Objective:To explore the effect of early rehabilitation training on the serum NGF, NSE, BDNF, and motor function in patients with acute cerebral infarction (ACI).Methods: A total of 150 patients with ACI who were admi...Objective:To explore the effect of early rehabilitation training on the serum NGF, NSE, BDNF, and motor function in patients with acute cerebral infarction (ACI).Methods: A total of 150 patients with ACI who were admitted in our hospital from October, 2015 to October, 2016 were included in the study and randomized into the observation group and the control group. The patients in the two groups were given anti-coagulation, anti-platelet aggregation, cerebral circulation improving, and brain cell activators. The patients in the control group were given routine neurological nursing, while the patients in the observation group were given early comprehensive rehabilitation training on the basis of stable vital signs and no disease progression within 48 h. The morning fasting peripheral venous blood before treatment, 2 and 4 weeks after treatment in the two groups was collected. The serum NGF, NSE, BDNF, IL-6, hs-CRP, and TNF-α were detected. The activities of daily living and motor function before treatment, 2 and 4 weeks after treatment in the two groups were evaluated.Results:IL-6, hs-CRP, and TNF-α levels 2 and 4 weeks after treatment in the observation group were significantly lower than those in the control group (P<0.05). NGF and BDNF levels 2 and 4 weeks after treatment in the observation group were significantly higher than those in the control group (P<0.05), while NSE level was significantly lower than that in the control group (P<0.05). MBI and FMA scores 2 and 4 weeks after treatment in the observation group were significantly higher than those in the control group (P<0.05).Conclusions: The early rehabilitation training can effectively reduce the inflammatory reaction of nervous system in patients with ACI, regulate NGF, BDNF, and NSE levels, and play the cerebral function remodeling in order to promote the neural function recovery, and improve the motor function.展开更多
BACKGROUND Stroke is a common disabling disease,whether it is ischemic stroke or hemorrhagic stroke,both can result in neuronal damage,leading to various manifestations of neurological dysfunction.AIM To explore of th...BACKGROUND Stroke is a common disabling disease,whether it is ischemic stroke or hemorrhagic stroke,both can result in neuronal damage,leading to various manifestations of neurological dysfunction.AIM To explore of the application value of swallowing treatment device combined with swallowing rehabilitation training in the treatment of swallowing disorders after stroke.METHODS This study selected 86 patients with swallowing disorders after stroke admitted to our rehabilitation department from February 2022 to December 2023 as research subjects.They were divided into a control group(n=43)and an observation group(n=43)according to the treatment.The control group received swallowing rehabilitation training,while the observation group received swallowing treatment device in addition to the training.Both groups underwent continuous intervention for two courses of treatment.RESULTS The total effective rate in the observation group(93.02%)was higher than that in the control group(76.74%)(P=0.035).After intervention,the oral transit time,swallowing response time,pharyngeal transit time,and laryngeal closure time decreased in both groups compared to before intervention.In the observation group,the oral transit time,swallowing response time,and pharyngeal transit time were shorter than those in the control group after intervention.However,the laryngeal closure time after intervention in the observation group was compared with that in the control group(P=0.142).After intervention,average amplitude value and duration of the genioglossus muscle group during empty swallowing and swallowing 5 mL of water are reduced compared to before intervention in both groups.After intervention,the scores of the chin-tuck swallowing exercise and the Standardized Swallowing Assessment are both reduced compared to pre-intervention levels in both groups.However,the observation group scores lower than the control group after intervention.Additionally,the Functional Oral Intake Scale scores of both groups are increased after intervention compared to pre-intervention levels,with the observation group scoring higher than the control group after intervention(P<0.001).The cumulative incidence of complications in the observation group is 9.30%,which is lower than the 27.91%in the control group(P=0.027).CONCLUSION The combination of swallowing therapy equipment with swallowing rehabilitation training can improve the muscle movement level of the genioglossus muscle group,enhance swallowing function,and prevent the occurrence of swallowing-related complications after stroke.展开更多
目的研究老年脑卒中合并吞咽障碍患者经高频重复经颅磁刺激(Repetitive Transcranial Magnetic Stimulation,rTMS)联合早期吞咽功能分级康复训练对神经及吞咽功能的临床应用价值。方法便利选取2021年1月-2023年1月泰州市第三人民医院收...目的研究老年脑卒中合并吞咽障碍患者经高频重复经颅磁刺激(Repetitive Transcranial Magnetic Stimulation,rTMS)联合早期吞咽功能分级康复训练对神经及吞咽功能的临床应用价值。方法便利选取2021年1月-2023年1月泰州市第三人民医院收治的70例老年脑卒中合并吞咽障碍患者为研究对象,按随机数表法分为对照组(n=35,常规治疗)和观察组(n=35,rTMS联合早期吞咽功能分级康复训练)。比较两组治疗前后舌体移动度(舌骨上移距离、舌骨前移距离),神经功能[美国国立卫生院卒中量表(National Institutes of Health Stroke Scale,NIHSS)]、吞咽功能[标准吞咽功能评分量表(Standard Swallowing Function Assessment Scale,SSA)]及生存质量[吞咽生存质量问卷(Swallowing Quality of Life,SWAL-QOL)]评分,观察两组不良反应发生情况。结果较治疗前,两组治疗后舌骨上移距离、舌骨前移距离及SWAL-QOL评分均升高,NIHSS评分、SSA评分均降低,且观察组较对照组更优,差异有统计学意义(P均<0.05)。观察组治疗总有效率(97.14%)高于对照组(82.86%),差异有统计学意义(χ^(2)=3.968,P<0.05)。两组不良反应总发生率对比,差异无统计学意义(P>0.05)。结论在rTMS治疗基础上,老年脑卒中合并吞咽障碍患者联合早期吞咽功能分级康复训练,对自身神经功能及吞咽功能均有显著改善作用,且安全性高。展开更多
目的探讨在机械通气患者的治疗中采用体外膈肌起搏器联合早期康复训练的应用效果。方法选取2021年1月—2023年4月福建医科大学附属漳州市医院内科监护室收治的119例膈肌功能障碍机械通气患者,根据不同的康复训练方式分为对照组(n=60,早...目的探讨在机械通气患者的治疗中采用体外膈肌起搏器联合早期康复训练的应用效果。方法选取2021年1月—2023年4月福建医科大学附属漳州市医院内科监护室收治的119例膈肌功能障碍机械通气患者,根据不同的康复训练方式分为对照组(n=60,早期康复训练)与研究组(n=59,体外膈肌起搏联合早期康复训练)。对比2组的血气指标、膈肌厚度及膈肌移动度、机械通气时间及住院时间、急性生理与慢性健康评分(acute physiology and chronic health score,APACHEⅡ)、肺部感染评分、并发症发生率。结果研究组动脉血二氧化碳分压(partial pressure of carbon dioxide in arterial blood,PaCO_(2))水平较低,血氧饱和度(oxygen saturation of blood,SaO_(2))、氧合指数(partial pressure of oxygen/fraction of inspiration oxygen,PaO_(2)/FiO_(2))水平高于对照组(P<0.05)。研究组吸气末与呼气末膈肌厚度、膈肌移动度高于对照组(P<0.05)。研究组APACHEⅡ、临床肺部感染评分(clinical pulmonary infection score,CPIS)低于对照组(P<0.05)。研究组并发症发生率为3.38%,低于对照组的16.67%(P<0.05);研究组机械通气时间(10.36±1.15)d及住院时间(19.16±1.53)d短于对照组[(13.58±1.43)d,(21.25±2.02)d](P<0.05)。结论在机械通气患者的治疗中采取体外膈肌起搏联合早期康复训练可改善其血气指标与膈肌功能,减少并发症的发生,促进患者病情好转,提高其健康水平。展开更多
目的探究肺癌术后实行系统化早期康复训练护理的效果。方法方便选取2022年3月—2023年9月赤峰市肿瘤医院收治的82例行肺癌手术的患者为研究对象,采用随机数表法分成两组,每组41例,对照组用常规护理,研究组用系统化早期康复训练护理,比...目的探究肺癌术后实行系统化早期康复训练护理的效果。方法方便选取2022年3月—2023年9月赤峰市肿瘤医院收治的82例行肺癌手术的患者为研究对象,采用随机数表法分成两组,每组41例,对照组用常规护理,研究组用系统化早期康复训练护理,比对两组肺功能、并发症发生率、改良版英国的呼吸问卷(Modified Medical Research Council,mMRC)评分、生活质量评定表(Generic Quality of Life Inventory-74,GQOLI-74)评分。结果研究组肺癌患者并发症率(2.44%)低于对照组(14.63%),差异有统计学意义(χ^(2)=3.905,P=0.048)。研究组干预后肺功能指标优于对照组,差异有统计学意义(P<0.05)。干预前,两组肺癌术后患者mMRC评分比较,差异无统计学意义(P>0.05);干预后,研究组手术患者mMRC问卷表中各项评分均低于对照组,差异有统计学意义(P<0.05)。干预前,两组生活质量评分比较,差异无统计学意义(P>0.05);干预后,研究组生活质量评分高于对照组,差异有统计学意义(P<0.05)。结论系统化早期康复训练护理用于肺癌术后,可以缩短患者住院时间,降低并发症发生率,优化患者肺功能,改善患者预后。展开更多
文摘Objective:To explore the effect of early rehabilitation training on the serum NGF, NSE, BDNF, and motor function in patients with acute cerebral infarction (ACI).Methods: A total of 150 patients with ACI who were admitted in our hospital from October, 2015 to October, 2016 were included in the study and randomized into the observation group and the control group. The patients in the two groups were given anti-coagulation, anti-platelet aggregation, cerebral circulation improving, and brain cell activators. The patients in the control group were given routine neurological nursing, while the patients in the observation group were given early comprehensive rehabilitation training on the basis of stable vital signs and no disease progression within 48 h. The morning fasting peripheral venous blood before treatment, 2 and 4 weeks after treatment in the two groups was collected. The serum NGF, NSE, BDNF, IL-6, hs-CRP, and TNF-α were detected. The activities of daily living and motor function before treatment, 2 and 4 weeks after treatment in the two groups were evaluated.Results:IL-6, hs-CRP, and TNF-α levels 2 and 4 weeks after treatment in the observation group were significantly lower than those in the control group (P<0.05). NGF and BDNF levels 2 and 4 weeks after treatment in the observation group were significantly higher than those in the control group (P<0.05), while NSE level was significantly lower than that in the control group (P<0.05). MBI and FMA scores 2 and 4 weeks after treatment in the observation group were significantly higher than those in the control group (P<0.05).Conclusions: The early rehabilitation training can effectively reduce the inflammatory reaction of nervous system in patients with ACI, regulate NGF, BDNF, and NSE levels, and play the cerebral function remodeling in order to promote the neural function recovery, and improve the motor function.
文摘BACKGROUND Stroke is a common disabling disease,whether it is ischemic stroke or hemorrhagic stroke,both can result in neuronal damage,leading to various manifestations of neurological dysfunction.AIM To explore of the application value of swallowing treatment device combined with swallowing rehabilitation training in the treatment of swallowing disorders after stroke.METHODS This study selected 86 patients with swallowing disorders after stroke admitted to our rehabilitation department from February 2022 to December 2023 as research subjects.They were divided into a control group(n=43)and an observation group(n=43)according to the treatment.The control group received swallowing rehabilitation training,while the observation group received swallowing treatment device in addition to the training.Both groups underwent continuous intervention for two courses of treatment.RESULTS The total effective rate in the observation group(93.02%)was higher than that in the control group(76.74%)(P=0.035).After intervention,the oral transit time,swallowing response time,pharyngeal transit time,and laryngeal closure time decreased in both groups compared to before intervention.In the observation group,the oral transit time,swallowing response time,and pharyngeal transit time were shorter than those in the control group after intervention.However,the laryngeal closure time after intervention in the observation group was compared with that in the control group(P=0.142).After intervention,average amplitude value and duration of the genioglossus muscle group during empty swallowing and swallowing 5 mL of water are reduced compared to before intervention in both groups.After intervention,the scores of the chin-tuck swallowing exercise and the Standardized Swallowing Assessment are both reduced compared to pre-intervention levels in both groups.However,the observation group scores lower than the control group after intervention.Additionally,the Functional Oral Intake Scale scores of both groups are increased after intervention compared to pre-intervention levels,with the observation group scoring higher than the control group after intervention(P<0.001).The cumulative incidence of complications in the observation group is 9.30%,which is lower than the 27.91%in the control group(P=0.027).CONCLUSION The combination of swallowing therapy equipment with swallowing rehabilitation training can improve the muscle movement level of the genioglossus muscle group,enhance swallowing function,and prevent the occurrence of swallowing-related complications after stroke.
文摘目的研究老年脑卒中合并吞咽障碍患者经高频重复经颅磁刺激(Repetitive Transcranial Magnetic Stimulation,rTMS)联合早期吞咽功能分级康复训练对神经及吞咽功能的临床应用价值。方法便利选取2021年1月-2023年1月泰州市第三人民医院收治的70例老年脑卒中合并吞咽障碍患者为研究对象,按随机数表法分为对照组(n=35,常规治疗)和观察组(n=35,rTMS联合早期吞咽功能分级康复训练)。比较两组治疗前后舌体移动度(舌骨上移距离、舌骨前移距离),神经功能[美国国立卫生院卒中量表(National Institutes of Health Stroke Scale,NIHSS)]、吞咽功能[标准吞咽功能评分量表(Standard Swallowing Function Assessment Scale,SSA)]及生存质量[吞咽生存质量问卷(Swallowing Quality of Life,SWAL-QOL)]评分,观察两组不良反应发生情况。结果较治疗前,两组治疗后舌骨上移距离、舌骨前移距离及SWAL-QOL评分均升高,NIHSS评分、SSA评分均降低,且观察组较对照组更优,差异有统计学意义(P均<0.05)。观察组治疗总有效率(97.14%)高于对照组(82.86%),差异有统计学意义(χ^(2)=3.968,P<0.05)。两组不良反应总发生率对比,差异无统计学意义(P>0.05)。结论在rTMS治疗基础上,老年脑卒中合并吞咽障碍患者联合早期吞咽功能分级康复训练,对自身神经功能及吞咽功能均有显著改善作用,且安全性高。
文摘目的探讨在机械通气患者的治疗中采用体外膈肌起搏器联合早期康复训练的应用效果。方法选取2021年1月—2023年4月福建医科大学附属漳州市医院内科监护室收治的119例膈肌功能障碍机械通气患者,根据不同的康复训练方式分为对照组(n=60,早期康复训练)与研究组(n=59,体外膈肌起搏联合早期康复训练)。对比2组的血气指标、膈肌厚度及膈肌移动度、机械通气时间及住院时间、急性生理与慢性健康评分(acute physiology and chronic health score,APACHEⅡ)、肺部感染评分、并发症发生率。结果研究组动脉血二氧化碳分压(partial pressure of carbon dioxide in arterial blood,PaCO_(2))水平较低,血氧饱和度(oxygen saturation of blood,SaO_(2))、氧合指数(partial pressure of oxygen/fraction of inspiration oxygen,PaO_(2)/FiO_(2))水平高于对照组(P<0.05)。研究组吸气末与呼气末膈肌厚度、膈肌移动度高于对照组(P<0.05)。研究组APACHEⅡ、临床肺部感染评分(clinical pulmonary infection score,CPIS)低于对照组(P<0.05)。研究组并发症发生率为3.38%,低于对照组的16.67%(P<0.05);研究组机械通气时间(10.36±1.15)d及住院时间(19.16±1.53)d短于对照组[(13.58±1.43)d,(21.25±2.02)d](P<0.05)。结论在机械通气患者的治疗中采取体外膈肌起搏联合早期康复训练可改善其血气指标与膈肌功能,减少并发症的发生,促进患者病情好转,提高其健康水平。
文摘目的探究肺癌术后实行系统化早期康复训练护理的效果。方法方便选取2022年3月—2023年9月赤峰市肿瘤医院收治的82例行肺癌手术的患者为研究对象,采用随机数表法分成两组,每组41例,对照组用常规护理,研究组用系统化早期康复训练护理,比对两组肺功能、并发症发生率、改良版英国的呼吸问卷(Modified Medical Research Council,mMRC)评分、生活质量评定表(Generic Quality of Life Inventory-74,GQOLI-74)评分。结果研究组肺癌患者并发症率(2.44%)低于对照组(14.63%),差异有统计学意义(χ^(2)=3.905,P=0.048)。研究组干预后肺功能指标优于对照组,差异有统计学意义(P<0.05)。干预前,两组肺癌术后患者mMRC评分比较,差异无统计学意义(P>0.05);干预后,研究组手术患者mMRC问卷表中各项评分均低于对照组,差异有统计学意义(P<0.05)。干预前,两组生活质量评分比较,差异无统计学意义(P>0.05);干预后,研究组生活质量评分高于对照组,差异有统计学意义(P<0.05)。结论系统化早期康复训练护理用于肺癌术后,可以缩短患者住院时间,降低并发症发生率,优化患者肺功能,改善患者预后。
