Research Progress on Functional Components and Pharmacological Effects of Red Jujube ( Ziziphus jujuba Mill.)

Red jujube(Ziziphus jujuba Mill.),as a traditional Chinese medicine and edible plant,has a long history and extensive uses.Red jujubes are not only widely used in the food industry and traditional Chinese medicine preparations,but also have attracted widespread research interest due to their rich functional components and various pharmacological effects.This paper reviewed the main functional components of jujubes,including polysaccharides,triterpenoid saponins,organic acids and alkaloids,and discussed in detail the pharmacological effects of these components such as blood sugar-regulating,antioxidant,anti-inflammatory and anti-tumor effects.Furthermore,the paper also summarized the safety issues such as drug interactions and toxic side effects of jujubes,and prospected the future development direction of jujube research.

EMPIRICAL BAYES TEST PROBLEMS OF VARIANCE COMPONENTS IN RANDOM EFFECTS MODEL

Bayes decision rule of variance components for one-way random effects model is derived and empirical Bayes (EB) decision rules are constructed by kernel estimation method. Under suitable conditions, it is shown that the proposed EB decision rules are asymptotically optimal with convergence rates near O(n-1/2). Finally, an example concerning the main result is given.

Review of Effects of Active Components of Gastrodiae Rhizoma on Central Nervous System

In order to explore the pharmacological effects of active components of Gastrodiae Rhizoma on the central nervous system,through consulting related literatures,this paper summarized the pharmacological effects of the active components of Gastrodiae Rhizoma.The pharmacological effects of the active components of Gastrodiae Rhizoma on the central nervous system include improving the ability of learning and memory,analgesia,sedation and hypnosis,anticonvulsant,anti-aging,anti-anxiety and neuroprotective effects.The active components of Gastrodiae Rhizoma have certain curative effect in the treatment of some diseases of the central nervous system.At present,it has been widely used clinically.There are no toxic and side effects at conventional doses,and it is worth popularizing and applying.

Advances in Research of Chemical Components and Pharmacological Effects of Platycladus orientalis Leaves

Platycladi Cacumen(Platycladus orientalis leaf)is a traditional Chinese medicine with a variety of medicinal values,and its efficacy has been recorded by many ancient books.Its chemical components mainly include flavonoids,volatile oil,tannins and so on.Pharmacological studies have confirmed that P.orientalis leaves have various pharmacological effects such as antibacterial,anti-oxidant,anti-tumor,hair growth promoting and hemostatic effects.Through review of the research on the chemical components and pharmacological effects of P.orientalis leaves,this study is intended to provide reference for the research,development and utilization of P.orientalis.

Technology for Extracting Effective Components from Fish Scale

The research of the category and extraction methods of effective ingredients of fish scale was reviewed at home and abroad. The extraction process of fish scale was studied, including collagen, hydroxyapatite, lecithin, guanine etc. The different extraction methods and the components were analyzed. The research of effective ingredients of fish scales was reviewed as theory basis to further research and comprehensive development.

Effect of Loading Paths on Hydroforming Tubular Square Components

The influence of loading path on tube hydroforming process is discussed in this paper with finiteelement simulation. Four different loading paths are utilized in simulating the forming process of square tubular component with hydroforming and the result of different loading path is presented. Among the result. the thickness distribution of bilinear loading path is the most uniform one. It shows that the increase of punch displacement in the stage of high pressure is beneficial to the forming of component for optimized Stress condition.

Comparison of REML and MINQUE for Estimated Variance Components and Predicted Random Effects

Linear mixed model (LMM) approaches have been widely applied in many areas of research data analysis because they offer great flexibility for different data structures and linear model systems. In this study, emphasis is placed on comparing the properties of two LMM approaches: restricted maximum likelihood (REML) and minimum norm quadratic unbiased estimation (MINQUE) with and without resampling techniques being included. Bias, testing power, Type I error, and computing time were compared between REML and MINQUE approaches with and without Jackknife technique based on 500 simulated data sets. Results showed that MINQUE and REML methods performed equally regarding bias, Type I error, and power. Jackknife-based MINQUE and REML greatly improved power compared to non-Jackknife based linear mixed model approaches. Results also showed that MINQUE is more time-saving compared to REML, especially with the use of resampling techniques and large data set analysis. Results from the actual cotton data analysis were in agreement with our simulated results. Therefore, Jackknife-based MINQUE approaches could be recommended to achieve desirable power with reduced time for a large data analysis and model simulations.

Antifungal Effect of Streptomyces 702 Antifungal Monomer Component DZP8 on Rhizoctonia solani and Magnaporthe grisea

The aim of this study was to investigate the in vitro antifungal effects of antifungal monomer component DZP8 isolated from Streptomyces 702 on the mycelium growth, sclerotium formation and germination of Rhizoctonia solani and on the mycelium growth, conidial formation, germination, appressorium formation of Magnaporthe grisea. The results showed that the antifungal monomer component DZP8 has strong antifungal effect on both the R. solani and M. grisea. The EC50 and EC90 of DZP8 were 1.81 and 3.35 μg/ml on Ft. solani respectively, and 37.01 and 136.21 μg/ml on M. grisea respectively. Under the treatment of 48.01 μg/ml DZP8, the sclerotium formation rate of R. solani was just 39.21%, the formation time delayed by 216 h and the dry weight decreased by 81.37% in comparison the con- trol; and 33.51 μg/ml DZP8 significantly inhibited the sclerotium germination. In the presence of 160.08 μg/ml DZP8, the sporulation of M. grisea was just 9.29% of control sample; 20.14 μg/ml DZP8 inhibited the conidial germination suppression rate by 95.16%, and the appressorium formation by 100%.

Ion adsorption components in liquid/solid systems

Experiments on Zn^2＋ and Cd^2＋ adsorptions on vermiculite in aqueous solutions were conducted to investigate the widely observed adsorbent concentration effect on the traditionally defined adsorption isotherm in the adsorbate range 25--500 mg/L and adsorbent range 10--150 g/L. The results showed that the equilibrium ion adsorption density did not correspond to a unique equilibrium ion concentration in liquid phase. Three adsorbate/adsorbent ratios, the equilibrium adsorption density, the ratio of equilibrium adsorbate concentration in liquid phase to adsorbent concentration, and the ratio of initial adsorbate concentration to adsorbent concentration, were found to be related with unique values in the tested range. Based on the assumption that the equilibrium state of a liquid/solid adsorption system is determined by four mutually related components： adsorbate in liquid phase, adsorbate in solid phase, uncovered adsorption site and covered adsorption site, and that the equilibrium chemical potentials of these components should be equalized, a new model was presented for describing ion adsorption isotherm in liquid/solid systems. The proposed model fit well the experimental data obtained from the examined samples.

Natural products and food components with anti-Helicobacter pylori activities

The bacterial pathogen Helicobacter pylori (H. pylori) colonizes in over half of the world’s population. H. pylori that establishes life-long infection in the stomach is definitely associated with gastro-duodenal diseases and a wide variety of non-gastrointestinal tract conditions such as immune thrombocytopenia. Triple therapy which consists of a proton pump inhibitor and combinations of two antibiotics (amoxicillin, clarithromycin or amoxicillin, metronidazol) is commonly used for H. pylori eradication. Recently, the occurrence of drug-resistant H. pylori and the adverse effect of antibiotics have severely weakened eradication therapy. Generally antibiotics induce the disturbance of human gastrointestinal microflora. Furthermore, there are inappropriate cases of triple therapy such as allergy to antibiotics, severe complications (liver and/or kidney dysfunction), the aged and people who reject the triple therapy. These prompt us to seek alterative agents instead of antibiotics and to develop more effective and safe therapy with these agents. The combination of these agents actually may result in lower a dose of antibiotics. There are many reports world-wide that non-antibiotic substances from natural products potentially have an anti-H. pylori agent. We briefly review the constituents derived from nature that fight against H. pylori in the literature with our studies.

The Influence of Some Key Parameters on Fatigue Life of Common Metallic Components

The effect of key parameters on fatigue life of common metallic components, e.g. steel, aluminium alloy, has been analysed quantitatively. The influential coverage and degree of these parameters have been investigated systematically, some phenomena which can′t be discovered with qualitative analysis method have been revealed, a series of valuable conclusions has been obtained, which would be very beneficial to fatigue resistant design and improvement of anti fatigue ability of metallic components.

Effects of acrous gramimeus and its main component alpha-asarone on the reactivity and convulsive threshold of immature rats to electric stimulation

BACKGROUND： The traditional Chinese medicine acrous gramimeus is the dry rhizome of Acrous gramimeus Soland, a kind of Araceae familial perennial herb, which has a sedation action, anticonvulsant and antiepileptic effect. Its effective component has not been known yet, and α-asarone, the major component of the volatile oil extracted from acrous gramineus, has been supposed to play a necessary role in it. OBJECTIVE： To explore the effects of acrous gramimeu and α-asarone on the reactivity and convulsive threshold to electric stimulation in immature rats, furthermore, attempt to definitize the anticonvulsant effect of α-asarone. DESIGN： A randomized controlled study.SETTINGS： Department of Pediatrics, First Hospital of Jilin University; Department of Histology and Embryology, School of Basic Medical Sciences of Jilin University; Department of Neurology, First Clinical Hospital affiliated to Harbin Medical University; Department of Internal Medicine, Children＇s Hospital of Changchun City. MATERIALS ： Seventy 3-week immature Wistar rats （either males or females） of 34-40 g were used. Acrous gramimeu （1 g/bag, the content of α-oasarone was 0.046 26%-0.070 16%） with the batch number of 0307113 was provided by Tianjiang Medicine Company Limited, Jiangyin City. α-asarone tablet （60 mg per tablet） with the batch number of 030219 was provided by Tianwei Pharmaceutical Factory, Shenyang City. α-asarone injectable preparation （2 mL per piece） with the batch number of 030105 was provided by Shuanghe Medicine Limited Company, Beijing City. METHODS ： The experiments were carried out in the Neurological Laboratory of the First Hospital of Jilin University between August and October in 2004.① The 70 rats were randomly divided into intragastric subset and intraperitoneal subset. The intragastric subset included four groups of control, phenobarbital sodium, acrous gramimeu and α-asarone; the intraperitoneal subset included three groups of control, phenobarbital sodium and α-asarone. There were 10 rats per group. ② In the intragastric subset, different group was treated with saline （1 mL for each time, phenobarbital sodium （18 mg/kg per day）, acrous gramineu （2 350 mg/kg per day） and α-asarone （29 mg/kg per day） respectively twice every day for 5 days. In the intraperitoneal subset, different group was treated with saline （0.5 mL）, phenobarbital sodium （29 mg/kg） and α-asarone （2.9 mg/kg） respectively. ③ Before and after administration for 5 days in the intragastric subset as well as before and after administration for about 1 hour in the intraperitoneal subset respectively, the rats were given electric stimulation with the NIHOM KOMDEM multifunctional electrophysiological recorder, and the reactivity and convulsive threshold to electric stimulation of the rats were recorded. MAIN OUTCOME MEASURES： The reactivity and convulsive threshold to electric stimulation in immature rats were compared. RESULTS： All the rats were involved in the analysis of results. ① Results for intragastric administration： Before intragastric administration, there were no obvious differences in the reactivity and convulsive threshold to electric stimulation among the groups （P 〉 0.05）. After intragastric administration for 5 days, the reactivity and convulsive threshold to the electric stimulation had no obvious changes in the control group, but those were significantly higher than before administration in the drug administration groups （t=-3.317-7.401, P 〈 0.01）, which were also obviously higher than those in the control group （t=3.027-8.941, P 〈 0.01）, and those in the acrous gramimeu group and α-asarone group were not markedly different from those in the phenobarbital sodium group. ② Results for intraperitoneal injection： Before intraperitoneal injection, the reactivity and convulsive threshold to the electric stimulation had no obvious differences among the groups. After the intraperitoneal injection for 1 hour, the reactivity and convulsive threshold to the electric stimulation had no obvious change in the control group, but those were significantly higher than before administration in the drug administration groups （P 〈 0.01）, which were also obviously higher than those in the control group （t=6.211-7.237, P 〈 0.01; t=4.085-5.633, P 〈 0.05）, and there was no marked difference between α-asarone group and phenobarbital sodium group （P 〉 0.05）.CONCLUSION ： ① As effective anticonvulsants, both acrous gramineu and α-asarone can enhance the reactivity and convulsive threshold of immature rats to electric stimulation. ② As one of the major effective components against convulsion of acrous gramineu, α-asarone is equivalent to phenobarbital sodium.

Effect of chemical component on shape memory effect of Fe-Mn-Si-Ni-C-RE shape memory alloy

Effect of chemical component on shape memory effect (SME) of Fe-Mn-Si-Ni-C-RE shape memory alloys was studied by bent measurement, thermal cycle training, SEM etc. Results of study indicate that the alloys with high Mn content (25%) appeare better SME, especially in lower strain. SME improves evidently when Si is higher content, especially it’s range from 3% up to 4%. But brittleness of Fe-Mn-Si-Ni-C-RE alloy increases by increasing the Si content. SME of the alloy is weakening gradually as carbon content increases under small strain (3%). But in the condition of large strain (above 6%), SME of the alloy whose carbon content ranges from 0.1 % to 0.12% shows small decreasing range, especially of alloy with the addition of compound RE.

Effect of chemical component on shape memory effect of Fe-Mn-Si-Ni-C-RE shape memory alloy

Effect of chemical component on shape memory effect (SME) of Fe-Mn-Si-Ni-C-REshape memory alloys was studied by bent measurement, thermal cycle training, SEM etc. Results ofstudy indicate that the alloys with high Mn content (25%) appeare better SME, especially in lowerstrain. SME improves evidently when Si is higher content, especially it's range from 3% up to 4%.But brittleness of Fe-Mn-Si-Ni-C-RE alloy increases by increasing the Si content. SME of the alloyis weakening gradually as carbon content increases under small strain (3%). But in the condition oflarge strain (above 6%), SME of the alloy whose carbon content ranges from 0.1 % to 0.12% showssmall decreasing range, especially of alloy with the addition of compound RE.

Impact of sampling interval on variance components of epoch-wise residual error in relative GPS positioning: A case study of a 40-km-long baseline

The study presents sampling interval impacts on variance components of the epoch-wise residual errors in relative GPS positioning. In the variance components estimation process, the 2-way nested ANOVA method was used. For that purpose, GPS observation data during four months at two permanent GPS stations, establishing a 40-km-long baseline as a part of the Montenegrin permanent network(Monte Pos), were used. The study results showed that there is no statistically significant impact of sampling interval changes on epoch-wise variance components related to the residual tropospheric and ionospheric delays(effect a) when it comes to such a baseline. However, it is not the case with epoch-wise variance components related to the interstation-distance-independent residual ‘far-field’ multipath effect(effect b). It turned out that the absolute values of relative differences of standard deviations of the effect a on the relative GPS coordinates(e, n and u) had maximum values 11.1%, 10.2% and 8.9%,respectively. Keeping the same order of presentation for the effect b, the values of 5.9%, 9.9% and 12.5%were obtained. In addition, absolute values of relative differences of standard deviations of horizontal and vertical position had maximum values of 3.8% and 7.7%, respectively.

EFFECTS OF S86019, AN ACTIVE COMPONENT FROM PURALIA LOB AT A, ON CELL DIFFERENTIATION AND CELL CYCLE TRAVERSE OF HL-60 CELLS

The effects of S86019, an active component from Puralia lobata, on the induction of cell differentiation and cell cycle traverse of HL-60 cells were described. It was shown that cell proliferation of HL-60 cells was inhibited by S86019 in vitro. Under the action of S86019 the HL-60 cells were induced to differentiate into metamyelocytes, myelocytes and much matured cells with banded or segmented nucleus. Flow cytometry demonstrated that the cell population of HL-60 cells was blocked at G1 phase which resulted in the elevation of percentage of G1 cells and decrease of percentage of cells in S phase. Experimental results demonstrated that S86019 is an active inducer of cell differentiation in HL-60 cells.

Study on the Lightning-radaited Electric Field Components at Mesospheric Altitudes

In this paper we have extended the semi-analytical model presented by Yashunin et al.to compute both of the lightning vertical and horizontal electric field considering the effect of nonlinear atmospheric electric parameters,and validate its accuracy by using our 2-D FDTD method.It is noted that the semi-analytical model can predict not only the lightning vertical field,but also the horizontal electric field with a satisfied accuracy in a small region with a radius ranging from 5 to 30 km at a height from 80 to 90 km above the lightning strike point.Compared with the results in the free space with a vacuum,the conducting altitude atmosphere has a relatively little effect on the radiated field component,but it has much effect on the electrostatic and induction component because their duration times are longer than the local relaxation time.For example,the induction field component in the conducting nonlinear medium decreases by about 43%,compared with that in the free space with a vacuum.The induction field is larger than the radiation field component within a radius of 25 km at a height of 80 km above the lightning strike point.Therefore,although the induction component may be likely one extra energy source(except for the radiation field)for creating the pancake shape of some elves with a luminous central part,we have to take into account the effect of nonlinear atmospheric electric parameters on the prediction of induced field component peak value that is needed for the production of elves.

当归不同药用部位的化学成分及药理作用研究进展

当归作为“分根梢”理论的代表药材,其以不同药用部位分别入药起源于唐代,形成于金元,兴盛于明清;经历代医家临床实践总结,逐渐确立了归头止血、归身补血、归尾活血的作用功效。现代研究表明,当归中含有当归多糖、挥发油、有机酸、无机盐等药效部位及阿魏酸、绿原酸、欧前胡素、藁本内酯等药效成分;在当归头、当归身及当归尾等不同药用部位中,上述药效物质基础的种类分布均匀、区别不大,但含量及相关比例差异明显;多数学者认为,含量、比例差异可能是导致当归不同药用部位存在较大药理作用差异的主要原因。通过对相关文献的检索,梳理和总结近年来国内外对当归不同药用部位中药效物质基础分布情况及相关药理作用的研究,从当归不同药用部位中药效物质基础的种类分布和含量差异两个方面综合分析,并结合相关药效物质基础对应的药理作用研究,找寻当归不同药用部位间存在的“成分-效用”关系,以期为历代医家将当归按当归头、当归身、当归尾分别入药提供更强有力的佐证,同时为当归提出进一步研究的主要方向和思路。

配方施肥对高肥力区凹叶厚朴生长及药用成分的影响

[目的]为明晰高肥力区凹叶厚朴树体生长及树皮药用成分含量对氮、磷、钾配方施肥的响应,获得氮、磷、钾肥优化的施肥量。[方法]以凹叶厚朴5年生树为研究对象,采用氮、磷、钾“3414”施肥设计进行田间施肥试验,测定不同处理的树高和地径增长量及药用成分厚朴酚、和厚朴酚、总酚的含量,拟合建立树高增长量的肥料效应模型,采用频次分析方法获得优化施肥量。[结果]凹叶厚朴氮、磷、钾配方施肥处理的树高增长量、地径增长量、和厚朴酚、厚朴酚、总酚的含量的平均值比不施肥处理分别提高了84.56%、48.74%、3.40%、3.10%、3.21%。氮、磷、钾对树高和地径生长量的影响均是N>P>K,对树皮厚朴酚、和厚朴酚、总酚含量的影响均是K>N>P。氮、磷、钾对树高增长量的单因素效应为正,氮与磷、氮与钾、磷与钾的交互效应也都是正。[结论]高肥力区凹叶厚朴树高最大增长量的施肥量为氮肥128.63克/株、磷肥79.84克/株、钾肥54.63克/株,树高最大增长量为129.91 cm;最优施肥量为氮肥98.12~123.31克/株、磷肥60.23~74.78克/株、钾肥41.62~51.24克/株,预期树高平均增长量121.22 cm。

中药有效成分防治结肠癌机制研究进展

结肠癌是世界范围内最常见的恶性肿瘤之一,其常规治疗手段在为患者提供生存益处的同时,副作用和局限性也不容忽视。中药因其多靶点、多途径、毒副作用较小的抗肿瘤优势备受国内外学者关注。不少中药及从中提取的以黄酮类、酚类、生物碱为代表的中药有效成分在抗肿瘤方面发挥了有效作用,其机制与抑制肿瘤细胞增殖、诱导细胞凋亡、调控自噬、抑制肿瘤细胞侵袭和转移、抑制肿瘤血管生成等有关。本文就近年来中药有效成分抑制结肠癌机制研究进行梳理,以期为中药应用于结肠癌的临床治疗提供参考。