Background: Electrochemical therapy (ECT) has been used to treat unresectable hepatic tumor. In order to improve its efficacy, we combined ECT with hyperthermia induced by electrothermal needle (ETN) (ETECT). The aim ...Background: Electrochemical therapy (ECT) has been used to treat unresectable hepatic tumor. In order to improve its efficacy, we combined ECT with hyperthermia induced by electrothermal needle (ETN) (ETECT). The aim of this study is to investigate the destructive effect of ETECT on normal rat liver. Methods: Twenty rats were randomized into 4 treatment groups (n=5 in each group): control, ECT alone, hyperthermia alone and ETECT. Following the treatment, sections of the livers were histologically examined by light microscopy and the destructive volumes were measured with micrometer. Results: We found that the destructive volumes in ETECT group were the largest (P<0.01). In ETECT group coagulative necrosis was found in both anode and cathode areas, around which transition zones existed. The transition zones can only be seen when coulomb was in- creased in ECT group. Conclusion: ETECT was demonstrated to enhance the destructive effect of ECT. This study provides theoretical and experimental basis for a new local ablative treatment for unresectable primary liver tumor.展开更多
Expcrimcntal study was Perfumed to explore the potential benefits of electrochemical therapy (ECT) in tumor-bearing mice. The mice were divided into four groups: Group A, received ECT alone; Group B,radiotherapy alone...Expcrimcntal study was Perfumed to explore the potential benefits of electrochemical therapy (ECT) in tumor-bearing mice. The mice were divided into four groups: Group A, received ECT alone; Group B,radiotherapy alone, Group C, ECT plus radiotherapy;and group D untreated control. We find that it causes tumor growth delayed when ECT of 10 coulombs and radiotherapy 10 GY have the similar arrion of resisted canter. We also find G2-phase arrest and increase apoptosis by cell flow cytometry after treatment when ECT and/or radiation. ECT plus radiotherapy have cooperative antitumor effects.展开更多
The clinical efficacy obtained from 211 cases of middle and late stage lung cancer treated byelectrochemical therapy (ECT) were summarized. The responses are divided into CR, PR, NR, PD accord-ing to the international...The clinical efficacy obtained from 211 cases of middle and late stage lung cancer treated byelectrochemical therapy (ECT) were summarized. The responses are divided into CR, PR, NR, PD accord-ing to the international standard of four grades. The short term effectiveness within one year was : CR(29. 4% ) and PR (40. 39% ) were assessed as the total effective rate being 69. 7% , NR (13. 39% ) and PD(17. 1% ) were assessed as ineffective. The efficacy of traditional Chinese medicine (TCM) group was54. 3% ; that of ECT group was 70. 4% ; while that of TCM combined with Western medicine group ( ECT +TCM) was 84. 3% . The efficacy of ECT + TCM group was superior to the formerr two groups f P < 0. 05 ) .The 5 years long term effectiveness of ECT group was 31. 0% , TCM groiJp 15. 7% , ECT + TOM group40. 0% . Clinical analysis showed that the effect ot ECT + TCM group was the best.展开更多
文摘Background: Electrochemical therapy (ECT) has been used to treat unresectable hepatic tumor. In order to improve its efficacy, we combined ECT with hyperthermia induced by electrothermal needle (ETN) (ETECT). The aim of this study is to investigate the destructive effect of ETECT on normal rat liver. Methods: Twenty rats were randomized into 4 treatment groups (n=5 in each group): control, ECT alone, hyperthermia alone and ETECT. Following the treatment, sections of the livers were histologically examined by light microscopy and the destructive volumes were measured with micrometer. Results: We found that the destructive volumes in ETECT group were the largest (P<0.01). In ETECT group coagulative necrosis was found in both anode and cathode areas, around which transition zones existed. The transition zones can only be seen when coulomb was in- creased in ECT group. Conclusion: ETECT was demonstrated to enhance the destructive effect of ECT. This study provides theoretical and experimental basis for a new local ablative treatment for unresectable primary liver tumor.
文摘Expcrimcntal study was Perfumed to explore the potential benefits of electrochemical therapy (ECT) in tumor-bearing mice. The mice were divided into four groups: Group A, received ECT alone; Group B,radiotherapy alone, Group C, ECT plus radiotherapy;and group D untreated control. We find that it causes tumor growth delayed when ECT of 10 coulombs and radiotherapy 10 GY have the similar arrion of resisted canter. We also find G2-phase arrest and increase apoptosis by cell flow cytometry after treatment when ECT and/or radiation. ECT plus radiotherapy have cooperative antitumor effects.
文摘The clinical efficacy obtained from 211 cases of middle and late stage lung cancer treated byelectrochemical therapy (ECT) were summarized. The responses are divided into CR, PR, NR, PD accord-ing to the international standard of four grades. The short term effectiveness within one year was : CR(29. 4% ) and PR (40. 39% ) were assessed as the total effective rate being 69. 7% , NR (13. 39% ) and PD(17. 1% ) were assessed as ineffective. The efficacy of traditional Chinese medicine (TCM) group was54. 3% ; that of ECT group was 70. 4% ; while that of TCM combined with Western medicine group ( ECT +TCM) was 84. 3% . The efficacy of ECT + TCM group was superior to the formerr two groups f P < 0. 05 ) .The 5 years long term effectiveness of ECT group was 31. 0% , TCM groiJp 15. 7% , ECT + TOM group40. 0% . Clinical analysis showed that the effect ot ECT + TCM group was the best.
