目的总结同源新生儿埃可病毒11型(Echovirus type 11,ECHO11)感染新生儿资料,为救治重症病例提供依据。方法选取2019年6月同一医院同间病房转入广州市妇女儿童医疗中心NICU的ECHO11患儿资料进行研究。结果 6例患儿与病毒感染相关的起病...目的总结同源新生儿埃可病毒11型(Echovirus type 11,ECHO11)感染新生儿资料,为救治重症病例提供依据。方法选取2019年6月同一医院同间病房转入广州市妇女儿童医疗中心NICU的ECHO11患儿资料进行研究。结果 6例患儿与病毒感染相关的起病日龄为1~16 d,首发症状是呕吐(50%)和发热(50%),病程早期出现血小板减少(100%),合并自身免疫性溶血病患儿(100%)。重症3例,谷丙转氨酶(ALT)、总胆红素(TBIL)升高,凝血功能异常。血浆置换后ALT(H=20.0,P<0.05)、TBIL(t=17.5,P<0.01)显著下降,凝血酶时间(PT)缩短(H=20.5,P<0.05)。结论新生儿感染ECHO11可引发免疫性血小板降低和自身免疫性溶血压;早期、多次使用血液净化治疗可能改善预后。自身免疫反应可能是造成重症病例的原因。展开更多
The objective of this study was to investigate the outbreak of echovirus 11 (ECHO 11) infection in newborns at a hospital in Guangdong Province, China, and to study the effectiveness of prevention and control measures...The objective of this study was to investigate the outbreak of echovirus 11 (ECHO 11) infection in newborns at a hospital in Guangdong Province, China, and to study the effectiveness of prevention and control measures to infer the epidemiological characteristics of ECHO 11 and explore the effective measures for its prevention and control. We performed retrospective analyses of hospital records and laboratory test data. In this outbreak, ten cases of ECHO 11 infection were identified, of which nine cases were nosocomial infections. Most of the cases (90%) were severe, and three died. The onset time interval of 10 patients was 1-4 days, most of which occur in 1-2 days. There were eight (80%) males and two females (20%). The gestational age of the patients was 31 to 40 weeks (mean, 35+4 weeks;median, 35+4 weeks). The onset time was 3-26 days (average 9 days;median 8 days). The birth weights of the patients ranged from 1,650 g to 3,450 g (mean 2,385 g;median 2,250 g). We concluded that neonatal infection with ECHO 11 will lead to serious symptoms and high mortality, and is prone to outbreaks of nosocomial infection. We speculate that ECHO 11 is most likely to spread via contact transmission;however, we do not rule out the possibility of droplet transmission. Prevention and control measures can effectively prevent and control hospital enteroviral infections.展开更多
文摘目的总结同源新生儿埃可病毒11型(Echovirus type 11,ECHO11)感染新生儿资料,为救治重症病例提供依据。方法选取2019年6月同一医院同间病房转入广州市妇女儿童医疗中心NICU的ECHO11患儿资料进行研究。结果 6例患儿与病毒感染相关的起病日龄为1~16 d,首发症状是呕吐(50%)和发热(50%),病程早期出现血小板减少(100%),合并自身免疫性溶血病患儿(100%)。重症3例,谷丙转氨酶(ALT)、总胆红素(TBIL)升高,凝血功能异常。血浆置换后ALT(H=20.0,P<0.05)、TBIL(t=17.5,P<0.01)显著下降,凝血酶时间(PT)缩短(H=20.5,P<0.05)。结论新生儿感染ECHO11可引发免疫性血小板降低和自身免疫性溶血压;早期、多次使用血液净化治疗可能改善预后。自身免疫反应可能是造成重症病例的原因。
基金financially supported by the National Natural Science Foundation of China(No.71704031).
文摘The objective of this study was to investigate the outbreak of echovirus 11 (ECHO 11) infection in newborns at a hospital in Guangdong Province, China, and to study the effectiveness of prevention and control measures to infer the epidemiological characteristics of ECHO 11 and explore the effective measures for its prevention and control. We performed retrospective analyses of hospital records and laboratory test data. In this outbreak, ten cases of ECHO 11 infection were identified, of which nine cases were nosocomial infections. Most of the cases (90%) were severe, and three died. The onset time interval of 10 patients was 1-4 days, most of which occur in 1-2 days. There were eight (80%) males and two females (20%). The gestational age of the patients was 31 to 40 weeks (mean, 35+4 weeks;median, 35+4 weeks). The onset time was 3-26 days (average 9 days;median 8 days). The birth weights of the patients ranged from 1,650 g to 3,450 g (mean 2,385 g;median 2,250 g). We concluded that neonatal infection with ECHO 11 will lead to serious symptoms and high mortality, and is prone to outbreaks of nosocomial infection. We speculate that ECHO 11 is most likely to spread via contact transmission;however, we do not rule out the possibility of droplet transmission. Prevention and control measures can effectively prevent and control hospital enteroviral infections.