Accurate frequency estimation in a wideband digital receiver using the FFT algorithm encounters challenges, such as spectral leakage resulting from the FFT’s assumption of signal periodicity. High-resolution FFTs pos...Accurate frequency estimation in a wideband digital receiver using the FFT algorithm encounters challenges, such as spectral leakage resulting from the FFT’s assumption of signal periodicity. High-resolution FFTs pose computational demands, and estimating non-integer multiples of frequency resolution proves exceptionally challenging. This paper introduces two novel methods for enhanced frequency precision: polynomial interpolation and array indexing, comparing their results with super-resolution and scalloping loss. Simulation results demonstrate the effectiveness of the proposed methods in contemporary radar systems, with array indexing providing the best frequency estimation despite utilizing maximum hardware resources. The paper demonstrates a trade-off between accurate frequency estimation and hardware resources when comparing polynomial interpolation and array indexing.展开更多
Bistatic/multistatic radar has great potential advantages over its monostatic counterpart. However, the separation of a transmitter and a receiver leads to difficulties in locating the target position accurately and g...Bistatic/multistatic radar has great potential advantages over its monostatic counterpart. However, the separation of a transmitter and a receiver leads to difficulties in locating the target position accurately and guaranteeing space-timefrequency synchronization of the transmitter and the receiver.The error model of space-time-frequency synchronization in a motion platform of bistatic/multistatic radar is studied. The relationship between the space synchronization error and the transmitter platform position, receiver platform position, moving state, and beam pointing error, is analyzed. The effect of space synchronization error on target echo power is studied. The target scattering characteristics are restructured by many separate scattering centers of the target in high frequency regions. Based on the scattering centers model of the radar target, this radar target echo model and the simulation method are discussed. The algorithm of bistatic/multistatic radar target echo accurately reflects the scattering characteristics of the radar target, pulse modulation speciality of radar transmitting signals, and spacetime-frequency synchronization error characteristics between the transmitter station and the receiver station. The simulation of bistatic radar is completed in computer, and the results of the simulation validate the feasibility of the method.展开更多
The effect of high frequency oscillatory ventilation(HFOV) at early stage on hemodynamic parameters, extravascular lung water(EVLW), lung capillary permeability, CC16 and s ICAM-1 in piglets with pulmonary or extr...The effect of high frequency oscillatory ventilation(HFOV) at early stage on hemodynamic parameters, extravascular lung water(EVLW), lung capillary permeability, CC16 and s ICAM-1 in piglets with pulmonary or extrapulmonary acute respiratory distress syndrome(ARDS) was explored. Central vein pressure(CVP) and pulse indicator continuous cardiac output(Pi CCO) were monitored in 12 anesthetized and intubated healthy piglets. Pulmonary ARDS(ARDSp) and extrapulmonary ARDS(ARDSexp) models were respectively established by lung lavage of saline solution and intravenous injection of oleic acid. Then the piglets received HFOV for 4 h. EVLW index(EVLWI), EVLW/intratroracic blood volume(ITBV) and pulmonary vascular permeability index(PVPI) were measured before and after modeling(T0 and T1), and T2(1 h), T3(2 h), T4(3 h) and T5(4 h) after HFOV. CC16 and s ICAM-1 were also detected at T1 and T5. Results showed at T1, T3, T4 and T5, EVLWI was increased more significantly in ARDSp group than in ARDSexp group(P〈0.05). The EVLWI in ARDSp group was increased at T1(P=0.008), and sustained continuously within 2 h(P=0.679, P=0.216), but decreased at T4(P=0.007) and T5(P=0.037). The EVLWI in ARDSexp group was also increased at T1(P=0.003), but significantly decreased at T3(P=0.002) and T4(P=0.019). PVPI was increased after modeling in both two groups(P=0.004, P=0.012), but there was no significant change within 4 h(T5) under HFOV in ARDSp group, while PVPI showed the increasing trends at first, then decreased in ARDSexp group after HFOV. The changes of EVLW/ITBV were similar to those of PVPI. No significant differences were found in ΔEVLWI(P=0.13), ΔPVPI(P=0.28) and ΔEVLW/ITBV between the two groups(P=0.63). The significant decreases in both CC16 and s ICAM-1 were found in both two groups 4 h after HFOV, but there was no significant difference between the two groups. It was concluded that EVLWI and lung capillary permeability were markedly increased in ARDSp and ARDSexp groups. EVLW could be decreased 4 h after the HFOV treatment. HFOV, EVLW/ITBV and PVPI were increased slightly at first, and then decreased in ARDSexp group, while in ARDSp group no significant difference was found after modeling. No significant differences were found in the decreases in EVLW and lung capillary permeability 4 h after HFOV.展开更多
Long-time cross correlation of ambient noise has been proved as a powerful tool to extract Green's function between two receivers. The study of composition of ambient noise is important for a better understanding of ...Long-time cross correlation of ambient noise has been proved as a powerful tool to extract Green's function between two receivers. The study of composition of ambient noise is important for a better understanding of this method. Previous studies confirm that ambient noise in the long period (3 s and longer) mostly consists of surface wave, and 0.25-2.5 s noise consists more of body waves. In this paper, we perform cross correlation processing at much higher frequency (30-70 Hz) using ambient noise recorded by a small aperture array. No surface waves emerge from noise correlation function (NCF), but weak P waves emerge. The absence of surface wave in NCF is not due to high attenuation since surface waves are strong from active source, therefore probably the high ambient noise mostly consists of body wave and lacks surface wave. Origin of such high frequency body waves in ambient noise remains to be studied.展开更多
The frequency range of electroacupuncture in treatment of Alzheimer's disease in rats is commonly 2-5 Hz(low frequency) and 50-100 Hz(high frequency). We established a rat model of Alzheimer's disease by injecti...The frequency range of electroacupuncture in treatment of Alzheimer's disease in rats is commonly 2-5 Hz(low frequency) and 50-100 Hz(high frequency). We established a rat model of Alzheimer's disease by injecting β-amyloid 1-42(Aβ1-42) into the bilateral hippocampal dentate gyrus to verify which frequency may be better suited in treatment. Electroacupuncture at 2 Hz or 50 Hz was used to stimulate Baihui(DU20) and Shenshu(BL23) acupoints. The water maze test and electrophysiological studies demonstrated that spatial memory ability was apparently improved, and the ranges of long-term potentiation and long-term depression were increased in Alzheimer's disease rats after electroacupuncture treatment. Moreover, the effects of electroacupuncture at 50 Hz were better than that at 2 Hz. These findings suggest that high-frequency electroacupuncture may enhance hippocampal synaptic transmission and potentially improve memory disorders in Alzheimer's disease rats.展开更多
Green's functions for Blot's dynamic equation in the frequency domain can be a highly useful tool for the investigation of dynamic responses of a saturated porous medium. Its applications are found in soil dynamics,...Green's functions for Blot's dynamic equation in the frequency domain can be a highly useful tool for the investigation of dynamic responses of a saturated porous medium. Its applications are found in soil dynamics, seismology, earthquake engineering, rock mechanics, geophysics, and acoustics. However, the mathematical work for deriving it can be daunting. Green's functions have been presented utilizing an analogy between the dynamic thermoelasticity and the dynamic poroelasticity in the frequency domain using the u-p formulation. In this work, a special term "decoupling coefficient" for the decomposition of the fast and slow dilatational waves is proposed and expressed to present a new methodology for deriving the poroelastodynamic Green's functions. The correct- ness of the solution is demonstrated by numerically comparing the current solution with Cheng's previous solution. The separation of the two waves in the present methodology allows the more accurate evaluation of Green's functions, particularly the solution of the slow dilatational wave. This can be advantageous for the numerical implementation of the boundary element method (BEM) and other applications.展开更多
Acupuncture has been shown to ameliorate cognitive impairment of Alzheimer’s disease.Acupoints and stimulation frequency influence the therapeutic effect of electroacupuncture.Rat models of Alzheimer’s disease were ...Acupuncture has been shown to ameliorate cognitive impairment of Alzheimer’s disease.Acupoints and stimulation frequency influence the therapeutic effect of electroacupuncture.Rat models of Alzheimer’s disease were established by injecting amyloid beta 1–42(Aβ_(1–42))into the bilateral lateral ventricles.Electroacupuncture at 2,30,and 50 Hz was carried out at Baihui(GV20;15°obliquely to a depth of 2mm)and Shenshu(BL23;perpendicularly to 4–6 mm depth),once a day for 20 minutes(each),for 15 days,taking a break every 7 days.The Morris water maze test was conducted to assess the learning and memory.The expression levels of glycogen synthase kinase-3β(GSK-3β),p Ser9-GSK-3β,p Tyr216-GSK-3β,amyloid precursor protein and Aβ_(1–40) in the hippocampus were determined by western blot assay.Results demonstrated that electroacupuncture treatment at different frequencies markedly improved learning and memory ability,increased synaptic curvatures,decreased the width of synaptic clefts,thickened postsynaptic densities,and downregulated the expression of GSK-3β,amyloid precursor protein,and Aβ_(1–40).pSer9-GSK-3βexpression markedly decreased,while p Tyr216-GSK-3βexpression increased.High-frequency(50 Hz)electroacupuncture was more effective than low(2 Hz)or medium-frequency(30 Hz)electroacupuncture.In conclusion,electroacupuncture treatment exerts a protective effect against Aβ_(1–42)-induced learning and memory deficits and synapse-ultrastructure impairment via inhibition of GSK-3βactivity.Moreover,high-frequency electroacupuncture was the most effective therapy.展开更多
Zipf's approach in linguistics is utilized to analyze the statistical features of frequency and correlation of 16 nearest neighboring nucleotides (AA, AC, AG, …, TT) in 12 human chro- mosomes (Y, 22, 21, 20, 19, ...Zipf's approach in linguistics is utilized to analyze the statistical features of frequency and correlation of 16 nearest neighboring nucleotides (AA, AC, AG, …, TT) in 12 human chro- mosomes (Y, 22, 21, 20, 19, 18, 17, 16, 15, 14, 13, and 12). It is found that these statistical features of nearest neighboring nucleotides in human genome: (i) the frequency distribution is a linear function, and (ii) the correlation distribution is an inverse function. The coefficients of the linear function and inverse function depend on the GC content. It proposes the correlation distribution of nearest neighboring nucleotides for the first time and extends the descriptor about nearest neighboring nueleotides.展开更多
There has been protracted historical evidence of a relative paucity in the distribution frequency of global earthquakes within the M = 3.5 to 4.0 range. We observed a similar phenomenon for all recently recorded earth...There has been protracted historical evidence of a relative paucity in the distribution frequency of global earthquakes within the M = 3.5 to 4.0 range. We observed a similar phenomenon for all recently recorded earthquakes from January 2009 through August 2013. Frequency distributions with increments of M = 0.1 verified the trough of the diminished incidence to be between M = 3.6 and 3.7 with an abrupt increase between M = 3.9 and 4.0. The calculated equivalent photon wavelength for the energies associated with M = 3.6 approaches Planck’s Length while the related time increment is the cutoff frequency for the Zero Point Fluctuation force coupled to gravity. The conspicuous congruence between Planck’s time and length and the lower than expected frequency based upon Gaussian assumptions of distribution for the discrete band of energy associated with this magnitude range of earthquakes suggests a conduit may exist between intrinsic features of Planck space-time and geophysical processes. The existence of such a connection would encourage alternative explanations for sun-seismic activities as due to solar instabilities. Instead, it may reflect influence upon both from alterations in the structure of space being traversed by the solar system as it moves through the galaxy.展开更多
The absolute frequency of 87Rb 5S1/2 (F=2)→5D5/2 (F" = 4) two-photon transition at 778nm is measured in an accuracy of 44kHz. A home-made erbium-doped fiber laser frequency comb with frequency stability of 5.0 ...The absolute frequency of 87Rb 5S1/2 (F=2)→5D5/2 (F" = 4) two-photon transition at 778nm is measured in an accuracy of 44kHz. A home-made erbium-doped fiber laser frequency comb with frequency stability of 5.0 × 10-13@1 s is employed for the light source. By using a periodically poled lithium niobate, the femtosecond pulse operating in 1556 nm is frequency-doubled to 778 nm to obtain the direct two-photon transition spectroscopy of thermal rubidium vapor. Through sweeping the carrier envelope offset frequency (fceo), the 5S1/2 (F=2)→5D5/2 (F" = 4) two-photon transition line is clearly resolved and its absolute frequency is determined via the peak-finding of the fitting curve. After the frequency correction, the measured result agrees well with the previous experiment on this transition. The entire potential candidate of optical frequency standard for system configuration is compact and robust, providing a telecommunication applications.展开更多
BACKGROUND: Subthalamic nucleus-high frequency stimulation (STN-HFS) plays an important role in the treatment of Parkinson's disease, but the mechanisms underlying STN-HFS remain unclear. Some studies have demonst...BACKGROUND: Subthalamic nucleus-high frequency stimulation (STN-HFS) plays an important role in the treatment of Parkinson's disease, but the mechanisms underlying STN-HFS remain unclear. Some studies have demonstrated that STN stimulation inhibits the firing activity of substantia nigra pars reticulata neurons. OBJECTIVE: To investigate the effects of different-frequency STN stimulation and microiontophoresis of gamma-aminobutyric acid (GABA) and its antagonist, bicuculline, on spontaneous firing activity in a rat model of Parkinson's disease, and to analyze the action pathway of high frequency stimulation in firing activity inhibition of substantia nigra pars reticulata neurons. DESIGN, TIME AND SETTING: This neuroelectrophysiological, animal experiment was performed at the Electrophysiology Laboratory of Liaoning Medical University, China from March to August 2008. MATERIALS: 6-hydroxydopamine (6-OHDA) (Sigma, USA), A320R isolated stimulus and DAM80 preamplifier (World Precision Instruments, USA), 6400A microiontophoresis apparatus (Dagan, USA), and Spike 2 biological signal acquisition system (CED, UK) were used in this study. METHODS: A total of 20 Sprague Dawley rats were used to establish a Parkinson's disease model via injection of 6-OHDA into the right striatum. Electrical stimulation (0.06-ms width, 0.4-mA intensity 20-200-Hz frequency, 5-second train duration) was delivered to the subthalamic nucleus. Peripheral channels were separately filled with GABA (pH 3.5, 0.2 mol/L), bicuculline (pH 4.0, 0.01 mol/L), and NaCI (pH 7.0, 3 mol/L). The electrode was positioned with a WK-2 microelectrode propulsion device, and was slowly inserted into the substantia nigra pars reticulata to record spontaneous firing activity of substantia nigra pars reticulata neurons. MAIN OUTCOME MEASURES: The number and firing rate of substantia nigra pars reticulata neurons which were either inhibited or excited were measured. RESULTS: Substantia nigra pars reticulata neurons were inhibited by STN stimulation. The proportion of inhibited substantia nigra pars reticulata neurons increased with increasing stimulation frequency. GABA had a tonic inhibitory effect on substantia nigra pars reticulata neurons. Microiontophoresis of bicuculline suppressed the inhibitory effect of STN-HFS on 67% (4/6) of substantia nigra pars reticulata neurons. CONCLUSION: STN-HFS ameliorated abnormal activity in substantia nigra pars reticulata neurons via the inhibitory effect of GABA treatment in a rat model of Parkinson's disease.展开更多
Based on the 2016 airgun experimental data of the Fujian Nanyi reservoir,we adopted the frequency domain water-level deconvolution method and cross-correlation time delay detection technique to study the influence of ...Based on the 2016 airgun experimental data of the Fujian Nanyi reservoir,we adopted the frequency domain water-level deconvolution method and cross-correlation time delay detection technique to study the influence of level scaling factor and the background noise level of the station on deconvolution calculation results, and analyze the effect of deconvolution on eliminating the influence of the source caused by different air-gun pressures. The results show that:( 1) When the level scaling factor is smaller,the signal to noise ratio of the waveform after the deconvolution is smaller,and when the level scaling factor is over smaller,the identification error of travel time is greater.( 2) When the SNR of the station record is higher,the recognition accuracy of travel time is higher,the influence of SNR on the reference station record is far greater than the far station,when the SNR of the far station record is more than 10,the error of travel time is within6 ms,but when the SNR of the reference station record is 30,the travel time error may reach to 20 ms.( 3) When the airgun source difference is big,the frequency domain waterlevel deconvolution method has better effect on eliminating the source influence,but the method error may be introduced when the source difference is small.展开更多
The authors state briefly the possibility of various simulators to handle propagation of electromagnetic waves along some interconnections, in 3D RF (Radio Frequency) circuits. The studies are first derived in the t...The authors state briefly the possibility of various simulators to handle propagation of electromagnetic waves along some interconnections, in 3D RF (Radio Frequency) circuits. The studies are first derived in the time domain: a Finite-Difference Time-Domain method is applied, taking spectra via FFTs (Fast Fourier Transform) as post-processors. Electric and magnetic field distributions, pulse propagations along stripline structures or vias are highlighted. The scattering parameters for various cases are extracted and compared. Some original issue of this work is an insight on crosstalk or shielding phenomena between lines.展开更多
3D chip stacking is considered known to overcome conventional 2D-IC issues, using through silicon vias to ensure vertical signal transmission. From any point source, embedded or not, we calculate the impedance spread ...3D chip stacking is considered known to overcome conventional 2D-IC issues, using through silicon vias to ensure vertical signal transmission. From any point source, embedded or not, we calculate the impedance spread out;our ultimate goal will to study substrate noise via impedance field method. For this, our approach is twofold: a compact Green function or a Transmission Line Model over a multi-layered substrate is derived by solving Poisson’s equation analytically. The Discrete Cosine Transform (DCT) and its variations are used for rapid evaluation. Using this technique, the substrate coupling and loss in IC’s can be analyzed. We implement our algorithm in MATLAB;it permits to extract impedances between any pair of embedded contacts. Comparisons are performed using finite element methods.展开更多
In this paper, the method of relaxed boundary conditions is applied to rectangular plates with edges which are a sort of the mixture of simply supported portions and clamped portions, so that the lower limit of fundam...In this paper, the method of relaxed boundary conditions is applied to rectangular plates with edges which are a sort of the mixture of simply supported portions and clamped portions, so that the lower limit of fundamental frequency of such plates is evaluated. A kind of polynomial satisfying the displacement boundary conditions is designed, os that it is enabled to evaluate the upper limit of fundamental frequency by Ritz' method. The practical calculation examples solved by these methods have given satisfactory results. At the end of this paper, it is pointed out that the socalled exact solution of such plates usually evaluated by the force superposition method is essentially a kind of lower limit of solution, if the truncated error of series which occurs in actual calculation is considered.展开更多
Fatigue damage assessment is carried out considering mean value effect by applying four criteria of failure. Three frequency domain methods, i.e., level crossing counting(LCC), range counting(RC) and a new proposed me...Fatigue damage assessment is carried out considering mean value effect by applying four criteria of failure. Three frequency domain methods, i.e., level crossing counting(LCC), range counting(RC) and a new proposed method, are applied. The core of frequency domain method is the construction of probability density function for the mean stress and stress range of the stress process. The applicability of these frequency domain methods are inspected by comparing with time domain method. Numerical simulations verify the applicability of LCC and the proposed method, while RC gives poor estimations.展开更多
This paper has an objective to show a developed quantitative criterion,based in two mathematical variables that explicit the deviation degree of a normal situation,applying simultaneously data from terminal impedances...This paper has an objective to show a developed quantitative criterion,based in two mathematical variables that explicit the deviation degree of a normal situation,applying simultaneously data from terminal impedances and frequency response.Based in more than 100-measured equipment,of different applications(step-up transformer,transmission transformer,etc.,),for a period of 10 years,the work presents some examples of practical application of this methodology in Brazilian Electrical System.展开更多
Based on the waveform data of 5,076 local earthquakes recorded at 25 stations in Xinjiang during the period from 2009 to 2014 and the observation reports provided by the Xinjiang Digital Seismic Network,a data set of ...Based on the waveform data of 5,076 local earthquakes recorded at 25 stations in Xinjiang during the period from 2009 to 2014 and the observation reports provided by the Xinjiang Digital Seismic Network,a data set of 19,140 attenuation factors t*is obtained by fitting the high-frequency attenuation of S-wave spectra with a genetic algorithm. The spatial distribution of Q_S is determined by inverting the t*data with seismic tomography. The results show that the average Q0 in eastern Tianshan is 520,and there is a significant correlation between the Q_S value distribution or attenuation characteristics it disclosed and the surface structure of the study area. The Q_S value is lower in the intersection area of the mountain basin which is located on the north and south sides of the Tianshan Mountains,and the high Q_S distribution is more concentrated inside the Tianshan orogenic belt. The M≥6. 0 earthquakes have been basically located in the Low-Q_S region since 1900. 24 high heat flow points in eastern Tianshan are located at the north and south of Tianshan Mountains where low Q_S exists,indicating a negative correlation. In addition,there is a positive correlation between the velocity structure and the attenuation structure in the study area,which reflects the consistency of the 2-D attenuation structure with the velocity structure and the two-dimensional density structure.展开更多
Visual real-time monitoring is the premise of low frequency oscillation control in power grids. This paper showed a visual method for the control center of power grids to monitor low frequency oscillation. It processe...Visual real-time monitoring is the premise of low frequency oscillation control in power grids. This paper showed a visual method for the control center of power grids to monitor low frequency oscillation. It processed the PMU real-time data with incomplete S-transform, and converted the waveforms to two-dimensional time-frequency figures which showed the initial time, frequency and amplitude of each low frequency oscillation mode directly. GPU was used to show figures and calculate FFT with the purpose of improving calculation efficiency. The results of practical cases show that the real-time characters of low frequency oscillation can be identified availably by this visualization real-time monitoring method which is helpful and suitable for practical application.展开更多
文摘Accurate frequency estimation in a wideband digital receiver using the FFT algorithm encounters challenges, such as spectral leakage resulting from the FFT’s assumption of signal periodicity. High-resolution FFTs pose computational demands, and estimating non-integer multiples of frequency resolution proves exceptionally challenging. This paper introduces two novel methods for enhanced frequency precision: polynomial interpolation and array indexing, comparing their results with super-resolution and scalloping loss. Simulation results demonstrate the effectiveness of the proposed methods in contemporary radar systems, with array indexing providing the best frequency estimation despite utilizing maximum hardware resources. The paper demonstrates a trade-off between accurate frequency estimation and hardware resources when comparing polynomial interpolation and array indexing.
基金supported by the National Natural Science Foundation of China(61271327)
文摘Bistatic/multistatic radar has great potential advantages over its monostatic counterpart. However, the separation of a transmitter and a receiver leads to difficulties in locating the target position accurately and guaranteeing space-timefrequency synchronization of the transmitter and the receiver.The error model of space-time-frequency synchronization in a motion platform of bistatic/multistatic radar is studied. The relationship between the space synchronization error and the transmitter platform position, receiver platform position, moving state, and beam pointing error, is analyzed. The effect of space synchronization error on target echo power is studied. The target scattering characteristics are restructured by many separate scattering centers of the target in high frequency regions. Based on the scattering centers model of the radar target, this radar target echo model and the simulation method are discussed. The algorithm of bistatic/multistatic radar target echo accurately reflects the scattering characteristics of the radar target, pulse modulation speciality of radar transmitting signals, and spacetime-frequency synchronization error characteristics between the transmitter station and the receiver station. The simulation of bistatic radar is completed in computer, and the results of the simulation validate the feasibility of the method.
文摘The effect of high frequency oscillatory ventilation(HFOV) at early stage on hemodynamic parameters, extravascular lung water(EVLW), lung capillary permeability, CC16 and s ICAM-1 in piglets with pulmonary or extrapulmonary acute respiratory distress syndrome(ARDS) was explored. Central vein pressure(CVP) and pulse indicator continuous cardiac output(Pi CCO) were monitored in 12 anesthetized and intubated healthy piglets. Pulmonary ARDS(ARDSp) and extrapulmonary ARDS(ARDSexp) models were respectively established by lung lavage of saline solution and intravenous injection of oleic acid. Then the piglets received HFOV for 4 h. EVLW index(EVLWI), EVLW/intratroracic blood volume(ITBV) and pulmonary vascular permeability index(PVPI) were measured before and after modeling(T0 and T1), and T2(1 h), T3(2 h), T4(3 h) and T5(4 h) after HFOV. CC16 and s ICAM-1 were also detected at T1 and T5. Results showed at T1, T3, T4 and T5, EVLWI was increased more significantly in ARDSp group than in ARDSexp group(P〈0.05). The EVLWI in ARDSp group was increased at T1(P=0.008), and sustained continuously within 2 h(P=0.679, P=0.216), but decreased at T4(P=0.007) and T5(P=0.037). The EVLWI in ARDSexp group was also increased at T1(P=0.003), but significantly decreased at T3(P=0.002) and T4(P=0.019). PVPI was increased after modeling in both two groups(P=0.004, P=0.012), but there was no significant change within 4 h(T5) under HFOV in ARDSp group, while PVPI showed the increasing trends at first, then decreased in ARDSexp group after HFOV. The changes of EVLW/ITBV were similar to those of PVPI. No significant differences were found in ΔEVLWI(P=0.13), ΔPVPI(P=0.28) and ΔEVLW/ITBV between the two groups(P=0.63). The significant decreases in both CC16 and s ICAM-1 were found in both two groups 4 h after HFOV, but there was no significant difference between the two groups. It was concluded that EVLWI and lung capillary permeability were markedly increased in ARDSp and ARDSexp groups. EVLW could be decreased 4 h after the HFOV treatment. HFOV, EVLW/ITBV and PVPI were increased slightly at first, and then decreased in ARDSexp group, while in ARDSp group no significant difference was found after modeling. No significant differences were found in the decreases in EVLW and lung capillary permeability 4 h after HFOV.
基金supported by Central Public-interest Scientific Institution Basal Research Fund (No. DQJB09B07)Knowledge Innovation Program of the Chinese Academy of Sciences under grant No. KZCX2-YW-116-1+1 种基金supported partially by National Natural Science Foundation of China (Nos. 40874095, 40730318 and 41004019)China Earthquake Administration Special Program Fund (Nos. 200808078 and 200808002)
文摘Long-time cross correlation of ambient noise has been proved as a powerful tool to extract Green's function between two receivers. The study of composition of ambient noise is important for a better understanding of this method. Previous studies confirm that ambient noise in the long period (3 s and longer) mostly consists of surface wave, and 0.25-2.5 s noise consists more of body waves. In this paper, we perform cross correlation processing at much higher frequency (30-70 Hz) using ambient noise recorded by a small aperture array. No surface waves emerge from noise correlation function (NCF), but weak P waves emerge. The absence of surface wave in NCF is not due to high attenuation since surface waves are strong from active source, therefore probably the high ambient noise mostly consists of body wave and lacks surface wave. Origin of such high frequency body waves in ambient noise remains to be studied.
基金supported by the National Natural Science Foundation of China,No.81373741
文摘The frequency range of electroacupuncture in treatment of Alzheimer's disease in rats is commonly 2-5 Hz(low frequency) and 50-100 Hz(high frequency). We established a rat model of Alzheimer's disease by injecting β-amyloid 1-42(Aβ1-42) into the bilateral hippocampal dentate gyrus to verify which frequency may be better suited in treatment. Electroacupuncture at 2 Hz or 50 Hz was used to stimulate Baihui(DU20) and Shenshu(BL23) acupoints. The water maze test and electrophysiological studies demonstrated that spatial memory ability was apparently improved, and the ranges of long-term potentiation and long-term depression were increased in Alzheimer's disease rats after electroacupuncture treatment. Moreover, the effects of electroacupuncture at 50 Hz were better than that at 2 Hz. These findings suggest that high-frequency electroacupuncture may enhance hippocampal synaptic transmission and potentially improve memory disorders in Alzheimer's disease rats.
基金Project supported by the National Natural Science Foundation of China(Nos.51478435,11402150,and 11172268)
文摘Green's functions for Blot's dynamic equation in the frequency domain can be a highly useful tool for the investigation of dynamic responses of a saturated porous medium. Its applications are found in soil dynamics, seismology, earthquake engineering, rock mechanics, geophysics, and acoustics. However, the mathematical work for deriving it can be daunting. Green's functions have been presented utilizing an analogy between the dynamic thermoelasticity and the dynamic poroelasticity in the frequency domain using the u-p formulation. In this work, a special term "decoupling coefficient" for the decomposition of the fast and slow dilatational waves is proposed and expressed to present a new methodology for deriving the poroelastodynamic Green's functions. The correct- ness of the solution is demonstrated by numerically comparing the current solution with Cheng's previous solution. The separation of the two waves in the present methodology allows the more accurate evaluation of Green's functions, particularly the solution of the slow dilatational wave. This can be advantageous for the numerical implementation of the boundary element method (BEM) and other applications.
基金supported by the National Natural Science Foundation of China,No.81373741a grant from the Chinese Medicine and Integrated Medicine Research Projects funded by the Health and Family Planning Commission of Hubei Province of China,No.24a grant from the Hubei Provincial Collaborative Innovation Center of Preventive Treatment by Acupuncture and Moxibustion of China in 2014,No.8
文摘Acupuncture has been shown to ameliorate cognitive impairment of Alzheimer’s disease.Acupoints and stimulation frequency influence the therapeutic effect of electroacupuncture.Rat models of Alzheimer’s disease were established by injecting amyloid beta 1–42(Aβ_(1–42))into the bilateral lateral ventricles.Electroacupuncture at 2,30,and 50 Hz was carried out at Baihui(GV20;15°obliquely to a depth of 2mm)and Shenshu(BL23;perpendicularly to 4–6 mm depth),once a day for 20 minutes(each),for 15 days,taking a break every 7 days.The Morris water maze test was conducted to assess the learning and memory.The expression levels of glycogen synthase kinase-3β(GSK-3β),p Ser9-GSK-3β,p Tyr216-GSK-3β,amyloid precursor protein and Aβ_(1–40) in the hippocampus were determined by western blot assay.Results demonstrated that electroacupuncture treatment at different frequencies markedly improved learning and memory ability,increased synaptic curvatures,decreased the width of synaptic clefts,thickened postsynaptic densities,and downregulated the expression of GSK-3β,amyloid precursor protein,and Aβ_(1–40).pSer9-GSK-3βexpression markedly decreased,while p Tyr216-GSK-3βexpression increased.High-frequency(50 Hz)electroacupuncture was more effective than low(2 Hz)or medium-frequency(30 Hz)electroacupuncture.In conclusion,electroacupuncture treatment exerts a protective effect against Aβ_(1–42)-induced learning and memory deficits and synapse-ultrastructure impairment via inhibition of GSK-3βactivity.Moreover,high-frequency electroacupuncture was the most effective therapy.
基金ACKNOWLEDGMENTS This work was supported by the National Natural Science Foundation of China (No.20173023 and No.90203012) and the Specialized Research Fund for the Doctoral Program of Higher Education of China
文摘Zipf's approach in linguistics is utilized to analyze the statistical features of frequency and correlation of 16 nearest neighboring nucleotides (AA, AC, AG, …, TT) in 12 human chro- mosomes (Y, 22, 21, 20, 19, 18, 17, 16, 15, 14, 13, and 12). It is found that these statistical features of nearest neighboring nucleotides in human genome: (i) the frequency distribution is a linear function, and (ii) the correlation distribution is an inverse function. The coefficients of the linear function and inverse function depend on the GC content. It proposes the correlation distribution of nearest neighboring nucleotides for the first time and extends the descriptor about nearest neighboring nueleotides.
文摘There has been protracted historical evidence of a relative paucity in the distribution frequency of global earthquakes within the M = 3.5 to 4.0 range. We observed a similar phenomenon for all recently recorded earthquakes from January 2009 through August 2013. Frequency distributions with increments of M = 0.1 verified the trough of the diminished incidence to be between M = 3.6 and 3.7 with an abrupt increase between M = 3.9 and 4.0. The calculated equivalent photon wavelength for the energies associated with M = 3.6 approaches Planck’s Length while the related time increment is the cutoff frequency for the Zero Point Fluctuation force coupled to gravity. The conspicuous congruence between Planck’s time and length and the lower than expected frequency based upon Gaussian assumptions of distribution for the discrete band of energy associated with this magnitude range of earthquakes suggests a conduit may exist between intrinsic features of Planck space-time and geophysical processes. The existence of such a connection would encourage alternative explanations for sun-seismic activities as due to solar instabilities. Instead, it may reflect influence upon both from alterations in the structure of space being traversed by the solar system as it moves through the galaxy.
基金Acknowledgments
This work was supported by the National High Technology Research and Development Program of China under grant No. 2006AAOAA102-12 and the National Natural Science Foundation of China (Grant No. 40774064). The authors would like to express their sincere thanks to TH oil field for providing field data sets.
基金Supported by the National Natural Science Foundation of China under Grant Nos 61405002,91336103,10934010,61535001 and 61078026
文摘The absolute frequency of 87Rb 5S1/2 (F=2)→5D5/2 (F" = 4) two-photon transition at 778nm is measured in an accuracy of 44kHz. A home-made erbium-doped fiber laser frequency comb with frequency stability of 5.0 × 10-13@1 s is employed for the light source. By using a periodically poled lithium niobate, the femtosecond pulse operating in 1556 nm is frequency-doubled to 778 nm to obtain the direct two-photon transition spectroscopy of thermal rubidium vapor. Through sweeping the carrier envelope offset frequency (fceo), the 5S1/2 (F=2)→5D5/2 (F" = 4) two-photon transition line is clearly resolved and its absolute frequency is determined via the peak-finding of the fitting curve. After the frequency correction, the measured result agrees well with the previous experiment on this transition. The entire potential candidate of optical frequency standard for system configuration is compact and robust, providing a telecommunication applications.
文摘BACKGROUND: Subthalamic nucleus-high frequency stimulation (STN-HFS) plays an important role in the treatment of Parkinson's disease, but the mechanisms underlying STN-HFS remain unclear. Some studies have demonstrated that STN stimulation inhibits the firing activity of substantia nigra pars reticulata neurons. OBJECTIVE: To investigate the effects of different-frequency STN stimulation and microiontophoresis of gamma-aminobutyric acid (GABA) and its antagonist, bicuculline, on spontaneous firing activity in a rat model of Parkinson's disease, and to analyze the action pathway of high frequency stimulation in firing activity inhibition of substantia nigra pars reticulata neurons. DESIGN, TIME AND SETTING: This neuroelectrophysiological, animal experiment was performed at the Electrophysiology Laboratory of Liaoning Medical University, China from March to August 2008. MATERIALS: 6-hydroxydopamine (6-OHDA) (Sigma, USA), A320R isolated stimulus and DAM80 preamplifier (World Precision Instruments, USA), 6400A microiontophoresis apparatus (Dagan, USA), and Spike 2 biological signal acquisition system (CED, UK) were used in this study. METHODS: A total of 20 Sprague Dawley rats were used to establish a Parkinson's disease model via injection of 6-OHDA into the right striatum. Electrical stimulation (0.06-ms width, 0.4-mA intensity 20-200-Hz frequency, 5-second train duration) was delivered to the subthalamic nucleus. Peripheral channels were separately filled with GABA (pH 3.5, 0.2 mol/L), bicuculline (pH 4.0, 0.01 mol/L), and NaCI (pH 7.0, 3 mol/L). The electrode was positioned with a WK-2 microelectrode propulsion device, and was slowly inserted into the substantia nigra pars reticulata to record spontaneous firing activity of substantia nigra pars reticulata neurons. MAIN OUTCOME MEASURES: The number and firing rate of substantia nigra pars reticulata neurons which were either inhibited or excited were measured. RESULTS: Substantia nigra pars reticulata neurons were inhibited by STN stimulation. The proportion of inhibited substantia nigra pars reticulata neurons increased with increasing stimulation frequency. GABA had a tonic inhibitory effect on substantia nigra pars reticulata neurons. Microiontophoresis of bicuculline suppressed the inhibitory effect of STN-HFS on 67% (4/6) of substantia nigra pars reticulata neurons. CONCLUSION: STN-HFS ameliorated abnormal activity in substantia nigra pars reticulata neurons via the inhibitory effect of GABA treatment in a rat model of Parkinson's disease.
基金“Analysis of Accuracyof Airgun Source in Monitoring Crustal Media Change and Its Influence Factors”,the National Natural Science Foundation of China(41774068)and Special Fund for Science and Technology,Fujian Earthquake Agency(SF201709)
文摘Based on the 2016 airgun experimental data of the Fujian Nanyi reservoir,we adopted the frequency domain water-level deconvolution method and cross-correlation time delay detection technique to study the influence of level scaling factor and the background noise level of the station on deconvolution calculation results, and analyze the effect of deconvolution on eliminating the influence of the source caused by different air-gun pressures. The results show that:( 1) When the level scaling factor is smaller,the signal to noise ratio of the waveform after the deconvolution is smaller,and when the level scaling factor is over smaller,the identification error of travel time is greater.( 2) When the SNR of the station record is higher,the recognition accuracy of travel time is higher,the influence of SNR on the reference station record is far greater than the far station,when the SNR of the far station record is more than 10,the error of travel time is within6 ms,but when the SNR of the reference station record is 30,the travel time error may reach to 20 ms.( 3) When the airgun source difference is big,the frequency domain waterlevel deconvolution method has better effect on eliminating the source influence,but the method error may be introduced when the source difference is small.
文摘The authors state briefly the possibility of various simulators to handle propagation of electromagnetic waves along some interconnections, in 3D RF (Radio Frequency) circuits. The studies are first derived in the time domain: a Finite-Difference Time-Domain method is applied, taking spectra via FFTs (Fast Fourier Transform) as post-processors. Electric and magnetic field distributions, pulse propagations along stripline structures or vias are highlighted. The scattering parameters for various cases are extracted and compared. Some original issue of this work is an insight on crosstalk or shielding phenomena between lines.
文摘3D chip stacking is considered known to overcome conventional 2D-IC issues, using through silicon vias to ensure vertical signal transmission. From any point source, embedded or not, we calculate the impedance spread out;our ultimate goal will to study substrate noise via impedance field method. For this, our approach is twofold: a compact Green function or a Transmission Line Model over a multi-layered substrate is derived by solving Poisson’s equation analytically. The Discrete Cosine Transform (DCT) and its variations are used for rapid evaluation. Using this technique, the substrate coupling and loss in IC’s can be analyzed. We implement our algorithm in MATLAB;it permits to extract impedances between any pair of embedded contacts. Comparisons are performed using finite element methods.
文摘In this paper, the method of relaxed boundary conditions is applied to rectangular plates with edges which are a sort of the mixture of simply supported portions and clamped portions, so that the lower limit of fundamental frequency of such plates is evaluated. A kind of polynomial satisfying the displacement boundary conditions is designed, os that it is enabled to evaluate the upper limit of fundamental frequency by Ritz' method. The practical calculation examples solved by these methods have given satisfactory results. At the end of this paper, it is pointed out that the socalled exact solution of such plates usually evaluated by the force superposition method is essentially a kind of lower limit of solution, if the truncated error of series which occurs in actual calculation is considered.
基金Supported by the National Natural Science Foundation of China(No.51379142 and No.51309179)the International Science and Technology Cooperation Program of China(No.2012DFA70490)the Tianjin Municipal Natural Science Foundation(No.13JCYBJC19100)
文摘Fatigue damage assessment is carried out considering mean value effect by applying four criteria of failure. Three frequency domain methods, i.e., level crossing counting(LCC), range counting(RC) and a new proposed method, are applied. The core of frequency domain method is the construction of probability density function for the mean stress and stress range of the stress process. The applicability of these frequency domain methods are inspected by comparing with time domain method. Numerical simulations verify the applicability of LCC and the proposed method, while RC gives poor estimations.
文摘This paper has an objective to show a developed quantitative criterion,based in two mathematical variables that explicit the deviation degree of a normal situation,applying simultaneously data from terminal impedances and frequency response.Based in more than 100-measured equipment,of different applications(step-up transformer,transmission transformer,etc.,),for a period of 10 years,the work presents some examples of practical application of this methodology in Brazilian Electrical System.
基金jointly funded by the Contract Oriented Work Task for Seismic Situation in 2017(2017010104)Science for Earthquake Resilience(XH17041Y)Fund of Earthquake Agency of Xinjiang Uygur Autonomous Region(201401)
文摘Based on the waveform data of 5,076 local earthquakes recorded at 25 stations in Xinjiang during the period from 2009 to 2014 and the observation reports provided by the Xinjiang Digital Seismic Network,a data set of 19,140 attenuation factors t*is obtained by fitting the high-frequency attenuation of S-wave spectra with a genetic algorithm. The spatial distribution of Q_S is determined by inverting the t*data with seismic tomography. The results show that the average Q0 in eastern Tianshan is 520,and there is a significant correlation between the Q_S value distribution or attenuation characteristics it disclosed and the surface structure of the study area. The Q_S value is lower in the intersection area of the mountain basin which is located on the north and south sides of the Tianshan Mountains,and the high Q_S distribution is more concentrated inside the Tianshan orogenic belt. The M≥6. 0 earthquakes have been basically located in the Low-Q_S region since 1900. 24 high heat flow points in eastern Tianshan are located at the north and south of Tianshan Mountains where low Q_S exists,indicating a negative correlation. In addition,there is a positive correlation between the velocity structure and the attenuation structure in the study area,which reflects the consistency of the 2-D attenuation structure with the velocity structure and the two-dimensional density structure.
文摘Visual real-time monitoring is the premise of low frequency oscillation control in power grids. This paper showed a visual method for the control center of power grids to monitor low frequency oscillation. It processed the PMU real-time data with incomplete S-transform, and converted the waveforms to two-dimensional time-frequency figures which showed the initial time, frequency and amplitude of each low frequency oscillation mode directly. GPU was used to show figures and calculate FFT with the purpose of improving calculation efficiency. The results of practical cases show that the real-time characters of low frequency oscillation can be identified availably by this visualization real-time monitoring method which is helpful and suitable for practical application.