Risk factors for early progression of diffuse low-grade glioma in adults

Background:To explore the risk factors for early progression of diffuse low-grade glioma in adults.Methods:A retrospective analysis of pathologic and clinical data of patients diagnosed with diffuse low-grade gliomas at Southwest Hospital between January 2010 and December 2014.The progression-free survival(PFS)less than 60 months was classified as the early progress group,and the PFS greater than 60 months was the control group for comparative analysis.Results:A total of 138 patients were included in this study,including 94 cases of astrocytoma and 44 cases of oligodendroglioma.There were 63 cases with 100%resection,56 cases with 90-100%resection degree,and 19 cases with resection degree<90%.The average follow-up time was 60 months,of which 80 patients progressed and 58 patients did not progress.The average progression-free survival was 61 months.The median progression-free survival was 60 months.There were 68 patients with PFS≤60 months and 70 patients with PFS>60 months.The two groups were compared for statistical analysis.In univariate analysis,there were significant differences in tumor subtype(p=0.005),range(p=0.011),volume(p=0.005),location(p=0.000),and extent of resection(p=0.000).Multifactor analysis shows tumor location(HR=4.549,95%CI:1.324-15.634,p=0.016)and tumor subtype(HR=3.347,95%CI=1.373-8.157,p=0.008),and imcomplete resection is factors influencing early progression of low-grade glioma.Conclusions:Low-grade gliomas involving deep location such as basal ganglia,inner capsule,and corpus callosum are more likely to progress early,while incomplete resection is a risk factor in early progression of astrocytoma.

RNA editingof SLC22A3 causes early tumor progression in familial esophageal cancer patients

Subject Code:H16With the support by the National Natural Science Foundation of China,a collaborative study by the Research groups led by Prof.Fu Li(付利)from the Cancer Research Center,Shenzhen University School of Medicine and Prof.Guan Xinyuan(关新元)from the University of Hong Kong reported that an

Decadal variations in the season advancement of spring water cycle over Eastern China

Spring is the critical period for atmospheric circulation transition from winter to summer. The spring water cycle is very im- portant to agriculture in planting crop and the initial growth of crop. Note that there was a significant abrupt decadal change in the water budget increase during early spring over eastern China in the late 1970s. Studied here are the decadal variations of water budgets over the key regions and the associated change of water cycle over East Asia and atmospheric circulation over Asia-West Pacific region in early spring, using the observed （OBS） precipitation, the ECMWF （ERA） and NCEP/NCAR rea- nalysis （NRA）, and the Mantua＇s Pacific decadal oscillation index （PDOI）. The water budget increments from March to April exhibited a sharp decrease over the key region around Huaihe River basin （HHR） （111°-120°E; 31°-36°N） after year 1978. Before 1977 the water vapor flux through south boundary of the HHR region increased greatly during March to April by 1.52 mm d^-1 in ERA and 1.88 mm d^-1 in NRA. Concurrently the moisture convergence and precipitation over the region also in- creased greatly. The increment for the moisture convergence was 1.11 mmd^-1 in ERA and 1.22 mm d^-1 in NRA, and for the precipitation was 1.05 mm d^-1 in observation and 1.05 mm d^-1 in ERA. April was the time that the water budgets over HHR increased most rapidly before 1977. But after 1978 the water budgets decreased conversely from Mach to April. The water vapor flux increment through the south boundary was -0.03 mmd^-1 in ERA and 0.01 mm d^-1 in NRA, the moisture conver- gence increment was -0.91 mm d^-1 in ERA and -0.53 mm d^-1 in NRA, and precipitation increment was -0.08 mm d^-1 in ob- servation and -0.15 mm d^-1 in ERA. Further investigation has shown that the large-scale atmospheric circulation in the early spring has correspondingly changed significantly after the late 1970s. During March to April, the weakening of the trough over East Asia became significantly slower, and the strengthening of the ridge over the west China became significantly faster in the middle troposphere after the late 1970s. At the same time, in the lower troposphere, the strengthening and northward extending of the west pan of the subtropical high and the weakening of the trough over the southwest part of the Aleutian low in the early spring became slower, and the weakening of the main part of Asian high became slower, but the strengthening of its west part became faster. This significant decadal change of circulation caused a sharp decrease in the northward extending speed of wa- ter vapor transport, and in the water budgets increasing speed over the southeastern China during early spring after the late 1970s.