The effects of decompressive craniectomy on cerebral blood flow volume and brain metabolism in different aged patients with severe traumatic brain injury

Objective To explore effects of decompressive craniectomy on cerebral blood flow volume and brain metabolism in different aged patients with severe traumatic brain injury. Methods 71 cases were divided into three groups according age: group A( 【 30 years) ,group B ( 30 ～ 50 years) 。

Electroosmotic oscillatory flow of micropolar fluid in microchannels:application to dynamics of blood flow in microfluidic devices

The electroosmotic flow of a micropolar fluid in a microchannel bounded by two parallel porous plates undergoing periodic vibration is studied. The equations for conservation of linear and angular momentums and Gauss＇s law of charge distribution are solved within the framework of the Debye-Hückel approximation. The fluid velocity and microrotation are assumed to depend linearly on the Reynolds number. The study shows that the amplitude of microrotation is highly sensitive to the changes in the magnitude of the suction velocity and the width of the microchannel. An increase in the micropolar parameter gives rise to a decrease in the amplitude of microrotation. Numerical estimates reveal that the microrotation of the suspended microelements in blood also plays an important role in controlling the electro-osmotically actuated flow dynamics in microbio-fluidic devices.

Assessment of Biological Reaction to Whole Body Vibration Training by Evaluating Changes in Salivary Components and Cutaneous Blood Flow

Aim: Whole body vibration (WBV) is thought to improve blood flow and autonomic balance and thereby induce a relaxation effect, which suggests its use for stress management. However, the relaxation effect of WBV training has not been objectively evaluated thus far. The purpose of this study was to determine the biological response to WBV training by measuring peripheral blood flow and salivary components using non-invasive techniques. Methods: Participants included 10 healthy volunteers (7 men, 3 women;mean age 33.8 ± 2.3) who provided oral consent and served as their own control. Each participant performed 15 types of stretching exercises for 10.5 min on the Power Plate? and cutaneous blood flow and salivary components were measured before and after the exercise. One week later, all participants performed the same exercise regimen for 10.5 min on a non-vibratory plate, and blood flow measurement and salivary tests were performed in a similar manner. Cutaneous blood flow was measured in the 4th digit for 1 min using the laser speckle flowgraphy. Saliva samples were evaluated for cortisol levels and α-amylase activity. To determine the effects of stretching exercises on the Power Plate? vs a non-vibratory plate, the differences in pre- and post-exercise peripheral blood flow, salivary cortisol levels, and salivary α-amylase activity were statistically evaluated by the t-test. Results: Mean blood flow before and after the exercise on the Power Plate? was 122.0 ± 54.2 and 156.7 ± 51.2, respectively;on a non-vibratory plate, blood flow was 136.6 ± 47.9 and 146.3 ± 38.3, respectively. The differences in pre-exercise and post-exercise values of the two training methods were not significant (p = 0.215). Mean cortisol levels before and after the exercise on the Power Plate? were 266.6 ± 125 and 204.9 ± 61.6, respectively;on a non-vibratory plate, the levels were 439.0 ± 121.7 and 425.8 ± 118.8, respectively. The differences in pre-exercise and post-exercise values of the two training methods were not significant (p = 0.384). Mean α-amylase activity before and after the exercise on the Power Plate? was 3.74 ± 2.89 and 5.40 ± 3.76, respectively;on a non-vibratory plate, the activity was 3.95 ± 2.23 and 3.28 ± 1.73. The differences in pre-exercise and post-exercise values of the two training methods were not significant (p = 0.115). Conclusion: Our results showed that a brief WBV training increased peripheral blood flow, reduced cortisol levels, and increased α-amylase activity. WBV appears to regulate autonomic activity, in particular, suppress sympathetic activity and improve bodily functions. Thus WBV exercise may be conductive for stress management, but further investigation is warranted to determine the optimal duration of WBV training for stress relief.

针药并用对缺血性脑卒中患者血流与神经损伤的影响

目的研究针灸和药物治疗对急性缺血性脑卒中患者大脑中动脉血流量的即刻效应及神经损害程度的影响。方法选取福建医科大学附属泉州第一医院2021年6月至2023年6月收治入院的100例急性缺血性脑卒中患者,采用随机数字表法分为针刺治疗组(35例)、非穴针刺组(32例)、常规药物治疗组(33例)。所有缺血性脑卒中患者入院后均予西医常规治疗,在此基础上,针刺治疗组与非穴针刺组均在入组的第1天未使用药物改善循环的情况下进行首次针灸治疗。三组患者连续治疗14d,观察患者治疗前后的大脑血流动力学指标:大脑中动脉的收缩期峰速(systolic peak velocity,Vs)、舒张期峰速(diastolic peak velocity,Vd)、搏动指数(pulsatility index,PI)、阻力指数(resistance index,RI)及平均血流速度(mean blood flow velocity,MFV);检测患者治疗前后的脑神经损伤标志物水平,并通过美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评估患者的神经功能损伤程度。结果与治疗前比较,治疗后常规药物治疗组和非穴针刺组患者的Vs、MFV水平提高(P<0.05),PI较治疗前显降低(P<0.05);针刺治疗组患者的Vs、Vd、MFV水平均提高(P<0.05);PI、RI较治疗前降低(P<0.05)。三组治疗后比较,针刺治疗组患者的Vs、Vd、PI、RI、MFV改善情况优于非穴针刺组与常规药物治疗组(P<0.05)。针刺治疗组患者首次针刺后的Vs、Vd、PI、RI、MFV均有改善,其改善程度优于非穴针刺组(P<0.05)。三组治疗后,患者的血清S-100β蛋白、心型脂肪酸结合蛋白(heart-type fatty acid binding protein,H-FABP)、神经元特异性烯醇化酶(neuron specific enolase,NSE)水平显著降低(P<0.05),其中针刺治疗组指标低于非穴针刺组和常规药物治疗组(P<0.05)。与非穴针刺组和常规药物治疗组比较,针刺治疗组在治疗2周后、随访30d后,患者的NIHSS评分更低,差异有统计学意义(P<0.05)。结论早期针刺治疗可改善急性缺血性脑卒中患者的大脑中动脉的血流情况,减轻患者神经损伤的程度。

尤瑞克林治疗脑梗死患者的效果及对脑血流、神经损伤的影响

目的:探究尤瑞克林在脑梗死患者中的应用效果及对脑血流、神经损伤的影响。方法:选择2020年1月—2022年1月三明市中西医结合医院收治的80例脑梗死患者作为研究对象,依据随机数表法分为两组,各40例。对照组进行常规脑梗死治疗,观察组则在对照组治疗措施的基础上加用尤瑞克林进行治疗。比较两组的临床总有效率、治疗前后的神经功能缺损程度[改良爱丁堡-斯堪的纳维亚(MESSS)评分]、脑血流指标(大脑前动脉、中动脉及后动脉血流速)及神经损伤相关血液指标[中枢神经特异蛋白(S100β)、神经元特异性烯醇化酶(NSE)及一氧化氮(NO)]。结果:观察组临床总有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗前,两组MESSS评分、脑血流指标及神经损伤相关血液指标比较,差异无统计学意义(P>0.05);治疗1周及2周后,观察组MESSS评分优于对照组,差异有统计学意义(P<0.05);治疗1周及2周后,两组的脑血流指标、神经损伤相关血液指标显著低于治疗前,且观察组显著低于对照组,差异有统计学意义(P<0.05)。结论:尤瑞克林在脑梗死患者中的应用效果较好,且可显著改善患者的脑血流及控制神经损伤。

一种基于线性零磁场的动脉血管扫描成像方法仿真

基于磁电耦合效应的血流检测及血管成像是实现心血管疾病早期诊疗的有效方法之一。该文基于磁场与血流耦合电效应,设计一种用于动脉血管扫描成像的组合线圈结构,产生带有零磁场线(FFL)区域的线性梯度磁场;在此结构的基础上,通过控制激励电流驱动FFL实现成像区域双向扫描;结合卷积神经网络(CNN)实现磁电耦合信号与血管信息的非线性映射,进而提出一种基于线性零磁场的动脉血管扫描成像新方法。采用多物理场仿真软件COMSOL对基于线性零磁场的血管扫描成像方法进行建模,求解磁电耦合信号,验证了所提出方法的合理性和有效性。结果表明,线性梯度磁场模式下的磁电耦合信号含有血管位置、半径等信息;CNN重建血管位置误差平均值为1.5694 mm,重建血管半径的方均误差(MSE)和相关系数(CC)平均值分别为0.0548和0.9870。研究结果可用于血管成像装置设计及后续相关临床应用提供研究支撑。

腺苷负荷与ATP负荷评估冠状动脉微血管疾病中的不良反应分析

背景 冠状动脉微血管疾病(CMVD)的诊疗一直是非冠状动脉阻塞性缺血性心脏病的重点。腺苷注射液和ATP注射液是目前测定冠状动脉血流储备(CFR)评估CMVD的临床常用负荷药物,两者有所关联,但具有显著区别。ATP是腺苷的前体,其价格低廉且血管扩张机制与腺苷类似,临床上常代替腺苷,但忽视了其潜在的不良反应。目的 比较腺苷负荷与ATP负荷在评估CMVD过程中的不良反应发生率。方法 选取2019年6月—2020年7月因典型心绞痛就诊于陕西省人民医院心内科行冠状动脉造影术/冠状动脉CT血管造影术(CTA)明确各支冠状动脉残余狭窄直径<50%的患者170例,依据随机数字表法分为腺苷组和ATP组,腺苷组88例,ATP组82例。腺苷组给予腺苷注射液负荷测定CFR,ATP组采用ATP负荷测定CFR,检测过程中记录患者的血压、心率、扫描时间及不良反应发生情况。结果 与腺苷组相比,ATP组患者胸闷[61.0%(50/82)和20.4%(18/88)]、头晕[72.0%(59/82)和31.8%(28/88)]、头痛[68.3%(56/82)和11.4%(10/88)]、胃肠道不适[13.4%(11/82)和4.5%(4/88)]、心悸[69.5%(57/82)和5.7%(5/88)]、气促[40.2%(33/82)和2.3%(2/88)]、大汗[28.0%(23/82)和3.4%(3/88)]、潮热[19.5%(16/82)和2.3%(2/88)]、颜面潮红[13.4%(11/82)和4.5%(4/88)]的发生率均较高(P<0.05);两组患者神经过敏、耳鸣、咽干、颈部不适的不良反应发生率比较,差异无统计学意义(P>0.05)。结论 与ATP负荷相比,腺苷负荷测定CFR的不良反应发生率更低。

子午流注择时耳穴压豆对2型糖尿病患者血糖控制、上消症状及失眠状况的干预效果

目的探讨子午流注择时耳穴压豆治疗对2型糖尿病(T2DM)患者血糖控制、上消症状及失眠状况的影响。方法选取2020年1月至2022年12月河南省中西医结合医院内分泌科收治的138例T2DM患者作为研究对象,依据电脑数表随机抽取法分为西医组(常规西医干预)46例、中医1组(耳穴压豆干预)46例和中医2组(子午流注择时耳穴压豆干预)46例,连续干预4周。比较三组患者的治疗总有效率、治疗前后的血糖水平[空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(Hb1Ac)]、上消症状、睡眠质量[匹兹堡睡眠治疗指数(PSQI)]、Toll样受体4(TLR4)/细胞核因子κB(NF-κB)炎症信号通路因子[外周血TLR4、NF-κB、血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]水平及不良反应发生情况。结果中医2组、中医1组患者的治疗总有效率分别为93.48%、84.78%,明显高于西医组的71.74%,差异均有统计学意义(P<0.05);干预4周后,中医2组患者的FBG、2 h PBG、Hb1Ac水平分别为(6.36±0.83)mmol/L、(8.18±1.05)mmol/L、(6.13±0.59)%,明显低于中医1组的(7.05±1.02)mmol/L、(9.37±1.16)mmol/L、(6.91±0.83)%及西医组的(7.81±1.10)mmol/L、(10.80±1.44)mmol/L、(7.88±0.75)%,差异均有统计学意义(P<0.05);干预4周后,中医2组患者的口干、多饮症状积分、PSQI各维度评分及总分明显低于中医1组、西医组,中医1组明显低于西医组,差异均有统计学意义(P<0.05);干预4周后,中医2组患者的外周血TLR4、NF-κB蛋白及血清TNF-α、IL-6水平分别为1.26±0.24、1.31±0.25、(26.76±4.38)pg/mL、(17.72±3.34)pg/mL,明显低于中医1组的1.59±0.31、1.53±0.29、(31.54±4.71)pg/mL、(20.53±4.11)pg/mL及西医组的2.02±0.35、2.06±0.37、(34.07±5.23)pg/mL、(23.18±3.62)pg/mL,差异均有统计学意义(P<0.05);三组患者治疗期间的总不良反应发生率比较差异无统计学意义(P>0.05)。结论子午流注择时耳穴压豆治疗T2DM具有一定的治疗效果,其可控制血糖水平,改善上消症状,提高睡眠质量,且具有一定安全性,其治疗机制可能与调节TLR4/NF-κB炎症信号通路有关。

肝有效血容量对肝癌术后肝功能不全的预测价值

目的:探讨肝有效血容量(EHBF)预测肝癌术后肝功能不全发生的价值。方法:回顾123例肝细胞癌手术患者的临床资料,测得EHBF和吲哚菁绿15 min滞留率(ICG R15),并行Child-Pugh评分,观察患者术后肝功能恢复情况。比较不同肝功恢复组中ICG R15、EHBF差异及ICG R15、EHBF不同分组中术后肝功能不全的发生率。通过受试者工作特征(ROC)曲线比较ICG R15、EHBF诊断价值。结果:123例患者中共有41例(33.3%)术后发生肝功能不全。肝功能良好组ICG R15平均值为(8.95±7.18)%,EHBF平均值为(1.01±0.37)L/min;肝功能不全组ICG R15平均值为(15.88±11.55)%,EHBF平均值为(0.75±0.28)L/min。两组差异均有统计学意义(P<0.05)。EHBF≥1.0 L/min组术后肝功能不全发生率13.0%,<1.0 L/min术后肝功能不全发生率45.5%,差异有统计学意义(P<0.05)。ICG R15 ROC曲线下面积0.710(95%CI:0.616~0.804),临界值为7.6,敏感度78.0%,特异度59.8%。EHBF ROC曲线下面积0.718(95%CI:0.624~0.813),临界值为0.35,敏感度73.2%,特异度70.7%。结论:EHBF可有效预测肝癌术后肝功能不全的发生,且可能与ICGR15具有相似检验效能。

Application of buried auricular point combined with Wenjing Sanhan prescription in arteriosclerosis obliterans patients with resting pain

BACKGROUND Research on the combined use of ear acupoint embedding beans and warming meridians with cold-dispersing formulas for alleviating resting pain in patients with arteriosclerosis obliterans(ASO)remains limited.AIM To explore the therapeutic efficacy of auricular point embedding beans combined with Wenjing Sanhan prescription in alleviating resting pain in patients with lower-limb ASO.METHODS A total of 100 patients with ASO experiencing resting pain who were treated at our hospital from January 2022 to January 2023 were enrolled.They were randomly allocated into two groups using a double-blind approach.The control group was treated using a warming meridian with a cold-dispersing formula,while the study group received additional treatment with ear acupoint embedding beans.The clinical efficacy,ankle-brachial artery pressure ratio,hemorheological indicators,and traditional Chinese medicine symptom scores were compared between the two groups.RESULTS The clinical efficacy rate in the study group was significantly higher(94.00%)than that in the control group(72.00%,P<0.05).Moreover,the ankle-brachial artery pressure ratio was significantly higher in the study group after treatment(P<0.05).Hemorheological parameters,including whole blood viscosity,plasma viscosity(1.83±0.11)mPa/s,fibrinogen levels(3.30±0.21)g/L,platelet adhesion rate(49.87%±10.51%),and erythrocyte aggregation index(1.79±0)were improved in the study group compared to the control group.In addition,the scores for decreased skin temperature(1.41±0.26),intermittent claudication(1.30±0.20),and resting pain(1.23±0.31)were significantly lower in the study group than those in the control group(all P<0.05).The level of oxidative stress in the study group also exhibited significant improvement(P<0.05),and the levels of inflammatory factors were considerably lower than those in the control group.CONCLUSION The combination of ear point embedding beans and Wenjing Sanhan prescription demonstrates promising clinical efficacy in alleviating resting pain associated with ASO.

醒脑静注射液联合尼莫地平注射液对脑出血术后患者颅内血流及康复效果的影响

目的观察醒脑静注射液联合尼莫地平注射液对脑出血术后患者颅内血流及康复效果的影响。方法选取2020年1月—2021年12月中国贵航集团三○二医院收治的脑出血术后患者100例,采用随机数字表法分为联合组(n=50)和单一组(n=50)。2组均接受脑出血术后常规治疗,单一组在常规治疗基础上加用尼莫地平注射液治疗,联合组在单一组基础上加用醒脑静注射液治疗,2组均持续治疗2周。比较2组治疗前后颅内血流指标(大脑中动脉、基底动脉血流速度)、血清神经损伤指标[神经特异性烯醇酶(NSE)、胶质纤维酸性蛋白(GFAP)],疗程结束时与随访1个月后美国国立卫生研究院卒中量表(NIHSS)评分、脑卒中专门化生活质量量表(SS-QOL)评分及不良反应。结果治疗2周后,2组大脑中动脉、基底动脉血流速度均大于治疗前,且联合组大于单一组(P<0.01);2组NSE、GFAP水平均低于治疗前,且联合组低于单一组(P<0.01)。随访1个月后,2组NIHSS评分低于疗程结束时,SS-QOL评分高于疗程结束时,且联合组低/高于单一组(P<0.01)。治疗期间2组均未见明显不良反应,联合组与单一组不良反应总发生率比较差异无统计学意义(12.00%vs.6.00%,χ^(2)=1.099,P=0.295)。结论醒脑静注射液联合尼莫地平注射液对脑出血术后患者的康复效果较好,可促进颅内血流恢复,减轻脑组织缺血缺氧性损伤,安全性较高。

经鼻高流量氧疗与无创呼吸机辅助通气对Ⅱ型呼吸衰竭患者的治疗效果比较

目的 分析Ⅱ型呼吸衰竭患者分别采用经鼻高流量氧疗与无创呼吸机辅助通气治疗的效果。方法 简单随机选取2022年1月—2023年12月仪征市人民医院收治的100例Ⅱ型呼吸衰竭患者为研究对象,按照随机数表法分为两组。对照组50例,予无创呼吸机辅助通气治疗,观察组50例,予经鼻高流量氧疗。比较两组临床治疗指标、血气指标、并发症与预后情况。结果 治疗后,两组临床治疗指标比较,差异无统计学意义(P>0.05)。治疗后,两组氧分压、二氧化碳分压、pH值比较,差异无统计学意义(P均>0.05)。观察组并发症发生率(6.00%)低于对照组(22.00%),差异有统计学意义(χ^(2)=5.316,P<0.05)。两组插管率、病死率比较,差异无统计学意义(P均>0.05)。结论 Ⅱ型呼吸衰竭患者采用经鼻高流量氧疗与无创呼吸机辅助通气治疗的疗效相当,均能有效改善患者的呼吸困难症状与血气指标,但经鼻高流量氧疗并发症较少,患者治疗耐受性较好。

心脏彩超对慢性心衰的心脏结构与血液流速及波动速度状态的鉴别诊断

目的分析心脏彩超对慢性心力衰竭患者心脏结构、血流速度及波动速度状况的鉴别诊断效果。方法将本院2022年1月-2023年6月治疗的90例慢性心衰患者(视为观察组)临床诊疗资料进行回顾性分析,按照左室射血分数分为正常组(n=23例)、下降组(n=67例);选取同期来院体检者视为对照组(n=90例),均实施心脏彩超检查,分析其临床鉴别诊断效能。结果与对照组相比,观察组LVEF较低,但是LVEDD、LAD较高,组间差异有统计学意义(P<0.05)。正常组LVEF表达水平低于下降组,但LVEDD、LAD表达水平均高于对照组,组间差异有统计学意义(P<0.05)。Ⅲ级、Ⅳ级患者LVEF表达水平低于Ⅰ级、Ⅱ级,组间差异有统计学意义(P<0.05)。结论心脏彩超检查可以清楚直观地体现慢性心衰患者心脏组织、血流速度与波动速度,能为临床医师鉴别区分疾病、制定个性化诊疗方式提供一定参考依据。

外周血涂片+骨髓涂片+流式细胞术联合应用对MDS早期诊断准确性的影响

目的 探讨在骨髓增生异常综合征(MDS)应用外周涂片联合骨髓涂片与流式细胞术进行早期诊断的临床效果。方法 选取2019年6月—2022年6月本院接收诊治的骨髓增生异常综合征患者120例作为此次研究对象,按照检验方式的不同将患者分为实验组和对照组,每组60例。其中,对照组单独使用外周血涂片进行MDS的早期诊断,实验组则联合外周血涂片、骨髓涂片和流式细胞术进行MDS的早期诊断。对比两组患者的诊断结果。结果 经过检查后,实验组患者的检测结果明显优于对照组,差异有统计学意义(P<0.05)。结论 将外周血涂片、骨髓涂片和流式细胞术联合起来进行MDS的早期诊断,检测准确性更高,能够为临床治疗提供更精准的数据支持。

经鼻高流量湿化氧疗对AECOPD患者临床疗效、血气分析及炎性因子指标的影响

目的:分析经鼻高流量湿化氧疗(High-flow nasel cannula oxygen therapy,HFNC)对慢性阻塞性肺疾病急性加重期(Acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者临床疗效、血气分析及炎性因子指标的影响。方法:回顾性分析2021年5月至2023年10月我院收治的AECOPD患者83例为研究对象,根据治疗方法的不同分为对照组(常规氧疗,n=40)和观察组(采用HFNC治疗,n=43)。对比两组临床疗效,并于治疗1 w后取动脉血进行血气分析,包括酸碱度(Potential of hydrogen potential of hydrogen,pH)、动脉血氧分压(Arterial partial pressure of oxygen,PaO_(2))、动脉二氧化碳分压(Partial pressure of carbon dioxide,PaCO_(2)),采用循环增强荧光免疫发光法及酶联免疫吸附法测定白介素-6(Interleukin,IL-6)、白介素-10(Interleukin,IL-10)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)水平。结果:观察组有效率为81.40%,对照组有效率为65.00%,观察组有效率高于对照组(P<0.05);两组治疗1 w后PaO_(2)明显升高、PaCO_(2)明显降低,且观察组治疗后PaO_(2)高于对照组,PaCO_(2)低于对照组(P<0.05);治疗24 h后,两组血清IL-6、IL-10、TNF-α水平均降低,且观察组血清IL-6、IL-10、TNF-α水平均低于对照组(P<0.05)。结论:HNFC可提高AECOPD患者的治疗疗效,有效改善血气分析以及炎性因子水平,值得临床推广应用。

Correlation of effective hepatic blood flow with liver pathology in patients with hepatitis B virus

Background and aims:Effective hepatic blood flow(EHBF)decreases with liver disease progression,and identifying liver pathology is critical for patients with liver disease.This study was designed to elucidate the correlation between EHBF and liver pathology and explore the potential of EHBF for predicting the degree of liver pathology.Methods:In this study,207 patients with hepatitis B virus(HBV)who underwent liver biopsy and indocyanine green(ICG)clearance tests were enrolled.EHBF was measured using the ICG clearance test,and liver tissue was histologically analyzed to determine the pathological stage according to the Scheuer scoring system.Demographic data,biochemical indexes,and FibroScan data were collected for statistical analysis.Results:EHBF levels decreased as the liver histological stages of inflammation and fibrosis increased(P<0.01).EHBF was significantly negatively associated with the levels of alanine aminotransferase,aspartate aminotransferase,gamma-glutamyl transpeptidase,alkaline phosphatase,aspartate aminotransferase-to-platelet ratio index,fibrosis index based on the four factors,and liver stiffness measurement(P<0.05).The EHBF levels of patients without liver inflammation(G0)were significantly higher than those of patients with liver inflammation(G1e4)(P<0.001).The area under the receiver operating characteristic curve(AUROC)value for discriminating patients without liver inflammation was 0.827,and the optimal cutoff value was 0.936 L/min.The EHBF levels of patients with severe liver inflammation(G4)were significantly lower than those of patients with G0e3 liver inflammation(P<0.001).The AUROC value for discriminating patients with severe liver inflammation was 0.792,and the optimal cutoff value was 0.552 L/min.The EHBF levels of patients without liver fibrosis(S0)were significantly higher than those of patients with liver fibrosis(S1e4)(P<0.001).The AUROC value for discriminating patients without liver fibrosis was 0.633,and the optimal cutoff value was 1.173 L/min.The EHBF levels of patients with liver cirrhosis(S4)were significantly lower than those of patients with S0e3 liver fibrosis(P<0.001).The AUROC value for discriminating patients with liver cirrhosis(S4)was 0.630,and the optimal cutoff value was 0.562 L/min.Conclusions:EHBF levels and liver pathology are significantly correlated.EHBF could effectively reflect liver inflammation and fibrosis in patients infected with HBV,especially for patients without liver inflammation or liver fibrosis.

Lattice Boltzmann Simulation of One Particle Migrating in a Pulsating Flow in Microvessel

A lattice Boltzmann model of two dimensions is used to simulate the movement of a single rigid particle suspended in a pulsating flow in micro vessel The particle is as big as a red blood cell, and the micro vessel is four times as wide as the diameter of the particle. It is found that Segrd-Silberberg effect will not respond to the pulsation of the flow when the Reynolds number is relatively high. However, when the Reynolds number is low enough, Segrd-Silberberg effect disappears. In the steady flow, different initial position leads to different equilibrium positions. In a pulsating flow, different frequencies of pulsation also cause different equilibrium positions. Particularly, when the frequency of pulsation is closed to the human heart rate, Segrd-Silberberg effect presents again. The evolutions of velocity, rotation, and trajectory of the particle are investigated to find the dynamics of such abnormal phenomenon.

Therapeutic Effects of Tongxinluo Capsule(通心络胶囊) on Patients with Acute Small Oerebral Infarction and Its Influence on SPECT Brain Periusion Image

Objective: To investigate the influence of Tongxinluo capsule (TXL,通心络胶囊) on regional cerebral blood flow (rCBF) with 99mTc-ECD single photon emission computed tomography (SPECT) brain perfusion imaging, and to observe the therapeutic effects of TXL on acute small cerebral infarction (ASCI). Methods: Thirty-four patients with ASCI were enrolled and randomly divided into two groups: the control group (n = 17) was treated with the conventional treatment, i.e. 1. Og of Citicoline added into 300 ml normal saline for intravenous dripping daily for 2 weeks and 0. 8 g of Piracetam taken three times a day orally for 4 weeks, and the treatment group (n = 17) was treated additionally with 4 TXL capsules three times a day for 4 weeks besides the conventional treatment. The 99mTc-ECD SPECT brain perfusion imaging was performed before and after treatment to observe the change of rCBF, and the neurological deficit was evaluated by Edinburgh-Scandinavia stroke scale (SSS) scores and Barthel index (Bl) at the same time. Results: After treatment, the rCBF in the treatment group was significantly improved (P<0. 01), while that in the control group remained unchanged, with the comparison of the rCBF in the two groups after treatment showing significant difference (P<0.01). In addition, the SSS score was significantly lower and Bl significantly higher in the treatment group than those in the control group respectively after treatment. Conclusion: TXL could effectively improve rCBF and lessen the neurological deficit symptoms in patients with ASCI.

基于小负荷血流限制训练的航天失重对抗研究展望

载人航天飞行必须应对失重暴露可能造成的一系列不良生理影响,运动锻炼是目前普遍采用的失重对抗策略。但传统的运动锻炼方案耗时大,且对运动器械的硬件要求高。血流限制(BFR)与运动锻炼相结合,只需较低的负荷即可改善肌肉结构和心血管功能。较低的训练负荷可有效降低运动损伤风险,同时降低对运动器械设备的性能配置要求。本文系统综述了BFR训练的作用机制、潜在风险及应对,提出基于小负荷的BFR训练可作为当前基于运动锻炼的失重对抗方案的有力补充。运动科学与航天医学“体医融合”的多层次多维度整合研究,有利于制定更为高效的失重防护方案,为中国空间站航天员长期驻留和未来深空探测提供更为有力的健康和安全保障。

纤溶酶联合丹红注射液溶栓疗法对缺血性脑血管病患者脑血流量和血清Hcy、S-100β水平的影响

目的纤溶酶联合丹红注射液溶栓疗法对缺血性脑血管病(ICVD)患者的疗效及对脑血流量和血清同型半胱氨酸(Hcy)、中枢神经特异蛋白(S-100β)水平的影响。方法将102例ICVD患者均分为观察组(n=51)及对照组(n=51),两组患者均给予抗血小板聚集、稳定斑块、降压、降糖等基础治疗,对照组患者给予丹红注射液治疗,观察组给予纤溶酶联合丹红注射液治疗;于治疗2周时,比较2组的治疗效果,治疗前后的脑血流灌注指标[平均流速(Vm)、峰流速(Vp)、脑血管阻力(CVR)、脉动指数(PI)]、检测血清中脑损伤指标[中枢神经特异蛋白(S-100β)、血清同型半胱氨酸(Hcy)、丙二醛(MDA)、特异性烯醇化酶(NSE)、脑源性神经营养因子(BDNF)];比较2组患者治疗前及治疗1周时的血液流变学指标(纤维蛋白原、低切全血黏度、红细胞压积、高切全血黏度、血浆黏度)及血清C反应蛋白(CRP)、白介素-6(IL-6)、肿瘤坏死因子(TNF-α)、单核细胞趋化蛋白(MCP-1)水平。结果治疗2周时,观察组患者疗效优于对照组,差异有统计学意义(P<0.05);治疗2周时,2组患者的Vm、Vp、CVR均高于治疗前,PI低于治疗前,观察组变化更显著,差异有统计学意义(P<0.05);治疗2周时,2组患者血清S-100β、Hcy、MDA、NSE均低于治疗前,BDNF高于治疗前,观察组变化更显著,差异有统计学意义(P<0.05);治疗1周时,2组患者血液高切全血黏度、低切全血黏度、血浆黏度、红细胞压积、纤维蛋白原水平及血清CRP、IL-6、TNF-α及MCP-1水平均较治疗前降低,观察组变化更显著,差异有统计学意义(P<0.05)。结论纤溶酶联合丹红注射液治疗可有效改善ICVD患者脑血流灌注,其机制可能与改变血液黏度、降低机体炎症反应有关。