Effect of early warning and evidence-based intervention combined with drug therapy on the infection process in children with mycoplasma pneumonia

Objective:To study the effect of early warning and evidence-based intervention combined with drug therapy on the infection process in children with mycoplasma pneumonia.Methods:Children who were treated and clearly diagnosed with mycoplasma pneumonia in Zigong Third People's Hospital between May 2014 and October 2017 were chosen and randomly divided into two groups, experimental group accepted early warning and evidence-based intervention combined with drug therapy, and control group accepted routine drug therapy. The levels of inflammatory cytokines and oxidative stress response indicators in serum as well as the expression of inflammation and oxidative stress signal molecules in peripheral blood were measured before treatment and 3 d after treatment.Results:Compared with those of same group before treatment, serum TNF-α, CysLTs, sTREM1, sP-selectin, sICAM1, MDA, SF and COR levels as well as peripheral blood TLR4, NF-κB, COX2, NOX4, MPO and iNOS expression intensity of both groups of patients significantly decreased whereas SOD and IgA levels significantly increased after treatment. Moreover, serum TNF-α, CysLTs, sTREM1, sP-selectin, sICAM1, MDA, SF and COR levels as well as peripheral blood TLR4, NF-κB, COX2, NOX4, MPO and iNOS expression intensity of experimental group were lower than those of control group whereas SOD and IgA levels were higher than those of control group. Conclusion: Early warning and evidence-based intervention combined with drug therapy can reduce the inflammatory response and oxidative stress response in the infection process of children with mycoplasma pneumonia.

预警结合循证干预联合药物治疗对支原体肺炎患儿感染进程的影响

目的:研究预警结合循证干预联合药物治疗对支原体肺炎患儿感染进程的影响。方法:选择2014年5月~2017年10月期间在自贡市第三人民医院就诊并明确诊断为支原体肺炎的患儿并随机分为两组,实验组患儿接受预警结合循证干预联合药物治疗,对照组接受常规药物治疗。治疗前及治疗后3天时,测定血清中炎症细胞因子、氧化应激反应指标的含量以及外周血中炎症、氧化应激信号分子的表达量。结果:与组内治疗前比较,两组患者治疗后血清中TNF-α、CysLTs、sTREM1、sP-selectin、sICAM1、MDA、SF、COR的含量以及外周血中TLR4、NF-κB、COX2、NOX4、MPO、iNOS的表达强度均显著降低,SOD、IgA的含量均显著升高且实验组患儿血清中TNF-α、CysLTs、sTREM1、sP-selectin、sICAM1、MDA、SF、COR的含量以及外周血中TLR4、NF-κB、COX2、NOX4、MPO、iNOS的表达强度低于对照组,SOD、IgA的含量高于对照组。结论:预警结合循证干预联合药物治疗能够减轻支原体肺炎患儿感染进程中的炎症反应及氧化应激反应。

预警视角下的联合干预对股骨颈骨折患者术后深静脉血栓的预防效果

目的探讨预警视角下的联合干预措施对股骨颈骨折患者术后深静脉血栓的预防效果。方法收集2017年6月至2021年6月佛山市中医院收治的200例股骨颈骨折患者的临床资料,按照干预方式的不同将患者分为观察组(n=98,给予常规干预联合预警视角下干预措施)和对照组(n=102,给予常规干预措施)。观察并记录两组患者干预后下肢深静脉血栓的发生率、疾病知识了解情况。比较两组患者干预前后的凝血功能指标,包括凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、D-二聚体(D-D)水平。比较两组患者的住院时间、护理满意度及术后并发症(感染、髋部疼痛、假体松动)发生情况。结果干预后,观察组患者下肢深静脉血栓的发生率低于对照组患者(P<0.05)。干预后,观察组患者的疾病知识问卷得分明显高于对照组患者,PT、APTT明显均长于对照组患者,FIB、D-D水平均明显低于对照组患者,住院时间明显短于对照组患者,护理满意度明显高于对照组患者(P<0.01)。干预后,观察组患者髋部疼痛的发生率低于对照组患者(P<0.05)。结论预警视角下的联合干预措施能够降低股骨颈骨折患者下肢深静脉血栓的发生率,增强患者对下肢深静脉血栓相关知识的认知,改善凝血功能,缩短住院时间,提高护理满意度,预防效果较好。