Objective: The aim of this study was to compare the clinical emcacy of integration of traditional Chinese medicine (TCM) and we stern medicine, and the western medicine therapy for H type hypertension. Methods: The ra...Objective: The aim of this study was to compare the clinical emcacy of integration of traditional Chinese medicine (TCM) and we stern medicine, and the western medicine therapy for H type hypertension. Methods: The randomized contmlled trials were collected via searching the internet. The literatures were screened according to inclusion and exclusion criteria. All the assignments were performed by two researchers. If there was disagreement between the two researchers, we would ask evidence based medicine expert for advice, to get an optimal result. The database included the ChianInfo (1978—2015), the Superstar database (1955—2017), the CBM(1985—2017), CNKI(1984—2017), PubMed(1966—2017). Accordingto Meta analysis, the RevMan 5.2 software was used to recover and analyze the literatures, and make the assessment of the integration of TCM and westem medicine in treating H Type Hypertension. Results: In the study, 12 trials were included. The total number of cases is 1139. The Meta analysis results showed that: Compared with western medicine the integration of TCM and western medicine would improve the antihypertensive efficacy [OR=0.39, 95%CI (0.25, 0.59), Z=4.38(P< 0.0001)],lower Hcy levels [WMD=-1.93, 95%CI (-2.27, 0.21), Z=4.38 (P< 0.0001)]. Conclusion: The combination therapy can effectively reduce Hcy levels, control blood pressure, better than Western medicine.展开更多
To study the efficacy of Chinese medicine (CM) on isolated systolic hypertension. Seven electronic databases were searched for randomized controlled trials (RCTs) published until August 2015. Subgroup analyses and met...To study the efficacy of Chinese medicine (CM) on isolated systolic hypertension. Seven electronic databases were searched for randomized controlled trials (RCTs) published until August 2015. Subgroup analyses and meta-analysis were performed to assess the efficacy and safety of the included studies. A total of 24 studies, including 2,096 patients (1,058 patients in the intervention group and 1,038 in the control group), were evaluated in the final analysis. Compared with a conventional therapy used alone, CM as additional intervention was more effective on systolic blood pressure [mean difference (MD)=-0.66, 95% confidence interval (CI)=(-0.97,-0.36), P < 0.00001] and significantly diminished the pulse pressure [MD=-7.49, CI=(-12.69,-2.29), P < 0.00001]. However it showed no additional benefit on diastolic blood pressure [MD=1.16, CI=(0.02, 2.29), P=0.87]. Adverse events were not explicitly reported in most RCTs. CM might be a promising approach for the elderly with isolated systolic hypertension, while the evidence for CM employed alone was insufficient. Considering the inherent limitations of the included studies, larger high-quality RCTs with extensive follow-up should be performed to validate our findings in the future.展开更多
目的:系统评价中医药对高血压前期血压的影响。方法:计算机检索国内外关于中医药干预高血压前期的临床随机对照试验,使用I^2评估各研究之间的异质性,并用Rev Man 5.2.0软件进行Meta分析。结果:共纳入8篇文献,1005例受试者。Meta分析结...目的:系统评价中医药对高血压前期血压的影响。方法:计算机检索国内外关于中医药干预高血压前期的临床随机对照试验,使用I^2评估各研究之间的异质性,并用Rev Man 5.2.0软件进行Meta分析。结果:共纳入8篇文献,1005例受试者。Meta分析结果提示,与对照组相比,试验组在降低收缩压(WMD:-3.65;95%CI:-5.35^-1.94;I^2∶87%)及舒张压(WMD:-2.58;95%CI:-4.30^-0.86;I^2∶93%)方面均优于对照组,2组间的差异具有统计学意义(P<0.01)。结论:在生活方式干预的基础上,加用中医药干预有助于进一步降低血压水平。展开更多
目的对国内已发表的中医非药物疗法治疗原发性高血压的效果进行系统评价,探讨其治疗高血压的有效性。方法通过计算机文献检索CNKI、VIP,万方数据库2005—2015年间发表的有关中医非药物治疗原发性高血压的相关文献。对符合纳入标准的文...目的对国内已发表的中医非药物疗法治疗原发性高血压的效果进行系统评价,探讨其治疗高血压的有效性。方法通过计算机文献检索CNKI、VIP,万方数据库2005—2015年间发表的有关中医非药物治疗原发性高血压的相关文献。对符合纳入标准的文献资料利用Rev Man 5.0分析软件对其进行异质性检验。再用森林图进行敏感性分析,绘制漏斗图分析发表性偏倚。结果相对于药物治疗组,药物治疗加中医非药物治疗组更能提高治疗原发性高血压的有效率,P<0.01。对剔除小样本后进行敏感性分析,结果与原结果相似。绘制非药物疗法的漏斗图,但图形不对称。结论在药物治疗的基础上结合中医非药物疗法治疗原发性高血压的效果明显优于单纯药物治疗,但由于文献数量较少,尚需进一步研究。展开更多
文摘Objective: The aim of this study was to compare the clinical emcacy of integration of traditional Chinese medicine (TCM) and we stern medicine, and the western medicine therapy for H type hypertension. Methods: The randomized contmlled trials were collected via searching the internet. The literatures were screened according to inclusion and exclusion criteria. All the assignments were performed by two researchers. If there was disagreement between the two researchers, we would ask evidence based medicine expert for advice, to get an optimal result. The database included the ChianInfo (1978—2015), the Superstar database (1955—2017), the CBM(1985—2017), CNKI(1984—2017), PubMed(1966—2017). Accordingto Meta analysis, the RevMan 5.2 software was used to recover and analyze the literatures, and make the assessment of the integration of TCM and westem medicine in treating H Type Hypertension. Results: In the study, 12 trials were included. The total number of cases is 1139. The Meta analysis results showed that: Compared with western medicine the integration of TCM and western medicine would improve the antihypertensive efficacy [OR=0.39, 95%CI (0.25, 0.59), Z=4.38(P< 0.0001)],lower Hcy levels [WMD=-1.93, 95%CI (-2.27, 0.21), Z=4.38 (P< 0.0001)]. Conclusion: The combination therapy can effectively reduce Hcy levels, control blood pressure, better than Western medicine.
基金Supported by the National Natural Science Foundation of China(No.81102721 and No.81202805)a Planned Technologic Item of State Administration of Traditional Chinese Medicine(No.04-05LP30)+2 种基金Chinese National Scientific Fund for Post-Doctor(No.20070410622)its Special Aid Item(No.201003226)the Key Technologies R&D Program of Shandong Province,China(No.2010 GSF 10289)
文摘To study the efficacy of Chinese medicine (CM) on isolated systolic hypertension. Seven electronic databases were searched for randomized controlled trials (RCTs) published until August 2015. Subgroup analyses and meta-analysis were performed to assess the efficacy and safety of the included studies. A total of 24 studies, including 2,096 patients (1,058 patients in the intervention group and 1,038 in the control group), were evaluated in the final analysis. Compared with a conventional therapy used alone, CM as additional intervention was more effective on systolic blood pressure [mean difference (MD)=-0.66, 95% confidence interval (CI)=(-0.97,-0.36), P < 0.00001] and significantly diminished the pulse pressure [MD=-7.49, CI=(-12.69,-2.29), P < 0.00001]. However it showed no additional benefit on diastolic blood pressure [MD=1.16, CI=(0.02, 2.29), P=0.87]. Adverse events were not explicitly reported in most RCTs. CM might be a promising approach for the elderly with isolated systolic hypertension, while the evidence for CM employed alone was insufficient. Considering the inherent limitations of the included studies, larger high-quality RCTs with extensive follow-up should be performed to validate our findings in the future.
文摘目的:系统评价中成药治疗高血压病左心室肥厚(LVH)疗效与安全性。方法:计算机检索Pub Med、EMbase、Cochrane图书馆、中国期刊全文数据库、万方数据库、维普数据库等,收集中成药治疗高血压病左心室肥厚的随机对照试验(RCT)文献(检索时限均为建库至2014年01月),用Rev Man 5.2软件进行Meta分析。结果:初筛425篇文献,最终纳入11个RCT,计1421例患者。Meta分析结果显示:1逆转LVH作用:LVDd[WMD=0.47,95%CI(-1.36,2.30),P=0.62];IVST[WMD=-0.26,95%CI(-0.52,0.01),P=0.06]、LVPWT[WMD=-0.22,95%CI(-0.45,0.00),P=0.05]、LVMI[WMD=-1.97,95%CI(-4.24,0.30),P=0.09],各P值均大于或等于0.05,指标组间比较差异无明显统计学意义,中成药逆转高血压病LVH的作用与单用西药无明显差异。2降压疗效:SBP[OR=0.98,95%CI(-0.68,0.63),P=0.25],DBP[WMD=0.58,95%CI(-0.85,2.01),P=0.43],SBP及DBP的组间比较差异均无统计学意义,中成药在降压方面疗效西药相当。3临床症状的改善率:[OR=3.83,95%CI(1.81,8.11),P=0.000 4],P<0.05,两组间比较差异具有统计学意义,中成药治疗高血压病LVH在改善临床症状方面体现出其优势。结论:本Meta分析结果提示中成药与单纯西药比较,逆转LVH及降压作用两者相当,在改善临床症状方面,中成药有其明显优势。不良反应方面,中成药主要是胃肠道反应,而对照组的不良反应主要集中在咳嗽,与对照药选择有关(大部分为血管转化酶抑制剂)。由于本Meta分析纳入研究较少,证据强度有限,上述结论仍需更多高质量研究加以验证。
文摘目的:系统评价中医药对高血压前期血压的影响。方法:计算机检索国内外关于中医药干预高血压前期的临床随机对照试验,使用I^2评估各研究之间的异质性,并用Rev Man 5.2.0软件进行Meta分析。结果:共纳入8篇文献,1005例受试者。Meta分析结果提示,与对照组相比,试验组在降低收缩压(WMD:-3.65;95%CI:-5.35^-1.94;I^2∶87%)及舒张压(WMD:-2.58;95%CI:-4.30^-0.86;I^2∶93%)方面均优于对照组,2组间的差异具有统计学意义(P<0.01)。结论:在生活方式干预的基础上,加用中医药干预有助于进一步降低血压水平。
文摘目的对国内已发表的中医非药物疗法治疗原发性高血压的效果进行系统评价,探讨其治疗高血压的有效性。方法通过计算机文献检索CNKI、VIP,万方数据库2005—2015年间发表的有关中医非药物治疗原发性高血压的相关文献。对符合纳入标准的文献资料利用Rev Man 5.0分析软件对其进行异质性检验。再用森林图进行敏感性分析,绘制漏斗图分析发表性偏倚。结果相对于药物治疗组,药物治疗加中医非药物治疗组更能提高治疗原发性高血压的有效率,P<0.01。对剔除小样本后进行敏感性分析,结果与原结果相似。绘制非药物疗法的漏斗图,但图形不对称。结论在药物治疗的基础上结合中医非药物疗法治疗原发性高血压的效果明显优于单纯药物治疗,但由于文献数量较少,尚需进一步研究。
