In October 2017,a small outbreak of echovirus 30(E30)associated with aseptic meningitis in nine cases occurred at a primary school in the Ningxia Hui Autonomous Region.That year,we observed a significant increase in E...In October 2017,a small outbreak of echovirus 30(E30)associated with aseptic meningitis in nine cases occurred at a primary school in the Ningxia Hui Autonomous Region.That year,we observed a significant increase in E30 levels in an acute flaccid paralysis(AFP)case surveillance system.To investigate their phylogenetic relationships,we determined the whole genomic sequences of 12 strains isolated from aseptic meningitis cases,AFP cases,and healthy children.We found that the E30 strains circulating in Ningxia belong to two lineages(H and J).The strains isolated in 2010,2012,and 2016 belonged to the H lineage.In 2017,a new lineage,J,emerged as the dominant lineage.Phylogenetic trees were constructed based on the whole genome andP1,P2,andP3 regions;clustering with other types of enterovirus species B was found,suggesting that recombination events had occurred.The recombination sites were mainly in regions2B,2C,and3D.This study confirmed that the E30 strains in Ningxia in 2010,2012,and 2016 had different recombination patterns and were recombined with different enteroviruses.The 2017 epidemic E30 originated from another new lineage with a complex recombination pattern and formed an independent transmission chain in Ningxia.展开更多
Background:Although aseptic meningitis associated with echovirus type 30 has emerged as a global public health concern,no data have been reported on children's immune status against echovirus type 30.The current s...Background:Although aseptic meningitis associated with echovirus type 30 has emerged as a global public health concern,no data have been reported on children's immune status against echovirus type 30.The current study aimed to investigate the seropositivity among Korean children for antibodies against echovirus 30.Methods:Two hundred and fifty residual serum samples were collected at St.Paul's Hospital.Individuals were categorized by age into four groups:group 1 (3 months-2 years),group 2 (3-6 years),group 3 (7-10 years) and group 4 (11-15 years).Neutralizing antibodies against echovirus 30 were measured.Results:Seroprotective neutralizing antibodies against echovirus 30 were detected in 129 (49%) individuals.Seropositivity rates were 23%,48%,55% and 73% in groups 1-4,respectively.For antibody titers,1:256-1:512 was the highest neutralizing antibody titer range in group 2,while 1:1024-1:2048 in group 3 and 4.Among the seropositive individuals in group 3 and 4,6% and 12% had neutralizing antibody titers of 1:2048,respectively.Conclusions:The seropositivity rate increased significantly with age..The distribution of neutralizing antibody titers varied by age group,and higher ranges of neutralizing antibody titers were observed in higher age groups.These findings suggest high susceptibility to echovirus 30 infection in children younger than 2 years old.Echovirus 30 infection in childhood may have contributed to increased neutralizing antibody titers with age.展开更多
基金supported by the Science and Natural Science of Ningxia (Grant No.2021AAC03415)the Science and Natural Science of China (Grant No.81960607)+1 种基金Science and Natural Science of Ningxia (Grant No.2022AAC03708)the National Key Research and Development Program of China (Project No.2021YFC2302003).
文摘In October 2017,a small outbreak of echovirus 30(E30)associated with aseptic meningitis in nine cases occurred at a primary school in the Ningxia Hui Autonomous Region.That year,we observed a significant increase in E30 levels in an acute flaccid paralysis(AFP)case surveillance system.To investigate their phylogenetic relationships,we determined the whole genomic sequences of 12 strains isolated from aseptic meningitis cases,AFP cases,and healthy children.We found that the E30 strains circulating in Ningxia belong to two lineages(H and J).The strains isolated in 2010,2012,and 2016 belonged to the H lineage.In 2017,a new lineage,J,emerged as the dominant lineage.Phylogenetic trees were constructed based on the whole genome andP1,P2,andP3 regions;clustering with other types of enterovirus species B was found,suggesting that recombination events had occurred.The recombination sites were mainly in regions2B,2C,and3D.This study confirmed that the E30 strains in Ningxia in 2010,2012,and 2016 had different recombination patterns and were recombined with different enteroviruses.The 2017 epidemic E30 originated from another new lineage with a complex recombination pattern and formed an independent transmission chain in Ningxia.
文摘Background:Although aseptic meningitis associated with echovirus type 30 has emerged as a global public health concern,no data have been reported on children's immune status against echovirus type 30.The current study aimed to investigate the seropositivity among Korean children for antibodies against echovirus 30.Methods:Two hundred and fifty residual serum samples were collected at St.Paul's Hospital.Individuals were categorized by age into four groups:group 1 (3 months-2 years),group 2 (3-6 years),group 3 (7-10 years) and group 4 (11-15 years).Neutralizing antibodies against echovirus 30 were measured.Results:Seroprotective neutralizing antibodies against echovirus 30 were detected in 129 (49%) individuals.Seropositivity rates were 23%,48%,55% and 73% in groups 1-4,respectively.For antibody titers,1:256-1:512 was the highest neutralizing antibody titer range in group 2,while 1:1024-1:2048 in group 3 and 4.Among the seropositive individuals in group 3 and 4,6% and 12% had neutralizing antibody titers of 1:2048,respectively.Conclusions:The seropositivity rate increased significantly with age..The distribution of neutralizing antibody titers varied by age group,and higher ranges of neutralizing antibody titers were observed in higher age groups.These findings suggest high susceptibility to echovirus 30 infection in children younger than 2 years old.Echovirus 30 infection in childhood may have contributed to increased neutralizing antibody titers with age.