Inventory data were available from 96 plots of even-aged,monoculture,tall-open forests of Eucalyptus pilularis Smith,aged 2-63 years,growing in sub-tropical regions along the east coast of Australia.A model was develo...Inventory data were available from 96 plots of even-aged,monoculture,tall-open forests of Eucalyptus pilularis Smith,aged 2-63 years,growing in sub-tropical regions along the east coast of Australia.A model was developed relating the maximum possible stem basal area growth rate of individual trees to their stem basal area.For any tree size,this maximum increased as site productivity increased.However,the size at which this maximum occurred decreased as productivity increased.Much research has shown that,at any stand age,trees of a particular stem basal area are taller on more productive sites than on less productive ones.Taller trees incur greater respiratory costs to ensure maintenance of the photo synthetic capacity of their canopies;this reduces their growth rates.It was concluded that trees with larger basal areas will have the maximum possible growth rate on a less productive site,whilst trees with smaller basal areas will have the maximum possible on a more productive site.The model developed may constitute the first stage of a complete individual tree growth model system to predict wood yields from these forests.展开更多
P values based on standard hypothesis testing are commonly reported in articles published by the Journal of Forestry Research(JFR).However,effect sizes are barely used and reported,even if they are of direct relevance...P values based on standard hypothesis testing are commonly reported in articles published by the Journal of Forestry Research(JFR).However,effect sizes are barely used and reported,even if they are of direct relevance to the primary questions of many of the published studies.The incorporation of effect sizes in studies published by JFR should be encouraged and promoted.Inclusion of effect sizes as a requirement in the journal guidelines will facilitate a major change in the way data are tested and interpreted,with the ultimate goal to exempt researchers from the custom of drawing conclusions merely based upon a dichotomous statistical result(P value).Such a policy can also lead to more informed decisions of whether identified effects are of practical relevance to the forestry.展开更多
Quantitative analysis of time scale effects is conducive to further understanding of vegetation water and soil conservation mechanism.Based on the observation data of the grass covered and bare soil( control) experime...Quantitative analysis of time scale effects is conducive to further understanding of vegetation water and soil conservation mechanism.Based on the observation data of the grass covered and bare soil( control) experimental plots located in Hetian Town,Changting County of Fujian Province from 2007 to 2010,the characteristics of 4 parameters( precipitation,vegetation,RE and SE) were analyzed at precipitation event,month,season,and annual scales,and then the linear regression models were established to describe the relationships between RE( SE)and its influencing factors of precipitation and vegetation. RE( SE) means the ratio of runoff depth( soil loss) of grass covered plot to that of the control plot. Results show that these 4 parameters presented different magnitude and variation on different time scales. RE and SE were relatively stable either within or among different time scales due to their ratios reducing the influence of other factors. The coupling of precipitation and vegetation led to better water conservation effect at lower RE( < 0. 3) at precipitation event scale as well as at season scale,while the water conservation effect was dominated by precipitation at slightly higher( 0. 3- 0. 4) and higher( > 0. 7) REs at precipitation event scale as well as at annual scale( R2> 0. 78). For the soil conservation effect,precipitation or / and vegetation was / were the dominated influence factor( s) at precipitation event and annual scales,and the grass LAI could basically describe the positive conservation effect( SE <1,R2> 0. 55),while the maximum 30 min intensity( I30) could describe the negative conservation effect more accurately( SE >1,R2> 0. 79). More uncertainties( R2≈0. 4) exist in the models of both RE and SE at two moderate time scales( month and season). Consequently,factors influencing water and soil conservation effect of grass present different variation and coupling characteristics on different time scales,indicating the importance of time scale at the study on water and soil conservation.展开更多
Using the survey data on 340 farmers in Chongqing City,this paper performs an empirical analysis of the factors influencing the non-point source pollution of pesticides. The results show that the older householders wi...Using the survey data on 340 farmers in Chongqing City,this paper performs an empirical analysis of the factors influencing the non-point source pollution of pesticides. The results show that the older householders will apply more pesticides,which may be due to the weak physical strength and weak ability to accept the concept of advanced cultivation; the householders with high level of education will choose to use less pesticides; the pesticide application rate is negatively correlated with whether farmers have participated in agricultural technology training,that is,the farmers having participated in agricultural technology training have stronger ability to scientifically apply pesticides,and in-depth understanding of advanced agricultural production technology and positive and negative effects of pesticides,so they often choose to reduce the application rate of pesticide; the cognitive factor on the role of pesticides in better promoting the growth of crops is significant,which requires the government and relevant departments to carry out concrete publicity of effectiveness and negative impact of different pesticides during the popularization of agricultural science knowledge,to prompt farmers to have a systematic and in-depth understanding of the agricultural nonpoint source pollution caused by pesticides.展开更多
Objective:To observe the protective effect of breviscapineon mice with cisplatin-induced nephrotoxicity.Methods:Mice were given a single injection of cisplalin(8 mg/kg,up.);then,breviscapine was given to mice at 25 mg...Objective:To observe the protective effect of breviscapineon mice with cisplatin-induced nephrotoxicity.Methods:Mice were given a single injection of cisplalin(8 mg/kg,up.);then,breviscapine was given to mice at 25 mg/kg and 50 mg/kg doses,respectively,once a day for seven days.Renal tissue structure was observed after animals were sacrificed.Blood urea nitrogen(BUN),serum creatinine(Scr),lipid peroxide(MDA) and superoxide dismutase(SOD) serum levels were detected;and MDA,glutathione peroxidase,and SOD levels in the renal cortex were detected.Results:Compared with the blank control group(BCG),the kidney pathological damage of mice in the model control group(MCG) was more severe.After applying different doses of breviscapine,different degrees of renal injury improvement appeared.Compared with the BCG,the serum levels of Scr and BUN in the MCG increased to(89.92±6.78) μmoL/L and(15.32±4.53) mmoL/L.The differences were statistical significant(P<0.01).Compared with the MCG,the serum levels of Scr and BUN in the Bre low-dose groups and Bre high-dose groups decreased significantly(P<0.05).Compared with the BCG,the MDA levels in serum and in the renal cortex in the MCG significantly increased,while the SOD levels significantly decreased.Both the differences were statistically significant(P<0.01).In the Bre low-dose groups and Bre high-dose groups,MDA levels in serum and in the renal cortex significantly decreased,while SOD and glutathione peroxidase levels in the renal cortex significantly increased,compared with the MCG;and the differences were statistically significant(P<0.05).Conclusions:Breviscapine can reduce cisplatin induced renal toxicity in mice and it's possible through inhibition of renal tubule cell lipid peroxidation and reduces the nephrotoxicity of cisplatin.展开更多
Topography can have signifi cant eff ects on seismic ground response during an earthquake because topographic irregularities cause considerable diff erences between the seismic waves emitted by the source and the wave...Topography can have signifi cant eff ects on seismic ground response during an earthquake because topographic irregularities cause considerable diff erences between the seismic waves emitted by the source and the waves reaching the ground surface. When a seismic motion happens in a topographically irregular area, seismic waves are trapped and refl ected between the topographic features. Therefore, the interaction between topographies can amplify seismic ground response. In order to reveal how interaction between topographies infl uences seismic response, several numerical fi nite element studies have been performed by using the ABAQUS program. The results show that topographic features a greater distance between the seismic source and the site would cause greater seismic motion amplifi cation and is perceptible for the hills far away from the source and the ridges. Also, site acceleration response is impacted by surrounding topography further than site velocity and displacement response.展开更多
The available models for eff ective periods of site and structure are reviewed in context of frequency tuning in the inelastic seismic response of soil-structure system. The eff ect of seismic intensity and ductility ...The available models for eff ective periods of site and structure are reviewed in context of frequency tuning in the inelastic seismic response of soil-structure system. The eff ect of seismic intensity and ductility demand, on the eff ective periods, is investigated, and inelastic site amplifi cation is shown to be strongly correlated to the normalized eff ective period. Two non-dimensional parameters, analogous to the conventional site amplifi cation factors in codes, are defi ned to quantify the inelastic site amplifi cation. It is shown that the inelastic site amplifi cation factor (i.e. ratio of constant ductility spectral ordinates at soil site to those at rock outcrop) is able to represent the site eff ects more clearly, as compared to the inelastic site amplifi cation ratio (i.e. ratio of inelastic spectral ordinates at soil site to the corresponding elastic spectral ordinates at rock outcrop). Further, the peak in the amplifi cation factor corresponding to the eff ective site period diminishes rapidly with increasing ductility demand.展开更多
Currently,the fault sliding speed functions or source–time functions used in theoretical seismogram calculations have only produced theoretical results;that is,the results of the fault speed–time functions have been...Currently,the fault sliding speed functions or source–time functions used in theoretical seismogram calculations have only produced theoretical results;that is,the results of the fault speed–time functions have been obtained only from theoretical studies,and have not been validated using the measured data.This paper signifi cantly improves the method for calculating fault sliding speed using the Doppler eff ect,from the following four perspectives.First,the paper theoretically demonstrates how to confirm that the seismic waves received in some frequency bands by two diff erent receivers are emitted by the same source.Second,the paper proposes a method to determine the similarity of seismic waves received by two diff erent receivers in some frequency bands;it applies the relative change at the two receivers in Fourier amplitude standard deviation in some frequency bands,and determines that similar seismic waves are emitted by the same frequency bands.Third,to eliminate the interference of reflected and refracted waves,this study uses fault sliding time S-wave records for data processing.Finally,the paper replaces the long-time Fourier transform with short-time Fourier transform to enhance the positioning accuracy of fault sliding times.Based on these perspectives,the paper systematically summarizes a general methodology for calculating the fault sliding speed using the Doppler effect.This method is employed to calculate the fault sliding speed of the Wenchuan earthquake;the calculations reveal that there is a general correlation between the fault sliding speeds of the Wenchuan earthquake and the seismic moment changes.The results confi rm that the sliding speed of the Wenchuan earthquake fault possesses the characteristics of abrupt change,whereby a sudden increase in the sliding speed is followed by a rapid decrease.Generally,the sliding speed is not fast,and sometimes,no sliding occurs.There are obvious diff erences from the currently used sliding speed functions,such as the Haskell function,bell-shaped function,exponential function,and triangular function.To determine the fault sliding speed using the Doppler eff ect,only the earthquake records and locations of the epicenter and receivers are required,instead of using unknown crust parameters.In short,the proposed calculation method has clear physical meaning,and the required parameters are easier to obtain.展开更多
Sepsis-induced acute lung injury(ALI)is a leading cause of death among septic complications.Tao-Hong-Si-Wu decoction(TSD),a classical recipe from traditional Chinese medicine used for treating ischemic stroke,has been...Sepsis-induced acute lung injury(ALI)is a leading cause of death among septic complications.Tao-Hong-Si-Wu decoction(TSD),a classical recipe from traditional Chinese medicine used for treating ischemic stroke,has been recently reported to alleviate inflammation and inflammation-stimulated injuries related to the pathology of ALI.Here,we first observed the therapeutic effect of TSD on sepsis-induced ALI.Based on integrated metabolomics and network pharmacology analysis(NPA)techniques,we aim to understand the mechanism of TSD alleviating ALI.TSD’s effects were observed in rats modeled by cecal ligation and puncture(CLP)and rat macrophages stimulated by lipopolysaccharide(LPS).Metabolomics analyses were applied to determine the ingredients in the medicine and key metabolites correlated to the NPA for the prediction of TSD targets.Gene and protein expressions of the key predicted targets were evaluated in the lung tissue and macrophages of septic model rat by quantitative polymerase chain reaction(PCR)and enzyme-linked immunosorbent assays,respectively.TSD improved survival rate and protected against lung injury in CLP rats.Eleven endogenous metabolites were related to TSD’s actions.TSD significantly suppressed IL-6 and TNF-αsecretions and their gene expressions both in the lung tissue of the model rats and in LPS-stimulated macrophages.TSD also restored decreased lung protein expression of VEGFA in septic model rats.Targeted proteins and their affecting metabolites were finally validated in an external test set of rats.This study shows that metabolomics coupled with NPA is a promising approach to explore potential targets of medicine with complex compositions.展开更多
Electrocatalytic glucose oxidation reaction(GOR)has attracted much attention owing to its crucial role in biofuel cell fabrication.Herein,we load MoO_(3)nanoparticles on carbon nanotubes(CNTs)and use a discharge proce...Electrocatalytic glucose oxidation reaction(GOR)has attracted much attention owing to its crucial role in biofuel cell fabrication.Herein,we load MoO_(3)nanoparticles on carbon nanotubes(CNTs)and use a discharge process to prepare a noblemetal-free MC-60 catalyst containing MoO_(3),Mo_(2)C,and a Mo_(2)C–MoO_(3)interface.In the GOR,MC-60 shows activity as high as 745μA/(mmol/L cm^(2)),considerably higher than those of the Pt/CNT(270μA/(mmol/L cm^(2)))and Au/CNT catalysts(110μA/(mmol/L cm^(2))).In the GOR,the response minimum on MC-60 is as low as 8μmol/L,with a steady-state response time of only 3 s.Moreover,MC-60 has superior stability and anti-interference ability to impurities in the GOR.The better performance of MC-60 in the GOR is attributed to the abundant Mo sites bonding to C and O atoms at the MoO_(3)–Mo_(2)C interface.These Mo sites create active sites for promoting glucose adsorption and oxidation,enhancing MC-60 performance in the GOR.Thus,these results help to fabricate more effi cient noble-metal-free catalysts for the fabrication of glucose-based biofuel cells.展开更多
Three-dimensional(3D)printing technology has been widely used to create artificial rock samples in rock mechanics.While 3D printing can create complex fractures,the material still lacks sufficient similarity to natura...Three-dimensional(3D)printing technology has been widely used to create artificial rock samples in rock mechanics.While 3D printing can create complex fractures,the material still lacks sufficient similarity to natural rock.Extrusion free forming(EFF)is a 3D printing technique that uses clay as the printing material and cures the specimens through high-temperature sintering.In this study,we attempted to use the EFF technology to fabricate artificial rock specimens.The results show the physico-mechanical properties of the specimens are significantly affected by the sintering temperature,while the nozzle diameter and layer thickness also have a certain impact.The specimens are primarily composed of SiO_(2),with mineral compositions similar to that of natural rocks.The density,uniaxial compressive strength(UCS),elastic modulus,and tensile strength of the printed specimens fall in the range of 1.65–2.54 g/cm3,16.46–50.49 MPa,2.17–13.35 GPa,and 0.82–17.18 MPa,respectively.It is capable of simulating different types of rocks,especially mudstone,sandstone,limestone,and gneiss.However,the simulation of hard rocks with UCS exceeding 50 MPa still requires validation.展开更多
The Bauschinger-like effect, which showed up in the straightening process of the AZ31 magnesium alloy wide sheet, was investigated through the multi-pass discrete three-point bending–unloading–bending(BUB) experimen...The Bauschinger-like effect, which showed up in the straightening process of the AZ31 magnesium alloy wide sheet, was investigated through the multi-pass discrete three-point bending–unloading–bending(BUB) experiments. The stress variable, anisotropy, and asymmetry of tension and compression on the straightening process were corresponding to the Bauschingerlike effect. The Bauschinger-like effect in the initial, intermediate, and end of the straightening process was dominated by the twinning, detwinning, and dislocation induced by pyramidal < c + a > slip, respectively. Also, they were responsible for the transformation of the Bauschinger stress parameter(BSP) and Bauschinger energy parameter(BEP). Later, the anisotropic nonlinear kinematic hardening model(ANK model) to describe the Bauschinger-like effect was optimized and simplified.展开更多
Ground-level ozone pollution is a menace for vegetation in the northern hemisphere,limiting photosynthetic pigments and suppressing photosynthesis in trees and other types of plants.Phaeophytinization is the process o...Ground-level ozone pollution is a menace for vegetation in the northern hemisphere,limiting photosynthetic pigments and suppressing photosynthesis in trees and other types of plants.Phaeophytinization is the process of converting chlorophylls into phaeophytins,for example by acidifi cation.Ozone is a highly oxidizing molecule and well known to degrade chlorophylls;however,the eff ect of ozone on phaeophytinization in leaves of higher plants is largely unknown.To reveal ozone eff ect on phaeophytinization and evaluate the potential of phaeophytinization as an index of ozone stress in trees,the absorbance at the optical density of 665 nm was measured before(OD_(665))and after(OD_(665a))acidifi cation in three independent experiments with nearly 30 conditions of ozone exposure.Both current ambient and elevated ozone widely aff ected phaeophytinization,as indicated by decreases or increases in the phaeophytinization quotient OD_(665)/OD_(665a).These eff ects were commonly moderate to large in magnitude and practically signifi cant,and occurred even in ozone-asymptomatic leaves.It emerges that the ozone eff ect on phaeophytinization is bimodal,likely depending on the intensity of ozone stress.These results indicate a promising feature of OD_(665)/OD_(665a)as a thorough index of ozone stress in the future,but further studies are needed to reveal the underlying biochemical mechanisms of the bimodal eff ect on phaeophytinization.展开更多
Climate change can intensify drought in many regions of the world and lead to more frequent drought events or altered cycles of soil water status.Therefore,it is important to enhance the tolerance to drought and thus ...Climate change can intensify drought in many regions of the world and lead to more frequent drought events or altered cycles of soil water status.Therefore,it is important to enhance the tolerance to drought and thus health,vigor,and success of transplantation seedlings used in the forestry by modifying fertilization and promoting mycorrhization.Here,we sowed seeds of Japanese larch(Larix kaempferi)in 0.2-L containers with 0.5 g(low fertilization;LF)or 2 g(high fertilization;HF)of slow-release fertilizer early in the growing season.One month later,we irrigated seedlings with non-sterilized ectomycorrhizal inoculum(ECM)or sterilized solution(non-ECM),and after about 2 months,plants were either kept well watered(WW;500 mL water/plant/week)or subjected to drought(DR;50 mL water per plant/week)until the end of the growing season.HF largely stimulated plant growth and above-and belowground biomass production,eff ects that are of practical signifi cance,but caused a small decrease in stomatal conductance(Gs 390)and transpiration rate(E 390),which in practice is insignifi cant.ECM treatment resulted in moderate inhibition of seedling growth and biomass and largely canceled out the enhancement of biomass and foliar K content by HF.DR caused a large decrease in CO 2 assimilation,and enhanced stomatal closure and induced senescence.DR also largely depleted foliar Mg and enriched foliar K.Although DR caused a large decrease in foliar P content in LF,it moderately increased P in HF.Likewise,DR increased foliar K in HF but not in LF,and decreased foliar P in ECM plants but not in non-ECM plants.Conversely,ECM plants exhibited a large enrichment in foliar P under WW and had a lower water potential under DR when grown in LF.These results indicate that the drought tolerance and health and vigor of Japanese larch seedlings can be modifi ed by soil fertility and soil microorganisms.This study provides a basis for new multifactorial research programs aimed at producing seedlings of superior quality for forestation under climate change.展开更多
With the rapid development of economy, the scale of city has become more and more large. Meanwhile, the population also grows rapidly. Although the standard of living condition has been improved greatly, industry and ...With the rapid development of economy, the scale of city has become more and more large. Meanwhile, the population also grows rapidly. Although the standard of living condition has been improved greatly, industry and domestic waste not only infl uence the quality of life by polluting the environment, but also become a signifi cant obstacle factor for economic development. waste power generation or waste-to-energy(WTE) is using the heat which is from garbage incinerator to generate electricity. This method can solve the problem of waste and generate the social benefi t, but by using the power on the internet to generate the economy benefit. In this paper, combined the method of FAHP and TOPSIS, a quotas system is set up to evaluate the social and economic benefi ts of the WTE project in Xiamen. Some advice is proposed for the Xiamen WTE project.展开更多
文摘Inventory data were available from 96 plots of even-aged,monoculture,tall-open forests of Eucalyptus pilularis Smith,aged 2-63 years,growing in sub-tropical regions along the east coast of Australia.A model was developed relating the maximum possible stem basal area growth rate of individual trees to their stem basal area.For any tree size,this maximum increased as site productivity increased.However,the size at which this maximum occurred decreased as productivity increased.Much research has shown that,at any stand age,trees of a particular stem basal area are taller on more productive sites than on less productive ones.Taller trees incur greater respiratory costs to ensure maintenance of the photo synthetic capacity of their canopies;this reduces their growth rates.It was concluded that trees with larger basal areas will have the maximum possible growth rate on a less productive site,whilst trees with smaller basal areas will have the maximum possible on a more productive site.The model developed may constitute the first stage of a complete individual tree growth model system to predict wood yields from these forests.
基金co-supported by the Outstanding Action Plan of Chinese Sci-tech Journals(Grant No.OAP–C–077)the Startup Foundation for Introducing Talent of Nanjing University of Information Science&Technology(NUIST),Nanjing,China(Grant No.003080)the Jiangsu Distinguished Professor Program of the People’s Government of Jiangsu Province。
文摘P values based on standard hypothesis testing are commonly reported in articles published by the Journal of Forestry Research(JFR).However,effect sizes are barely used and reported,even if they are of direct relevance to the primary questions of many of the published studies.The incorporation of effect sizes in studies published by JFR should be encouraged and promoted.Inclusion of effect sizes as a requirement in the journal guidelines will facilitate a major change in the way data are tested and interpreted,with the ultimate goal to exempt researchers from the custom of drawing conclusions merely based upon a dichotomous statistical result(P value).Such a policy can also lead to more informed decisions of whether identified effects are of practical relevance to the forestry.
基金Supported by National Natural Science Foundation Project(41071281)Natural Science Foundation of Jiangsu Province(BK20131078)"Qing Lan Project" of Jiangsu Provincial Department of Education
文摘Quantitative analysis of time scale effects is conducive to further understanding of vegetation water and soil conservation mechanism.Based on the observation data of the grass covered and bare soil( control) experimental plots located in Hetian Town,Changting County of Fujian Province from 2007 to 2010,the characteristics of 4 parameters( precipitation,vegetation,RE and SE) were analyzed at precipitation event,month,season,and annual scales,and then the linear regression models were established to describe the relationships between RE( SE)and its influencing factors of precipitation and vegetation. RE( SE) means the ratio of runoff depth( soil loss) of grass covered plot to that of the control plot. Results show that these 4 parameters presented different magnitude and variation on different time scales. RE and SE were relatively stable either within or among different time scales due to their ratios reducing the influence of other factors. The coupling of precipitation and vegetation led to better water conservation effect at lower RE( < 0. 3) at precipitation event scale as well as at season scale,while the water conservation effect was dominated by precipitation at slightly higher( 0. 3- 0. 4) and higher( > 0. 7) REs at precipitation event scale as well as at annual scale( R2> 0. 78). For the soil conservation effect,precipitation or / and vegetation was / were the dominated influence factor( s) at precipitation event and annual scales,and the grass LAI could basically describe the positive conservation effect( SE <1,R2> 0. 55),while the maximum 30 min intensity( I30) could describe the negative conservation effect more accurately( SE >1,R2> 0. 79). More uncertainties( R2≈0. 4) exist in the models of both RE and SE at two moderate time scales( month and season). Consequently,factors influencing water and soil conservation effect of grass present different variation and coupling characteristics on different time scales,indicating the importance of time scale at the study on water and soil conservation.
基金Supported by Chongqing Humanities and Social Science Key Research Project(11SKB31)Chongqing Philosophy and Social Science Planning Project(2014YBGL130)
文摘Using the survey data on 340 farmers in Chongqing City,this paper performs an empirical analysis of the factors influencing the non-point source pollution of pesticides. The results show that the older householders will apply more pesticides,which may be due to the weak physical strength and weak ability to accept the concept of advanced cultivation; the householders with high level of education will choose to use less pesticides; the pesticide application rate is negatively correlated with whether farmers have participated in agricultural technology training,that is,the farmers having participated in agricultural technology training have stronger ability to scientifically apply pesticides,and in-depth understanding of advanced agricultural production technology and positive and negative effects of pesticides,so they often choose to reduce the application rate of pesticide; the cognitive factor on the role of pesticides in better promoting the growth of crops is significant,which requires the government and relevant departments to carry out concrete publicity of effectiveness and negative impact of different pesticides during the popularization of agricultural science knowledge,to prompt farmers to have a systematic and in-depth understanding of the agricultural nonpoint source pollution caused by pesticides.
基金supported by the National Natural Science Foundation of China(No.81401428)
文摘Objective:To observe the protective effect of breviscapineon mice with cisplatin-induced nephrotoxicity.Methods:Mice were given a single injection of cisplalin(8 mg/kg,up.);then,breviscapine was given to mice at 25 mg/kg and 50 mg/kg doses,respectively,once a day for seven days.Renal tissue structure was observed after animals were sacrificed.Blood urea nitrogen(BUN),serum creatinine(Scr),lipid peroxide(MDA) and superoxide dismutase(SOD) serum levels were detected;and MDA,glutathione peroxidase,and SOD levels in the renal cortex were detected.Results:Compared with the blank control group(BCG),the kidney pathological damage of mice in the model control group(MCG) was more severe.After applying different doses of breviscapine,different degrees of renal injury improvement appeared.Compared with the BCG,the serum levels of Scr and BUN in the MCG increased to(89.92±6.78) μmoL/L and(15.32±4.53) mmoL/L.The differences were statistical significant(P<0.01).Compared with the MCG,the serum levels of Scr and BUN in the Bre low-dose groups and Bre high-dose groups decreased significantly(P<0.05).Compared with the BCG,the MDA levels in serum and in the renal cortex in the MCG significantly increased,while the SOD levels significantly decreased.Both the differences were statistically significant(P<0.01).In the Bre low-dose groups and Bre high-dose groups,MDA levels in serum and in the renal cortex significantly decreased,while SOD and glutathione peroxidase levels in the renal cortex significantly increased,compared with the MCG;and the differences were statistically significant(P<0.05).Conclusions:Breviscapine can reduce cisplatin induced renal toxicity in mice and it's possible through inhibition of renal tubule cell lipid peroxidation and reduces the nephrotoxicity of cisplatin.
文摘Topography can have signifi cant eff ects on seismic ground response during an earthquake because topographic irregularities cause considerable diff erences between the seismic waves emitted by the source and the waves reaching the ground surface. When a seismic motion happens in a topographically irregular area, seismic waves are trapped and refl ected between the topographic features. Therefore, the interaction between topographies can amplify seismic ground response. In order to reveal how interaction between topographies infl uences seismic response, several numerical fi nite element studies have been performed by using the ABAQUS program. The results show that topographic features a greater distance between the seismic source and the site would cause greater seismic motion amplifi cation and is perceptible for the hills far away from the source and the ridges. Also, site acceleration response is impacted by surrounding topography further than site velocity and displacement response.
文摘The available models for eff ective periods of site and structure are reviewed in context of frequency tuning in the inelastic seismic response of soil-structure system. The eff ect of seismic intensity and ductility demand, on the eff ective periods, is investigated, and inelastic site amplifi cation is shown to be strongly correlated to the normalized eff ective period. Two non-dimensional parameters, analogous to the conventional site amplifi cation factors in codes, are defi ned to quantify the inelastic site amplifi cation. It is shown that the inelastic site amplifi cation factor (i.e. ratio of constant ductility spectral ordinates at soil site to those at rock outcrop) is able to represent the site eff ects more clearly, as compared to the inelastic site amplifi cation ratio (i.e. ratio of inelastic spectral ordinates at soil site to the corresponding elastic spectral ordinates at rock outcrop). Further, the peak in the amplifi cation factor corresponding to the eff ective site period diminishes rapidly with increasing ductility demand.
基金supported by the Educational Department Project of Liaoning province:LJYL040(No.551610001219)。
文摘Currently,the fault sliding speed functions or source–time functions used in theoretical seismogram calculations have only produced theoretical results;that is,the results of the fault speed–time functions have been obtained only from theoretical studies,and have not been validated using the measured data.This paper signifi cantly improves the method for calculating fault sliding speed using the Doppler eff ect,from the following four perspectives.First,the paper theoretically demonstrates how to confirm that the seismic waves received in some frequency bands by two diff erent receivers are emitted by the same source.Second,the paper proposes a method to determine the similarity of seismic waves received by two diff erent receivers in some frequency bands;it applies the relative change at the two receivers in Fourier amplitude standard deviation in some frequency bands,and determines that similar seismic waves are emitted by the same frequency bands.Third,to eliminate the interference of reflected and refracted waves,this study uses fault sliding time S-wave records for data processing.Finally,the paper replaces the long-time Fourier transform with short-time Fourier transform to enhance the positioning accuracy of fault sliding times.Based on these perspectives,the paper systematically summarizes a general methodology for calculating the fault sliding speed using the Doppler effect.This method is employed to calculate the fault sliding speed of the Wenchuan earthquake;the calculations reveal that there is a general correlation between the fault sliding speeds of the Wenchuan earthquake and the seismic moment changes.The results confi rm that the sliding speed of the Wenchuan earthquake fault possesses the characteristics of abrupt change,whereby a sudden increase in the sliding speed is followed by a rapid decrease.Generally,the sliding speed is not fast,and sometimes,no sliding occurs.There are obvious diff erences from the currently used sliding speed functions,such as the Haskell function,bell-shaped function,exponential function,and triangular function.To determine the fault sliding speed using the Doppler eff ect,only the earthquake records and locations of the epicenter and receivers are required,instead of using unknown crust parameters.In short,the proposed calculation method has clear physical meaning,and the required parameters are easier to obtain.
基金supported by the National Natural Science Foundation of China(81873986)Anhui Natural Science Foundation(2008085QH364)+1 种基金the funding of Anhui Medical University(2020xkjT019,2021lcxk026)Scientific Research Platform Improvement Project of Anhui Medical University(2022xkjT045)
文摘Sepsis-induced acute lung injury(ALI)is a leading cause of death among septic complications.Tao-Hong-Si-Wu decoction(TSD),a classical recipe from traditional Chinese medicine used for treating ischemic stroke,has been recently reported to alleviate inflammation and inflammation-stimulated injuries related to the pathology of ALI.Here,we first observed the therapeutic effect of TSD on sepsis-induced ALI.Based on integrated metabolomics and network pharmacology analysis(NPA)techniques,we aim to understand the mechanism of TSD alleviating ALI.TSD’s effects were observed in rats modeled by cecal ligation and puncture(CLP)and rat macrophages stimulated by lipopolysaccharide(LPS).Metabolomics analyses were applied to determine the ingredients in the medicine and key metabolites correlated to the NPA for the prediction of TSD targets.Gene and protein expressions of the key predicted targets were evaluated in the lung tissue and macrophages of septic model rat by quantitative polymerase chain reaction(PCR)and enzyme-linked immunosorbent assays,respectively.TSD improved survival rate and protected against lung injury in CLP rats.Eleven endogenous metabolites were related to TSD’s actions.TSD significantly suppressed IL-6 and TNF-αsecretions and their gene expressions both in the lung tissue of the model rats and in LPS-stimulated macrophages.TSD also restored decreased lung protein expression of VEGFA in septic model rats.Targeted proteins and their affecting metabolites were finally validated in an external test set of rats.This study shows that metabolomics coupled with NPA is a promising approach to explore potential targets of medicine with complex compositions.
基金supported by the National Natural Science Foundation of China(Nos.82170426 and 22078193)Double Thousand Plan of Jiangxi Province(Nos.461654,jxsq2019102052).
文摘Electrocatalytic glucose oxidation reaction(GOR)has attracted much attention owing to its crucial role in biofuel cell fabrication.Herein,we load MoO_(3)nanoparticles on carbon nanotubes(CNTs)and use a discharge process to prepare a noblemetal-free MC-60 catalyst containing MoO_(3),Mo_(2)C,and a Mo_(2)C–MoO_(3)interface.In the GOR,MC-60 shows activity as high as 745μA/(mmol/L cm^(2)),considerably higher than those of the Pt/CNT(270μA/(mmol/L cm^(2)))and Au/CNT catalysts(110μA/(mmol/L cm^(2))).In the GOR,the response minimum on MC-60 is as low as 8μmol/L,with a steady-state response time of only 3 s.Moreover,MC-60 has superior stability and anti-interference ability to impurities in the GOR.The better performance of MC-60 in the GOR is attributed to the abundant Mo sites bonding to C and O atoms at the MoO_(3)–Mo_(2)C interface.These Mo sites create active sites for promoting glucose adsorption and oxidation,enhancing MC-60 performance in the GOR.Thus,these results help to fabricate more effi cient noble-metal-free catalysts for the fabrication of glucose-based biofuel cells.
基金financially supported by the Beijing Natural Science Foundation for Young Scientists(Grant No.8214052)the Talent Fund of Beijing Jiaotong University(Grant No.2021RC226)the State Key Laboratory for GeoMechanics and Deep Underground Engineering,China University of Mining and Technology(Grant No.SKLGDUEK2115).
文摘Three-dimensional(3D)printing technology has been widely used to create artificial rock samples in rock mechanics.While 3D printing can create complex fractures,the material still lacks sufficient similarity to natural rock.Extrusion free forming(EFF)is a 3D printing technique that uses clay as the printing material and cures the specimens through high-temperature sintering.In this study,we attempted to use the EFF technology to fabricate artificial rock specimens.The results show the physico-mechanical properties of the specimens are significantly affected by the sintering temperature,while the nozzle diameter and layer thickness also have a certain impact.The specimens are primarily composed of SiO_(2),with mineral compositions similar to that of natural rocks.The density,uniaxial compressive strength(UCS),elastic modulus,and tensile strength of the printed specimens fall in the range of 1.65–2.54 g/cm3,16.46–50.49 MPa,2.17–13.35 GPa,and 0.82–17.18 MPa,respectively.It is capable of simulating different types of rocks,especially mudstone,sandstone,limestone,and gneiss.However,the simulation of hard rocks with UCS exceeding 50 MPa still requires validation.
基金financially supported by the National Key Research and Development Program of China(No.2016YFB0301104)the National Natural Science Foundation of China(No.51771043)the Programmer of Introducing Talents of Discipline Innovation to Universities 2.0(the 111 Project 2.0 of China,No.BP0719037)。
文摘The Bauschinger-like effect, which showed up in the straightening process of the AZ31 magnesium alloy wide sheet, was investigated through the multi-pass discrete three-point bending–unloading–bending(BUB) experiments. The stress variable, anisotropy, and asymmetry of tension and compression on the straightening process were corresponding to the Bauschingerlike effect. The Bauschinger-like effect in the initial, intermediate, and end of the straightening process was dominated by the twinning, detwinning, and dislocation induced by pyramidal < c + a > slip, respectively. Also, they were responsible for the transformation of the Bauschinger stress parameter(BSP) and Bauschinger energy parameter(BEP). Later, the anisotropic nonlinear kinematic hardening model(ANK model) to describe the Bauschinger-like effect was optimized and simplified.
基金partly supported by the National Natural Science Foundation of China (No. 4210070867)the Research grant#201605 of the Forestry and Forest Products Research Institute (FFPRI),JapanKAKENHI grant#JP17F17102 of the Japan Society for the Promotion of Science (JSPS)
文摘Ground-level ozone pollution is a menace for vegetation in the northern hemisphere,limiting photosynthetic pigments and suppressing photosynthesis in trees and other types of plants.Phaeophytinization is the process of converting chlorophylls into phaeophytins,for example by acidifi cation.Ozone is a highly oxidizing molecule and well known to degrade chlorophylls;however,the eff ect of ozone on phaeophytinization in leaves of higher plants is largely unknown.To reveal ozone eff ect on phaeophytinization and evaluate the potential of phaeophytinization as an index of ozone stress in trees,the absorbance at the optical density of 665 nm was measured before(OD_(665))and after(OD_(665a))acidifi cation in three independent experiments with nearly 30 conditions of ozone exposure.Both current ambient and elevated ozone widely aff ected phaeophytinization,as indicated by decreases or increases in the phaeophytinization quotient OD_(665)/OD_(665a).These eff ects were commonly moderate to large in magnitude and practically signifi cant,and occurred even in ozone-asymptomatic leaves.It emerges that the ozone eff ect on phaeophytinization is bimodal,likely depending on the intensity of ozone stress.These results indicate a promising feature of OD_(665)/OD_(665a)as a thorough index of ozone stress in the future,but further studies are needed to reveal the underlying biochemical mechanisms of the bimodal eff ect on phaeophytinization.
基金supported by JSPS KAKENHI Grant Number JP17F17102 (to EA and MK)Startup Foundation for Introducing Talent of Nanjing University of Information Science and Technology (NUIST)(No. 003080)the Jiangsu Distinguished Professor program of the People’s Government of Jiangsu Province
文摘Climate change can intensify drought in many regions of the world and lead to more frequent drought events or altered cycles of soil water status.Therefore,it is important to enhance the tolerance to drought and thus health,vigor,and success of transplantation seedlings used in the forestry by modifying fertilization and promoting mycorrhization.Here,we sowed seeds of Japanese larch(Larix kaempferi)in 0.2-L containers with 0.5 g(low fertilization;LF)or 2 g(high fertilization;HF)of slow-release fertilizer early in the growing season.One month later,we irrigated seedlings with non-sterilized ectomycorrhizal inoculum(ECM)or sterilized solution(non-ECM),and after about 2 months,plants were either kept well watered(WW;500 mL water/plant/week)or subjected to drought(DR;50 mL water per plant/week)until the end of the growing season.HF largely stimulated plant growth and above-and belowground biomass production,eff ects that are of practical signifi cance,but caused a small decrease in stomatal conductance(Gs 390)and transpiration rate(E 390),which in practice is insignifi cant.ECM treatment resulted in moderate inhibition of seedling growth and biomass and largely canceled out the enhancement of biomass and foliar K content by HF.DR caused a large decrease in CO 2 assimilation,and enhanced stomatal closure and induced senescence.DR also largely depleted foliar Mg and enriched foliar K.Although DR caused a large decrease in foliar P content in LF,it moderately increased P in HF.Likewise,DR increased foliar K in HF but not in LF,and decreased foliar P in ECM plants but not in non-ECM plants.Conversely,ECM plants exhibited a large enrichment in foliar P under WW and had a lower water potential under DR when grown in LF.These results indicate that the drought tolerance and health and vigor of Japanese larch seedlings can be modifi ed by soil fertility and soil microorganisms.This study provides a basis for new multifactorial research programs aimed at producing seedlings of superior quality for forestation under climate change.
文摘With the rapid development of economy, the scale of city has become more and more large. Meanwhile, the population also grows rapidly. Although the standard of living condition has been improved greatly, industry and domestic waste not only infl uence the quality of life by polluting the environment, but also become a signifi cant obstacle factor for economic development. waste power generation or waste-to-energy(WTE) is using the heat which is from garbage incinerator to generate electricity. This method can solve the problem of waste and generate the social benefi t, but by using the power on the internet to generate the economy benefit. In this paper, combined the method of FAHP and TOPSIS, a quotas system is set up to evaluate the social and economic benefi ts of the WTE project in Xiamen. Some advice is proposed for the Xiamen WTE project.