The conventional two dimensional(2D)inverse synthetic aperture radar(ISAR)imaging fails to provide the targets'three dimensional(3D)information.In this paper,a 3D ISAR imaging method for the space target is propos...The conventional two dimensional(2D)inverse synthetic aperture radar(ISAR)imaging fails to provide the targets'three dimensional(3D)information.In this paper,a 3D ISAR imaging method for the space target is proposed based on mutliorbit observation data and an improved orthogonal matching pursuit(OMP)algorithm.Firstly,the 3D scattered field data is converted into a set of 2D matrix by stacking slices of the 3D data along the elevation direction dimension.Then,an improved OMP algorithm is applied to recover the space target's amplitude information via the 2D matrix data.Finally,scattering centers can be reconstructed with specific three dimensional locations.Numerical simulations are provided to demonstrate the effectiveness and superiority of the proposed 3D imaging method.展开更多
Based on the theory of multibody system dynamics, the spatial kinematics analysis of the Mcpherson independent suspension widely used in the car was carried out. A practical and simpler method was provided to reduce t...Based on the theory of multibody system dynamics, the spatial kinematics analysis of the Mcpherson independent suspension widely used in the car was carried out. A practical and simpler method was provided to reduce the number of the generalized coordinates and constraint functions. By solving the nonlinear equations, the motion of any points in the whole suspension and wheel system can be predicted, including the spatial changes of the wheel alignment parameters which are of great importance to the car performances.展开更多
Three dimensional(3D) displacements, which can be translated further into 3D strain, are key parameters tor design, manufacturing and quality control. Using different optical setups, phase-shift methods, and algorit...Three dimensional(3D) displacements, which can be translated further into 3D strain, are key parameters tor design, manufacturing and quality control. Using different optical setups, phase-shift methods, and algorithms, several different 3D electronic speckle pattern interferometry(ESPl) systems for displacement and strain measurements have been achieved and commercialized. This paper provides a review of the recent developments in ESPI systems for 3D displacement and strain measurement. After an overview of the fundamentals of ESP! theory, temporal phase-shift, and spatial phase-shift techniques, 3D deformation measurements by the temporal phase-shift ESPI system, which is suited well for static measurement, and by the spatial phase-shift ESPI system, which is particularly useful for dynamic measurement, are discussed. For each method, the basic theory, a brief derivation and different optical layouts are presented. The state of art application, potential and limitation of the ESPI systems are shown and demonstrated.展开更多
According to the latest data of geological structure, geophysics, in-situ stress measurement and focal mechanism,3-D tectonic stress field model in North China is built and 3-D tectonic stress field pattern of North C...According to the latest data of geological structure, geophysics, in-situ stress measurement and focal mechanism,3-D tectonic stress field model in North China is built and 3-D tectonic stress field pattern of North China aresimulated by finite element method. Then the overall characteristics and regional specific feature of North Chinaare studied. Finally, the influences of the valid dynamic boundary conditions of North China Block, active faultsand the inhomogeneity of crustal medium on tectonic stress field of North China are investigated.展开更多
Objective: To treat humerus fracture with three dimensional pattern and finite element analysis, providing mechanical basis for treating humerus fracture. Methods: Humerus pattern was established based on the CT image...Objective: To treat humerus fracture with three dimensional pattern and finite element analysis, providing mechanical basis for treating humerus fracture. Methods: Humerus pattern was established based on the CT images, and calculation was done by ANSYS5. 6 software. Three dimensional ten-node tetrahedron unit was selected and were divided into 2 729 nodes, 49 041 units. Distribution and amount of axial compression of humerus were analyzed when clip angle was 30°, 45°, 90° between fracture face and axial line with fixed X, Y, Z directions. Results: The distribution of stress was greatly different between fracture face and non fracture face. Stress in fracture part was fairly concentrated with incomplete symmetric distribution around the center of fracture face; Greater stress distributed in the regions 10 mm from fracture face, which was 2-3 times that of other stress regions. Conclusion: Required load must be estimated under various conditions as to select the suitable internal fixation implants during the treatment of humerus fracture, which can provide helpful stress environment for fracture healing.展开更多
The use of three dimensional in vitro systems in cancer research is a promising path for developing effective anticancer therapies.The aim of this study was to engineer a functional 3-D in vitro model of normal and ca...The use of three dimensional in vitro systems in cancer research is a promising path for developing effective anticancer therapies.The aim of this study was to engineer a functional 3-D in vitro model of normal and cancerous cervical tissue.Normal epithelial and immortalized cervical epithelial carcinoma cell lines were used to construct 3-D artificial normal cervical and cervical cancerous tissues.De-epidermised dermis(DED) was used as a scaffold for both models.Morphological analyses were conducted by using hematoxylin and eosin staining and characteristics of the models were studied by analyzing the expression of different structural cytokeratins and differential protein marker MAX dimerisation protein 1(Mad1) using immunohistochemical technique.Haematoxylin and eosin staining results showed that normal cervical tissue had multi epithelial layers while cancerous cervical tissue showed dysplastic changes.Immunohistochemistry staining revealed that for normal cervix model cytokeratin 10 was expressed in the upper stratified layer of the epithelium while cytokeratin 5 was expressed mainly in the middle and basal layer.Cytokeratin 19 was weakly expressed in a few basal cells.Cervical cancer model showed cytokeratin 19 expression in different epithelial layers and weak or no expression for cytokeratin 5 and cytokeratin 10.Madl expression was detected in some suprabasal cells.The 3-D in vitro models showed stratified epithelial layers and expressed the same types and patterns of differentiation marker proteins as seen in corresponding in vivo tissue in either normal cervical or cervical cancerous tissue.These findings imply that they can serve as functional normal and cervical cancer models.展开更多
Objective: To evaluate the clinical effect of transarterial infusion chemotherapy of gemcitabine plus three dimen- sional conformal radiotherapy on patients with local advanced pancreatic cancer. Methods: Fifty-one pa...Objective: To evaluate the clinical effect of transarterial infusion chemotherapy of gemcitabine plus three dimen- sional conformal radiotherapy on patients with local advanced pancreatic cancer. Methods: Fifty-one patients with local ad- vanced pancreatic cancer from June 2002 to February 2004 were enrolled, twenty-four patients of combined group were treat- ed with transarterial infusion chemotherapy of gemcitabine plus three dimensional conformal radiotherapy, while twenty-seven patients of control group were treated only with transarterial infusion chemotherapy of gemcitabine. Results: There were significant statistical differences between two groups in clinical benefit response (91.7% versus 74.1%, P < 0.01) and overall remission rate (70.8% versus 33.3%, P < 0.01). The 6-month survival rate, 12-month survival rate and 24-month survival rate of combined group were 83.3%, 62.5% and 37.5% respectively, while that of control group were 55.6%, 33.3% and 11.1% respectively. This showed significant difference between the two groups. Conclusion: Transarterial infusion chemotherapy of gemcitabine plus three dimensional conformal radiotherapy may be better than single transarterial infusion chemotherapy of gemcitabine in improving survival rates and elongating survival time of patients with local advanced pancreatic cancer.展开更多
The dynamic updating of the model included: the change of space border,addi- tion and reduction of spatial component (disappearing,dividing and merging),the change of the topological relationship and synchronous dynam...The dynamic updating of the model included: the change of space border,addi- tion and reduction of spatial component (disappearing,dividing and merging),the change of the topological relationship and synchronous dynamic updating of database.Firstly, arming at the deficiency of OO-Solid model in the aspect of dynamic updating,modeling primitives of OO-Solid model were modified.And then the algorithms of dynamic updating of 3D geological model with the node data,line data or surface data change were dis- cussed.The core algorithms was done by establishing space index,following the way of facing the object from bottom to top,namely the dynamic updating from the node to arc, and then to polygon,then to the face of the component and finally to the geological object. The research has important theoretical and practical values in the field of three dimen- sional geological modeling and is significant in the field of mineral resources.展开更多
Objective:To explore the mechanical behavior of acetabulum loaded by static stress and provide the mechanical basis for clinical analysis and judgement on acetabular mechanical distribution and effect of static stress...Objective:To explore the mechanical behavior of acetabulum loaded by static stress and provide the mechanical basis for clinical analysis and judgement on acetabular mechanical distribution and effect of static stress.Methods:By means of computer simulation, acetabular three dimensional model was input into three dimensional finite element analysis software ANSYS7.0. The acetabular mechanical behavior was calculated and the main stress value, stress distribution and acetabular unit displacement in the direction of main stress were analyzed when anterior wall of acetabulum and acetabular crest were loaded by 1 000 N static stress. Results:When acetabular anterior wall loaded by X direction and Z direction composition force, the stress passed along 4 directions: (1)from acetabular anterior wall to pubic symphysis along superior branch of pubis firstly, (2)from acetabular anterior wall to cacroiliac joint along pelvic ring,(3)in the acetabulum,(4)from the suffered point to ischium. When acetabular crest loaded by X direction and Y direction composition force, the stress transmitted to 4 directions: (1)from acetabular crest to ilium firstly, (2)from suffered point to cacroiliac joint along pelvic ring,(3) in the acetabulum ,(4)along the pubic branch,but no stress transmitted to the ischium branch.Conclusion:Analyzing the stress distribution of acetabulum and units displacement when static stress loaded can provide internal fixation point for acetabular fracture treatment and help understand the stress distribution of acetabulum.展开更多
BACKGROUND Floating thrombus within the thoracic aorta is a rare entity but may cause systemic embolism.The pathogenesis of floating aortic thrombi is not yet fully understood.No definitive guidelines are available fo...BACKGROUND Floating thrombus within the thoracic aorta is a rare entity but may cause systemic embolism.The pathogenesis of floating aortic thrombi is not yet fully understood.No definitive guidelines are available for the management of floating aortic thrombus.CASE SUMMARY We report a 48-year-old patient,without a history of trauma and infection,who presented with sudden severe back pain.A floating thrombus within the aortic arch was found by computed tomography angiography(CTA).No evidence of coagulopathies was found.However,with the assistance of a three dimensionalprinted model,this floating thrombus was identified to be caused by occult aortic dissection(AD).Subsequently,an emergency thoracic endovascular repair was performed.The patient’s back pain was rapidly alleviated postoperatively.CTA at 1 year showed no filling defect in the stent-graft and aorta.CONCLUSION Occult AD is a potential factor causing floating aortic thrombi,endovascular stent-graft exclusion may be an optimal therapeutic choice with promising results.Moreover,the combination of CTA and three dimensional-printed models can contribute to the diagnosis and treatment of floating aortic thrombi due to occult AD.展开更多
The primary objective of this article is to explore effects of latest development in the area of three dimensional(3D)printing&to assess its abilities,and further undertake helpful reporting.Here the focus is to a...The primary objective of this article is to explore effects of latest development in the area of three dimensional(3D)printing&to assess its abilities,and further undertake helpful reporting.Here the focus is to assess ad vantages of 3D printing in orthopedics and analyze how 3D printed models help solve complex 3D orthopedics distortions.This study identified that 3D models manufactured by 3D printing models reduce medical parts de velopment cost and surgical planning time.Integrating 3D printing with orthopaedics helps in understanding the conditions of problems and achieving the operation succssfully.This technology can enable doctors/surgeons to design,produce,recreate and plan operations more accurately,carefully,and economicaly.3D models can assist specialists with a visual comprehension of the patient-particular pathology and life structures.Innovation in 3D printing initiated a scaffold for the virtual outline and execution of medical procedures.This research proposes the utilisation of 3D printers as an elective procedure for the fabrication of parts.It empowers surgeons/patients for better raining,education and research.In the future,there is a foreseeable expansion of additive manufacturing in orthopedics.展开更多
An ultraviolet(UV) curable support material pre-polymer for three dimensional printing was prepared based on the synergistic effect between PEO-PPO-PEO tri-block copolymer(F127) and polyethylene glycol (400) di-...An ultraviolet(UV) curable support material pre-polymer for three dimensional printing was prepared based on the synergistic effect between PEO-PPO-PEO tri-block copolymer(F127) and polyethylene glycol (400) di-acrylate(SR344). The effects of jetting conditions, thermal stability, curing time, mechanical properties and shrinking rate on printing models were studied. The situation of removing support material from build model was investigated after building progress was completed. The experimental result shows that when F127 is 6.0wt%, SR344 is 20.0wt%, 4-Methoxy phenol is 0.15wt% and Irgacure 2959 is 1.5wt%, the support material pre-polymer could be jetted out from the nozzles smoothly during building up of three dimensional printing models at 50-55 ℃. In addition, the support material could be removed easily from building model without spoiling the model; furthermore, the forming precision of building model is improved.展开更多
This paper introduces a new three dimensional autonomous system with five equilibrium points. It demonstrates complex chaotic behaviours within a wide range of parameters, which are described by phase portraits, Lyapu...This paper introduces a new three dimensional autonomous system with five equilibrium points. It demonstrates complex chaotic behaviours within a wide range of parameters, which are described by phase portraits, Lyapunov exponents, frequency spectrum, etc. Analysis of the bifurcation and Poincar@ map is used to reveal mechanisms of generating these complicated phenomena. The corresponding electronic circuits are designed, exhibiting experimental chaotic attractors in accord with numerical simulations. Since frequency spectrum analysis shows a broad frequency bandwidth, this system has perspective of potential applications in such engineering fields as secure communication.展开更多
In this paper a series of digital image processing methods were adopted for getting separated coarse aggregates from asphalt mixture specimen using high-resolution X-ray Computed Tomography (CT) images.The existing th...In this paper a series of digital image processing methods were adopted for getting separated coarse aggregates from asphalt mixture specimen using high-resolution X-ray Computed Tomography (CT) images.The existing three dimensional (3D) particles matching methods based on two dimensional (2D) continuous cross-sections were analyzed and a new 'overlap area method' was presented.After the 3D particles were extracted one by one successfully,the basic parameters of each aggregate:perimeter,area,surface area,and volume were calculated by chain code method.Finally,the 3D mass center coordinates and the sphericity index were introduced.展开更多
We assembled approximately 328 seismic records. The data set was from 4 digitally recording long-period and broadband stations of CDSN. We carried out the inversion based on the partitioned waveform inversion (PWI). I...We assembled approximately 328 seismic records. The data set was from 4 digitally recording long-period and broadband stations of CDSN. We carried out the inversion based on the partitioned waveform inversion (PWI). It partitions the large-scale optimization problem into a number of independent small-scale problems. We adopted surface waveform inversion with an equal block (2((2() discretization in order to acquire the images of shear velocity structure at different depths (from surface to 430 km) in the crust and upper-mantle. The resolution of all these anomalies has been established with (check-board( resolution tests. These results show significant difference in velocity, lithosphere and asthenosphere structure between South China Sea and its adjacent regions.展开更多
In this paper, based on the random characteristic analysis of Tianjin Hospital earthquake waves of Tangshan aftershock, the three dimensional acceleration power spectrum density ratio has been presented.
We have presented a three dimensional optical protein chip that fulfills the demanding for point-of-care diagnostics in terms of ease-of-use (one step assay), miniaturization (5 μl). The artful combination of magneti...We have presented a three dimensional optical protein chip that fulfills the demanding for point-of-care diagnostics in terms of ease-of-use (one step assay), miniaturization (5 μl). The artful combination of magnetic nanoparticles on chip and total internal reflection imaging (TIRI) technology permits the sensitive and rapid detection of hs-CRP (high-sensitivity C-reactive protein). The whole test was complete within 10 min using “all in one step” assay with a limit of detection of 0.1 ng/mL hs-CRP. The measuring range for hs-CRP could be extended to 10 ng/mL. The chip can also be used to detect more parameters in blood samples.展开更多
The objective of the present work is to model the magnetohydrodynamic(MHD) three dimensional flow of viscoelastic fluid passing a stretching surface. Heat transfer analysis is carried out in the presence of variable t...The objective of the present work is to model the magnetohydrodynamic(MHD) three dimensional flow of viscoelastic fluid passing a stretching surface. Heat transfer analysis is carried out in the presence of variable thermal conductivity and thermal radiation. Arising nonlinear analysis for velocity and temperature is computed. Discussion to importantly involved parameters through plots is presented. Comparison between present and previous limiting solutions is shown. Numerical values of local Nusselt number are computed and analyzed. It can be observed that the effects of viscoelastic parameter and Hartman number on the temperature profile are similar in a qualitative way. The variations in temperature are more pronounced for viscoelastic parameter K in comparison to the Hartman number M. The parameters N and ε give rise to the temperature. It is interesting to note that values of local Nusselt number are smaller for the larger values of ε.展开更多
Contribution:This paper designs a learning and training platform that can systematically help radiologists learn automated medical image analysis technology.The platform can help radiologists master deep learning theo...Contribution:This paper designs a learning and training platform that can systematically help radiologists learn automated medical image analysis technology.The platform can help radiologists master deep learning theories and medical applications such as the three-dimensional medical decision support system,and strengthen the teaching practice of deep learning related courses in hospitals,so as to help doctors better understand deep learning knowledge and improve the efficiency of auxiliary diagnosis.Background:In recent years,deep learning has been widely used in academia,industry,andmedicine.An increasing number of companies are starting to recruit a large number of professionals in the field of deep learning.Increasing numbers of colleges and universities also offer courses related to deep learning to help radiologists learn automated medical image analysis techniques.For now,however,there is no practical training platform that can help radiologists learn automated medical image analysis systematically.ApplicationDesign:The platform proposes the basic learning,model combat,business application(BMR)concept,including the learning guidance system and the assessment training system,which constitutes a closed-loop learning guidance mode of“learning-assessment-training-learning”.Findings:The survey results show that most of radiologists met their learning expectations by using this platform.The platform can help radiologists master deep learning techniques quickly,comprehensively and firmly.展开更多
Objective: The aim of our study was to evaluate the outcome and complications of cervical cancer patients undergoing conventional intracavitary brachytherapy (ICBT) treated with 3D-conformal radiotherapy (3DCRT). Meth...Objective: The aim of our study was to evaluate the outcome and complications of cervical cancer patients undergoing conventional intracavitary brachytherapy (ICBT) treated with 3D-conformal radiotherapy (3DCRT). Methods: Sixty cervical cancer patients were divided randomly into the conformal group and the conventional group. Thirty patients treated with 3D-conformal radiotherapy in the 3DCRT group, when the whole pelvic received DT 40 Gy, a planning CT scan of each patient was obtained and the second 3DCRT therapy plan was taken. Then, continued to irradiate to 50 Gy. At last, 3DCRT was boosted at local involved volumes to the total dose of 60 Gy. When 3DCRT was combined with intracavitary brachytherapy, the dose of brachytherapy to point A was 30 Gy/5 fractions. In the conventional group, after a total tumor dose of 40 Gy was delivered by the whole pelvic irradiation, the four-field technique was used to irradiate the total pelvic and regional nodes (median dose of 10 Gy), and the involved volumes were boosted to 60 Gy and the dose of brachytherapy to point A was 30 Gy-36 Gy/5-6 fractions. Moreover, both groups were combined with intracavitary brachytherapy respectively. Results: The 1, 2, 3-year survival rates for the 3DCRT group and the conventional group were 96.7%, 93.3%, 90.0% and 86.6%, 76.7%, 70% respectively (P = 0.04, P = 0.02 and P = 0.02). There was a statistically significant difference between the two groups. Compared to the two groups each other in toxic effects, except for the I-II grade rectal and bladder reaction and pelvic fibrosis which was lower in the 3DCRT group (P = 0. 007, P = 0. 006 and P = 0. 015), the side effects were similar and well tolerated in two groups. Conclusion: The all-course 3DCRT combined with intracavitary brachytherapy can be considered as an effective and feasible approach to cervical cancer and may significantly improve the survival rate and reduce the late toxicity. This new role for 3DCRT merits need further evaluation with large patient numbers and longer follows up.展开更多
文摘The conventional two dimensional(2D)inverse synthetic aperture radar(ISAR)imaging fails to provide the targets'three dimensional(3D)information.In this paper,a 3D ISAR imaging method for the space target is proposed based on mutliorbit observation data and an improved orthogonal matching pursuit(OMP)algorithm.Firstly,the 3D scattered field data is converted into a set of 2D matrix by stacking slices of the 3D data along the elevation direction dimension.Then,an improved OMP algorithm is applied to recover the space target's amplitude information via the 2D matrix data.Finally,scattering centers can be reconstructed with specific three dimensional locations.Numerical simulations are provided to demonstrate the effectiveness and superiority of the proposed 3D imaging method.
文摘Based on the theory of multibody system dynamics, the spatial kinematics analysis of the Mcpherson independent suspension widely used in the car was carried out. A practical and simpler method was provided to reduce the number of the generalized coordinates and constraint functions. By solving the nonlinear equations, the motion of any points in the whole suspension and wheel system can be predicted, including the spatial changes of the wheel alignment parameters which are of great importance to the car performances.
基金supported by National Natural Science Foundation of China(Grant Nos.51275054,51075116)
文摘Three dimensional(3D) displacements, which can be translated further into 3D strain, are key parameters tor design, manufacturing and quality control. Using different optical setups, phase-shift methods, and algorithms, several different 3D electronic speckle pattern interferometry(ESPl) systems for displacement and strain measurements have been achieved and commercialized. This paper provides a review of the recent developments in ESPI systems for 3D displacement and strain measurement. After an overview of the fundamentals of ESP! theory, temporal phase-shift, and spatial phase-shift techniques, 3D deformation measurements by the temporal phase-shift ESPI system, which is suited well for static measurement, and by the spatial phase-shift ESPI system, which is particularly useful for dynamic measurement, are discussed. For each method, the basic theory, a brief derivation and different optical layouts are presented. The state of art application, potential and limitation of the ESPI systems are shown and demonstrated.
文摘According to the latest data of geological structure, geophysics, in-situ stress measurement and focal mechanism,3-D tectonic stress field model in North China is built and 3-D tectonic stress field pattern of North China aresimulated by finite element method. Then the overall characteristics and regional specific feature of North Chinaare studied. Finally, the influences of the valid dynamic boundary conditions of North China Block, active faultsand the inhomogeneity of crustal medium on tectonic stress field of North China are investigated.
文摘Objective: To treat humerus fracture with three dimensional pattern and finite element analysis, providing mechanical basis for treating humerus fracture. Methods: Humerus pattern was established based on the CT images, and calculation was done by ANSYS5. 6 software. Three dimensional ten-node tetrahedron unit was selected and were divided into 2 729 nodes, 49 041 units. Distribution and amount of axial compression of humerus were analyzed when clip angle was 30°, 45°, 90° between fracture face and axial line with fixed X, Y, Z directions. Results: The distribution of stress was greatly different between fracture face and non fracture face. Stress in fracture part was fairly concentrated with incomplete symmetric distribution around the center of fracture face; Greater stress distributed in the regions 10 mm from fracture face, which was 2-3 times that of other stress regions. Conclusion: Required load must be estimated under various conditions as to select the suitable internal fixation implants during the treatment of humerus fracture, which can provide helpful stress environment for fracture healing.
基金supported by the Middlesex University,particularly in the award of a Postgraduate Research Studentship that provided the necessary financial support for this research
文摘The use of three dimensional in vitro systems in cancer research is a promising path for developing effective anticancer therapies.The aim of this study was to engineer a functional 3-D in vitro model of normal and cancerous cervical tissue.Normal epithelial and immortalized cervical epithelial carcinoma cell lines were used to construct 3-D artificial normal cervical and cervical cancerous tissues.De-epidermised dermis(DED) was used as a scaffold for both models.Morphological analyses were conducted by using hematoxylin and eosin staining and characteristics of the models were studied by analyzing the expression of different structural cytokeratins and differential protein marker MAX dimerisation protein 1(Mad1) using immunohistochemical technique.Haematoxylin and eosin staining results showed that normal cervical tissue had multi epithelial layers while cancerous cervical tissue showed dysplastic changes.Immunohistochemistry staining revealed that for normal cervix model cytokeratin 10 was expressed in the upper stratified layer of the epithelium while cytokeratin 5 was expressed mainly in the middle and basal layer.Cytokeratin 19 was weakly expressed in a few basal cells.Cervical cancer model showed cytokeratin 19 expression in different epithelial layers and weak or no expression for cytokeratin 5 and cytokeratin 10.Madl expression was detected in some suprabasal cells.The 3-D in vitro models showed stratified epithelial layers and expressed the same types and patterns of differentiation marker proteins as seen in corresponding in vivo tissue in either normal cervical or cervical cancerous tissue.These findings imply that they can serve as functional normal and cervical cancer models.
文摘Objective: To evaluate the clinical effect of transarterial infusion chemotherapy of gemcitabine plus three dimen- sional conformal radiotherapy on patients with local advanced pancreatic cancer. Methods: Fifty-one patients with local ad- vanced pancreatic cancer from June 2002 to February 2004 were enrolled, twenty-four patients of combined group were treat- ed with transarterial infusion chemotherapy of gemcitabine plus three dimensional conformal radiotherapy, while twenty-seven patients of control group were treated only with transarterial infusion chemotherapy of gemcitabine. Results: There were significant statistical differences between two groups in clinical benefit response (91.7% versus 74.1%, P < 0.01) and overall remission rate (70.8% versus 33.3%, P < 0.01). The 6-month survival rate, 12-month survival rate and 24-month survival rate of combined group were 83.3%, 62.5% and 37.5% respectively, while that of control group were 55.6%, 33.3% and 11.1% respectively. This showed significant difference between the two groups. Conclusion: Transarterial infusion chemotherapy of gemcitabine plus three dimensional conformal radiotherapy may be better than single transarterial infusion chemotherapy of gemcitabine in improving survival rates and elongating survival time of patients with local advanced pancreatic cancer.
基金the National Natural Science Foundation of China(40572165)
文摘The dynamic updating of the model included: the change of space border,addi- tion and reduction of spatial component (disappearing,dividing and merging),the change of the topological relationship and synchronous dynamic updating of database.Firstly, arming at the deficiency of OO-Solid model in the aspect of dynamic updating,modeling primitives of OO-Solid model were modified.And then the algorithms of dynamic updating of 3D geological model with the node data,line data or surface data change were dis- cussed.The core algorithms was done by establishing space index,following the way of facing the object from bottom to top,namely the dynamic updating from the node to arc, and then to polygon,then to the face of the component and finally to the geological object. The research has important theoretical and practical values in the field of three dimen- sional geological modeling and is significant in the field of mineral resources.
文摘Objective:To explore the mechanical behavior of acetabulum loaded by static stress and provide the mechanical basis for clinical analysis and judgement on acetabular mechanical distribution and effect of static stress.Methods:By means of computer simulation, acetabular three dimensional model was input into three dimensional finite element analysis software ANSYS7.0. The acetabular mechanical behavior was calculated and the main stress value, stress distribution and acetabular unit displacement in the direction of main stress were analyzed when anterior wall of acetabulum and acetabular crest were loaded by 1 000 N static stress. Results:When acetabular anterior wall loaded by X direction and Z direction composition force, the stress passed along 4 directions: (1)from acetabular anterior wall to pubic symphysis along superior branch of pubis firstly, (2)from acetabular anterior wall to cacroiliac joint along pelvic ring,(3)in the acetabulum,(4)from the suffered point to ischium. When acetabular crest loaded by X direction and Y direction composition force, the stress transmitted to 4 directions: (1)from acetabular crest to ilium firstly, (2)from suffered point to cacroiliac joint along pelvic ring,(3) in the acetabulum ,(4)along the pubic branch,but no stress transmitted to the ischium branch.Conclusion:Analyzing the stress distribution of acetabulum and units displacement when static stress loaded can provide internal fixation point for acetabular fracture treatment and help understand the stress distribution of acetabulum.
基金Sichuan Foundation of Science and Technology,No.2019YJ0066Sichuan Foundation of Science and Technology,No.2019YFS0346.
文摘BACKGROUND Floating thrombus within the thoracic aorta is a rare entity but may cause systemic embolism.The pathogenesis of floating aortic thrombi is not yet fully understood.No definitive guidelines are available for the management of floating aortic thrombus.CASE SUMMARY We report a 48-year-old patient,without a history of trauma and infection,who presented with sudden severe back pain.A floating thrombus within the aortic arch was found by computed tomography angiography(CTA).No evidence of coagulopathies was found.However,with the assistance of a three dimensionalprinted model,this floating thrombus was identified to be caused by occult aortic dissection(AD).Subsequently,an emergency thoracic endovascular repair was performed.The patient’s back pain was rapidly alleviated postoperatively.CTA at 1 year showed no filling defect in the stent-graft and aorta.CONCLUSION Occult AD is a potential factor causing floating aortic thrombi,endovascular stent-graft exclusion may be an optimal therapeutic choice with promising results.Moreover,the combination of CTA and three dimensional-printed models can contribute to the diagnosis and treatment of floating aortic thrombi due to occult AD.
文摘The primary objective of this article is to explore effects of latest development in the area of three dimensional(3D)printing&to assess its abilities,and further undertake helpful reporting.Here the focus is to assess ad vantages of 3D printing in orthopedics and analyze how 3D printed models help solve complex 3D orthopedics distortions.This study identified that 3D models manufactured by 3D printing models reduce medical parts de velopment cost and surgical planning time.Integrating 3D printing with orthopaedics helps in understanding the conditions of problems and achieving the operation succssfully.This technology can enable doctors/surgeons to design,produce,recreate and plan operations more accurately,carefully,and economicaly.3D models can assist specialists with a visual comprehension of the patient-particular pathology and life structures.Innovation in 3D printing initiated a scaffold for the virtual outline and execution of medical procedures.This research proposes the utilisation of 3D printers as an elective procedure for the fabrication of parts.It empowers surgeons/patients for better raining,education and research.In the future,there is a foreseeable expansion of additive manufacturing in orthopedics.
基金Funded by National High-tech Research and Development Projects of China(No. 2002AA6Z3083)
文摘An ultraviolet(UV) curable support material pre-polymer for three dimensional printing was prepared based on the synergistic effect between PEO-PPO-PEO tri-block copolymer(F127) and polyethylene glycol (400) di-acrylate(SR344). The effects of jetting conditions, thermal stability, curing time, mechanical properties and shrinking rate on printing models were studied. The situation of removing support material from build model was investigated after building progress was completed. The experimental result shows that when F127 is 6.0wt%, SR344 is 20.0wt%, 4-Methoxy phenol is 0.15wt% and Irgacure 2959 is 1.5wt%, the support material pre-polymer could be jetted out from the nozzles smoothly during building up of three dimensional printing models at 50-55 ℃. In addition, the support material could be removed easily from building model without spoiling the model; furthermore, the forming precision of building model is improved.
基金supported by the National Natural Science Foundation of China (Grant No. 10771088)Natural Science Foundation of Jiangsu Province,China (Grant No. 2007098)+3 种基金Outstanding Personnel Program in Six Fields of Jiangsu Province,China (Grant No. 6-A-029)National Natural Science (Youth) Foundation of China (Grant No. 10801140)Youth Foundation of Chongqing Normal University,China (Grant No. 08XLQ04)the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (Grant No. 09B 202Z)
文摘This paper introduces a new three dimensional autonomous system with five equilibrium points. It demonstrates complex chaotic behaviours within a wide range of parameters, which are described by phase portraits, Lyapunov exponents, frequency spectrum, etc. Analysis of the bifurcation and Poincar@ map is used to reveal mechanisms of generating these complicated phenomena. The corresponding electronic circuits are designed, exhibiting experimental chaotic attractors in accord with numerical simulations. Since frequency spectrum analysis shows a broad frequency bandwidth, this system has perspective of potential applications in such engineering fields as secure communication.
基金Sponsored by the Key Projects of National Natural Science Foundation of China (Grant No.51038004)the Western China Communications Construction and Technology Project (Grant No.2009318000078)
文摘In this paper a series of digital image processing methods were adopted for getting separated coarse aggregates from asphalt mixture specimen using high-resolution X-ray Computed Tomography (CT) images.The existing three dimensional (3D) particles matching methods based on two dimensional (2D) continuous cross-sections were analyzed and a new 'overlap area method' was presented.After the 3D particles were extracted one by one successfully,the basic parameters of each aggregate:perimeter,area,surface area,and volume were calculated by chain code method.Finally,the 3D mass center coordinates and the sphericity index were introduced.
基金State Natural Scientific Foundation (49734150) and National High Performance Computation Foundation.
文摘We assembled approximately 328 seismic records. The data set was from 4 digitally recording long-period and broadband stations of CDSN. We carried out the inversion based on the partitioned waveform inversion (PWI). It partitions the large-scale optimization problem into a number of independent small-scale problems. We adopted surface waveform inversion with an equal block (2((2() discretization in order to acquire the images of shear velocity structure at different depths (from surface to 430 km) in the crust and upper-mantle. The resolution of all these anomalies has been established with (check-board( resolution tests. These results show significant difference in velocity, lithosphere and asthenosphere structure between South China Sea and its adjacent regions.
文摘In this paper, based on the random characteristic analysis of Tianjin Hospital earthquake waves of Tangshan aftershock, the three dimensional acceleration power spectrum density ratio has been presented.
文摘We have presented a three dimensional optical protein chip that fulfills the demanding for point-of-care diagnostics in terms of ease-of-use (one step assay), miniaturization (5 μl). The artful combination of magnetic nanoparticles on chip and total internal reflection imaging (TIRI) technology permits the sensitive and rapid detection of hs-CRP (high-sensitivity C-reactive protein). The whole test was complete within 10 min using “all in one step” assay with a limit of detection of 0.1 ng/mL hs-CRP. The measuring range for hs-CRP could be extended to 10 ng/mL. The chip can also be used to detect more parameters in blood samples.
基金supported by the Deanship of Scientific Research (DSR) of King Abdulaziz University, Jeddah, Saudi Arabia
文摘The objective of the present work is to model the magnetohydrodynamic(MHD) three dimensional flow of viscoelastic fluid passing a stretching surface. Heat transfer analysis is carried out in the presence of variable thermal conductivity and thermal radiation. Arising nonlinear analysis for velocity and temperature is computed. Discussion to importantly involved parameters through plots is presented. Comparison between present and previous limiting solutions is shown. Numerical values of local Nusselt number are computed and analyzed. It can be observed that the effects of viscoelastic parameter and Hartman number on the temperature profile are similar in a qualitative way. The variations in temperature are more pronounced for viscoelastic parameter K in comparison to the Hartman number M. The parameters N and ε give rise to the temperature. It is interesting to note that values of local Nusselt number are smaller for the larger values of ε.
基金This work is supported in part by the Major Fundamental Research of Natural Science Foundation of Shandong Province under Grant ZR2019ZD05Joint Fund for Smart Computing of Shandong Natural Science Foundation under Grant ZR2020LZH013+1 种基金the Scientific Research Platform and Projects of Department of Education of Guangdong Province under Grant 2019GKQNCX121the Intelligent Perception and Computing Innovation Platform of the Shenzhen Institute of Information Technology under Grant PT2019E001.
文摘Contribution:This paper designs a learning and training platform that can systematically help radiologists learn automated medical image analysis technology.The platform can help radiologists master deep learning theories and medical applications such as the three-dimensional medical decision support system,and strengthen the teaching practice of deep learning related courses in hospitals,so as to help doctors better understand deep learning knowledge and improve the efficiency of auxiliary diagnosis.Background:In recent years,deep learning has been widely used in academia,industry,andmedicine.An increasing number of companies are starting to recruit a large number of professionals in the field of deep learning.Increasing numbers of colleges and universities also offer courses related to deep learning to help radiologists learn automated medical image analysis techniques.For now,however,there is no practical training platform that can help radiologists learn automated medical image analysis systematically.ApplicationDesign:The platform proposes the basic learning,model combat,business application(BMR)concept,including the learning guidance system and the assessment training system,which constitutes a closed-loop learning guidance mode of“learning-assessment-training-learning”.Findings:The survey results show that most of radiologists met their learning expectations by using this platform.The platform can help radiologists master deep learning techniques quickly,comprehensively and firmly.
文摘Objective: The aim of our study was to evaluate the outcome and complications of cervical cancer patients undergoing conventional intracavitary brachytherapy (ICBT) treated with 3D-conformal radiotherapy (3DCRT). Methods: Sixty cervical cancer patients were divided randomly into the conformal group and the conventional group. Thirty patients treated with 3D-conformal radiotherapy in the 3DCRT group, when the whole pelvic received DT 40 Gy, a planning CT scan of each patient was obtained and the second 3DCRT therapy plan was taken. Then, continued to irradiate to 50 Gy. At last, 3DCRT was boosted at local involved volumes to the total dose of 60 Gy. When 3DCRT was combined with intracavitary brachytherapy, the dose of brachytherapy to point A was 30 Gy/5 fractions. In the conventional group, after a total tumor dose of 40 Gy was delivered by the whole pelvic irradiation, the four-field technique was used to irradiate the total pelvic and regional nodes (median dose of 10 Gy), and the involved volumes were boosted to 60 Gy and the dose of brachytherapy to point A was 30 Gy-36 Gy/5-6 fractions. Moreover, both groups were combined with intracavitary brachytherapy respectively. Results: The 1, 2, 3-year survival rates for the 3DCRT group and the conventional group were 96.7%, 93.3%, 90.0% and 86.6%, 76.7%, 70% respectively (P = 0.04, P = 0.02 and P = 0.02). There was a statistically significant difference between the two groups. Compared to the two groups each other in toxic effects, except for the I-II grade rectal and bladder reaction and pelvic fibrosis which was lower in the 3DCRT group (P = 0. 007, P = 0. 006 and P = 0. 015), the side effects were similar and well tolerated in two groups. Conclusion: The all-course 3DCRT combined with intracavitary brachytherapy can be considered as an effective and feasible approach to cervical cancer and may significantly improve the survival rate and reduce the late toxicity. This new role for 3DCRT merits need further evaluation with large patient numbers and longer follows up.