Objective: To investigate the clinical effects of the mask continuous positive airway pressure (CPAP) mechanical ventilation in children with severe pneumonia. Methods: A total of 100 cases of children with severe pne...Objective: To investigate the clinical effects of the mask continuous positive airway pressure (CPAP) mechanical ventilation in children with severe pneumonia. Methods: A total of 100 cases of children with severe pneumonia were randomly divided into two groups, study group with 50 children and control group with 50 children. These 100 children were given comprehensive treatment measures: treatment of anti-infection, anti-respiratory failure, anti-heart failure (if necessary), relieving cough and reducing sputum, aerosol inhalation, limited fluid volume, nutrition support etc. Children in the study group were added mask continuous positive airway pressure mechanical ventilation (CPAP). Children in the control group were added ordinary mask oxygen inhalation. Investigated and checked the treatment effect in these two groups. Results: After treatment, SaO2, PaO2 in both two groups were showed significantly higher than before the treatment. PaO2 of the study group is obviously higher than the control group. The oxygen inhalation time of the study group was obviously lesser than the control group. The total effective rate of the study group was significantly higher than the control group which was 96.0% vs 66.0%. Conclusion: The mask continuous positive airway pressure (CPAP) mechanical ventilation can significantly improve the related symptoms and blood gas status of the children with severe pneumonia, shorten the oxygen inhalation time and had remarkable effect.展开更多
BACKGROUND The pathophysiological characteristics of severe pneumonia complicated by respiratory failure comprise pulmonary parenchymal changes leading to ventilation imbalance,alveolar capillary injury,pulmonary edem...BACKGROUND The pathophysiological characteristics of severe pneumonia complicated by respiratory failure comprise pulmonary parenchymal changes leading to ventilation imbalance,alveolar capillary injury,pulmonary edema,refractory hypoxemia,and reduced lung compliance.Prolonged hypoxia can cause acid-base balance disorder,peripheral circulatory failure,blood-pressure reduction,arrhythmia,and other adverse consequences.AIM To investigate sequential mechanical ventilation’s effect on severe pneumonia complicated by respiratory failure.METHODS We selected 108 patients with severe pneumonia complicated by respiratory failure who underwent mechanical ventilation between January 2018 and September 2020 at the Luhe Hospital’s Intensive Care Unit and divided them into sequential and regular groups according to a randomized trial,with each group comprising 54 patients.The sequential group received invasive and non-invasive sequential mechanical ventilation,whereas the regular group received invasive mechanical ventilation.Blood-gas parameters,hemodynamic parameters,respiratory mechanical parameters,inflammatory factors,and treatment outcomes were compared between the two groups before and after mechanical-ventilation treatment.RESULTS The arterial oxygen partial pressure and stroke volume variation values of the sequential group at 24,48,and 72 h of treatment were higher than those of the conventional group(P<0.05).The carbon dioxide partial pressure value of the sequential group at 72 h of treatment and the Raw value of the treatment group at 24 and 48 h were lower than those of the conventional group(P<0.05).The pH value of the sequential group at 24 and 72 h of treatment,the central venous pressure value of the treatment at 24 h,and the Cst value of the treatment at 24 and 48 h were higher than those of the conventional group(P<0.05).The tidal volume in the sequential group at 24 h of treatment was higher than that in the conventional group(P<0.05),the measured values of interleukin-6 and tumor necrosis factor-αin the sequential group at 72 h of treatment were lower than those in the conventional group(P<0.05),and the total time of mechanical ventilation in the sequential group was shorter than that in the conventional group,with a statistically significant difference(P<0.05).CONCLUSION Treating severe pneumonia complicated by respiratory failure with sequential mechanical ventilation is more effective in improving respiratory system compliance,reducing inflammatory response,maintaining hemodynamic stability,and improving patient blood-gas levels;however,from this study’s perspective,it cannot reduce patient mortality.展开更多
目的探讨俯卧位机械通气配合布地奈德雾化吸入疗法对重症肺炎患儿肺功能与免疫功能的影响。方法便利选取2023年3月—2024年3月贵阳市妇幼保健院收治的236例重症肺炎患儿为研究对象,根据治疗方法不同分为普通组(118例)和配合组(118例)。...目的探讨俯卧位机械通气配合布地奈德雾化吸入疗法对重症肺炎患儿肺功能与免疫功能的影响。方法便利选取2023年3月—2024年3月贵阳市妇幼保健院收治的236例重症肺炎患儿为研究对象,根据治疗方法不同分为普通组(118例)和配合组(118例)。所有患儿均接受布地奈德雾化吸入疗法,普通组患儿采用普通俯卧位机械通气,配合组患儿采用俯卧位机械通气,对比两组患儿的肺功能[用力肺活量(forced vital capacity,FVC)、呼气峰值体积流量(peak expiratory flow,PEF)、第1秒钟用力呼气容积(forced expiratory vol⁃ume in the first second,FEV_(1))]、免疫功能和不良反应发生情况。结果治疗前,两组患儿的肺功能指标对比,差异无统计学意义(P>0.05)。治疗后,配合组患儿的FVC、PEF、FEV_(1)均高于普通组,差异有统计学意义(P均<0.05)。治疗前,两组患儿的免疫功能指标对比,差异无统计学意义(P>0.05)。治疗后,配合组患儿的成熟T淋巴细胞(cluster of differentiation 3^(+),CD3^(+))、辅助性T淋巴细胞(cluster of differentiation 4^(+),CD4^(+))、CD4^(+)/CD8^(+)均高于普通组患儿,差异有统计学意义(P均<0.05)。配合组患儿不良反应发生率为3.39%(4/118),低于普通组患儿的5.93%(7/118),差异无统计学意义(χ^(2)=0.858,P>0.05)。结论针对重症肺炎患儿,应用俯卧位机械通气配合布地奈德雾化吸入疗法能实现较为理想的临床效果,患儿肺功能与免疫功能得到了有效改善,且安全性较高。展开更多
文摘Objective: To investigate the clinical effects of the mask continuous positive airway pressure (CPAP) mechanical ventilation in children with severe pneumonia. Methods: A total of 100 cases of children with severe pneumonia were randomly divided into two groups, study group with 50 children and control group with 50 children. These 100 children were given comprehensive treatment measures: treatment of anti-infection, anti-respiratory failure, anti-heart failure (if necessary), relieving cough and reducing sputum, aerosol inhalation, limited fluid volume, nutrition support etc. Children in the study group were added mask continuous positive airway pressure mechanical ventilation (CPAP). Children in the control group were added ordinary mask oxygen inhalation. Investigated and checked the treatment effect in these two groups. Results: After treatment, SaO2, PaO2 in both two groups were showed significantly higher than before the treatment. PaO2 of the study group is obviously higher than the control group. The oxygen inhalation time of the study group was obviously lesser than the control group. The total effective rate of the study group was significantly higher than the control group which was 96.0% vs 66.0%. Conclusion: The mask continuous positive airway pressure (CPAP) mechanical ventilation can significantly improve the related symptoms and blood gas status of the children with severe pneumonia, shorten the oxygen inhalation time and had remarkable effect.
文摘BACKGROUND The pathophysiological characteristics of severe pneumonia complicated by respiratory failure comprise pulmonary parenchymal changes leading to ventilation imbalance,alveolar capillary injury,pulmonary edema,refractory hypoxemia,and reduced lung compliance.Prolonged hypoxia can cause acid-base balance disorder,peripheral circulatory failure,blood-pressure reduction,arrhythmia,and other adverse consequences.AIM To investigate sequential mechanical ventilation’s effect on severe pneumonia complicated by respiratory failure.METHODS We selected 108 patients with severe pneumonia complicated by respiratory failure who underwent mechanical ventilation between January 2018 and September 2020 at the Luhe Hospital’s Intensive Care Unit and divided them into sequential and regular groups according to a randomized trial,with each group comprising 54 patients.The sequential group received invasive and non-invasive sequential mechanical ventilation,whereas the regular group received invasive mechanical ventilation.Blood-gas parameters,hemodynamic parameters,respiratory mechanical parameters,inflammatory factors,and treatment outcomes were compared between the two groups before and after mechanical-ventilation treatment.RESULTS The arterial oxygen partial pressure and stroke volume variation values of the sequential group at 24,48,and 72 h of treatment were higher than those of the conventional group(P<0.05).The carbon dioxide partial pressure value of the sequential group at 72 h of treatment and the Raw value of the treatment group at 24 and 48 h were lower than those of the conventional group(P<0.05).The pH value of the sequential group at 24 and 72 h of treatment,the central venous pressure value of the treatment at 24 h,and the Cst value of the treatment at 24 and 48 h were higher than those of the conventional group(P<0.05).The tidal volume in the sequential group at 24 h of treatment was higher than that in the conventional group(P<0.05),the measured values of interleukin-6 and tumor necrosis factor-αin the sequential group at 72 h of treatment were lower than those in the conventional group(P<0.05),and the total time of mechanical ventilation in the sequential group was shorter than that in the conventional group,with a statistically significant difference(P<0.05).CONCLUSION Treating severe pneumonia complicated by respiratory failure with sequential mechanical ventilation is more effective in improving respiratory system compliance,reducing inflammatory response,maintaining hemodynamic stability,and improving patient blood-gas levels;however,from this study’s perspective,it cannot reduce patient mortality.
文摘目的探讨俯卧位机械通气配合布地奈德雾化吸入疗法对重症肺炎患儿肺功能与免疫功能的影响。方法便利选取2023年3月—2024年3月贵阳市妇幼保健院收治的236例重症肺炎患儿为研究对象,根据治疗方法不同分为普通组(118例)和配合组(118例)。所有患儿均接受布地奈德雾化吸入疗法,普通组患儿采用普通俯卧位机械通气,配合组患儿采用俯卧位机械通气,对比两组患儿的肺功能[用力肺活量(forced vital capacity,FVC)、呼气峰值体积流量(peak expiratory flow,PEF)、第1秒钟用力呼气容积(forced expiratory vol⁃ume in the first second,FEV_(1))]、免疫功能和不良反应发生情况。结果治疗前,两组患儿的肺功能指标对比,差异无统计学意义(P>0.05)。治疗后,配合组患儿的FVC、PEF、FEV_(1)均高于普通组,差异有统计学意义(P均<0.05)。治疗前,两组患儿的免疫功能指标对比,差异无统计学意义(P>0.05)。治疗后,配合组患儿的成熟T淋巴细胞(cluster of differentiation 3^(+),CD3^(+))、辅助性T淋巴细胞(cluster of differentiation 4^(+),CD4^(+))、CD4^(+)/CD8^(+)均高于普通组患儿,差异有统计学意义(P均<0.05)。配合组患儿不良反应发生率为3.39%(4/118),低于普通组患儿的5.93%(7/118),差异无统计学意义(χ^(2)=0.858,P>0.05)。结论针对重症肺炎患儿,应用俯卧位机械通气配合布地奈德雾化吸入疗法能实现较为理想的临床效果,患儿肺功能与免疫功能得到了有效改善,且安全性较高。
