patients at the CHU-IOTA between January 1 and July 31, 2021. Results: Over the period, 521 cases of ophthalmological self-medication were collected out of a total of 24,512 consultations, which corresponds to a frequency of 2.12%. The average age was 37.7 years, [2 months - 78]. The sex ratio was 0.50. Economic factors were the main factor mentioned, 66.79%. Corticosteroids accounted for 45.26% of the pharmacological class with dexamethasone/neomycin eye drops being the most widely used, i.e. 22.94%. The most common complication was corticosteroid-induced ocular hypertension on ametropia, i.e. 15.54%. Our patients were 68.13% educated. Among his educated patients 53.35% had no knowledge of the products. Conclusion: Given the harm associated with this practice, awareness and information campaigns aimed at the population, caregivers and pharmacists or pharmacy vendors are necessary in order to reduce the frequency of the practice of self-medication.

Comparison of Anticancer Drug Preparation Techniques between Chemotherapy Specialist Pharmacists and Non-Chemotherapy Pharmacists Using Eye-Tracking Techniques

Anticancer drug preparation by pharmacists is a critical task directly related to medical incidents. This study examined the factors influencing medical errors in chemotherapy, that is, errors by specialist pharmacists (CPh) and pharmacists in other departments (NCPh), by measuring their gaze during the preparation of anticancer drugs. The eye-tracking results showed that the gazing time of NCPh was significantly longer than that of CPh for items such as “preparation of a closed-system device” and “preparation of the syringe” and all preparation times (P < 0.05). The NCPh were not assigned to prepare drugs on a regular basis, indicating their lack of familiarity with the process. There was no significant difference in gaze ratio between CPh and NCPh. This outcome was suggested to be a result of the use of an anticancer drug preparation support system. The results for the pupil diameter variation rate showed that NCPh were significantly more mydriatic in the “mixing injections” category than CPh. However, CPh tended to be more mydriatic in the “checking” category. CPh exhibited a smooth workflow and focused on the important items to be checked. This study showed that the differences in procedure flow and concentration points may lead to errors. Furthermore, the results are of interest from the perspective of medical incident prevention. They will be useful in identifying potential human factors, such as where the pharmacist focuses their attention by measuring eye movements.

APPLICATION OF GREY SYSTEM THEORY TO PROCESSING OF MEASURING DATA IN REVERSE ENGINEERING

The processing of measuri ng data plays an important role in reverse engineering. Based on grey system the ory, we first propose some methods to the processing of measuring data in revers e engineering. The measured data usually have some abnormalities. When the abnor mal data are eliminated by filtering, blanks are created. The grey generation an d GM(1,1) are used to create new data for these blanks. For the uneven data sequ en ce created by measuring error, the mean generation is used to smooth it and then the stepwise and smooth generations are used to improve the data sequence.

Scheimpflug Imaging of the Anterior Eye Segment during Standardized Accommodation Stimulation in Patients with Emmetropia, Myopia and Hypermetropia

Understanding of the biomechanics of the accommodative apparatus in the eyes with different refraction is important for solving the problems of theoretical and practical ophthalmology. Purpose: To determine the changes of anterior eye segment dimensions during accommodation response in normal eyes and in patients with myopia, hypermetropia. Methods and Material: 116 eyes (56 patients aged from 18 to 30 years, refraction from -2.0 to + 2.0 D) were examined. All the patients underwent a full ophthalmological examination. The ocular anterior segment was imaged using a rotational Scheimpflug camera Pentacam HR (Oculus, Wetzlar, Germany) under non- and 3.0 D of accommodative demands. The statistical data were represented as the mean value ± standard deviation (M ± SD). The Shapiro-Wilk test was used to assess the normality distribution. Wilcoxon test was used for comparison. Results: Results showed an increase in the optical density of the crystalline lens, a pupil diameter decrease and changing of the iris profile during accommodation in all patients. An increase in the total corneal aberrations and decrease in the corneal spherical aberration were revealed only in emmetropic eyes. Conclusions: The accommodative response is a multicomponent process. Scheimpflug visualization revealed the differences in the accommodative response in normal and ametropic eyes.

Mechanical Eye Trauma Epidemiology, Prognostic Factors, and Management Controversies—An Update

Purpose of Review: The management of eye injuries is both difficult and argumentative. This study attempts to highlight the management of ocular trauma using currently available information in the literature and author experience. This review presents a workable framework from the first presentation, epidemiology, classification, investigations, management principles, complications, prognostic factors, final visual outcome and management debates. Review Findings: Mechanical ocular trauma is a leading cause of monocular blindness and possible handicap worldwide. Among several classification systems, the most widely accepted is Birmingham Eye Trauma Terminology (BETT). Mechanical ocular trauma is a topic of unsolved controversy. Patching for corneal abrasion, paracentesis for hyphema, the timing of cataract surgery and intraocular lens implantation are all issues in anterior segment injuries. Regarding posterior segment controversies, the timing of vitrectomy, use of prophylactic cryotherapy, the necessity of intravitreal antibiotics in the absence of infection, the use of vitrectomy vs vitreous tap in traumatic endophthalmitis is the issues. The pediatric age group needs to be approached by a different protocol due to the risk of amblyopia, intraocular inflammation, and significant vitreoretinal adhesions. The various prognostic factors have a role in the final visual outcome. B scan is used to exclude R.D, Intraocular foreign body (IOFB), and vitreous haemorrhage in hazy media. Individual surgical strategies are used for every patient according to the classification and extent of the injuries. Conclusion: This article examines relevant evidence on the management challenges and controversies of mechanical trauma of the eye and offers treatment recommendations based on published research and the authors’ own experience.

双参数Morley元的误差估计

用双参数法离散Morley有限元得到新单元,给出此单元的插值误差估计.并用此单元求解薄板弯曲问题,得到有限 元误差估计.

EY60回声探测仪在青海湖鱼类资源量评估中的应用

2006年8月16-18日通过使用回声探测仪(Simrad公司EY60型,200kHz换能器)对青海湖的鱼类资源进行了探测评估.结果表明:青海湖裸鲤(Gymnocypris przewalskii)水平分布具不均匀性,有小型鱼群聚集现象;在不同的设定分区,鱼类密度在0.168-12.8ind./1000m3之间,均值为1.16ind./1000m3;布哈河口鱼类较为密集,密度最大值为12.8ind./1000m3.初步估算青海湖裸鲤达可捕规格(体长大于20cm)个体数量为6.5×107ind.,95%置信度区间为35.6×107-118.4×107ind.,应用资源密度体积法估算青海湖裸鲤的可捕资源量约为15275t.探测实验还证实,EY60回声探测仪在青海湖中进行鱼类资源评估时探测效果良好,分析软件Sonar5可以对鱼类个体自动识别、计数,便于进行鱼类资源量评估.

东海北部外陆架EY02-1孔磁性地层研究

对长达70.20 m的东海浅钻EY02-1进行了岩石磁学和古地磁分析,证明沉积物的载磁矿物主要为低矫顽力的磁铁矿,磁性地层揭示了发生于9.62-8.58 m的磁极性事件,结合钻孔上部的AMS14C测年证明它为全新世初期的哥德堡磁极性漂移,线性外推的时间是距今12 681-10 206 Ma,为全新世开始时地磁场是否发生过短期的磁极性漂移提供了新证据;与东海高分辨率的浅地层地震剖面以及典型钻孔（中法联合东海地震调查和DZQ4钻孔）对比还揭示,在中更新世地层中也出现过两次磁倾角变化。在钻孔中下部54.00-50.94 m（2271—2151号样品）出现一段磁倾角变小甚至变成负值,但是由于该段沉积物以粗颗粒的砂为主并且负向样品并不连续,依据研究的标准不作为反磁极性事件。第二个比较连续的负向样品段出现在最底部70.20-64.31 m。虽然研究区域内不乏揭示中更新统地层的地震剖面,但至今没有足够长的钻孔在时间上予以佐证。根据东海地震相对比和沉积物中海侵和海退旋回的不同特征以及布容期以来报道的反磁极性事件发生的时间来推测下部地层的时代归属。由于钻孔最底部的沉积主要是粗颗粒的粉砂质砂和细砂,同时钻孔也穿透了倒数第二冰期的杂乱地震相地层和其下的平行透明海相层,所以推测下部的倒转可能为发生在MIS8晚期的CR0反磁极性事件（距今265-255 ka）。

M68HC908EY16在汽车LIN总线灯控系统中的应用

结合现有汽车电子技术及汽车网络技术的发展概况,提出了一种基于Freescale8位单片机M68HC908EY16的LIN总线汽车灯光控制系统解决方案。简要介绍了LIN通讯协议,结合本芯片较为详细的介绍了LIN总线技术在灯控模块中的应用。完成了灯控系统协议的制定,并给出了系统硬件原理图以及软件设计流程。

基于RapidEye影像的农村居民地遥感监测--以江西省泰和县为例

农村居民地遥感信息获取对于监测农村居民地时空变化、服务"三农"和国土资源管理具有重要意义。以Rapid Eye卫星影像数据为数据源,江西省泰和县为研究区,利用最大似然法进行居民地等土地覆盖类别的分类提取与精度评价及分析。结果表明:分类总体精度达到84.33%,其中农村居民地的制图精度和用户精度分别为76.01%和82.28%,与第二次全国土地调查中的居民地数据对比,其一致性达到71.0%。结合实地验证,对本分类精度的误差原因进行分析。本研究表明利用5 m分辨率的Rapid Eye影像进行县级农村居民地监测是可行的,可为后续同类研究提供技术参考。

EYA1通过调控PTEN/PI3K/AKT信号通路抑制胃癌SGC-7901细胞的恶性生物学行为

目的:探讨EYA1(eyes absent 1)通过调控PTEN/PI3K/AKT信号通路抑制胃癌SGC-7901细胞的恶性进展及其相关机制。方法:收集2016年6月至2018年6月陆军军医大学附属西南医院全军普通外科中心29例胃癌组织及其癌旁组织标本,采用Wb和q PCR实验检测胃癌组织和癌旁组织中EYA1 mRNA和蛋白的表达水平。人胃癌细胞株SGC-7901培养完成后,采用过表达EYA1质粒或siRNA干扰质粒转染胃癌SGC-7901细胞;分别采用MTT、流式细胞术、划痕愈合和Transwell实验检测胃癌SGC-7901细胞的增殖、凋亡、迁移和侵袭能力。结果:胃癌组织中EYA1 m RNA和蛋白表达水平较癌旁组织均明显降低(P<0.01);过表达EYA1可明显提高SGC-7901细胞的增殖、迁移和侵袭能力(均P<0.05)、抑制细胞凋亡(P<0.05)。过表达EYA1可明显促进PTEN的表达、抑制PI3K/AKT通路的激活(均P<0.05或P<0.01);但在PTEN干扰后以上作用均受到了明显抑制(均P<0.05或P<0.01)。结论:EYA1可通过促进PTEN的表达抑制PI3K/AKT信号通路,从而抑制胃癌SGC-7901细胞的恶性生物学行为。