Real world analysis on renal impairment of elemene emulsion injection based on propensity score matching

Objective:To explore the main factors of renal function injury caused by the combination of elemene emulsion injection in the real world.Methods:Based on the hospital information system medical database constructed by the Institute of Clinical Basic Medicine of Chinese Academy of Traditional Chinese Medicine,taking the patient information of elemene emulsion injection used in 21 top three hospitals in China as the research object,the nested case control study method was used to compare the combined medication of patients with renal function injury group and control group,The main factors that may lead to renal function injury were screened by MCP variable selection method,and the above main factors were further analyzed by classical logistic regression and propensity score logistic regression method.Results:The analysis found that the combined use of potassium chloride within 7 d before the use of elemene emulsion injection or the combined use of furosemide during the use of elemene emulsion injection may be the main factor leading to renal function injury.Conclusion:The combination of elemene emulsion injection and the above main factors that may lead to renal injury should be avoided.If it must be used,clinical monitoring should be strengthened,and abnormal reactions should be treated immediately.The results of this study have certain clinical significance,and the clinical mechanism can be further studied and explored in the future.

Elemene Emulsion Injection Administration Reduces Neuropathic Pain by Inhibiting Astrocytic NDRG2 Expression within Spinal Dorsal Horn

Objective To investigate the mechanisms underlying elemene-induced analgesia in rats with spared nerve injury(SNI).Methods Sixty-five rats were equally divided into 5 groups using a random number table:naive group,sham group,SNI group,SNI+elemene(40 mg·kg−1·d−1)group and naive+elemene(40 mg·kg−1·d−1)group.An SNI rat model was established and the intervention were given respectively for 14 consecutive days.Von Frey filament tests and elevated plus-maze(EPM)tests were used to evaluate the effect of elemene on the mechanical threshold and anxiety,respectively.Immunoblotting and immunostaining were used to measure the expression of glial fibrillary acidic protein(GFAP)and NMYC downstream-regulated gene 2(NDRG2)within the lumbar spinal dorsal horn(SDH).Results The SNI rat model exhibited a significant decrease in paw withdrawal threshold and exploratory behaviour in the EPM(P<0.05).Consecutive administration of elemene alleviated SNI-induced mechanical allodynia and anxiety in rats(P<0.05).Immunohistochemical data showed that elemene decreased SNI-induced upregulation of NDRG2 within the SDH(P<0.05).Double immunofluorescent staining data further showed that elemene decreased SNI-induced upregulation of the number of GFAP immunoreactive(-ir),NDRG-ir,and GFAP/NDRG2 double-labelled cells within the SDH(P<0.05).Immunoblotting data showed that elemene decreased SNI-induced upregulation of GFAP and NDRG2 within the SDH(P<0.05).Conclusion Elemene possibly alleviated neuropathic pain by downregulating the expression of NDRG2 in spinal astrocytes in a rat model of SNI.