As a leading cause for morbidity and mortality in young adults,traumatic brain injury（TBI）,along with the poorly understood TBI-related seizures inducing their predispositions,pose a major health and socioeconomic p...As a leading cause for morbidity and mortality in young adults,traumatic brain injury（TBI）,along with the poorly understood TBI-related seizures inducing their predispositions,pose a major health and socioeconomic problem in the world（Huang,2013）.展开更多
Background Early post-traumatic seizures(EPTS)refer to epileptic seizures occurring within one week after brain injury.This study aimed to define the risk factors of EPTS and the protective factors that could prevent ...Background Early post-traumatic seizures(EPTS)refer to epileptic seizures occurring within one week after brain injury.This study aimed to define the risk factors of EPTS and the protective factors that could prevent its occurrence.Methods This is a single-center retrospective study in the PICU,Beijing Children's Hospital.Patients diagnosed with traumatic brain injury(TBI),admitted with and without EPTS between January 2016 and December 2020 were included in the study.Results We included 108 patients diagnosed with TBI.The overall EPTS incidence was 33.98%(35/108).The correlation between EPTS and depressed fractures is positive(P=0.023).Positive correlations between EPTS and intracranial hemorrhage and subarachnoid hemorrhage had been established(P=0.011 and P=0.004,respectively).The detection rates of EPTS in the electroencephalogram(EEG)monitoring was 80.00%.There was a significant difference in the EEG monitoring rate between the two groups(P=0.041).Forty-one(37.86%,41/108)post-neurosurgical patients were treated with prophylactic antiepileptic drugs(AEDs),and eight(19.51%,8/41)still had seizures.No statistical significance was noted between the two groups in terms of prophylactic AEDs use(P=0.519).Logistic regression analysis revealed that open craniocerebral injury and fever on admission were risk factors for EPTS,whereas,surgical intervention and use of hypertonic saline were associated with not developing EPTS.Conclusions Breakthrough EPTS occurred after severe TBI in 33.98%of pediatric cases in our cohort.This is a higher seizure incidence than that reported previously.Patients with fever on admission and open craniocerebral injuries are more likely to develop EPTS.展开更多
文摘As a leading cause for morbidity and mortality in young adults,traumatic brain injury（TBI）,along with the poorly understood TBI-related seizures inducing their predispositions,pose a major health and socioeconomic problem in the world（Huang,2013）.
基金This study was supported by Research Unit of Critical infection in Children,Chinese Academy of Medical Sciences(2019RU016)CAMS Innovation Fund for Medical Sciences.CIFMS(2019-I2M-5-026).
文摘Background Early post-traumatic seizures(EPTS)refer to epileptic seizures occurring within one week after brain injury.This study aimed to define the risk factors of EPTS and the protective factors that could prevent its occurrence.Methods This is a single-center retrospective study in the PICU,Beijing Children's Hospital.Patients diagnosed with traumatic brain injury(TBI),admitted with and without EPTS between January 2016 and December 2020 were included in the study.Results We included 108 patients diagnosed with TBI.The overall EPTS incidence was 33.98%(35/108).The correlation between EPTS and depressed fractures is positive(P=0.023).Positive correlations between EPTS and intracranial hemorrhage and subarachnoid hemorrhage had been established(P=0.011 and P=0.004,respectively).The detection rates of EPTS in the electroencephalogram(EEG)monitoring was 80.00%.There was a significant difference in the EEG monitoring rate between the two groups(P=0.041).Forty-one(37.86%,41/108)post-neurosurgical patients were treated with prophylactic antiepileptic drugs(AEDs),and eight(19.51%,8/41)still had seizures.No statistical significance was noted between the two groups in terms of prophylactic AEDs use(P=0.519).Logistic regression analysis revealed that open craniocerebral injury and fever on admission were risk factors for EPTS,whereas,surgical intervention and use of hypertonic saline were associated with not developing EPTS.Conclusions Breakthrough EPTS occurred after severe TBI in 33.98%of pediatric cases in our cohort.This is a higher seizure incidence than that reported previously.Patients with fever on admission and open craniocerebral injuries are more likely to develop EPTS.
